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E-grāmata: Advances in CRISPR/Cas and Related Technologies

Edited by (Assistant Professor, Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, India)
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Advances in CRISPR/Cas and Related TechnologiesPalielināt
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Advances in CRISPR/Cas and related technologies, Volume 179, the latest release in this ongoing series, deals with a wide variety of research topics related to recent advancement in the genome editing techniques. Associated chapters in this new release include Challenges for Therapeutic application of CRISPR Cas techniques, Mitochondrial DNA modification by CRISPR Cas System: Challenges and future direction, Trends in CRISPR Cas technology application in cancer, Modified CRISPR-Cas for next generation application, Application of CRISPR Cas in Synthetic Biology: Challenges and Scopes, History of CRISPR Cas system from bacterial Adaptive Immune System to research application, and more.
  • Covers the Cas9 protein modification for reduced off-target effect
  • Includes discussions on Cas9 utilization for Metabolic Engineering
  • Provides information on the use of Cas9 for targeted delivery in therapeutic application
Contributors ix
Preface xi
1 The evolution and history of gene editing technologies
1(62)
Shubhchintan Randhawa
Shatakshi Sengar
1 Introduction
2(4)
2 Gene editing technologies
6(23)
3 Applications of gene editing technologies
29(12)
4 Drawbacks of gene editing technologies
41(2)
5 Ethics of gene editing technologies
43(4)
6 Conclusions
47(1)
References
48(15)
2 CRISPR-Cas9: A fascinating journey from bacterial immune system to human gene editing
63(22)
Munshi Azad Hossain
1 Introduction
64(3)
2 CRISPR-Cas9: An exciting journey from bacteria to human
67(8)
3 Therapeutic applications of the CRISPR-Cas9: Technology for precise gene therapy
75(2)
4 Therapeutic applications of the CRISPR-Cas9: Problems and challenges
77(2)
5 Future research
79(1)
References
80(5)
3 Modification of Cas9, gRNA and PAM: Key to further regulate genome editing and its applications
85(14)
Rahul Gupta
Darshana Gupta
Kazi Tawsif Ahmed
Dhritiman Dey
Rajveer Singh
Snehasikta Swarnakar
V. Ravichandiran
Syamal Roy
Dipanjan Ghosh
1 Introduction
86(1)
2 Cas9 engineering
87(4)
3 Structural based re-designing of Cas9
91(2)
4 Customizing PAM specificity by leveraging directed evolution
93(1)
5 Guide RNA (gRNA) engineering
94(2)
6 Conclusion
96(1)
Acknowledgment
96(1)
Conflict of interest
97(1)
References
97(2)
4 CRISPR/dCas system as the modulator of gene expression
99(24)
Tawsif Ahmed Kazi
Swadesh Ranjan Biswas
1 Introduction
100(1)
2 CRISPRi
101(1)
3 CRISPRa
102(2)
4 Applications
104(2)
5 Epigenome engineering and CRISPRi/a
106(6)
6 dCas9 toolboxes beyond CRISPRi/a
112(2)
7 Conclusion
114(1)
Conflict of interest
115(1)
Acknowledgment
115(1)
References
115(8)
5 CRISPR-Cas system, antibiotic resistance and virulence in bacteria: Through a common lens
123(52)
Subhasree Roy
Sharmi Naha
Ankur Rao
Sulagna Basu
1 A place to begin
126(2)
2 Bacterial CRISPR-Cas system
128(2)
3 Bacterial antimicrobial resistance
130(5)
4 Interference of CRISPR-Cas with bacterial antimicrobial resistance
135(9)
5 Association of CRISPR-Cas with bacterial virulence
144(4)
6 Detection of CRISPR-Cas system in bacteria
148(4)
7 Applications of CRISPR-Cas for controlling antimicrobial resistance and virulence
152(14)
8 A place to reflect
166(1)
Acknowledgments
166(1)
Conflict of interest
167(1)
References
167(8)
6 Trends in CRISPR-Cas9 technology application in cancer
175(18)
Subhadip Mukhopadhyay
Sujit Kumar Bhutia
1 Introduction
175(1)
2 Genome-wide CRISPR-Cas9 library screening in cancer cells
176(3)
3 Potential clinical application of CRISPR in cancer therapy
179(3)
4 Quality control and bioinformatics of CRISPR guide design
182(3)
5 Perils of CRISPR-Cas technology
185(2)
6 Conclusion and future perspective
187(1)
Acknowledgment
187(1)
References
187(6)
7 Mitochondrial DNA modification by CRISPR/Cas system: Challenges and future direction
193(20)
Rajalakshmi Prakash
Anbarasu Kannan
1 Introduction
194(4)
2 Mitochondrial DNA modification in disease condition
198(5)
3 CRISPR/Cas mechanism
203(2)
4 Implementation of CRISPR/Cas in mitochondrial DNA modification
205(1)
5 Future perspective
206(2)
References
208(3)
Further reading
211(2)
8 Immune responses to CRISPR-Cas protein
213(18)
Sobhan Roy
1 Introduction
214(1)
2 The overview of CRISPR-Cas9 technology
215(1)
3 The structure of CRISPR-Cas9
215(1)
4 Challenges associated with the implication of CRISPR-CAS9 technology
216(2)
5 Immunogenicity of Cas9 proteins
218(8)
6 Future direction and strategies to deal with immunogenicity
226(1)
7 Conclusion
227(1)
Acknowledgment
227(1)
References
227(4)
9 Application of CRISPR-Cas systems in neuroscience
231(34)
Deepro Bonnerjee
Sangram Bagh
1 A basic overview of the CRISPR-Cas system
232(2)
2 Delivery and expression mechanisms in applications of CRISPR-Cas9 based disruption of genes in the mammalian CNS
234(10)
3 Gene editing with CRISPR-Cas9 in neurons
244(5)
4 The repurposed CRISPR-Cas9: Nuclease deficient-cas9 (dcas9) and neuroscience
249(8)
5 RNA-targeting with CRISPR in the neuron
257(2)
6 Perspectives and concluding remarks
259(2)
References
261(4)
Index 265
Dr. Dipanjan Ghosh has almost 19 years of research experience in the field of Molecular Biology, Cell Biology, Biochemistry, Immunology and genome editing. Presently Dr. Ghosh is working as Assistant Professor in the Department of Natural Products at National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata. After getting MSc. in Biochemistry from University of Calcutta, Dr. Ghosh went to Indian Institute of Technology (IIT) Kharagpur where he did his MTech in Biotechnology and Bioprocess Engineering and then PhD in the field of Immunology, Cancer Biology Biochemistry. In his first postdoc at University of Texas Health Science Centre at Houston he worked in the field of catalytic enzyme. He then moved to UT MD Anderson Cancer Centre, Houston TX where he gained enough experience in field of genome editing using ZFN and CRISPR Cas systems. Dr. Ghosh received DST FAST TRACK YOUNG SCIENTIST GRANT from Department of Science and Technology, India. Presently he has initiated Synthetic Biology through metabolic bioengineering at his lab and acting as leading investigator of two major funded projects (one from DBT and another one from WBDBT) in the field of CRISPR Cas mediated genome editing. Dr. Ghosh has enough experience, skill, knowledge and publication in the field of genome editing.
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