| Foreword |
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v | |
| Reviewers |
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vi | |
| Acknowledgements |
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vii | |
| Symposium |
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1 | (2) |
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Molecular mechanisms of general anesthetic action |
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GABAA receptor interactions with propofol: Binding site location and conformational changes |
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3 | (6) |
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Significances of protein structure and dynamics in anesthetic action |
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9 | (6) |
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The four-helix bundle: An attractive fold |
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15 | (6) |
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Potentiation of GABAA receptors by neurosteroids: Mechanisms and sites |
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21 | (5) |
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Structural elements governing activation and modulation of GABAA receptors |
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26 | (6) |
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Equilibrium and kinetic allosteric mechanisms for anesthetic and structure function studies of GABAA receptors |
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32 | (6) |
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Anesthetic sensitivity is reduced in hippocampal pyramidal neurons from GABAA receptor α5 subunit null mutant mice |
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38 | (5) |
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Anesthetics modulate the release of glutamate and GABA via neuronal nicotinic acetylcholine receptors |
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43 | (6) |
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Kinetics of metoclopramide effects on human 5-HT3A receptors |
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49 | (6) |
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Alcohol and anesthetic action at the gate of a voltage-dependent K+ channel |
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55 | (6) |
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Identification of general anesthetic targets |
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Anesthetic sites on GABAA receptors |
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61 | (6) |
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The GABAA receptor: An important target for the general anaesthetic etomidate |
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67 | (6) |
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Non-immobilizers put to the test: F6 and the GABAA receptor |
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73 | (6) |
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General anesthetic action on 5-HT3 receptors: Influence of subunit composition |
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79 | (6) |
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Cation--π interactions modulate the NMDA receptor inhibitory potencies of inhaled aromatic anesthetics |
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85 | (5) |
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Two-pore K channels: Still viable sites of action? |
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90 | (6) |
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The yin and yang of volatile anesthetic action on cardiac potassium channels |
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96 | (6) |
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A multifunctional protein, calreticulin, in pathway(s) of volatile anesthetics in Drosophila |
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102 | (6) |
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G-protein-coupled receptors as targets for anesthetics |
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108 | (5) |
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Genetic evidence in Caenorhabditis elegans implicates a syntaxin-1A-binding protein as critical for presynaptic volatile anesthetic action |
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113 | (6) |
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An ion channel that influences anesthesia sensitivity: Designing a genetic test for assessing a candidate anesthetic target |
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119 | (7) |
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Integration of anesthetic targets into systems |
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The spinal cord, anesthesia and immobility: A re-examination |
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126 | (6) |
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Mechanisms of nitrous oxide-induced analgesic effects |
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132 | (5) |
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Possible role of the N-methyl-D-aspartate receptor GluRε1 subunit in ketamine hypnosis and analgesia |
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137 | (6) |
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β3-containing GABAA receptors mediate the immobilizing and, in part, the hypnotic actions of etomidate and propofol |
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143 | (8) |
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149 | (2) |
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Theoretical models for anesthetic modification of gating in LGICs |
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Structural prediction of barbital-acetylcholine receptor complex from docking simulation |
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151 | (4) |
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Structural changes in a four-alpha-helix bundle protein following sevoflurane binding |
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155 | (5) |
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Normal mode analysis reveals the channel gating motion within a ligand gated ion channel model |
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160 | (4) |
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Spinal mechanisms of anesthetic action |
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Action of isoflurane on the substantia gelatinosa neurons of the adult rat spinal cord |
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164 | (4) |
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Differentiation of spinal and cerebral effects of anaesthetics in humans using clinical electrophysiology techniques |
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168 | (4) |
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The lamprey isolated spinal cord as a model for anesthetic effects on vertebrate locomotor systems |
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172 | (5) |
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Potassium and related channels |
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Action and mechanism of ethanol on Ca2+-activated potassium channels |
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177 | (4) |
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TRESK is a mammalian anesthetic-sensitive K channel |
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181 | (4) |
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Effects of anesthetics on ATP-sensitive K channels in rat substantia nigra |
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185 | (4) |
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The α5 GABAA receptor subunit confers resistance to isoflurane inhibition |
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189 | (4) |
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The tonic inhibition mediated by GABAA receptor in substantia gelatinosa neurons |
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193 | (2) |
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Will neural networks provide the answer to anesthetic mechanisms of action? |
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Effects of general anesthetics on excitatory and inhibitory synaptic pathways of hippocampus in vitro |
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195 | (4) |
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Excitatory effects of low concentrations of general anesthetics on hippocampal pathways |
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199 | (4) |
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Physiochemical aspects of anesthesia |
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Mobility and location of anesthetics in lipid bilayer membranes by high-resolution, high-field-gradient NMR |
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203 | (4) |
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Comparative study of specific and non-specific interactions between bio-macromolecules and ligands |
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207 | (4) |
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Effect of volatile anesthetics on the structure of photosynthetic antenna complex in lipid bilayers |
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211 | (4) |
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Thermodynamic aspect of anesthetic action |
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Anesthetic and non-anesthetic effects on interfacial lipids around an ion channel |
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215 | (4) |
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The binding of 10 general anesthetics to a four-alpha-helix bundle protein displays enthalpy--entropy compensation |
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219 | (4) |
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Antagonism of general anesthetics |
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223 | (4) |
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Theoretical model of anesthetic action upon ion channels mediated by lipid membrane |
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227 | (4) |
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Monitoring the depth of anesthesia |
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What are electroencephalogram entropies really measuring? |
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231 | (4) |
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Clinical monitoring for depth of anesthesia: Bispectral index (BIS) |
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235 | (4) |
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What we can know from bispectral analysis of EEG? |
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239 | (4) |
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Ligand-gated receptors/channels and general anesthetics |
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General anesthetic modulation of neuronal nicotinic acetylcholine receptors |
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243 | (4) |
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5-HT3A receptor kinetics: Agonist and anesthetic action |
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247 | (6) |
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251 | (2) |
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Distinct molecular targets for the central respiratory and cardiac actions of etomidate and propofol |
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253 | (3) |
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Xenon acts by inhibition of non-NMDA receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans |
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256 | (2) |
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Identification of differentially regulated genes in rat dorsal root ganglia after the treatment of artemin |
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258 | (2) |
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Ether-resistant mutant of laminin alpha subunit (LanA) in Drosophila melanogaster |
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260 | (3) |
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Drosophila A-kinase anchor protein 200, protein kinase A and diethylether anesthesia |
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263 | (2) |
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Relationship between the splicing pattern of the Drosophila sodium channel gene and the phenotypic variety |
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265 | (2) |
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Isoflurane sensitivity of Drosophila axons is enhanced in an Na+ channel mutant |
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267 | (2) |
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Ligand-gated ion channels and anesthesia |
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Inhibitory effects of pentobarbital on glutamate-induced calcium increase in presynaptic nerve terminals |
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269 | (2) |
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Irreversible modulation of GABAA receptors by azi-etomidate, a photo-reactive general anesthetic |
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271 | (2) |
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A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors |
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273 | (2) |
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Effects of general anesthetics on P2X7 receptors in rat microglia |
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275 | (2) |
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Volatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes |
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277 | (2) |
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Ion channels and anesthesia |
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Ionic mechanisms of thiopental on prolongation of action potential duration in rat ventricular myocytes |
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279 | (2) |
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Reversible effect of lidocaine on raft formation |
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281 | (2) |
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The modulation of GIRK channels by halothane is essentially determined by its C terminus |
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283 | (2) |
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B. Steinecker-Frohnwieser |
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Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes |
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285 | (3) |
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Interpreting the impact of GABAA receptor structural modifications using an allosteric co-agonist mechanism for etomidate actions |
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288 | (2) |
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How long does it take for your favorite drug to diffuse into and out of a tight spot? |
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290 | (2) |
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The effect of sevoflurane on mitochondrial function in brain synaptosomes |
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292 | (2) |
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Interaction of the amyloid precursor-like protein 1 with α2-adrenoceptors |
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294 | (2) |
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Actions of anesthetics on networks |
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Comparison of antagonizing potencies of dodecane analogues with isoflurane in goldfish |
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296 | (2) |
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Comparison of antagonizing potencies of saturated and unsaturated long-chain free fatty acids with isoflurane in goldfish |
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298 | (2) |
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The effect of propofol, midazolam and remifentanil on the paired-pulse-depression of the human H-reflex |
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300 | (2) |
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Thiopental prevents anoxic depolarization during anoxia in area CA1 of rat hippocampal slices |
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302 | (2) |
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Differential actions of volatile and intravenous anesthetics on recurrent inhibitory interneurons in rat hippocampal slices |
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304 | (2) |
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The structure of the neural network is related to the anesthetic potency of inhalation anesthetics |
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306 | (2) |
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Physiochemical aspects of anesthesia |
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Adsorption mechanism of volatile anesthetic molecules on a phospholipid monolayer |
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308 | (2) |
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Naphthalene compound, 2-toluidino-6-naphthalenesulfonate, increases effective concentrations of halothane and isoflurane in goldfish |
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310 | (2) |
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Propofol acts on different sites than ethanol and butanol in recombinant glycine receptors: Evidence from pressure studies |
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312 | (3) |
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Nanobubble formation and its implication for a channel blocking mechanism of anaesthetic action |
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315 | (3) |
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Validation of hypothesis of pressure reversal mechanisms: ``Anesthetic binds to site, and squeezed out by pressure'' |
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318 | (2) |
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Local anesthetic tetracaine induces the interdigitation of lipid bilayers |
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320 | (2) |
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Effect of an inhalation anesthetic on the viscosity of aqueous bovine serum albumin solutions |
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322 | (2) |
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Recognition for long-chain saturated fatty acids, by dipalmitoylphosphatidylcholine bilayer membranes |
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324 | (2) |
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Study on the interaction between bovine serum albumin and inhalation anesthetic halothane by differential scanning calorimetry |
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326 | (2) |
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Partition coefficients of local anesthetic into phospholipid-cholesterol mixed bilayer membranes |
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328 | (2) |
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Distribution of charged and uncharged local anesthetics into phospholipid bilayer membrane: Correlation between partition coefficients and anesthetic potency |
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330 | (2) |
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Effect of heavy water on the synaptic transmission |
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332 | (3) |
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| Author index |
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335 | (4) |
| Keyword index |
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339 | |
