Preface |
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xix | |
About the Author |
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xxi | |
Chapter 1 Introduction |
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1 | (1) |
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2 | (4) |
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6 | (30) |
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6 | (1) |
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1.3.2 Eukaryotes & prokaryotes |
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6 | (1) |
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6 | (8) |
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1.3.3.1 Multicellular eukaryotes |
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6 | (2) |
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8 | (5) |
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13 | (1) |
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13 | (1) |
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14 | (14) |
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14 | (12) |
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26 | (2) |
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28 | (5) |
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33 | (1) |
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34 | (2) |
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1.4 General considerations |
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36 | (25) |
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1.4.1 Microbial resistance |
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36 | (2) |
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1.4.2 Evaluation of efficacy |
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38 | (12) |
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1.4.2.1 Suspension testing |
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38 | (5) |
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43 | (2) |
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45 | (1) |
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1.4.2.4 Biological, chemical, and other indicators |
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46 | (3) |
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1.4.2.5 Parametric control |
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49 | (1) |
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1.4.2.6 Microscopy and other techniques |
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49 | (1) |
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1.4.3 Disinfection versus sterilization |
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50 | (2) |
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1.4.4 Choosing a process or product |
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52 | (1) |
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1.4.5 Guidelines and standards |
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53 | (1) |
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1.4.6 Formulation effects |
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53 | (2) |
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55 | (2) |
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1.4.8 The importance of surface cleaning |
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57 | (2) |
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59 | (2) |
Chapter 2 Physical Disinfection |
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61 | (1) |
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61 | (7) |
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61 | (2) |
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63 | (3) |
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2.2.3 Spectrum of activity |
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66 | (1) |
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67 | (1) |
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67 | (1) |
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68 | (1) |
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68 | (1) |
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68 | (9) |
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68 | (1) |
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2.4.2 Electromagnetic radiation |
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69 | (2) |
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71 | (2) |
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71 | (1) |
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72 | (1) |
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72 | (1) |
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73 | (1) |
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73 | (1) |
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74 | (1) |
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74 | (1) |
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2.4.5 Spectrum of activity |
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74 | (1) |
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74 | (1) |
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75 | (1) |
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75 | (1) |
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75 | (1) |
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75 | (1) |
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75 | (1) |
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75 | (1) |
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76 | (1) |
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76 | (1) |
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76 | (1) |
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76 | (1) |
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76 | (1) |
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76 | (1) |
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77 | (1) |
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77 | (1) |
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77 | (8) |
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2.5.1 Types and applications |
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77 | (5) |
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2.5.2 Spectrum of activity |
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82 | (2) |
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84 | (1) |
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84 | (1) |
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84 | (1) |
Chapter 3 Chemical Disinfection |
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85 | (1) |
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3.2 Acids and acid derivatives |
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85 | (4) |
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85 | (2) |
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87 | (1) |
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3.2.3 Spectrum of activity |
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88 | (1) |
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88 | (1) |
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88 | (1) |
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89 | (1) |
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89 | (2) |
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89 | (1) |
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90 | (1) |
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3.3.3 Spectrum of activity |
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90 | (1) |
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90 | (1) |
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91 | (1) |
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91 | (1) |
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91 | (6) |
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91 | (1) |
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91 | (2) |
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3.4.2.1 Glutaraldehyde and OPA |
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91 | (1) |
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92 | (1) |
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3.4.3 Spectrum of activity |
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93 | (1) |
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3.4.3.1 Glutaraldehyde and OPA |
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93 | (1) |
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94 | (1) |
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94 | (1) |
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3.4.4.1 Glutaraldehyde and OPA |
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94 | (1) |
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94 | (1) |
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95 | (1) |
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3.4.5.1 Glutaraldehyde and OPA |
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95 | (1) |
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95 | (1) |
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95 | (2) |
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3.4.6.1 Glutaraldehyde and OPA |
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95 | (2) |
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97 | (1) |
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97 | (2) |
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97 | (1) |
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97 | (1) |
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3.5.3 Spectrum of activity |
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98 | (1) |
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98 | (1) |
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99 | (1) |
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99 | (1) |
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99 | (2) |
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99 | (1) |
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100 | (1) |
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3.6.3 Spectrum of activity |
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100 | (1) |
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100 | (1) |
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100 | (1) |
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100 | (1) |
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101 | (3) |
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101 | (1) |
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101 | (1) |
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3.7.3 Spectrum of activity |
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102 | (1) |
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103 | (1) |
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103 | (1) |
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103 | (1) |
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104 | (3) |
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104 | (1) |
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104 | (1) |
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3.8.3 Spectrum of activity |
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105 | (1) |
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106 | (1) |
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106 | (1) |
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106 | (1) |
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107 | (1) |
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107 | (1) |
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107 | (1) |
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3.9.3 Spectrum of activity |
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107 | (1) |
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108 | (1) |
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108 | (1) |
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108 | (1) |
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3.10 Essential oils and plant extracts |
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108 | (3) |
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108 | (1) |
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109 | (1) |
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3.10.3 Spectrum of activity |
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109 | (1) |
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110 | (1) |
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110 | (1) |
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110 | (1) |
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3.11 Halogens and halogen-releasing agents |
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111 | (10) |
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111 | (4) |
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115 | (2) |
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115 | (1) |
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116 | (1) |
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117 | (1) |
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3.11.3 Spectrum of activity |
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117 | (1) |
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117 | (1) |
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117 | (1) |
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118 | (1) |
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118 | (1) |
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118 | (1) |
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118 | (1) |
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118 | (1) |
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119 | (1) |
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119 | (1) |
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119 | (1) |
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119 | (1) |
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120 | (1) |
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120 | (1) |
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120 | (1) |
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121 | (1) |
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121 | (5) |
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121 | (1) |
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122 | (1) |
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122 | (1) |
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123 | (1) |
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3.12.3 Spectrum of activity |
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123 | (1) |
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123 | (1) |
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124 | (1) |
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124 | (1) |
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124 | (1) |
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124 | (1) |
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124 | (1) |
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124 | (1) |
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124 | (1) |
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125 | (1) |
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125 | (1) |
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125 | (1) |
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3.13 Peroxygens and other forms of oxygen |
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126 | (17) |
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126 | (3) |
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129 | (7) |
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129 | (1) |
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3.13.2.2 Hydrogen peroxide |
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130 | (4) |
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134 | (1) |
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3.13.2.4 Chlorine dioxide |
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135 | (1) |
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3.13.3 Spectrum of activity |
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136 | (3) |
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136 | (1) |
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3.13.3.2 Hydrogen peroxide |
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137 | (1) |
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138 | (1) |
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3.13.3.4 Chlorine dioxide |
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139 | (1) |
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139 | (1) |
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139 | (1) |
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3.13.4.2 Hydrogen peroxide |
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139 | (1) |
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140 | (1) |
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3.13.4.4 Chlorine dioxide |
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140 | (1) |
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140 | (2) |
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140 | (1) |
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3.13.5.2 Hydrogen peroxide |
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140 | (1) |
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141 | (1) |
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3.13.5.4 Chlorine dioxide |
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141 | (1) |
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142 | (1) |
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142 | (1) |
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3.13.6.2 Hydrogen peroxide |
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142 | (1) |
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143 | (1) |
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3.13.6.4 Chlorine dioxide |
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143 | (1) |
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143 | (4) |
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144 | (1) |
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144 | (1) |
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3.14.3 Spectrum of activity |
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145 | (1) |
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145 | (1) |
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146 | (1) |
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146 | (1) |
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3.15 Antiseptic phenolics |
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147 | (8) |
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147 | (1) |
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148 | (1) |
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3.15.3 Antimicrobial activity |
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149 | (1) |
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150 | (1) |
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151 | (1) |
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152 | (3) |
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152 | (2) |
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154 | (1) |
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154 | (1) |
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3.16 Quaternary ammonium compounds and surfactants |
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155 | (4) |
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155 | (1) |
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156 | (1) |
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3.16.3 Antimicrobial efficacy |
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157 | (1) |
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158 | (1) |
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158 | (1) |
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158 | (1) |
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3.17 Other miscellaneous biocides or applications |
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159 | (6) |
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159 | (1) |
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3.17.2 Isothiazolones derivatives |
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159 | (1) |
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3.17.3 Biocides integrated into surfaces |
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160 | (2) |
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3.17.4 Micro-or nano-particles |
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162 | (1) |
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3.17.5 Antimicrobial enzymes, proteins, or peptides |
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163 | (2) |
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165 | (2) |
Chapter 4 Antiseptics and Antisepsis |
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167 | (1) |
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4.2 Some definitions specific to antisepsis |
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167 | (1) |
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168 | (1) |
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169 | (1) |
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4.5 Antiseptic applications |
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169 | (8) |
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4.5.1 Routine skin washing/antisepsis |
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170 | (3) |
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4.5.2 Pretreatment of skin prior to surgical intervention |
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173 | (1) |
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4.5.3 Treatment of skin or wound infections |
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174 | (3) |
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4.5.4 Treatment of oral and other mucous membranes |
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177 | (1) |
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4.5.5 Material-integrated applications |
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177 | (1) |
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4.6 Biocides used as antiseptics |
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177 | (8) |
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4.6.1 General considerations |
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177 | (3) |
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4.6.2 Major types of biocides in antiseptics |
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180 | (3) |
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4.6.3 Other antiseptic biocides |
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183 | (2) |
Chapter 5 Physical Sterilization |
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185 | (1) |
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5.2 Moist heat sterilization |
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185 | (12) |
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187 | (5) |
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192 | (1) |
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5.2.3 Spectrum of activity |
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193 | (3) |
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196 | (1) |
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196 | (1) |
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197 | (1) |
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5.3 Dry heat sterilization |
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197 | (3) |
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197 | (1) |
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198 | (1) |
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5.3.3 Spectrum of activity |
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199 | (1) |
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199 | (1) |
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199 | (1) |
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200 | (1) |
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5.4 Radiation sterilization |
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200 | (9) |
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200 | (3) |
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203 | (3) |
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5.4.3 Spectrum of activity |
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206 | (2) |
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208 | (1) |
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208 | (1) |
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209 | (1) |
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209 | (1) |
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5.6 Other physical sterilization methods |
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209 | (6) |
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209 | (2) |
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211 | (2) |
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5.6.3 Supercritical fluids |
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213 | (1) |
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5.6.4 Pulsed electric fields |
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214 | (1) |
Chapter 6 Chemical Sterilization |
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215 | (1) |
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215 | (7) |
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216 | (1) |
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216 | (3) |
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6.2.3 Spectrum of activity |
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219 | (2) |
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221 | (1) |
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221 | (1) |
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222 | (1) |
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6.3 Low temperature steam-formaldehyde |
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222 | (3) |
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6.3.1 Types and applications |
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222 | (3) |
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6.3.2 Spectrum of activity |
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225 | (1) |
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225 | (1) |
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225 | (1) |
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225 | (1) |
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6.4 High temperature formaldehyde-alcohol |
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6.4.1 Types and applications |
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225 | (1) |
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6.4.2 Spectrum of activity |
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226 | (1) |
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226 | (1) |
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226 | (1) |
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226 | (1) |
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226 | (7) |
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226 | (2) |
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228 | (4) |
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6.5.3 Spectrum of activity |
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232 | (1) |
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233 | (1) |
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233 | (1) |
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233 | (1) |
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6.6 Other oxidizing agent-based processes |
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233 | (14) |
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6.6.1 Liquid peracetic acid |
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234 | (1) |
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234 | (5) |
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234 | (2) |
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236 | (1) |
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6.6.2.3 Spectrum of activity |
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237 | (1) |
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237 | (1) |
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238 | (1) |
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238 | (1) |
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6.6.3 Gaseous peracetic acid |
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239 | (1) |
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240 | (2) |
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242 | (1) |
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242 | (5) |
Chapter 7 Mechanisms of Action |
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247 | (1) |
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248 | (3) |
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7.2.1 Antibacterials (antibiotics) |
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248 | (3) |
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251 | (1) |
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251 | (1) |
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7.2.4 Antiparasitic drugs |
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251 | (1) |
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7.3 Macromolecular structure |
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251 | (4) |
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7.4 General mechanisms of action |
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255 | (30) |
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255 | (2) |
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257 | (6) |
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7.4.3 Cross-linking or coagulating agents |
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263 | (7) |
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270 | (6) |
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7.4.5 Other structure-disrupting agents |
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276 | (9) |
Chapter 8 Mechanisms of Microbial Resistance |
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285 | (1) |
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8.2 Biocide/Microorganism interaction |
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285 | (2) |
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8.3 Intrinsic bacterial resistance mechanisms |
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287 | (42) |
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8.3.1 General stationary phase phenomenon |
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288 | (1) |
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8.3.2 Motility and chemotaxis |
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289 | (1) |
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289 | (6) |
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295 | (4) |
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8.3.5 Enzymatic and chemical protection |
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299 | (1) |
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8.3.6 Intrinsic mechanisms to heavy metals |
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300 | (2) |
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8.3.7 Capsules, slime formation, and S-layers |
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302 | (2) |
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8.3.8 Biofilm development |
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304 | (6) |
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8.3.9 Bacteria with extreme intrinsic resistance |
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310 | (2) |
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312 | (4) |
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316 | (11) |
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8.3.12 Revival mechanisms |
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327 | (2) |
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8.4 Intrinsic resistance of mycobacteria |
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329 | (4) |
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8.5 Intrinsic resistance of other Gram-positive bacteria |
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333 | (4) |
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8.6 Intrinsic resistance of Gram-negative bacteria |
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337 | (4) |
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8.7 Acquired bacterial resistance mechanisms |
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341 | (25) |
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341 | (3) |
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8.7.2 Mutational resistance |
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344 | (11) |
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8.7.3 Plasmids and transmissible elements |
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355 | (11) |
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8.8 Mechanisms of viral resistance |
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366 | (6) |
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8.9 Mechanisms of prion resistance |
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372 | (4) |
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8.10 Mechanisms of fungal resistance |
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376 | (10) |
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8.11 Mechanisms of resistance in other eukaryotic microorganisms |
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386 | (7) |
Index |
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393 | |