Anandamide in Health and Disease, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, is a complete reference on the roles of anandamide in health and disease states. Following the characteristics of the series, this book provides a comprehensive overview of the effects of the mediator on human health.
The book is divided into two parts, the first of which provides background information on biology, regulation, synthesis and degradation and modulation of anandamide. The second part is dedicated to covering the role of anandamide in various diseases. A comprehensive panel of authors cover several somatic and psychiatric disorders, such as anxiety disorders, mood disorders, psychosis and substance use disorders. Additionally, the role of anandamide across epilepsy, Alzheimer's disease, and digestive conditions is explored.
Anandamide in Health and Disease is the perfect reference for bioscience researchers seeking to understand anandamide pharmacology, biochemistry, cellular, and molecular biology. Clinicians may also be interested in better understanding the wide-ranging health effects of the mediator.
PART I Introduction to anandamide
1 Regulation of the levels of anandamide and its bioactive congeners by
biosynthesis and degradation
Vincenzo Di Marzo and Cristoforo Silvestri
2 Imaging the endocannabinoid enzyme fatty acid amide hydrolase in the living
human brain
Claire Shyu, Shamantha Lora, Laura M. Best, Sheldon Bereznick and Isabelle
Boileau
3 Anandamide: From modulation of neuronal excitation to antimicrobial
activities--What is in common?
Ronit Vogt Sionov and Doron Steinberg
PART II Anandamide in diseases
4 Anandamide and mood disorders
Jacklynn M. Fitzgerald and Cecilia J. Hillard
5 Anandamide and anxiety
Sara Liane Kroll and Leah M. Mayo
6 Anandamide and disease. Role in stress, fear, and PTSD
Luke J. Ney and Allison Matthews
7 Anandamide in disease: Role in psychosis
M. Belen Blasco, Carlos A. Pretell Annan and Romina Mizrahi
8 Anandamide in personality disorders
Nathan J. Kolla and Michelle De Pol
9 A brief review of anandamide in cannabis use and cannabis use disorder
Raesham Mahmood, Claudia Poluga, Isabelle Boileau and Laura M. Best
10 Anandamide signaling dysfunction in the development of alcohol use
disorders
Balapal S. Basavarajappa
11 Role of Anandamide in Nicotine Addiction
Bernard Le Foll
12 The role of anandamide in the sleep--wake cycle
Monica Mendez Daz, Yalitza Azucena Alvarado Ramrez, Aline Ostos Valverde,
Oscar E. Prospero Garca and Andrea M. Herrera Sols
13 Anandamide in disease: The good and bad in epilepsy
Renaud Gom, Pasindu Wickramarachchi, Roberto Colangeli and G. Campbell
Teskey
14 Role of anandamide in Alzheimers disease
Dina Medina-Vera and Simone Tambaro
15 The role of anandamide in digestive and defensive functions of the gut
Keith A. Sharkey and Derek K.L. Tsang
16 The role of anandamide and the endocannabinoids in the treatment and
regulation of nausea and vomiting
Erin M. Rock and Linda A. Parker
Dr. Bernard Le Foll is a Clinician Scientist specializing in Addiction. He is Chair of Addiction Psychiatry within the Department of Psychiatry of University of Toronto. He is Head of the Translational Addiction Research Laboratory in the Campbell Family Mental Health Research Institute. He is also the Lead, Clinical Research Innovation Service within the Addiction Division at CAMH. He is Head of the Alcohol Research and Treatment Clinic at CAMH. He is Professor at University of Toronto in the departments of Family and Community Medicine, Pharmacology and Toxicology, Psychiatry ,Institute of Medical Sciences and Dalla Lana School of Public Health.
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