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E-grāmata: Activity-Based Protein Profiling

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This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.


Activity-Based Protein Profiling---Enabling Multimodal Functional Studies of Microbial Communities
1(22)
Christopher Whidbey
Aaron T. Wright
Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles
23(26)
Shabnam Sharifzadeh
Joshua D. Shirley
Erin E. Carlson
Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria
49(24)
Hiren V. Patel
Michael Li
Jessica C. Seeliger
Activity-Based Protein Profiling at the Host-Pathogen Interface
73(20)
Yekaterina Kovalyova
Stavroula K. Hatzios
Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens
93(18)
Tao Peng
Howard C. Hang
How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling
111(20)
Gerbrand J. van der Heden van Noort
Huib Ovaa
ABPP and Host-Virus Interactions
131(24)
Genevieve F. Desrochers
John Paul Pezacki
Activity-Based Protein Profiling for the Study of Parasite Biology
155(20)
Henry J. Benns
Edward W. Tate
Matthew A. Child
Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling
175(36)
Adam L. Borne
Tao Huang
Rebecca L. McCloud
Boobalan Pachaiyappan
Timothy N. J. Bullock
Ku-Lung Hsu
Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics
211(22)
Ilsa T. Kirby
Michael S. Cohen
Development of Activity-Based Proteomic Probes for Protein Citrullination
233(20)
Venkatesh V. Nemmara
Paul R. Thompson
Recent Advances in Activity-Based Protein Profiling of Proteases
253(30)
Suravi Chakrabarty
Jan Pascal Kahler
Merel A. T. van de Plassche
Roeland Vanhoutte
Steven H. L. Verhelst
Opportunities for Lipid-Based Probes in the Field of Immunology
283(38)
Sebastiaan T. A. Koenders
Berend Gagestein
Mario van der Stelt
Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases
321(30)
Fumihiro Ishikawa
Genzoh Tanabe
Hideaki Kakeya
Target Identification of Bioacti ve Covalently Acting Natural Products
351(24)
Daniel K. Nomura
Thomas J. Maimone
Applications of Reactive Cysteine Profiling
375
Keriann M. Backus
Benjamin F. Cravatt, Ph.D.





Department of Chemistry





The Scripps Research Institute





La Jolla, CA, USA





cravatt@scripps.edu





 





Ku-Lung Hsu Ph.D.





University of Virginia School of Medicine





Department of Chemistry





Charlottesville, VA, USA





kh4ch@virginia.edu





 





Eranthie Weerapana Ph.D.





Boston College





Merkert Chemistry





Chestnut Hill, MA, USA





eranthie@bc.edu