The editors (all of St. Boniface General Hospital, Canada) present 22 multidisciplinary papers that investigate molecular mechanisms of dysfunction in diabetes and cardiovascular disease. Insulin's influence on protein and energy metabolism is a key concern at various levels of sub-cellular signaling, intracellular calcium handling, protein expression, and energy regulation. Reprinted from Molecular and Cellular Biochemistry , vol. 249 (2003). Annotation (c) Book News, Inc., Portland, OR (booknews.com)
Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes. This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.
Preface; J. Gilchrist, et al.
1. Inhibition of glycation reaction in
tissue protein incubations by water soluble rutin derivative; T. Nagasawa,
et al.
2. Comparative analysis of the phenolic content of selected Chilean,
Canadian and American Merlot wines; R.S. Faustino, et al.
3. Absence of
ischemic preconditioning protection in diabetic sheep hearts: role of
sarcolemmal KATP channel dysfunction; H.F. del Valle, et al.
4. Protein
Kinase B in the Diabetic Heart; B. Huisamen.
5. Inhibition of interleukin-1b
convertase is associated with decrease of neointimal hyperplasia after
coronary artery stenting in pigs; M. Gyongyosi, et al.
6. Effects of
MCC-135 on Ca2+ uptake by Sarcoplasmic Reticulum and myofilament sensitivity
to Ca2+ in isolated ventricular muscles of rats with diabetic
cardiomyopathy; N. Satoh, Y. Kitada.
7. Effect of sarpogrelate on altered
STZ-diabetes induced cardiovascular responses to 5-hydroxytrypamine in rats;
D.N. Umrani, et al.
8. Mitogen-activate protein kinases in the acute
diabetic myocardium; M. Strniskova, et al.
9. Association between coronary
endothelial dysfunction and local inflammation of atherosclerotic coronary
arteries; T. Matsubara, et al.
10. Arteriosclerosis in rat aortic
allografts: Dynamics of cell growth, apoptosis and expression of
extracellular matrix proteins; P. Religa, et al.
11. Effect of chronic
treatment with losartan on streptozotocin-induced renal dysfunction; B.
Murali, et al.
12. The relationship between human cytomegalovirus infection
and atherosclerosis development; R. Chen, et al.
13. Changes in substrate
metabolism in isolated mouse hearts following ischemia-reperfusion; E.
Aasum, et al.
14. A comparison between NMR and GCMS 13C-isotopomer analysis
in cardiac metabolism; J.C. Chatham, et al.
15. Chronic diabetes alters
function and expression of ryanodine receptor calcium release channels in
rat hearts; K.R. Bidasee, et al.
16. The relationship between QTc interval
and cardiac autonomic neuropathy in diabetes mellitus; A. Pourmoghaddas, A.
Hekmatnia.
17. Antioxidants decreases the intensification of low density
lipoprotein in vivo peroxidation during therapy with statins; V.Z. Lankin,
et al.
18. Native and minimally oxidized low density lipoproteins depress
smooth muscle matrix metalloproteinase levels; D. Wilson, et al.
19. Low
matrix metalloproteinase levels precede vascular lesion formation in the
JCR:LA-cp rat; D. Wilson, et al.
20. Impairment of glucose metabolism and
energy transfer in the hypertriglyceridemic rat heart; K. Carvajal, et al.
21. Ischemic tolerance of rat hearts in acute and chronic phases of
experimental diabetes; T. Ravingerova, et al.
22. Remodeling of the
sarcolemma in diabetic rat hearts: The role of membrane fluidity; B.
Ziegelhoffer-Mihalovicova, et al.
