This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
Catalysis.- Emergence and Evolution.- Architecture.- Protein-protein Interactions and Multicomponent Complexes.- Interactions with RNAs.- Secretion and Circulation.- Regulatory Roles.- Neural Diseases.- Cancer.- Immune Diseases.- Pathologic Implications of Mitochondrial tRNA Synthetases .- Infectious Diseases.- Reprogramming of Genetic Code.- Novel functions of tRNAs.- Perspectives for Systems and Synthetic Bio-Medicine.
19831986 Researcher, Genetic Eng. Center, KAIST, Korea 19911994 Post-doc, MIT, USA 19931994 Senior Scientist, Cubist Pharmaceuticals, USA 1994-2001 Associate Professor, Sung Kyun Kwan University, Korea 2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ. 1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University 2008- Director, Information Center of Bio-pharmacological Network 2008- Director, Integrated Bioscience and Biotechnology Institute
