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Autonomic Dysfunction in Parkinson's Disease, Volume 1 [Mīkstie vāki]

Edited by (Chair, Department of Neurology, County Emergency Clinic Hospital, Associate Professor of Neurology, Faculty of Medicine, Transilvania University, Brasov, Romania), Edited by (Emeritus Professor of Pharmacology, Institute of Pharmaceutical Scienc)
  • Formāts: Paperback / softback, 314 pages, height x width: 229x152 mm, weight: 450 g
  • Sērija : International Review of Movement Disorders
  • Izdošanas datums: 29-Sep-2021
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0323851223
  • ISBN-13: 9780323851220
  • Mīkstie vāki
  • Cena: 227,68 €
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  • Formāts: Paperback / softback, 314 pages, height x width: 229x152 mm, weight: 450 g
  • Sērija : International Review of Movement Disorders
  • Izdošanas datums: 29-Sep-2021
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0323851223
  • ISBN-13: 9780323851220

Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson’s disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction.

  • Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson’s disease
  • Each chapter covers a specific autonomic symptom: classification, assessment, treatment
  • Presents the newest information on each autonomic symptom in Parkinson’s disease
Contributors ix
Preface xiii
1 Autonomic nervous system-Anatomy, physiology, biochemistry
1(18)
Iva Stankovic
Ivan Adamec
Vladimir Kostic
Mario Habek
1 Anatomy of the autonomic nervous system (ANS)
1(7)
2 Physiology and biochemistry of the autonomic nervous system
8(5)
3 Autonomic control of selected organ systems
13(6)
References
16(3)
2 General approach to patients with autonomic dysfunction in Parkinson's disease
19(22)
Valentina Leta
Vanessa Raeder
K. Ray Chaudhuri
1 Introduction
19(1)
2 Epidemiology
20(4)
3 Pathophysiology
24(3)
4 Clinical expression
27(1)
5 Diagnosis
28(3)
6 Treatment
31(3)
7 Prognosis
34(1)
8 Conclusion
34(7)
References
35(6)
3 Rating scales for dysautonomia in Parkinson's disease
41(50)
Stefania Diaconu
Laura Irincu
Irina Ivan
Cristian Falup-Pecurariu
1 Introduction
43(1)
2 Method
43(1)
3 Scales
43(3)
4 General assessment scales
46(7)
5 Dysautonomia rating scales
53(2)
6 Symptom specific scales
55(18)
7 Sexual dysfunction
73(18)
References
80(11)
4 Assessing autonomic dysfunction with functional imaging in Parkinson's disease
91(28)
Jacob Horsager
Casper Skjaerbaek
Per Borghammer
1 Introduction
91(1)
2 Imaging synaptic dysfunction and denervation of the autonomic nervous system
92(8)
3 Imaging functional disturbances of the autonomic nervous system
100(10)
4 Conclusion
110(9)
References
110(9)
5 Cardiovascular autonomic failure in Parkinson's disease
119(28)
Fabian Leys
Gregor K. Wenning
Alessandra Fanciulli
1 Introduction
119(1)
2 Clinical presentation of cardiovascular autonomic failure in PD
120(6)
3 Diagnostic work-up of cardiovascular autonomic failure
126(9)
4 Treatment of cardiovascular autonomic failure in PD
135(7)
5 Summary
142(5)
References
143(4)
6 Drooling and dysphagia in Parkinson's disease
147(32)
Mauricio Paez Maggio
Santiago Perez-Lloret
Marcelo Merello
1 Introduction
147(1)
2 Physiology of salivation and swallowing
148(2)
3 Pathophysiology of drooling and dysphagia in PD
150(4)
4 Prevalence of drooling and dysphagia and clinical correlates
154(1)
5 Evaluation of drooling and dysphagia in PD
155(4)
6 Treatment options for drooling in PD
159(7)
7 Treatment options for dysphagia in PD
166(5)
8 Conclusion
171(8)
References
171(8)
7 Gastrointestinal dysfunction in Parkinson's disease
179(30)
Jonathan Timpka
Per Odin
1 Introduction and historical perspective
180(2)
2 Epidemiology of gastrointestinal dysfunction in Parkinson's disease
182(1)
3 The enteric nervous system
183(1)
4 Pathophysiology of gastrointestinal dysfunction in Parkinson's disease
184(4)
5 Braak staging and the dual hit theory
188(2)
6 Microbiota and Parkinson's disease
190(5)
7 The brain-gut-microbiota axis
195(1)
8 Treatment of gastrointestinal dysfunction in Parkinson's disease
196(5)
9 Looking forward
201(1)
10 Conclusions
202(7)
References
203(6)
8 Urinary dysfunction in Parkinson's disease
209(42)
Roongroj Bhidayasiri
Warongporn Phuenpathom
Yoshio Tsuboi
1 Introduction
209(2)
2 The basic neurology of micturition and how it is affected in Parkinson's disease
211(4)
3 Symptoms and prevalence of urinary dysfunction in Parkinson's disease
215(10)
4 Lower urinary tract symptoms in multiple system atrophy: Key distinguished features
225(2)
5 Investigations for urinary dysfunction in Parkinson's disease
227(4)
6 Management of urinary dysfunction in Parkinson's disease
231(9)
7 Conclusion
240(11)
References
242(9)
9 Autonomic dysfunction during sleep in Parkinson's disease
251(34)
Francesca Baschieri
Pietro Guaraldi
Pietro Cortelli
Giovanna Calandra-Buonaura
1 Introduction
251(2)
2 Neuroanatomical and neurophysiological aspects linking sleep and the autonomic nervous system
253(3)
3 Sleep disorders in PD associated with or causing autonomic dysfunction
256(13)
4 Autonomic dysfunction associated with PD causing sleep disturbances
269(5)
5 Conclusions
274(11)
References
275(10)
10 Thermoregulatory dysfunctions in idiopathic Parkinson's disease
285
Bianca Brim
Walter Struhal
1 Pathogenesis
287(1)
2 Symptoms
288(3)
3 Diagnosis of sudomotor dysfunction in Parkinson's disease
291(4)
4 Management of thermoregulatory symptoms in Parkinson's disease
295
References
296
Cristian Falup-Pecurariu is Head of the Department of Neurology, County Clinic Hospital from Brasov, and is Full Professor of Neurology at the Transilvania University from Brasov, Romania. He received his medical degree from the University of Medicine and Pharmacy Iuliu Hatieganu” from Cluj-Napoca. He hold a 1 year fellowship of the European Neurological Society in movement disorders at Hospital Clinic, University of Barcelona, Spain.

During his career Cristian Falup-Pecurariu was President of the European Association of Young Neurologists and Trainees (EAYNT), EAYNT Liasion Officer with World Federation of Neurological Society, co-representative of Europe on the International Working Group for Young Neurologists and Trainees (World Federation of Neurology). He was also Secretary of the EFNS/MDS-ES Panel on Movement Disorders, member of the Educational Committee of MDS-ES, member of the MDS Leadership Task Force and European Academy of Neurology Scientific Panel Movement Disorders, member of the Teaching Course sub-Committee of the European Academy of Neurology (EAN), currently being member of the Program Committee of EAN. Falup-Pecurariu is former Chair of the Education Committee of the MDS-ES, former member of the Executive Committee of MDS-ES, former member of the International Executive Committee of MDS. He is the initiator and Course Director of the Movement Disorders Teaching Course held in Brasov (12th editions). His research focuses on motor and non-motor aspects of Parkinsons diseases.

Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinsons disease. He has spent the major part of his career at Kings College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of Kings College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders.

Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinsons disease patient-carer groups across the UK.