This selection of articles reflects the growing concern for experimental animals and the continuing moral dilemma surrounding the use of animals in research. The increase in knowledge, improvement of health care and creation of useful products that is derived from experimentation on animals, carries the cost of pain and distress that the animals experience, but if such experimentation was not carried out, the alleviation of suffering in the longterm for both man and animals would not be possible. This book addresses on a technical and scientific level, the obligations that man has to animals and to their welfare. It provides insight and information on the high level of professionalism required in the handling of research animals and discusses whether the use of animals in research could be reduced, replaced or refined so as to limit distress. Experimental scientists will find the articles of interest in their endeavor to minimise distress by improving the scientific quality of experimental work.
Acknowledgements. Contributors. Addresses of Authors. Preface (Ian F.H.
Purhase)
1. Animal Experimentation and the Concept of Alternatives (Coenraad
F.M. Hendriksen).
2. Current Guidelines and Regulations in Toxicology
Research (Herman B.W.M. Koeter).
3. Long-Term Policy in Toxicology (Marcel
Roberfroid).
4. The use of Animals in the Production and Quality Control of
Biologicals: Current Practice and Possible Alternatives (Coenraad F.M.
Hendriksen).
5. Production of Biological Products and the Use of Laboratory
Animals (E. Joost Ruitenberg and Peter C. van Mourik).
6. Basic Research in
Physiology and Pharmacology, Some Introductory Remarks (Karl J. Obrink).
7.
An Overview of the Role of In Vivo and In Vitro Testing in Physiology and
Pharmacology (Carol L. Meschter, Guy Mazue and Gary H. Williams).
8.
Neurotransmission: Automated In-Vitro Assays (Cor J. de Vos, Anton M.L. van
Delft, Thijs de Boer, Ge S.F. Ruight and Joop S. de Graaf).
9. The Role of
Animal Experiments and Alternatives in Industrial Pharmacological Research
(Rian de Jonge, Jan H. Reinders and Wim J. Pereboom).
10. Experimental Animal
Reduction in Connection with Pharmacopoeial Requirements for Pharmaceuticals
(Feddo C. Hillen).
11. Education and Animal Experimentation (Bert F.M. van
Zutphen).
12. The use of Animals in Veterinary Training (Andrew N. Rowan).
13. Nutritional Factors in Animal Experimentation (Anton C. Beynen).
14. The
Role of Animal Husbandry in Promoting Welfare of Laboratory Animals (Ellen P.
Reese).
15. The Reduction of Animal Use Through Genetic Control of Laboratory
Animals (Michael F.W. Festing).
16. Prevention and Relief of Pain and
Distress (Paul A. Flecknell).
17. Clinical Assessment of Pain, Distress and
Discomfort (P.H.M. Griffiths).
18. Discomfort and Distress in Rodents During
Chronic Studies (Marga H.M. Kuijpers and H.C. Walvoort).
19. Assessment of
Distress Through Pathological Examination (Henk C. Walvoort).
20. The Effect
of Alternative Methods on the use of Animals in Biomedical Research (Coenraad
F.M. Hendriksen).
21. Perspectives (Herman B.W.M. Koeter and Coenraad F.M.
Hendriksen).
