Chemists review recent and ongoing research into the chemistry of axially chiral compounds, and survey their applications relating to the biological activity of natural and synthetic derivatives. They cover the asymmetric synthesis of axially chiral biaryls and heterobiaryls; applications of axially chiral organo-catalysts; axially chiral P,P-ligands for asymmetric metal-catalyzed reactions; axially chiral monodentate phosphorous ligands for asymmetric metal-catalyzed reactions; axially chiral P,X-ligands (X = N, O, and S) for asymmetric metal-catalyzed reactions; axially chiral X,S-ligands (X - N, O) for asymmetric metal-catalyzed reactions; non-biaryl atropisomers: anilides, amides, lactams, and analogues with C-C and C-X stereogenic axes; axial chirality beyond atropisomerism: allenes and related compounds; and axially chiral natural products and bioactive compounds. Annotation ©2019 Ringgold, Inc., Portland, OR (protoview.com)
Atropoisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropoisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products. The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.
