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E-grāmata: Basic Knowledge of Pharmacology

  • Formāts: EPUB+DRM
  • Izdošanas datums: 19-Jul-2019
  • Izdevniecība: Springer Nature Switzerland AG
  • Valoda: eng
  • ISBN-13: 9783030188993
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Basic Knowledge of PharmacologyPalielināt
  • Formāts: EPUB+DRM
  • Izdošanas datums: 19-Jul-2019
  • Izdevniecība: Springer Nature Switzerland AG
  • Valoda: eng
  • ISBN-13: 9783030188993
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This is the perfect pharmacology textbook for medical and pharmacy students. The book was developed on the +30-year experience of the author as pharmacology professor in the United States and Germany. The book discusses the most important drugs (400) in the context of relevant diseases. Summary tables and schemes, MCQ exam questions, case studies and a list of drugs aid memorization of the material before an exam. All chapters are written in the same concise style and use a modern and precise pharmacological nomenclature. After reading of the book, the student will be able to critically assess the proper use of the most important drugs and advise patients properly. The didactic concept of the book has been developed on the author"s own pharmacology courses for which he has received numerous teaching awards. The book takes advantage of the learning spiral, in which material is presented repeatedly from various angles.  This book is an adaptation for an international audience of th

e German textbook "Basiswissen Pharmakologie" (2018); ISBN: 978-3-662-56303-8.

I. General Principles.- 1. Pharmacodynamics. 2. Pharmacokinetics. 3. Drug allergy. 4. Treatment of drug intoxications.- II. Pharmacology of Integrative Systems.- 5. Cholinergic and adrenergic system. 6. Serotonergic system. 7. Histaminergic system. 8. Dopaminergic system. 9. NO-cGMP system. 10. Pain pharmacology. 11. Immunopharmacology. 12. Pharmacology of the kidney.- III. Pharmacotherapy.- 13. Drugs for treatment of gastrointestinal diseases. 14. Drugs for treatment of airway diseases. 15. Antihypertensive drugs. 16. Drugs for treatment of heart failure and coronary heart disease. 17. Antiarrhythmic drugs. 18. Drugs for treatment of thromboembolic diseases . 19. Antidiabetics. 20. Drugs for treatment of osteoporosis. 21. Drugs for treatment of thryroid gland diseases. 22. Drugs for treatment of lipid metabolism disorders. 23. Drugs for treatment of gout. 24. Sex hormones. 25. Antiepileptic drugs and benzodiazepines. 26. Local anesthetics. 27. Inhalation and injection narcotics.

28. Antidepressants and mood stabilizer. 29. Antipsychotics. 30. Drugs for treatment of neurodegenerative diseases. 31. Drugs for treatment of eye diseases. 32. Drugs for treatment of tumor diseases. 33. Drugs for treatment of bacterial infections. 34. Drugs for treatment of viral infections. 35. Drugs for treatment of fungal infections. 36. Drugs for treatment of tropical diseases.- IV. Exam section.- 37. MC questions and answers. 38. Answers for case studies.- V. Service section.- 39. Drug list. 40. Index.

 Prof. Dr. Roland Seifert is Full Professor and Institute Director at Medical School Hannover (MHH), Germany. He has been teaching pharmacology for medical students for more than 30 years and since 2010 has regularly received the Best Teacher Award from the medical students, MHH. Roland Seifert is the current Editor-in-chief of the prestigious Springer journal Naunyn-Schmiedeberg"s Archives of Pharmacology.
I General Principles
1 Introduction and Pharmacodynamics
3(28)
1.1 Drugs and Poisons
5(1)
1.2 Drugs and Medicines
5(1)
1.3 International Nonproprietary Names (INN) Versus Brand Names
5(2)
1.4 Cultural Differences in Drug Use
7(1)
1.5 Mechanism-Oriented Nomenclature of Drug Classes
7(7)
1.6 Drug Development
14(1)
1.7 Pharmacological Targets: Receptors, Enzymes, Transporters, and Ion Channels
15(5)
1.8 Concentration-Response Relations: Agonists and Antagonists
20(3)
1.9 Therapeutic Index: Drug Safety
23(5)
1.10 Questions and Answers
28(1)
1.11 Exercises
29(1)
Further Reading
29(2)
2 Pharmacokinetics
31(18)
2.1 ADME Parameters: Pharmacotherapeutic Relevance
32(3)
2.2 Significance of the First-Pass Effect
35(2)
2.3 Significance of the Blood-Brain Barrier (BBB)
37(3)
2.4 Significance of the Plasma Half-Life
40(3)
2.5 Significance of CYP Inducers and CYP Inhibitors
43(3)
2.6 Question and Answers
46(1)
2.7 Exercises
47(1)
Further Reading
47(2)
3 Drug Allergy
49(8)
3.1 Pathophysiological Background
50(2)
3.2 Overview on Type I to Type IV Drug Allergies
52(1)
3.3 Pathophysiology and Therapy of Type I Reaction and Pseudoallergic Reactions
52(2)
3.4 Pathophysiology and Prevention of Type IV Reactions
54(1)
3.5 Question and Answers
54(2)
3.6 Exercises
56(1)
Further Reading
56(1)
4 Treatment of Drug Intoxications
57(12)
4.1 General Aspects on Intoxications
58(4)
4.2 Primary Poison Elimination
62(1)
4.3 Secondary Poison Elimination
62(1)
4.4 Cardinal Symptoms, Treatment, and Antidotes for Important Drug Intoxications
63(1)
4.5 Question and Answers
64(1)
4.6 Exercises
65(1)
Further Reading
65(4)
II Pharmacology of Integrative Systems
5 Cholinergic and Adrenergic System
69(14)
5.1 Physiological Background
70(1)
5.2 Acetylcholine Receptors and Adrenergic Receptors
70(5)
5.3 Pharmacological Modulation of Selected Organ Functions by Acetylcholine Receptors and Adrenergic Receptors
75(2)
5.4 Pharmacological Modulation of the Cholinergic Synapse
77(2)
5.5 Pharmacological Modulation of the Noradrenergic Synapse
79(2)
5.6 Questions and Answers
81(1)
5.7 Exercises
81(1)
Further Reading
81(2)
6 Serotonergic System
83(10)
6.1 (Patho)physiological Background
84(1)
6.2 Pharmacological Modulation of Serotonin Receptors
84(2)
6.3 Pharmacological Modulation of the Serotonergic Synapse
86(1)
6.4 Pharmacological Treatment of Migraine
87(2)
6.5 Pharmacological Treatment of Vomiting
89(1)
6.6 Questions and Answers
90(1)
6.7 Exercises
91(1)
Further Reading
91(2)
7 Histaminergic System
93(8)
7.1 (Patho)physiological Background and Histamine Receptors
94(2)
7.2 H,R Antagonists
96(1)
7.3 Pharmacological Modulation of Gastric Proton Secretion
97(1)
7.4 Pharmacological Modulation of the Mast Cell
98(1)
7.5 Questions and Answers
99(1)
7.6 Exercises
100(1)
Further Reading
100(1)
8 Dopaminergic System
101(10)
8.1 (Patho)physiological Background and Pharmacological Interventions in the Dopaminergic System
102(3)
8.2 Pathophysiology and Pharmacotherapy of Parkinson's Disease (PD)
105(3)
8.3 Pathophysiology and Pharmacotherapy of Attention Deficit Hyperactivity Disorder (ADHD)
108(1)
8.4 Questions and Answers
109(1)
8.5 Exercises
110(1)
Further Reading
110(1)
9 NO-cGMP System
111(6)
9.1 (Patho)physiological Background
112(2)
9.2 NO Donors
114(1)
9.3 PDE5 Inhibitors
114(2)
9.4 sGC Stimulators and Activators
116(1)
9.5 Question and Answers
116(1)
9.6 Exercises
116(1)
Further Reading
116(1)
10 Pain Pharmacology
117(16)
10.1 Pain Pathophysiology
118(2)
10.2 Pharmacological Interventions for Pain Therapy
120(5)
10.3 Non-MOR Agonists: COX Inhibitors, Paracetamol, and Metamizole
125(3)
10.4 MOR Agonists
128(2)
10.5 Questions and Answers
130(1)
10.6 Exercises
130(1)
Further Reading
131(2)
11 Immunopharmacology
133(16)
11.1 Pathophysiology of Autoimmune Diseases and Transplant Rejection: Pharmacological Interventions
134(8)
11.2 Glucocorticoids (GCR Agonists)
142(1)
11.3 Inhibitors of Purine and Pyrimidine Metabolism and DNA Synthesis
143(1)
11.4 Immunophilin Ligands
144(1)
11.5 Biologicals
145(1)
11.6 Questions and Answers
146(1)
11.7 Exercises
146(1)
Further Reading
147(2)
12 Pharmacology of the Kidney
149(18)
12.1 Pathophysiology of Chronic Kidney Disease (CKD)
150(9)
12.2 Pharmacotherapeutic Principles and Specific Drugs for CKD Treatment
159(1)
12.3 Dose Adjustment in CKD
160(1)
12.4 ADRs of Drugs on Kidney Function
161(1)
12.5 Questions and Answers
162(1)
12.6 Exercises
163(1)
Further Reading
163(4)
III Pharmacotherapy
13 Drugs for Treatment of Gastrointestinal Diseases
167(14)
13.1 Pathophysiology and Pharmacotherapy of Gastroesophageal Reflux Disease (GERD)
168(4)
13.2 Pathophysiology and Pharmacotherapy of Peptic Ulcer Disease (PUD)
172(2)
13.3 Pathophysiology and Pharmacotherapy of Diarrhea
174(1)
13.4 Pathophysiology and Pharmacotherapy of Constipation
175(2)
13.5 Pathophysiology and Pharmacotherapy of Ulcerative Colitis (UC) and Crohn's Disease (CD)
177(2)
13.6 Questions and Answers
179(1)
13.7 Exercises
179(1)
Further Reading
180(1)
14 Drugs for Treatment of Respiratory Tract Diseases
181(14)
14.1 Pathophysiology of Asthma
182(4)
14.2 Pharmacotherapy of Asthma
186(2)
14.3 Pathophysiology of Chronic-Obstructive Lung Disease (COPD)
188(1)
14.4 Pharmacotherapy of COPD
189(1)
14.5 Pathophysiology of Cystic Fibrosis (CF)
190(1)
14.6 Pharmacotherapy of CF
191(1)
14.7 Questions and Answers
192(1)
14.8 Exercises
192(1)
Further Reading
193(2)
15 Drugs for Treatment of Hypertension
195(12)
15.1 Pathophysiology of Hypertension
196(3)
15.2 Vascular Smooth Muscle Cells as Targets for Antihypertensive Drugs
199(1)
15.3 Pharmacological Modulation of Blood Pressure via the RAAS
200(1)
15.4 Class A Antihypertensive Drugs
201(1)
15.5 Class B Antihypertensive Drugs
202(1)
15.6 Class C Antihypertensive Drugs
202(1)
15.7 Class D Antihypertensive Drugs
203(1)
15.8 Drugs for Resistant Hypertension
203(1)
15.9 Practical Aspects of Hypertension Therapy
204(1)
15.10 Therapy of Hypertensive Emergencies
205(1)
15.11 Questions and Answers
205(1)
15.12 Exercises
206(1)
Further Reading
206(1)
16 Drugs for Treatment of Chronic Heart Failure and Coronary Heart Disease
207(12)
16.1 Pathophysiology of Chronic Heart Failure (CHF)
208(4)
16.2 Important Clinical Studies on CHF Pharmacotherapy
212(1)
16.3 CHF Pharmacotherapy
213(1)
16.4 Pathophysiology of Coronary Heart Disease (CHD) and Pharmacotherapeutic Concepts
214(2)
16.5 Questions and Answers
216(1)
16.6 Exercises
217(1)
Further Reading
217(2)
17 Drug-Induced Arrhythmias and Drugs for the Treatment of Arrhythmias
219(10)
17.1 Pathophysiology of Arrhythmias and Pharmacological Interventions
220(1)
17.2 Atrial Fibrillation (AF)
221(3)
17.3 Ventricular Tachycardia (VT)
224(1)
17.4 Torsade-de-pointes Arrhythmia (TdP)
224(2)
17.5 Questions and Answers
226(1)
17.6 Exercises
226(1)
Further Reading
226(3)
18 Drugs for Treatment of Thromboembolic Diseases
229(12)
18.1 Hemostasis, Fibrinolysis, and Pharmacological Interventions for Thromboembolic Diseases
230(4)
18.2 Heparins
234(1)
18.3 Vitamin K Antagonists (VKAs)
234(1)
18.4 Direct-Acting Oral Anticoagulants (DOACs)
235(1)
18.5 Fibrinolytics
236(1)
18.6 (Patho)physiological Regulation of Platelet Activation
236(1)
18.7 Platelet Aggregation Inhibitors (PAIs)
236(2)
18.8 Questions and Answers
238(1)
18.9 Exercises
239(1)
Further Reading
239(2)
19 Drugs for Treatment of Diabetes Mellit us
241(12)
19.1 Pathophysiology of Diabetes Mellitus (DM) and Pharmacotherapeutic Concepts
242(4)
19.2 Insulins
246(1)
19.3 Metformin
247(1)
19.4 PPAR-γ Agonists
248(1)
19.5 Sulfonylureas
248(1)
19.6 GLP-1R Agonists and DPP4 Inhibitors
248(1)
19.7 SGLT-2 Inhibitors
249(1)
19.8 α-Glucosidase Inhibitors
249(1)
19.9 Therapy of Hypoglycemia
249(1)
19.10 Therapy of Diabetic Coma
249(1)
19.11 Questions and Answers
250(1)
19.12 Exercises
250(1)
Further Reading
251(2)
20 Drugs for Treatment of Osteoporosis
253(8)
20.1 Pathophysiology of Osteoporosis and Pharmacological Interventions
254(1)
20.2 Vitamin D, and Calcium
255(3)
20.3 Bisphosphonates
258(1)
20.4 Selective Estrogen Receptor Modulators (SERMs)
258(1)
20.5 Denosumab
258(1)
20.6 Teriparatide
259(1)
20.7 Questions and Answers
259(1)
20.8 Exercises
259(1)
Further Reading
260(1)
21 Drugs for Treatment of Thyroid Gland Diseases
261(10)
21.1 Physiology of the Thyroid Gland
262(1)
21.2 Pathophysiology and Pharmacotherapy of Hyperthyroidism
263(4)
21.3 Pathophysiology and Pharmacotherapy of Hypothyroidism
267(1)
21.4 Questions and Answers
268(1)
21.5 Exercises
268(1)
Further Reading
269(2)
22 Drugs for Treatment of Dyslipidemias
271(8)
22.1 Pathogenesis of Atherosclerosis and Pharmacological Interventions
272(3)
22.2 HMG-CoA Reductase Inhibitors
275(1)
22.3 Inhibitors of Cholesterol Absorption
276(1)
22.4 Bile Acid Sequestrants
276(1)
22.5 PPAR-a Agonists
277(1)
22.6 PCSK9 Inhibitors
277(1)
22.7 Questions and Answers
277(1)
22.8 Exercises
278(1)
Further Reading
278(1)
23 Drugs for Treatment of Gout
279(8)
23.1 Pathophysiology of Gout
280(3)
23.2 Drugs for Treatment of Acute Gout
283(1)
23.3 Drugs for Treatment of Chronic Gout
284(1)
23.4 Questions and Answers
285(1)
23.5 Exercises
285(1)
Further Reading
286(1)
24 Sex Hormones: Hormonal Contraception and Hormone Replacement Therapy
287(16)
24.1 Physiology of Sex Hormones
288(2)
24.2 Pharmacological Interventions
290(4)
24.3 Hormonal Contraceptives
294(4)
24.4 Hormone Replacement Therapy (HRT) for Women
298(1)
24.5 Questions and Answers
299(1)
24.6 Exercises
300(1)
Further Reading
301(2)
25 Neuron Inhibitors with Pleiotropic Effects and Allosteric GABAAR Modulators
303(14)
25.1 Neuropsychiatric Diseases with Neuronal Imbalance: Neuron Inhibitors with Pleiotropic Effects (NIPEs) as Pharmacological Strategy
304(1)
25.2 Epilepsies as Paradigm for Diseases with Neuronal Imbalance and Treated with NIPEs
305(1)
25.3 Selected NIPEs
306(4)
25.4 Allosteric GABAAR Modulators
310(4)
25.5 Questions and Answers
314(1)
25.6 Exercises
314(1)
Further Reading
315(2)
26 Local Anesthetics
317(6)
26.1 Mechanism of Action of Local Anesthetics
318(1)
26.2 Important Local Anesthetics, Applications, and ADRs
319(2)
26.3 Vasoconstrictors in Local Anesthesia
321(1)
26.4 Questions and Answers
321(1)
26.5 Exercises
322(1)
Further Reading
322(1)
27 Inhalation and Injection Anesthetics
323(8)
27.1 Principles of Inhalation Anesthesia
324(2)
27.2 Important Inhalation Anesthetics
326(2)
27.3 Important Injection Anesthetics
328(1)
27.4 Questions and Answers
329(1)
27.5 Exercises
329(1)
Further Reading
330(1)
28 Drugs for Treatment of Depression and Bipolar Disorder
331(14)
28.1 Pathophysiology of Depression and Pharmacotherapeutic Concepts
332(6)
28.2 NSMRIs
338(1)
28.3 SSRIs
339(1)
28.4 SSNRIs
339(1)
28.5 α2AR Antagonists
339(1)
28.6 Monoamine Oxidase Inhibitors (MAOIs)
340(1)
28.7 Pathophysiology of Bipolar Disorder
340(1)
28.8 Lithium and NIPEs
340(2)
28.9 Nontraditional Indications of NE/5-HT Enhancers and Lithium
342(1)
28.10 Treatment of Depression with p-mGPCR Antagonists
342(1)
28.11 Questions and Answers
343(1)
28.12 Exercises
344(1)
Further Reading
344(1)
29 Drugs for Treatment of Schizophrenia
345(12)
29.1 Pathophysiology of Schizophrenia and Pharmacotherapeutic Concepts
346(4)
29.2 D2R-mGPCR Antagonists
350(2)
29.3 p-mGPCR Antagonists
352(1)
29.4 Nontraditional Indications of mGPCR Antagonists
353(1)
29.5 Treatment of Schizophrenia with NE/5-HT Enhancers, Lithium, and NIPEs
354(1)
29.6 Questions and Answers
354(1)
29.7 Exercises
355(1)
Further Reading
355(2)
30 Drugs for the Treatment of Alzheimer's Disease
357(8)
30.1 Pathophysiology of Dementias and Pharmacotherapeutic Concepts
358(2)
30.2 Currently Used Drugs
360(1)
30.3 Pharmacological Strategies to Reduce Tau Aggregates
361(1)
30.4 Pharmacological Strategies to Reduce Amyloid Plaques
361(1)
30.5 Questions and Answers
362(1)
30.6 Exercises
362(1)
Further Reading
363(2)
31 Drugs for the Treatment of Glaucoma and Age-Related Macular Degeneration
365(10)
31.1 Pathophysiology of Glaucoma
366(1)
31.2 Pharmacotherapy of Glaucoma
367(3)
31.3 Pathophysiology of Age-Related Macular Degeneration (AMD)
370(1)
31.4 Pharmacotherapy of AMD
370(2)
31.5 Questions and Answers
372(1)
31.6 Exercises
372(1)
Further Reading
373(2)
32 Drugs for the Treatment of Malignant Tumor Diseases
375(16)
32.1 Pathophysiology of Malignant Tumors and Pharmacological Interventions
377(6)
32.2 Principles of Tumor Therapy
383(1)
32.3 Classic Cytostatics
384(2)
32.4 Targeted Therapeutics
386(2)
32.5 Questions and Answers
388(1)
32.6 Exercises
388(1)
Further Reading
389(2)
33 Drugs for the Treatment of Bacterial Infections
391(20)
33.1 Principles of Antibacterial Chemotherapy
392(10)
33.2 Important Bacterial Infections and Their Pharmacotherapy
402(1)
33.3 Antibiotics Inhibiting Cell Wall Biosynthesis
403(1)
33.4 Antibiotics Inhibiting DNA Replication
404(1)
33.5 Antibiotics Inhibiting Protein Biosynthesis
405(1)
33.6 Antibiotics Inhibiting Dihydrofolate Reductase
406(1)
33.7 Anti-TB Drugs
407(1)
33.8 Questions and Answers
408(1)
33.9 Exercises
408(1)
Further Reading
408(3)
34 Drugs for the Treatment of Viral Infections
411(12)
34.1 Overview of Viral Infections and Pharmacological Interventions
412(5)
34.2 Virustatics for Treatment of Herpes Virus Infections
417(1)
34.3 Virustatics for Treatment of HIV Infections
418(1)
34.4 Virustatics for Treatment of Hepatitis C
419(1)
34.5 Questions and Answers
420(1)
34.6 Exercises
420(1)
Further Reading
421(2)
35 Drugs for the Treatment of Fungal Infections
423(10)
35.1 Overview of Important Fungal Infections and Their Pharmacotherapy
424(5)
35.2 Azole Antimycotics
429(1)
35.3 Polyene Antimycotics
429(1)
35.4 Echinocandins
430(1)
35.5 Questions and Answers
430(1)
35.6 Exercises
431(1)
Further Reading
431(2)
36 Integrative Case Studies
433(12)
36.1 Lessons from History: Arrhythmias After Tropical Fruit Party
435(1)
36.2 Questions and Answers
435(1)
36.3 Generalized Pruritus and Lack of Antibiotic Efficacy in Uncomplicated Cystitis
436(1)
36.4 Questions and Answers
436(1)
36.5 Pain Despite Therapy with Analgesics
436(1)
36.6 Questions and Answers
437(1)
36.7 Toddler with GI Infection and Spasmodic Torticollis in the Emergency Room
437(1)
36.8 Questions and Answers
438(1)
36.9 Critical Assessment of a Medication Plan
438(1)
36.10 Questions and Answers
438(1)
36.11 Ballerina with Nervousness and Hypertension
439(1)
36.12 Questions and Answers
439(1)
36.13 Gestational DM Due to Fenoterol Infusion?
440(1)
36.14 Questions and Answers
440(1)
36.15 Meaningful Long-Term Therapy with Pantoprazole?
440(1)
36.16 Questions and Answers
441(1)
36.17 Nervous Breakdown After Nocturnal Computer Sessions
441(1)
36.18 Questions and Answers
442(1)
36.19 Sufficient Analgesic Therapy for Metastasizing Mammary Carcinoma?
442(1)
36.20 Questions and Answers
442(1)
Further Reading
443(2)
37 The "100 List" of Drugs
445(25)
37.1 How the "100 List" Was Compiled
447(1)
37.2 Important Indications Covered by the "100 List"
447(13)
37.3 Unique Drugs in the"100 List" and Structurally Related Drugs
460(1)
37.4 Clinical Application of the "100 List"
461(1)
37.5 Important Medical Fields Covered by the "100 List"
461(1)
37.6 Risk of Abuse of the "100 List"
462(1)
37.7 Cultural Differences in the Availability and Use of the "100 List"
463(1)
37.8 Pricing of the "100 List"
464(1)
37.9 20 Drugs from the "100 List" that Every Physician Should Prescribe
465(1)
37.10 Why Certain Commonly Prescribed Drugs Are Not in the "100 List"
466(1)
37.11 Questions and Answers
467(1)
37.12 Exercises
467(1)
Further Reading
468(2)
Supplementary Information
List of Generic Drugs 470(15)
Index 485
Prof. Dr. Roland Seifert is Full Professor and Institute Director at Medical School Hannover (MHH), Germany. He has been teaching pharmacology for medical students for more than 30 years and since 2010 has regularly received the Best Teacher Award from the medical students, MHH.

Roland Seifert is the current Editor-in-chief of the prestigious Springer journal Naunyn-Schmiedeberg's Archives of Pharmacology.
Biežāk uzdotie jautājumi par e-grāmatām Biežāk uzdotie jautājumi par e-grāmatām
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