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E-grāmata: Bacteriophage Therapy: From Lab to Clinical Practice

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  • Formāts: EPUB+DRM
  • Sērija : Methods in Molecular Biology 1693
  • Izdošanas datums: 07-Nov-2017
  • Izdevniecība: Humana Press Inc.
  • Valoda: eng
  • ISBN-13: 9781493973958
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  • Formāts: EPUB+DRM
  • Sērija : Methods in Molecular Biology 1693
  • Izdošanas datums: 07-Nov-2017
  • Izdevniecība: Humana Press Inc.
  • Valoda: eng
  • ISBN-13: 9781493973958
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This volume details the experimental approaches suitable for isolating and characterizing bacteriophages to formulating bacteriophage medicinal products and clinical application. Chapters guide readers through regulatory compliance and safety aspects of bacteriophage therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Bacteriophage Therapy: From Lab to Clinical Practice aims to ensure successful results in the further study of this vital field.

Preface v
Contributors ix
PART I ISOLATION OF BACTERIOPHAGES
1 Isolation of Bacteriophages for Fastidious Bacteria
3(8)
Shigenobu Matsuzaki
Jumpei Uchiyama
Iyo Takemura-Uchiyama
Takako Ujihara
Masanori Daibata
2 Isolation of Bacteriophages of the Anaerobic Bacteria Bacteroides
11(12)
Cristina Garcia-Aljaro
Maite Muniesa
Juan Jofre
3 Isolation of Bacteriophages for Clinically Relevant Bacteria
23(10)
Sanna Sillankorva
PART II CHARACTERIZATION OF BACTERIOPHAGES
4 In Vitro Activity of Bacteriophages Against Planktonic and Biofilm Populations Assessed by Flow Cytometry
33(10)
Diana P. Pires
Luis D.R. Melo
5 Observation of Bacteriophage Ultrastructure by Cryo-electron Microscopy
43(14)
Ana Cuervo
Jose L. Carrascosa
6 Bacteriophage Taxonomy: An Evolving Discipline
57(18)
Igor Tolstoy
Andrew M. Kropinski
J. Rodney Brister
PART III BACTERIOPHAGE SELECTION AND COCKTAIL FORMULATION
7 Determination of the Bacteriophage Host Range: Culture-Based Approach
75(10)
Andrey V. Letarov
Eugene E. Kulikov
8 Recovery and Characterization of Bacteria Resisting Infection by Lytic Bacteriophage
85(14)
Libera Latino
Christine Pourcel
9 Guidelines to Compose an Ideal Bacteriophage Cocktail
99(14)
Maia Merabishvili
Jean-Paul Pirnay
Daniel De Vos
PART IV BIODISTRIBUTION, HOST INTERACTION AND CLINICAL APPLICATION
10 Interaction of Bacteriophages with Mammalian Cells
113(10)
Zuzanna Kazmierczak
Krystyna Dabrowska
11 In Vivo Bacteriophage Biodistribution
123(16)
Nicolas Dufour
Raphaelle Delattre
Laurent Debarbieux
12 Interaction of Bacteriophages with the Immune System: Induction of Bacteriophage-Specific Antibodies
139(12)
Krystyna Dabrowska
13 Bacteriophage Treatment of Infected Diabetic Foot Ulcers
151(8)
Vera V. Morozova
Yulia N. Kozlova
Denis A. Ganichev
Nina V. Tikunova
14 Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials
159(14)
Randolph Fish
Elizabeth Kutter
Gordon Wheat
Bob Blasdel
Mzia Kutateladze
Sarah Kuhl
PART V PRODUCTION, PURIFICATION AND BACTERIOPHAGE STORAGE
15 Bacteriophage Production in Bioreactors
173(22)
Maryam Agboluaje
Dominic Sauvageau
16 Computational Modeling of Bacteriophage Production for Process Optimization
195(24)
Konrad Krysiak-Baltyn
Gregory J.O. Martin
Sally L. Gras
17 Methods for Bacteriophage Preservation
219(14)
Malgorzata B. Lobocka
Aleksandra Glowacka
Piotr Golec
PART VI SAFETY AND REGULATION
18 Bacteriophage Production in Compliance with Regulatory Requirements
233(20)
Jean-Paul Pirnay
Maia Merabishvili
Hilde Van Raemdonck
Daniel De Vos
Gilbert Verbeken
19 Guidelines for Bacteriophage Product Certification
253(18)
Alan Fauconnier
PART VII NEW PHAGE THERAPY APPROACHES
20 Nano/Micro Formulations for Bacteriophage Delivery
271(14)
Pilar Cortes
Mary Cano-Sarabia
Joan Colom
Jennifer Otero
Daniel Maspoch
Montserrat Llagostera
21 Synthetic Biology to Engineer Bacteriophage Genomes
285(16)
Ana Rita Costa
Catarina Milho
Joana Azeredo
Diana Priscila Pires
Index 301