| Contributors |
|
xiii | |
| Preface |
|
xvii | |
|
1 Perspectives on the evolution of aquaporin superfamily |
|
|
1 | (28) |
|
|
|
|
|
|
|
1 Introduction: Aquaporin (AQP) superfamily |
|
|
2 | (1) |
|
|
|
3 | (7) |
|
3 Distribution of AQP subfamilies |
|
|
10 | (12) |
|
4 Summary and perspectives |
|
|
22 | (2) |
|
|
|
24 | (1) |
|
|
|
24 | (1) |
|
|
|
24 | (5) |
|
2 Structure and dynamics of aquaporin-1 |
|
|
29 | (18) |
|
|
|
|
|
|
|
|
|
30 | (2) |
|
|
|
32 | (3) |
|
|
|
35 | (6) |
|
4 Conclusions and outlook |
|
|
41 | (3) |
|
|
|
44 | (1) |
|
|
|
44 | (3) |
|
3 Selectivity and transport in aquaporins from molecular simulation studies |
|
|
47 | (24) |
|
|
|
|
|
1 Conformational dynamics and water transport |
|
|
50 | (5) |
|
2 Selectivity: Proton exclusion |
|
|
55 | (3) |
|
3 Selectivity: Permeation of other solutes |
|
|
58 | (2) |
|
4 Quantifying water permeability |
|
|
60 | (2) |
|
5 Interaction with lipids |
|
|
62 | (2) |
|
6 Response to electric field |
|
|
64 | (1) |
|
|
|
65 | (1) |
|
|
|
66 | (1) |
|
|
|
67 | (1) |
|
|
|
67 | (4) |
|
4 Aquaporin regulation in metabolic organs |
|
|
71 | (24) |
|
|
|
|
|
1 Aquaporins and nuclear receptors |
|
|
71 | (3) |
|
2 Aquaporins regulation in the adipose tissue |
|
|
74 | (2) |
|
3 Aquaporins in the digestive system |
|
|
76 | (5) |
|
4 Aquaporins regulation in kidney |
|
|
81 | (1) |
|
|
|
82 | (1) |
|
6 Clinical relevance of AQPs |
|
|
83 | (1) |
|
7 Conclusions and future directions |
|
|
84 | (1) |
|
|
|
84 | (11) |
|
5 Phosphorylation of human AQP2 and its role in trafficking |
|
|
95 | (24) |
|
Susanna Tornroth-Horsefield |
|
|
1 The role of AQP2 in regulating urine volume |
|
|
96 | (1) |
|
|
|
96 | (3) |
|
3 AQP2 phosphorylation and its role in trafficking |
|
|
99 | (3) |
|
4 Phosphorylation-dependent protein-protein interactions in AQP2 trafficking |
|
|
102 | (9) |
|
|
|
111 | (1) |
|
|
|
111 | (8) |
|
6 Regulation of aquaporin-2 by RNA interference |
|
|
119 | (28) |
|
|
|
|
|
|
|
|
|
1 General features of RNA interference |
|
|
120 | (4) |
|
2 Identification of small RNA molecules |
|
|
124 | (3) |
|
3 Small RNA expression in response to vasopressin or aldosterone in the kidney |
|
|
127 | (7) |
|
4 Small RNA expression in common kidney diseases: Diabetic nephropathy, acute kidney injury, and chronic kidney disease |
|
|
134 | (3) |
|
5 Conclusions and future directions |
|
|
137 | (1) |
|
|
|
138 | (1) |
|
|
|
138 | (9) |
|
7 Aquaporin regulation: Lessons from secretory vesicles |
|
|
147 | (16) |
|
|
|
|
|
161 | (1) |
|
|
|
161 | (2) |
|
8 CFTR regulation of aquaporin-mediated water transport |
|
|
163 | (16) |
|
|
|
|
|
|
|
|
|
1 Cystic fibrosis transmembrane conductance regulator (CFTR) |
|
|
164 | (2) |
|
2 CFTR regulation of aquaporin-mediated water transport |
|
|
166 | (5) |
|
3 Conclusions and future perspectives |
|
|
171 | (1) |
|
|
|
172 | (1) |
|
|
|
172 | (1) |
|
|
|
172 | (7) |
|
9 Glucocorticoid gene regulation of aquaporin-7 |
|
|
179 | (30) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Alfredo Varela-Echavarria |
|
|
|
|
|
|
180 | (2) |
|
|
|
182 | (1) |
|
3 Hormone regulation of aquaporin-7 and obesity |
|
|
183 | (2) |
|
4 Cortisone short-term regulation of AQP7 is correlated to GK and HSD1B11 gene expression in white and brown adipocytes |
|
|
185 | (14) |
|
5 Adrenergic stimulation effects over AQP7, GK and HSD1B11 mRNA expression |
|
|
199 | (2) |
|
6 Conclusions and future directions |
|
|
201 | (1) |
|
|
|
202 | (1) |
|
|
|
203 | (4) |
|
|
|
207 | (2) |
|
10 Modulation by steroid hormones and other factors on the expression of aquaporin-1 and aquaporin-5 |
|
|
209 | (34) |
|
|
|
|
|
|
|
|
|
1 Aquaporin family of water-specific channels |
|
|
210 | (5) |
|
2 Physiological relevance of aquaporins in uterus |
|
|
215 | (6) |
|
3 Hormonal regulation of AQP expression |
|
|
221 | (9) |
|
4 The effect of forskolin (AC activator) and cAMP in regulation on aquaporin expression |
|
|
230 | (2) |
|
|
|
232 | (2) |
|
6 Conclusion and future directions |
|
|
234 | (1) |
|
|
|
234 | (1) |
|
|
|
235 | (1) |
|
|
|
235 | (7) |
|
|
|
242 | (1) |
|
11 Estrogen regulates aquaporin-2 expression in the kidney |
|
|
243 | (22) |
|
|
|
|
|
|
|
|
|
244 | (1) |
|
|
|
244 | (2) |
|
3 Estrogen receptors in the kidney |
|
|
246 | (3) |
|
4 Renoprotective effects of estrogen |
|
|
249 | (2) |
|
5 Selective estrogen receptor modulators and the kidney |
|
|
251 | (1) |
|
6 Regulation of water and salt homeostasis by estrogen |
|
|
252 | (1) |
|
7 Estrogen-mediated regulation of AQP2 in the kidney |
|
|
253 | (2) |
|
8 Selective estrogen receptor modulators affect renal AQP2 |
|
|
255 | (1) |
|
9 Estrogen-mediated regulation of AQP2 in other organ systems |
|
|
256 | (2) |
|
10 Conclusions and perspectives |
|
|
258 | (1) |
|
|
|
258 | (1) |
|
|
|
258 | (7) |
|
12 Hormonal regulation of aquaporins in fishes |
|
|
265 | (24) |
|
|
|
|
|
266 | (1) |
|
2 Teleost strategies to maintain hydromineral balance |
|
|
267 | (1) |
|
3 Hormonal control of osmoregulation in teleost fishes |
|
|
268 | (2) |
|
4 Endocrine control of AQPs in osmoregulatory tissues |
|
|
270 | (7) |
|
5 Endocrine control of AQPs during gamete production |
|
|
277 | (2) |
|
|
|
279 | (1) |
|
|
|
280 | (1) |
|
|
|
280 | (9) |
|
13 Calcium sensing receptor exerts a negative regulatory action toward vasopressin-induced aquaporin-2 expression and trafficking in renal collecting duct |
|
|
289 | (22) |
|
|
|
|
|
|
|
|
|
|
|
290 | (1) |
|
2 Regulation of renal collecting duct water permeability by the vasopressin---aquaporin-2 system |
|
|
291 | (5) |
|
3 Aquaporin-2 and calcium-sensing receptor (CaSR) interplay |
|
|
296 | (6) |
|
|
|
302 | (1) |
|
|
|
303 | (1) |
|
|
|
303 | (8) |
|
14 Aquaporins and placenta |
|
|
311 | (16) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
312 | (8) |
|
|
|
320 | (7) |
|
15 Aquaporins during pregnancy |
|
|
327 | |
|
|
|
1 From the blastocyst to the placenta: The expression of aquaporins |
|
|
328 | (7) |
|
2 Classical roles of AQPs throughout gestation |
|
|
335 | (3) |
|
3 Non-classical roles of AQPs throughout gestation |
|
|
338 | (2) |
|
4 Regulation of placenta and fetal membranes AQPs |
|
|
340 | (7) |
|
5 Influence of the membrane lipid bilayer of the trophoblast cells on placental AQPs |
|
|
347 | (1) |
|
6 Influence of maternal dietary status on placental AQPs |
|
|
348 | (1) |
|
|
|
348 | (1) |
|
|
|
348 | |
