This book provides valuable information for investigators interested in the signaling and regulatory functions of adenosine and the adenine nucleotides. Topics covered in this comprehensive volume include the historical development of research on adenosine and adenosine triphosphate; various aspects of the formation, metabolism, release, transport, and receptors for endogenous adenosine and the adenosine triphosphate; functions of purines at the cellular level; the role of adenosine in the regulation of flow in different vascular beds; and angiogenesis. The book also addresses the purinergic regulation of the cardiac, renal, gastro-intestinal, and central nervous system, as well as potential therapeutic avenues for purine use. The book will be valuable to physiologists, pharmacologists, and other basic and clinical scientists interested in updating their knowledge of the expanding biological roles of these substances.
INTRODUCTION. Historical Perspectives-Adenosine (D.J. Cushing and S.J.
Mustafa). Historical Perspectives-ATP (D. Satchell). PURINE RECEPTORS,
METABOLISM, RELEASE, AND TRANSPORT. Adenosine Receptors: Ligand-Binding
Studies (U. Schwabe). Adenosine Receptors, Adenylate Cyclase; Relationships
to Pharmacological Actions of Adenosine (R.D. Green). Formation and
Metabolism of Adenosine and Adenine Nucleotides in Cardiac Tissue (J.
Schrader). Adenosine Deaminase Regulation of Purine Actions (J.D. Geiger,
R.A. Padua, and J.I. Nagy). Nucleoside Transport in Cells: Kinetics and
Inhibitor Effects (L. Hertz). Adenosine and Adenine Nucleotides in Tissues
and Perfusates (T.D. White and K. Hoehn). FUNCTIONS OF PURINES AT THE
CELLULAR LEVEL. Adenosine, Adenine Nucleotides and Platelet Function (N.J.
Cusack and S.M.O. Hourani). Purines and Inflammation: Neutrophils Possess P1
and P2 Purine Receptors (B.N. Cronstein). Adenosine and Immune System
Function (T.S. Priebe and J.A. Nelson). Purinergic Regulation of Transmitter
Release (J.A. Ribeiro). ADENOSINE AND BLOOD FLOW IN VASCULAR BEDS. Effect of
Adenosine on the Coronary Circulation (M.G. Collis). Purinergic Control of
Skeletal Muscle Blood Flow (M.W. Gorman, S.S. Kelley, L. Kaiser, and H.V.
Sparks). Adenosine and the Regulation of Cerebral Blood Flow (D.G.L. Van
Wylen, V.M. Sciotti, and H.R. Winn). Adenosine and Blood Flow Through the
Gastrointestinal Tract (K.G. Proctor and B. Langkamp-Henken).
Adenosine-Mediated Regulation of Hepatic Blood Flow (W.E. Lautt). Effects of
Adenosine and Adenine Nucleotides on the Pulmonary Circulation (A. Hyman, B.
Cai, C. Feng, Q. Hao, and H. Lippton). The Role of Adenosine in Angiogenesis
(C.J. Meininger and H.J. Granger). ACTIONS OF ADENOSINE ON BODY SYSTEMS.
Influence of Adenosine on Cardiac Activity (M.G. Collis). Adenosine Receptor
Activation and Renal Function (W.G. Spielman). Purinergic Regulation of
Gastrointestinal Motility and Secretion (M.A. Cook). Effects of Adenosine
Infusion on the Cons
John W. Phillis
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