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Biology: How Life Works, Volume 1 2nd ed. 2090 [Mīkstie vāki]

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  • Formāts: Paperback / softback, 800 pages, 800 p., 1 Paperback / softback
  • Izdošanas datums: 27-Nov-2015
  • Izdevniecība: W.H.Freeman & Co Ltd
  • ISBN-10: 131904882X
  • ISBN-13: 9781319048822
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  • Formāts: Paperback / softback, 800 pages, 800 p., 1 Paperback / softback
  • Izdošanas datums: 27-Nov-2015
  • Izdevniecība: W.H.Freeman & Co Ltd
  • ISBN-10: 131904882X
  • ISBN-13: 9781319048822
Citas grāmatas par šo tēmu:
Rethinking biology means rethinking the text, the visual program, and assessment.Ordinarily, textbooks are developed by first writing chapters, then making decisions about art and images, and finally, once the book is complete, assembling a test bank and ancillary media. This process dramatically limits the integration across resources, and reduces art, media, and assessments to ancillary material, rather than essential resources for student learning.Biology: How Life Works is the first project to develop three pillars—the text, the visual program, and the assessment—at the same time. All three pillars were developed in parallel to make sure that each idea is addressed in the most appropriate medium, and to ensure authentic integration. These three pillars are all tied to the same set of core concepts, share a common language, and use the same visual palette. In this way, the text, visual program, and assessments are integral parts of student learning, rather than just accessories to the text.RETHINKING THE TEXTIntegratedBiology: How Life Works moves away from a focus on disparate topics, towards an integrated approach. Chemistry is presented in context, structure and function are covered together, the flow of information in a cell is introduced where it makes the most conceptual sense, and cases serve as a framework for connecting and assimilating information.SelectiveBiology: How Life Works was envisioned not as a reference book for all of biology, but a resource focused on foundational concepts, terms, and experiments. This allows students to more easily identify, understand, and apply critical concepts, and develop a framework on which to build their understanding of biology.ThematicBiology: How Life Works was written with six themes in mind. Introduced in Chapter 1 and revisited throughout, these themes provide a framework that helps students see biology as a set of connected concepts. In particular, the theme of evolution is emphasized for its ability to explain and predict so many patterns in biology.RETHINKING THE VISUAL PROGRAMIntegratedAcross Biology: How Life Works—whether students are looking at a figure in the book, watching an animation, or interacting with a simulation—they always see a consistent use of color, shapes, and design.EngagingEvery image—still and in motion—engages students by being vibrant, clear, and approachable. The result is a visual environment that is expertly designed to pull students in, deepens their interest, and helps them see a world of biological processes.A Visual FrameworkTo help students think like biologists, the visual program is designed to be a framework for students to hang the concepts and connect ideas. Individual figures present foundational concepts; Visual Synthesis figures tie multiple concepts across chapters together; animations bring these figures to life; and simulations let students interact with the concepts. Collectively, this visual framework allows students to move seamlessly back and forth between the big picture and the details.RETHINKING THE ASSESSMENTRangeDeveloped by a broad community of leading science
About the Authors vi
Preface viii
Acknowledgments xxiii
Chapter 1 Life Chemical, Cellular, and Evolutionary Foundations 3(26)
1.1 The Scientific Method
4(4)
Observation allows us to draw tentative explanations called hypotheses
4(1)
A hypothesis makes predictions that can be tested by observation and experiments
5(1)
General explanations of natural phenomena supported by many experiments and observations are called theories
6(2)
How Do We Know? What caused the extinction of the dinosaurs?
7(1)
1.2 Chemical and Physical Principles
8(4)
The living and nonliving worlds share the same chemical foundations and obey the same physical laws
8(2)
The scientific method shows that living organisms come from other living organisms
10(2)
How Do We Know? Can living organisms arise from nonliving matter?
10(1)
How Do We Know? Can microscopic life arise from nonliving matter?
11(1)
1.3 The Cell
12(3)
Nucleic acids store and transmit information needed for growth, function, and reproduction
12(2)
Membranes define cells and spaces within cells
14(1)
Metabolism converts energy from the environment into a form that can be used by cells
14(1)
A virus is genetic material in need of a cell
15(1)
1.4 Evolution
15(4)
Variation in populations provides the raw material for evolution
15(1)
Evolution predicts a nested pattern of relatedness among species, depicted as a tree
16(1)
Evolution can be studied by means of experiments
17(2)
How Do We Know? Can evolution be demonstrated in the laboratory?
18(1)
1.5 Ecological Systems
19(1)
Basic features of anatomy, physiology, and behavior shape ecological systems
19(1)
Ecological interactions play an important role in evolution
20(1)
1.6 The Human Footprint
20(9)
Case 1: The First Cell: Life's Origins
25(4)
Chapter 2 The Molecules Of Life 29(20)
2.1 Properties of Atoms
30(2)
Atoms consist of protons, neutrons, and electrons
30(1)
Electrons occupy regions of space called orbitals
30(1)
Elements have recurring, or periodic, chemical properties
31(1)
2.2 Molecules and Chemical Bonds
32(3)
A covalent bond results when two atoms share electrons
33(1)
A polar covalent bond is characterized by unequal sharing of electrons
33(1)
An ionic bond forms between oppositely charged ions
34(1)
A chemical reaction involves breaking and forming chemical bonds
35(1)
2.3 Water: The Medium of Life
35(2)
Water is a polar molecule
35(1)
A hydrogen bond is an interaction of a hydrogen atom and an electronegative atom
35(1)
Hydrogen bonds give water many unusual properties
36(1)
pH is a measure of the concentration of protons in solution
37(1)
2.4 Carbon: Life's Chemical Backbone
37(2)
Carbon atoms form four covalent bonds
38(1)
Carbon-based molecules are structurally and functionally diverse
38(1)
2.5 Organic Molecules
39(6)
Functional groups add chemical character to carbon chains
39(1)
Proteins are composed of amino acids
40(1)
Nucleic acids encode genetic information in their nucleotide sequence
40(2)
Complex carbohydrates are made up of simple sugars
42(1)
Lipids are hydrophobic molecules
43(2)
2.6 How Did the Molecules of Life Form?
45(4)
The building blocks of life can be generated in the laboratory
45(1)
How Do We Know? Could the building blocks of organic molecules have been generated on the early Earth?
46(1)
Experiments show how life's building blocks can form macromolecules
46(3)
Chapter 3 Nucleic Acids And Transcription 49(20)
3.1 Major Biological Functions of DNA
50(3)
DNA can transfer biological characteristics from one organism to another
50(1)
How Do We Know ? What is the nature of the genetic material?
51(1)
DNA molecules are copied in the process of replication
51(1)
Genetic information flows from DNA to RNA to protein
51(2)
How Do We Know ? What is the nature of the genetic material?
52(1)
3.2 Chemical Composition and Structure of DNA
53(5)
A DNA strand consists of subunits called nucleotides
53(1)
DNA is a linear polymer of nucleotides linked by phosphodiester bonds
54(1)
Cellular DNA molecules take the form of a double helix
55(1)
The three-dimensional structure of DNA gave important clues about its functions
56(2)
Cellular DNA is coiled and packaged with proteins
58(1)
3.3 Retrieval of Genetic Information Stored in DNA: Transcription
58(5)
What was the first nucleic acid molecule, and how did it arise?
59(1)
RNA is a polymer of nucleotides in which the 5-carbon sugar is ribose
59(1)
In transcription, DNA is used as a template to make complementary RNA
60(1)
Transcription starts at a promoter and ends at a terminator
60(2)
RNA polymerase adds successive nucleotides to the 3' end of the transcript
62(1)
The RNA polymerase complex is a molecular machine that opens, transcribes, and closes duplex DNA
63(1)
3.4 Fate of the RNA Primary Transcript
63(6)
Messenger RNA carries information for the synthesis of a specific protein
63(1)
Primary transcripts in eukaryotes undergo several types of chemical modification
64(1)
Some RNA transcripts are processed differently from protein- coding transcripts and have functions of their own
65(4)
Chapter 4 Translation And Protein Structure 69(20)
4.1 Molecular Structure of Proteins
70(7)
Amino acids differ in their side chains
71(1)
Successive amino acids in proteins are connected by peptide bonds
72(1)
The sequence of amino acids dictates protein folding, which determines function
73(1)
Secondary structures result from hydrogen bonding in the polypeptide backbone
73(2)
How Do We Know? What are the shapes of proteins?
74(1)
Tertiary structures result from interactions between amino acid side chains
75(1)
Polypeptide subunits can come together to form quaternary structures
76(1)
Chaperones help some proteins fold properly
76(1)
4.2 Translation: How Proteins Are Synthesized
77(9)
Translation uses many molecules found in all cells
77(2)
The genetic code shows the correspondence between codons and amino acids
79(2)
How Do We Know? How was the genetic code deciphered?
80(1)
Translation consists of initiation, elongation, and termination
81(5)
How did the genetic code originate?
83(1)
Visual Synthesis: Gene Expression
84(2)
4.3 Protein Evolution and the Origin of New Proteins
86(3)
Most proteins are composed of modular folding domains
86(1)
Amino acid sequences evolve through mutation and selection
86(3)
Chapter 5 Organizing Principles Lipids, Membranes, and Cell Compartments 89(26)
5.1 Structure of Cell Membranes
90(4)
Cell membranes are composed of two layers of lipids
90(2)
How did the first cell membranes form?
91(1)
Cell membranes are dynamic
92(1)
Proteins associate with cell membranes in different ways
93(1)
5.2 The Plasma Membrane and Cell Wall
94(6)
How Do We Know? Do proteins move in the plane of the membrane?
95(1)
The plasma membrane maintains homeostasis
96(1)
Passive transport involves diffusion
96(1)
Primary active transport uses the energy of ATP
97(1)
Secondary active transport is driven by an electrochemical gradient
98(1)
Many cells maintain size and composition using active transport
99(1)
The cell wall provides another means of maintaining cell shape
100(1)
5.3 The Internal Organization of Cells
100(4)
Eukaryotes and prokaryotes differ in internal organization
101(1)
Prokaryotic cells lack a nucleus and extensive internal compartmentalization
101(1)
Eukaryotic cells have a nucleus and specialized internal structures
101(3)
5.4 The Endomembrane System
104(7)
The endomembrane system compartmentalizes the cell
104(1)
The nucleus houses the genome and is the site of RNA synthesis
105(1)
The endoplasmic reticulum is involved in protein and lipid synthesis
105(1)
The Golgi apparatus modifies and sorts proteins and lipids
105(2)
Lysosomes degrade macromolecules
107(1)
Protein sorting directs proteins to their proper location in or out of the cell
108(3)
5.5 Mitochondria and Chloroplasts
111(4)
Mitochondria provide the eukaryotic cell with most of its usable energy
111(1)
Chloroplasts capture energy from sunlight
111(4)
Chapter 6 Making Life Work Capturing and Using Energy 115(16)
6.1 An Overview of Metabolism
116(2)
Organisms can be classified according to their energy and carbon sources
116(1)
Metabolism is the set of chemical reactions that sustain life
117(1)
6.2 Kinetic and Potential Energy
118(1)
Kinetic and energy potential energy are two forms of energy
118(1)
Chemical energy is a form of potential energy
118(1)
ATP is a readily accessible form of cellular energy
119(1)
6.3 The Laws of Thermodynamics
119(1)
The first law of thermodynamics: Energy is conserved
119(1)
The second law of thermodynamics: Energy transformation always results in an increase of disorder in the universe
119(1)
6.4 Chemical Reactions
120(4)
A chemical reaction occurs when molecules interact
120(1)
The laws of thermodynamics determine whether a chemical reaction requires or releases energy available to do work
121(1)
The hydrolysis of ATP releases energy
122(1)
Non-spontaneous reactions are often coupled to spontaneous reactions
123(1)
6.5 Enzymes and the Rate of Chemical Reactions
124(7)
Enzymes reduce the activation energy of a chemical reaction
124(1)
Enzymes form a complex with reactants and products
125(1)
Enzymes are highly specific
126(1)
How Do We Know? Do enzymes form complexes with substrates?
126(1)
Enzyme activity can be influenced by inhibitors and activators
127(1)
Allosteric enzymes regulate key metabolic pathways
127(5)
What naturally occurring elements might have spurred the first reactions that led to life?
128(3)
Chapter 7 Cellular Respiration Harvesting Energy from Carbohydrates and Other Fuel Molecules 131(22)
7.1 An Overview of Cellular Respiration
132(3)
Cellular respiration uses chemical energy stored in molecules such as carbohydrates and lipids to provide ATP
132(1)
ATP is generated by substrate-level phosphorylation and oxidative phosphorylation
133(1)
Redox reactions play a central role in cellular respiration
133(2)
Cellular respiration occurs in four stages
135(1)
7.2 Glycolysis: The Splitting of Sugar
135(2)
Glycolysis is the partial breakdown of glucose
137(1)
7.3 Pyruvate Oxidation
137(1)
The oxidation of pyruvate connects glycolysis to the citric acid cycle
137(1)
7.4 The Citric Acid Cycle
138(2)
The citric acid cycle produces ATP and reduced electron carriers
138(2)
What were the earliest energy-harnessing reactions?
139(1)
7.5 The Electron Transport Chain and Oxidative Phosphorylation
140(4)
The electron transport chain transfers electrons and pumps protons
140(2)
The proton gradient is a source of potential energy
142(1)
ATP synthase converts the energy of the proton gradient into the energy of ATP
142(2)
How Do We Know? Can a proton gradient drive the synthesis of ATP?
143(1)
7.6 Anaerobic Metabolism and the Evolution of Cellular Respiration
144(3)
Fermentation extracts energy from glucose in the absence of oxygen
145(2)
How did early cells meet their energy requirements?
146(1)
7.7 Metabolic Integration
147(6)
Excess glucose is stored as glycogen in animals and starch in plants
147(1)
Sugars other than glucose contribute to glycolysis
147(1)
Fatty acids and proteins are useful sources of energy
148(1)
The intracellular level of ATP is a key regulator of cellular respiration
149(1)
Exercise requires several types of fuel molecules and the coordination of metabolic pathways
150(3)
Chapter 8 Photosynthesis Using Sunlight to Build Carbohydrates 153(26)
8.1 Photosynthesis: An Overview
154(3)
Photosynthesis is widely distributed
154(1)
Photosynthesis is a redox reaction
155(1)
The photosynthetic electron transport chain takes place on specialized membranes
155(2)
How Do We Know? Does the oxygen released by photosynthesis come from H20 or CO2?
156(1)
8.2 The Calvin Cycle
157(3)
The incorporation of CO2 is catalyzed by the enzyme rubisco
157(1)
NADPH is the reducing agent of the Calvin cycle
158(1)
The regeneration of RuBP requires ATP
158(1)
The steps of the Calvin cycle were determined using radioactive CO2
158(1)
Carbohydrates are stored in the form of starch
158(2)
How Do We Know? How is CO2 used to synthesize carbohydrates?
159(1)
8.3 Capturing Sunlight into Chemical Forms
160(6)
Chlorophyll is the major entry point for light energy in photosynthesis
160(1)
Photosystems use light energy to drive the photosynthetic electron transport chain
161(1)
The photosynthetic electron transport chain connects two photosystems
162(2)
How Do We Know? Do chlorophyll molecules operate on their own or in groups?
163(1)
The accumulation of protons in the thylakoid lumen drives the synthesis of ATP
164(2)
Cyclic electron transport increases the production of ATP
166(1)
8.4 Challenges to Photosynthetic Efficiency
166(4)
Excess light energy can cause damage
166(2)
Photorespiration leads to a net loss of energy and carbon
168(1)
Photosynthesis captures just a small percentage of incoming solar energy
169(1)
8.5 The Evolution of Photosynthesis
170(9)
How did early cells use sunlight to meet their energy requirements?
170(1)
The ability to use water as an electron donor in photosynthesis evolved in cyanobacteria
170(1)
Eukaryotic organisms are believed to have gained photosynthesis by endosymbiosis
171(9)
Visual Synthesis: Harnessing Energy: Photosynthesis and Cellular Respiration
172(4)
Case 2: Cancer: When Good Cells Go Bad
176(3)
Chapter 9 Cell Signaling 179(18)
9.1 Principles of Cell Communication
180(2)
Cells communicate using chemical signals that bind to specific receptors
180(1)
Signaling involves receptor activation, signal transduction, response, and termination
181(1)
9.2 Cell Signaling over Long and Short Distances
182(3)
Endocrine signaling acts over long distances
183(1)
Signaling can occur over short distances
183(1)
How Do We Know? Where do growth factors come from?
184(1)
Signaling can occur by direct cell-cell contact
184(1)
9.3 Cell-Surface and Intracellular Receptors
185(2)
Receptors for polar signaling molecules are on the cell surface
185(1)
Receptors for nonpolar signaling molecules are in the interior of the cell
186(1)
Cell-surface receptors act like molecular switches
186(1)
9.4 G Protein-Coupled Receptors and Short-Term Responses
187(4)
The first step in cell signaling is receptor activation
187(1)
Signals are often amplified in the cytosol
188(1)
Signals lead to a cellular response
188(2)
Signaling pathways are eventually terminated
190(1)
9.5 Receptor Kinases and Long-Term Responses
191(6)
Receptor kinases phosphorylate each other, activate intercellular signaling pathways, lead to a response, and are terminated
192(1)
How do cell signaling errors lead to cancer?
192(1)
Signaling pathways are integrated to produce a response in a cell
193(4)
Chapter 10 Cell And Tissue Architecture 197(22)
10.1 Tissues and Organs
198(2)
Tissues and organs are communities of cells
198(1)
The structure of skin relates to its function
199(1)
10.2 The Cytoskeleton
200(6)
Microtubules and microfilaments are polymers of protein subunits
200(1)
Microtubules and microfilaments are dynamic structures
201(1)
Motor proteins associate with microtubules and micro- filaments to cause movement
202(2)
Intermediate filaments are polymers of proteins that vary according to cell type
204(1)
The cytoskeleton is an ancient feature of cells
205(1)
10.3 Cell Junctions
206(4)
Cell adhesion molecules allow cells to attach to other cells and to the extracellular matrix
206(1)
Anchoring junctions connect adjacent cells and are reinforced by the cytoskeleton
207(1)
Tight junctions prevent the movement of substances through the space between cells
208(2)
Communicating junctions allow the passage of molecules between cells
210(1)
10.4 The Extracellular Matrix
210(9)
The extracellular matrix of plants is the cell wall
211(1)
The extracellular matrix is abundant in connective tissues of animals
212(2)
How do cancer cells spread throughout the body?
213(1)
Extracellular matrix proteins influence cell shape and gene expression
214(6)
How Do We Know? Can extracellular matrix proteins influence gene expression?
215(4)
Chapter 11 Cell Division Variations, Regulation, and Cancer 219(28)
11.1 Cell Division
220(2)
Prokaryotic cells reproduce by binary fission
220(1)
Eukaryotic cells reproduce by mitotic cell division
221(1)
The cell cycle describes the life cycle of a eukaryotic cell
221(1)
11.2 Mitotic Cell Division
222(4)
The DNA of eukaryotic cells is organized as chromosomes
222(1)
Prophase: Chromosomes condense and become visible
223(1)
Prometaphase: Chromosomes attach to the mitotic spindle
224(1)
Metaphase: Chromosomes align as a result of dynamic changes in the mitotic spindle
224(1)
Anaphase: Sister chromatids fully separate
224(1)
Telophase: Nuclear envelopes re-form around newly segregated chromosomes
225(1)
The parent cell divides into two daughter cells by cytokinesis
225(1)
11.3 Meiotic Cell Division
226(7)
Pairing of homologous chromosomes is unique to meiosis
226(1)
Crossing over between DNA molecules results in exchange of genetic material
227(1)
The first meiotic division brings about the reduction in chromosome number
227(1)
The second meiotic division resembles mitosis
228(3)
Division of the cytoplasm often differs between the sexes
231(1)
Meiosis is the basis of sexual reproduction
231(2)
11.4 Regulation of the Cell Cycle
233(3)
Protein phosphorylation controls passage through the cell cycle
233(2)
How Do We Know? How is progression through the cell cycle controlled?
234(1)
Different cyclin-CDK complexes regulate each stage of the cell cycle
235(1)
Cell cycle progression requires successful passage through multiple checkpoints
235(1)
11.5 What Genes Are Involved in Cancer?
236(11)
Oncogenes promote cancer
236(2)
How Do We Know? Can a virus cause cancer?
237(1)
Proto-oncogenes are genes that when mutated may cause cancer
238(1)
Tumor suppressors block specific steps in the development of cancer
238(1)
Most cancers require the accumulation of multiple mutations
238(10)
Visual Synthesis: Cellular Communities
240(4)
Case 3: You, from A to T: Your Personal Genome
244(3)
Chapter 12 Dna Replication And Manipulation 247(24)
12.1 DNA Replication
248(6)
During DNA replication, the parental strands separate and new partners are made
248(2)
How Do We Know? How is DNA replicated?
249(1)
New DNA strands grow by the addition of nucleotides to the 3' end
250(1)
In replicating DNA, one daughter strand is synthesized continuously and the other in a series of short pieces
251(1)
A small stretch of RNA is needed to begin synthesis of a new DNA strand
252(1)
Synthesis of the leading and lagging strands is coordinated
252(2)
DNA polymerase is self-correcting because of its proof- reading function
254(1)
12.2 Replication of Chromosomes
254(3)
Replication of DNA in chromosomes starts at many places almost simultaneously
254(1)
Telomerase restores tips of linear chromosomes shortened during DNA replication
255(2)
12.3 Isolation, Identification, and Sequencing of DNA Fragments
257(7)
The polymerase chain reaction selectively amplifies regions of DNA
257(2)
Electrophoresis separates DNA fragments by size
259(1)
Restriction enzymes cleave DNA at particular short sequences
260(1)
DNA strands can be separated and brought back together again
261(2)
DNA sequencing makes use of the principles of DNA replication
263(1)
What new technologies are being developed to sequence your personal genome?
264(1)
12.4 Genetic Engineering
264(7)
Recombinant DNA combines DNA molecules from two or more sources
264(2)
Recombinant DNA is the basis of genetically modified organisms
266(1)
DNA editing can be used to alter gene sequences almost at will
267(4)
Chapter 13 Genomes 271(20)
13.1 Genome Sequencing
272(3)
How Do We Know? How are whole genomes sequenced?
272(1)
Complete genome sequences are assembled from smaller pieces
272(1)
Sequences that are repeated complicate sequence assembly
273(2)
Why sequence your personal genome?
274(1)
13.2 Genome Annotation
275(3)
Genome annotation identifies various types of sequence
275(1)
Genome annotation includes searching for sequence motifs
276(1)
Comparison of genomic DNA with messenger RNA reveals the intron—exon structure of genes
276(1)
An annotated genome summarizes knowledge, guides research, and reveals evolutionary relationships among organisms
277(1)
The HIV genome illustrates the utility of genome annotation and comparison
277(1)
13.3 Gene Number, Genome Size, and Organismal Complexity
278(3)
Gene number is not a good predictor of biological complexity
278(1)
Viruses, bacteria, and archaeons have small, compact genomes
279(1)
Among eukaryotes, there is no relationship between genome size and organismal complexity
279(1)
About half of the human genome consists of transposable elements and other types of repetitive DNA
280(1)
13.4 Organization of Genomes
281(4)
Bacterial cells package their DNA as a nucleoid composed of many loops
281(1)
Eukaryotic cells package their DNA as one molecule per chromosome
282(1)
The human genome consists of 22 pairs of chromosomes and two sex chromosomes
282(3)
Organelle DNA forms nucleoids that differ from those in bacteria
285(1)
13.5 Viruses and Viral Genomes
285(6)
Viruses can be classified by their genomes
286(1)
The host range of a virus is determined by viral and host surface proteins
287(1)
Viruses have diverse sizes and shapes
287(1)
Viruses are capable of self-assembly
288(3)
Chapter 14 Mutation And Dna Repair 291(18)
14.1 The Rate and Nature of Mutations
292(5)
For individual nucleotides, mutation is a rare event
292(1)
Across the genome as a whole, mutation is common
293(1)
Only germ-line mutations are transmitted to progeny
293(2)
What can your personal genome tell you about your genetic risk factors?
294(1)
Mutations are random with regard to an organism's needs
295(2)
How Do We Know? Do mutations occur randomly, or are they directed by the environment?
296(1)
14.2 Small-Scale Mutations
297(4)
Point mutations are changes in a single nucleotide
297(1)
Small insertions and deletions involve several nucleotides
298(2)
Some mutations are due to the insertion of a transposable element
300(1)
How Do We Know? What causes sectoring in corn kernels?
300(1)
14.3 Chromosomal Mutations
301(2)
Duplications and deletions result in gain or loss of DNA
301(1)
Gene families arise from gene duplication and evolutionary divergence
302(1)
An inversion has a chromosomal region reversed in orientation
303(1)
A reciprocal translocation joins segments from nonhomologous chromosomes
303(1)
14.4 DNA Damage and Repair
303(6)
DNA damage can affect both DNA backbone and bases
303(1)
Most DNA damage is corrected by specialized repair enzymes
304(5)
Chapter 15 Genetic Variation 309(16)
15.1 Genotype and Phenotype
310(4)
Genotype is the genetic makeup of a cell or organism; phenotype is its observed characteristics
310(1)
The effect of a genotype often depends on several factors
310(1)
Some genetic differences are major risk factors for disease
311(1)
Not all genetic differences are harmful
312(1)
A few genetic differences are beneficial
313(1)
15.2 Genetic Variation and Individual Uniqueness
314(2)
Areas of the genome with variable numbers of tandem repeats are useful in DNA typing
314(1)
Some polymorphisms add or remove restriction sites in the DNA
315(1)
15.3 Genomewide Studies of Genetic Variation
316(2)
Single-nucleotide polymorphisms (SNPs) are single-base changes in the genome
316(2)
How can genetic risk factors be detected?
317(1)
Copy-number variation constitutes a significant proportion of genetic variation
318(1)
15.4 Genetic Variation in Chromosomes
318(7)
Nondisjunction in meiosis results in extra or missing chromosomes
319(1)
Some human disorders result from nondisjunction
319(1)
How Do We Know? What is the genetic basis of Down syndrome?
320(1)
Extra or missing sex chromosomes have fewer effects than extra autosomes
320(2)
Nondisjunction is a major cause of spontaneous abortion
322(3)
Chapter 16 Mendelian Inheritance 325(20)
16.1 Early Theories of Inheritance
326(1)
Early theories of heredity predicted the transmission of acquired characteristics
326(1)
Belief in blending inheritance discouraged studies of hereditary transmission
326(1)
16.2 The Foundations of Modern Transmission Genetics
327(3)
Mendel's experimental organism was the garden pea
327(1)
In crosses, one of the traits was dominant in the offspring
328(2)
16.3 Segregation: Mendel's Key Discovery
330(5)
Genes come in pairs that segregate in the formation of reproductive cells
330(1)
The principle of segregation was tested by predicting the outcome of crosses
331(1)
A testcross is a mating to an individual with the homozygous recessive genotype
332(1)
Segregation of alleles reflects the separation of chromosomes in meiosis
332(1)
Dominance is not universally observed
332(1)
The principles of transmission genetics are statistical and stated in terms of probabilities
333(1)
Mendelian segregation preserves genetic variation
334(1)
16.4 Independent Assortment
335(4)
Independent assortment is observed when genes segregate independently of one another
335(2)
How Do We Know? How are single-gene traits inherited?
336(1)
Independent assortment reflects the random alignment of chromosomes in meiosis
337(1)
Phenotypic ratios can be modified by interactions between genes
338(1)
16.5 Patterns of Inheritance Observed in Family Histories
339(6)
Dominant traits appear in every generation
339(1)
Recessive traits skip generations
340(1)
Many genes have multiple alleles
340(1)
Incomplete penetrance and variable expression can obscure inheritance patterns
341(5)
How do genetic tests identify disease risk factors?
342(3)
Chapter 17 Inheritance Of Sex Chromosomes, Linked Genes, And Organelles 345(18)
17.1 The X and Y Sex Chromosomes
346(2)
In many animals, sex is genetically determined and associated with chromosomal differences
346(1)
Segregation of the sex chromosomes predicts a 1:1 ratio of females to males
347(1)
17.2 Inheritance of Genes in the X Chromosome
348(5)
X-linked inheritance was discovered through studies of male fruit flies with white eyes
348(1)
Genes in the X chromosome exhibit a "crisscross" inheritance pattern
348(2)
X-linkage provided the first experimental evidence that genes are in chromosomes
350(1)
Genes in the X chromosome show characteristic patterns in human pedigrees
351(2)
17.3 Genetic Linkage and Recombination
353(4)
Nearby genes in the same chromosome show linkage
353(2)
The frequency of recombination s a measure of the distance between linked genes
355(1)
Genetic mapping assigns a location to each gene along a chromosome
355(1)
How Do We Know? Can recombination be used to construct a genetic map of a chromosome?
356(1)
Genetic risk factors for disease can be localized by genetic mapping
356(1)
17.4 Inheritance of Genes in the Y Chromosome
357(2)
Y-linked genes are transmitted from father to son to grandson
357(2)
How can the Y chromosome be used to trace ancestry?
358(1)
17.5 Inheritance of Mitochondria! and Chloroplast DNA
359(4)
Mitochondrial and chloroplast genomes often show uniparental inheritance
359(1)
Maternal inheritance is characteristic of mitochondrial diseases
360(4)
How can mitochondrial DNA be used to trace ancestry?
360(3)
Chapter 18 The Genetic And Environmental Basis Of Complex Traits 363(14)
18.1 Heredity and Environment
364(4)
Complex traits are affected by the environment
365(1)
Complex traits are affected by multiple genes
366(1)
The relative importance of genes and environment can be determined by differences among individuals
367(1)
Genetic and environmental effects can interact in unpredictable ways
367(1)
18.2 Resemblance Among Relatives
368(3)
For complex traits, offspring resemble parents but show regression toward the mean
369(1)
Heritability is the proportion of the total variation due to genetic differences among individuals
370(1)
18.3 Twin Studies
371(2)
Twin studies help separate the effects of genes and environment in differences among individuals
371(2)
How Do We Know? What is the relative importance of genes and of the environment for common traits?
372(1)
18.4 Complex Traits in Health and Disease
373(4)
Most common diseases and birth defects are affected by many genes that each have relatively small effects
373(1)
Human height is affected by hundreds of genes
374(4)
Can personalized medicine lead to effective treatments of common diseases?
375(2)
Chapter 19 Genetic And Epigenetic Regulation 377(22)
19.1 Chromatin to Messenger RNA in Eukaryotes
378(6)
Gene expression can be influenced by chemical modification of DNA or histones
378(2)
Gene expression can be regulated at the level of an entire chromosome
380(2)
Transcription is a key control point in gene expression
382(3)
RNA processing is also important in gene regulation
385
19.2 Messenger RNA to Phenotype in Eukaryotes
384(2)
Small regulatory RNAs inhibit translation or promote mRNA degradation
384(1)
Translational regulation controls the rate, timing, and location of protein synthesis
384(1)
Protein structure and chemical modification modulate protein effects on phenotype
385(1)
How do lifestyle choices affect expression of your personal genome?
386(1)
19.3 Transcriptional Regulation in Prokaryotes
386(13)
Transcriptional regulation can be positive or negative
387(1)
Lactose utilization in E. coli is the pioneering example of transcriptional regulation
388(1)
How Do We Know? How does lactose lead to the production of active Beta-galactosidase enzyme?
388(1)
The repressor protein binds with the operator and prevents transcription, but not in the presence of lactose
389(1)
The function of the lactose operon was revealed by genetic studies
390(1)
The lactose operon is also positively regulated by CRP-cAMP
390(1)
Transcriptional regulation determines the outcome of infection by a bacterial virus
391(9)
Visual Synthesis: Virus: A Genome in Need of a Cell
394(5)
Chapter 20 Genes And Development 399(26)
20.1 Genetic Programs of Development
400(4)
The fertilized egg is a totipotent cell
400(1)
Cellular differentiation increasingly restricts alternative fates
401(3)
How Do We Know? How do stem cells lose their ability to differentiate into any cell type?
402(1)
Can cells with your personal genome be reprogrammed for new therapies?
403(1)
20.2 Hierarchical Control of Development
404(6)
Drosophila development proceeds through egg, larval, and adult stages
404(1)
The egg is a highly polarized cell
405(1)
Development proceeds by progressive regionalization and specification
406(2)
Homeotic genes determine where different body parts develop in the organism
408(2)
20.3 Evolutionary Conservation of Key Transcription Factors in Development
410(2)
Animals have evolved a wide variety of eyes
410(1)
Pax6 is a master regulator of eye development
410(2)
20.4 Combinatorial Control in Development
412(3)
Floral differentiation is a model for plant development
412(1)
The identity of the floral organs is determined by combinatorial control
413(2)
20.5 Cell Signaling in Development
415(10)
A signaling molecule can cause multiple responses in the cell
415(1)
Developmental signals are amplified and expanded
416(10)
Visual Synthesis: Genetic Variation and Inheritance
418(4)
Case 4: Malaria: Coevolution of Humans and a Parasite
422(3)
Chapter 21 Evolution How Genotypes and Phenotypes Change over Time 425(20)
21.1 Genetic Variation
426(1)
Population genetics is the study of patterns of genetic variation
426(1)
Mutation and recombination are the two sources of genetic variation
427(1)
21.2 Measuring Genetic Variation
427(3)
To understand patterns of genetic variation, we require information about allele frequencies
427(1)
Early population geneticists relied on observable traits and gel electrophoresis to measure variation
428(1)
DNA sequencing is the gold standard for measuring genetic variation
428(2)
How Do We Know? How is genetic variation measured?
429(1)
21.3 Evolution and the Hardy—Weinberg Equilibrium
430(2)
Evolution is a change in allele or genotype frequency over time
430(1)
The Hardy-Weinberg equilibrium describes situations in which allele and genotype frequencies do not change
430(1)
The Hardy-Weinberg equilibrium relates allele frequencies and genotype frequencies
431(1)
The Hardy-Weinberg equilibrium is the starting point for population genetic analysis
432(1)
21.4 Natural Selection
432(6)
Natural selection brings about adaptations
432(2)
The Modern Synthesis combines Mendelian genetics and Darwinian evolution
434(1)
Natural selection increases the frequency of advantageous mutations and decreases the frequency of deleterious mutations
434(1)
What genetic differences have made some individuals more and some less susceptible to malaria?
434(1)
Natural selection can be stabilizing, directional, or disruptive
435(2)
How Do We Know? How far can artificial selection be taken?
436(1)
Sexual selection increases an individual's reproductive success
437(1)
21.5 Migration, Mutation, Genetic Drift, and Non-Random Mating
438(2)
Migration reduces genetic variation between populations
438(1)
Mutation increases genetic variation
438(1)
Genetic drift has a large effect in small populations
438(1)
Non-random mating alters genotype frequencies without affecting allele frequencies
439(1)
21.6 Molecular Evolution
440(5)
The molecular clock relates the amount of sequence difference between species and the time since the species diverged
440(1)
The rate of the molecular clock varies
440(5)
Chapter 22 Species And Speciation 445(18)
22.1 The Biological Species Concept
446(3)
Species are reproductively isolated from other species
446(1)
The BSC is more useful in theory than in practice
447(1)
The BSC does not apply to asexual or extinct organisms
447(1)
Ring species and hybridization complicate the BSC
448(1)
Ecology and evolution can extend the BSC
448(1)
22.2 Reproductive Isolation
449(1)
Pre-zygotic isolating factors occur before egg fertilization
450(1)
Post-zygotic isolating factors occur after egg fertilization
450(1)
22.3 Speciation
450(9)
Speciation is a by-product of the genetic divergence of separated populations
451(1)
Allopatric speciation is speciation that results from the geographical separation of populations
451(1)
Dispersal and vicariance can isolate populations from each other
451(4)
How Do We Know? Can vicariance cause speciation?
452(3)
Co-speciation is speciation that occurs in response to speciation in another species
455(1)
How did malaria come to infect humans?
455(1)
Sympatric populations—those not geographically separated— may undergo speciation
456(2)
Speciation can occur instantaneously
458(1)
22.4 Speciation and Selection
459(4)
Speciation can occur with or without natural selection
459(1)
Natural selection can enhance reproductive isolation
459(5)
Visual Synthesis: Speciation
460(3)
Chapter 23 Evolutionary Patterns Phylogeny and Fossils 463(22)
23.1 Reading a Phylogenetic Tree
464(4)
Phylogenetic trees provide hypotheses of evolutionary relationships
464(1)
The search for sister groups lies at the heart of phylogenetics
465(1)
A monophyletic group consists of a common ancestor and all its descendants
466(1)
Taxonomic classifications are information storage and retrieval systems
467(1)
23.2 Building a Phylogenetic Tree
468(6)
Homology is similarity by common descent
468(1)
Shared derived characters enable biologists to reconstruct evolutionary history
469(1)
The simplest tree is often favored among multiple possible trees
469(2)
Molecular data complement comparative morphology in reconstructing phylogenetic history
471(1)
Phylogenetic trees can help solve practical problems
472(2)
How Do We Know? Did an HIV-positive dentist spread the AIDS virus to his patients?
473(1)
23.3 The Fossil Record
474(8)
Fossils provide unique information
474(1)
Fossils provide a selective record of past life
474(2)
Geological data indicate the age and environmental setting of fossils
476(3)
Fossils can contain unique combinations of characters
479(2)
How Do We Know? Can fossils bridge the evolutionary gap between fish and tetrapod vertebrates?
481(1)
Rare mass extinctions have altered the course of evolution
481(1)
23.4 Comparing Evolution's Two Great Patterns
482(3)
Phylogeny and fossils complement each other
482(1)
Agreement between phylogenies and the fossil record provides strong evidence of evolution
482(3)
Chapter 24 Human Origins And Evolution 485
24.1 The Great Apes
486(5)
Comparative anatomy shows that the human lineage branches off the great apes tree
486(1)
Molecular analysis reveals that our lineage split from the chimpanzee lineage about 5-7 million years ago
487(1)
How Do We Know? How closely related are humans and chimpanzees?
488(1)
The fossil record gives us direct information about our evolutionary history
488(3)
24.2 African Origins
491(4)
Studies of mitochondrial DNA reveal that modern humans evolved in Africa relatively recently
491(3)
How Do We Know? When and where did the most recent common ancestor of all living humans live?
492(2)
Studies of the Ychromosome provide independent evidence for a recent origin of modern humans
494(1)
Neanderthals disappear from the fossil record as modern humans appear, but have contributed to the modern human gene pool
494(1)
24.3 Distinct Features of Our Species
495(3)
Bipedalism was a key innovation
495(1)
Adult humans share many features with juvenile chimpanzees
496(1)
Humans have large brains relative to body size
496(2)
The human and chimpanzee genomes help us identify genes that make us human
498(1)
24.4 Human Genetic Variation
498(4)
The prehistory of our species has had an impact on the distribution of genetic variation
499(1)
The recent spread of modern humans means that there are few genetic differences between groups
500(1)
Some human differences have likely arisen by natural selection
500(2)
What human genes are under selection for resistance to malaria?
501(1)
24.5 Culture, Language, and Consciousness
502
Culture changes rapidly
502(1)
Is culture uniquely human?
503(1)
Is language uniquely human?
503(1)
Is consciousness uniquely human?
503
Quick Check Answers Q-1
Glossary G-1
Index I-1
9780190304447
Preface iii
About the authors iv
Acknowledgements iv
Abbreviations xxiii
A 1(90)
ABB Australia Pty Ltd v FC of T
AGC (Advances) Ltd v FC of T
AGC (Investments) Ltd v FC of T
AVCO Financial Services Ltd v FC of T
Abbott v Philbin (Inspector of Taxes)
Ahern v DFC of T AID/WATCH Incorporated v FC of T
Air Caledonie International v Commonwealth
Allman v FC of T All States Frozen Foods Pty Ltd v FC of T
Allders International Pty Ltd v Commr of State Revenue (VIC)
Allen Allen & Hemsley v DFC of T
Alliance Holdings Ltd v FC of T
Allied Mills Industries Pty Ltd v FC of T
Allied Pastoral Holdings Pty Ltd v FC of T
Allina Pty Ltd v FC of T
Alloyweld Pty Ltd v FC of T
Allsop v FC of T
Amalgamated Zinc (De Bavay's) Ltd v FC of T
Anderson v FC of T
Anstis; FC of T v
Applegate; FC of T v
Archer Brothers Pty Ltd (in vol liq) v FC of T
Arthur Murray (NSW) Pty Ltd v FC of T
Ash; C of T (NSW) v
Ashgrove Pty Ltd v DFC of T
Associated Portland Cement Manufacturers Ltd v Kerr
Atkinson v FC of T
Austin v Commonwealth of Australia
Australasian Catholic Assurance Co Ltd v FC of T
Australasian Jam Co Pty Ltd v FC of T
Australia and New Zealand Banking Group Limited v FC of T
Australia and New Zealand Banking Group Ltd v Konza
Australia and New Zealand Savings Bank Ltd; FC of T v
Australian Gas Light Co; FC of T v Newcastle Gas Co Ltd; FC of T v
Australian Guarantee Corporation Ltd; FC of T v
Australian Machinery & Investment Co Ltd v DFC of T
Australian Music Traders Association; FC of T v
Australian National Hotels Ltd v FC of T
Australian Tape Manufacturers Association Ltd v The Commonwealth of Australia
Avondale Motors (Parts) Pty Ltd v FC of T
B 91(72)
BHP Billiton Petroleum (Bass Strait) Pty Ltd v FC of T
BP Australia Ltd v FC of T
Babka v FC of T
Baker v Campbell
Ballarat Brewing Company Limited v FC of T
Ballesty; FC of T v
Balnaves v DFC of T
Bamford; FC of T v
Barger; R v
Barratt v FC of T
Batagol v FC of T
Begg v FC of T
Bellinz Pty Ltd v FC of T
Bennett v FC of T
Bentivoglio v FC of T
Bert Needham Automotive Company Pty Ltd v FC of T
Beville; FC of T v
Bidencope; FC of T v
Binetter v DFC of T (No 2)
Black; DFC of T v
Blake; FC of T v
Blakely; FC of T v
Blockey v FC of T
Bluebottle UK Ltd v DFC of T
Bohemians Club (The) v Acting FC of T
Booth v FC of T
Boulder Perseverance Ltd v FC of T (WA)
Brady King Pty Ltd v FC of T
Brajkovich v FC of T
Brebner; Inland Revenue Commissioners v
Brent v FC of T
Brewing Investments Ltd; FC of T v
Briggs v DFC of T
British Insulated & Helsby Cables Ltd v Atherton
Broken Hill Theatres Pty Ltd v FC of T
Brown; FC of T v
Bunting v FC of T
Burton v FC of T
C 163(140)
CMI Services Pty Ltd v FC of T
CSR Ltd; FC of T v
CTC Resources NL v FC of T
Cainero; FC of T v
Californian Copper Syndicate Ltd v Harris (Surveyor of Taxes)
Californian Oil Products Ltd (in liq) v FC of T
Calvert (Inspector of Taxes) v Wainwright
Cam & Sons Ltd; C of T (NSW) v
Cameron v DFC of T (TAS)
Cape Flattery Silica Mines Pty Ltd v FC of T
Carapark Holdings Ltd v FC of T
Carberry; FC of T v
Carborundum Realty Pty Ltd v RAIA Archicentre Pty Ltd
Carpentaria Transport Pty Ltd v FC of T
Case 78
Case 80
Case 98
Case 110
Case B4
Case B11
Case E47
Case P45
Case Q53
Case Q68
Case R111
Case S19
Case S75
Case U162
Case V160
Case W58
Case X86
Case Y4
Case Y13
Case Y28
Case Z9
Case 29/95
Case 43/95
Case 10/2011
Casimaty v FC of T
Cecil Bros Pty Ltd v FC of T
Century Yuasa Batteries Pty Ltd; FC of T v
Chamber of Manufactures Insurance Ltd (The) v FC of T
Chamberlain v DFC of T
Chapman v FC of T
Charles v FC of T
Charles Moore & Co (WA) Pty Ltd v FC of T
Chaudhri v FC of T
Church of the New Faith (The) v Commissioner of Pay-Roll Tax (VIC)
Citibank Ltd; FC of T v
Citibank Ltd; FC of T v
Citylink Melbourne Ltd; FC of T v
Clarke & Kann; DFC of T v
Cliffs International Inc v FC of T
Coleambally Irrigation Mutual Co-operative Ltd v FC of T
Coles Myer Finance Ltd v FC of T
Collings; FC of T v
Colonial Mutual Life Assurance Society Ltd v FC of T
Commercial and General Acceptance Ltd v FC of T
Commercial Nominees of Australia Ltd; FC of T v
Commercial Union Assurance Company of Australia Ltd v FC of T
Commonwealth Aluminium Corporation Ltd; FC of T v
Consolidated Fertilizers Ltd; FC of T v
Consolidated Press Holding Ltd v FC of T
Consolidated Press Holdings Ltd; FC of T v
Constable v FC of T
Cooke and Sherden; FC of T v
Cooling; FC of T v
Coombes (No 2); FC of T v
Cooper; FC of T v
Cooper Brookes (Wollongong) Pty Ltd v FC of T
Couch v FC of T
Coughlan v FC of T
Cranstoun v FC of T
Cridland v FC of T
Crommelin v DFC of T
Cronulla-Sutherland Leagues Club Ltd v FC of T
Crow v FC of T
Curran v FC of T
Cyclone Scaffolding Pty Ltd; FC of T v
D 303(43)
D&W Murray Ltd; C of T (WA) v
Dalco; FC of T v
David Jones Finance and Investments Pty Ltd v FC of T
David Securities Pty Ltd v Commonwealth Bank of Australia
Davis v FC of T
Day; FC of T v
De Beers Consolidated Mines Ltd v Howe
De Luxe Red and Yellow Cabs Co-operative (Trading) Society Ltd; FC of T v
De Vonk v DFC of T
Dean v FC of T
Deane v FC of T; Croker v FC of T
Dickenson v FC of T
Dingwall v FC of T
Dixon; FC of T v
Donovan v DFC of T
Dormer v FC of T
Drummond v FC of T
Ducker (Inspector of Taxes) v Rees Roturbo Development Syndicate Ltd
Dunn; FC of T v
Dwight v FC of T
Dymond, Re
E 346(61)
EA Marr and Sons (Sales) Ltd; FC of T v
ECC Southbank Pty Ltd as Trustee for Nest Southbank Unit Trust v FC of T
East Finchley Pty Ltd v FC of T
Eastern Nitrogen Ltd v FC of T
Economedes v FC of T
Edelsten v Wilcox
Edwards; FC of T v
Edwards (Inspector of Taxes) v Bairstow
Efstathakis; FC of T v
Egerton-Warburton v DFC of T
Eisner v FC of T
Elmslie v FC of T
Emu Bay Railway Co Ltd v FC of T
Energy Resources of Australia Ltd; FC of T v
Equitable Life and General Insurance Co Ltd; FC of T v
Esquire Nominees Ltd (as Trustee of Manolas Trust) v FC of T
Essenbourne Pty Ltd v FC of T
Esso Australia Resources Ltd v FC of T
Europa Oil (NZ) Ltd (No 1); Commissioner of Inland Revenue (NZ) v
Europa Oil (NZ) Ltd (No 2) v Commissioner of Inland Revenue (NZ)
Evans v FC of T
Evans v FC of T
Everett; FC of T v
Executor Trustee and Agency Co of South Australia Ltd (The) (Carden's Case); C of T (SA) v
F 407(52)
FJ Bloemen Pty Ltd v FC of T
Faichney; FC of T v
Fairfax v FC of T
Fairway Estates Pty Ltd v FC of T
Farnsworth v FC of T
Federal Coke Co Pty Ltd v FC of T
Federal Wharf Co Ltd v DFC of T
Ferguson v FC of T
Finn; FC of T v
First Provincial Building Society Limited v FC of T
Firstenberg; FC of T v
Firth; FC of T v
Fitzgerald v DFC of T
Fletcher v FC of T
Foley (Lady) v Fletcher
Forsyth; FC of T v
Forsyth; R v
Fortescue Metals Group Limited v The Commonwealth
Foxwood (Tolga) Pty Ltd; FC of T v
Freeman v FC of T
French; FC of T v
Fullerton v FC of T
Furniss (Inspector of Taxes) v Dawson
Futuris Corporation Ltd; FC of T v (2008)
Futuris Corporation Ltd; FC of T v (2010; 2012)
G 459(45)
GE Crane Sales Pty Ltd v FC of T
GKN Kwikform Services Pty Ltd; FC of T v
GP International Pipecoaters Pty Ltd v FC of T
GRE Insurance Ltd v FC of T; Unitraders Investments Pty Ltd v FC of T
Galland; FC of T v
Garrett v FC of T
Gartside v Inland Revenue Commissioners
Gasparin v FC of T
Gauci v FC of T
George; DFC of T v
Gibb v FC of T
Giris Pty Ltd v FC of T Glenboig Union Fireclay Co Ltd (The) v Inland Revenue Commissioners
Glenville Pastoral Co Pty Ltd (in liq) v FC of T
Goodman Fielder Wattie Ltd v FC of T
Government of India, Ministry of Finance (Revenue Division) v Taylor
Granby Pty Ltd v FC of T
Grant; FC of T v
Gray v FC of T
Grealy v FC of T
Gregrhon Investments Pty Ltd; FC of T v
Gulland, FC of T v; Watson v FC of T; Pincus v FC of T
H 504(60)
HR Sinclair & Son Pty Ltd v FC of T
HA v State of New South Wales; Walter Hammond & Associates Pty Ltd v State of New South Wales
Hadlee & Sydney Bridge Nominees Ltd v Commissioner of Inland Revenue (NZ)
Hallstroms Pty Ltd v FC of T
Handley v FC of T
Happ; FC of T v
Harding v FC of T
Harmer v FC of T
Harris; FC of T v
Harrowell v FC of T
Hart; FC of T v
Hartley; FC of T v
Hartley v FC of T
Hatchett; FC of T v
Hayes v FC of T
Heavy Minerals Pty Ltd v FC of T
Henderson v FC of T
Henry Jones (IXL) Ltd v FC of T
Hepples v FC of T
Herald and Weekly Times Ltd (The) v FC of T
Higgs (Inspector of Taxes) v Olivier
Highfield; FC of T v
Hillsdon Watts Ltd; C of T (NSW) v
Hoare Trustees v Gardner (Inspector of Taxes); Hart (Inspector of Taxes) v Briscoe
Hobbs v FC of T
Hochstrasser (Inspector of Taxes) v Mayes
Holmes; FC of T v
Homewood; DFC of T v
Hunter Douglas Ltd; FC of T v
Hyteco Hiring Pty Ltd; FC of T v
I 564(9)
Ilbery; FC of T v
Imperial Chemical Industries of Australia and New Zealand Ltd v FC of T
Indooroopilly Children Services (Qtd) Pty Ltd; FC of T v
Interchase Corporation Ltd v ACN 010 087 573 Pty Ltd
International Nickel Australia Ltd v FC of T
Investment and Merchant Finance Corporation Ltd v FC of T
J 573(28)
J & G Knowles & Associates Pty Ltd v FC of T
J Rowe & Son Pty Ltd v FC of T
Jackson; FC of T v
James Fenwick & Co Ltd v FC of T
James Flood Pty Ltd; FC of T v
Jamieson v Commissioner for Internal Revenue
Jamieson v Commissioner of Inland Revenue (New Zealand)
Janmor Nominees Pty Ltd; FC of T v
Jarrold (Inspector of Taxes) v Boustead; McInnes (Inspector of Taxes) v Large; McInnes (Inspector of Taxes) v Simms
Jayatilake v FC of T
Jefferies; FC of T v
Jenkins; FC of T v
Joachim v FC of T
John v FC of T
John Fairfax and Sons Pty Ltd v FC of T
John Holland Group Pty Ltd v FC of T
Jolley v FC of T
Jones; FC of T v
Jones v Leeming
Just Jeans Pty Ltd; FC of T v
K 601(16)
Keily v FC of T
Kelly v FC of T
Kidston Goldmines Ltd v FC of T
Re Kingston Thoroughbred Horse Stud and ATO
Kirk; C of T v
Koitaki Para Rubber Estates Ltd v FC of T
Kosciusko Thredbo Pty Ltd v FC of T
Krakos Investments Pty Ltd; FC of T v
Kratzmann v FC of T
Kumagai Gumi Co Ltd v FC of T
Kwikspan Purlin System Pty Ltd v FC of T
L 617(50)
La Rosa; FC of T v
Lamesa Holdings BV; FC of T v
Lau; FC of T v
Law Shipping Company Ltd (The) v Inland Revenue Commissioners
Lawford; C of T (NSW) v
Leary v FC of T
Lees & Leech Pty Ltd v FC of T
Levene v Inland Revenue Commissioners
Lewis Berger & Sons (Australia) Ltd; FC of T v
Liedig v FC of T
Liftronic Pty Ltd v FC of T
Lighthouse Philatelics Pty Ltd v FC of T
Lilyvale Hotel Pty Ltd v FC of T
Lindsay v FC of T
Lindsay v Inland Revenue Commissioners
Lodge v FC of T
Lomax (Hm Inspector of Taxes) v Peter Dixon and Son Ltd
London Australia Investment Co Ltd v FC of T
Lopez v DFC of T
Loxton v FC of T
Ludekens; FC of T v
Lunney v FC of T; Hayley v FC of T
Luton v Lessels
Lysaght; Inland Revenue Commissioners v
M 667(102)
McCauley v FC of T
McClelland v FC of T
MacCormick v FC of T; Camad Investments Pty Ltd v FC of T
McCurry v FC of T
McDonald; FC of T v (allowable deductions)
McDonald v FC of T (legally binding and enforceable contract)
MacFarlane v FC of T
McIntosh v FC of T
McLaurin v FC of T
McNeil; FC of T v
McPhail; FC of T v
Macquarie Finance Limited v FC of T
Madad Pty Ltd v FC of T
Maddalena; FC of T v
Madigan v FC of T
Malouf; FC of T v
Magna Alloys & Research Pty Ltd v FC of T
Malayan Shipping Company Ltd v FC of T
Mansfield v FC of T
Marana Holdings Pty Ltd v FC of T
Marshall and Brougham Pty Ltd; FC of T v
Martin v FC of T (gambling wins)
Martin v FC of T (childminding expenses)
Matthews v The Chicory Marketing Board (VIC)
Mazuran, Re; Ex parte DFC of T
Memorex Pty Ltd v FC of T
Mercantile Mutual Insurance (Workers Compensation) Ltd; FC of T v
Meredith v FC of T
Mery Brown Pty Ltd; FC of T v
Metal Manufacturers Ltd; FC of T v
Michell v FC of T
Midland Railway Company of Western Australia Ltd; The FC of T v
Miller; FC of T v
Mitchum; FC of T v
Mitsubishi Motors New Zealand Ltd; Commr of IR (NZ) v
Moana Sand Pty Ltd v FC of T
Moneymen Pty Ltd v FC of T
Montgomery; FC of T v
Moore v Griffiths (Inspector of Taxes)
Moorebank Pty Ltd; DFC of T v
Moorhouse (Inspector of Taxes) v Dooland
Moriarty (Inspector of Taxes) v Evans Medical Supplies Ltd
Morris v FC of T
Mostyn; DFC of T v
Mount Isa Mines Ltd v FC of T
Mullens v FC of T
Munro; FC of T v
Murry; FC of T v
Mutual Acceptance Ltd v FC of T
Mutual Pools and Staff Pty Ltd v FC of T
Myer Emporium Ltd (The); FC of T v
N 769(28)
NV Philips' Gloeilampenfabrieken; Commissioner of Inland Revenue (NZ) v
Nathan v FC of T
National Australia Bank Ltd v FC of T (fringe benefits)
National Australia Bank Ltd v FC of T (defence force housing loans)
National Bank of Australasia Ltd (The) v FC of T
Nchanga Consolidated Copper Mines Ltd; C of T v
Neale v Atlas Products (Vic) Pty Ltd
New Zealand Flax Investments Ltd v FC of T
Newsom v Robertson (Inspector of Taxes)
Newton v FC of T
Nilsen Development Laboratories Pty Ltd v FC of T
Norman v FC of T
North Australian Pastoral Company Ltd v FC of T
Northern Suburbs General Cemetery Reserve Trust v The Commonwealth of Australia
Northumberland Development Co Pty Ltd; FC of .T v
O 797(11)
O'Brien (Inspector of Taxes) v Benson's Hosiery (Holdings) Ltd
Odeon Associated Theatres Ltd v Jones (Inspector of Taxes)
Ogilvy & Mather Pty Ltd v FC of T
O'Reilly v Commissioners of The State Bank of Victoria
Orica Ltd (Formerly ICI Australia Ltd); FC of T v
Osborne; FC of T v
P 808(54)
P & N Beverages Australia Pty Ltd v FC of T
PBL Marketing Pty Ltd v FC of T
Packer v DFC of T
Pape v FC of T
Parke Davis & Co v FC of T
Parton v Milk Board (Vic)
Partridge v Mallandaine (Surveyor of Taxes)
Pastoral & Development Pty Ltd v FC of T
Patcorp Investments Ltd v FC of T
Payne v FC of T
Payne; FC of T v
Peabody; FC of T v
Peate v FC of T
Peyton v FC of T
Philip Morris Ltd v FC of T
Phillips; C of T (Vic) v
Phillips; FC of T v
Pillay v FC of T
Placer Pacific Management Pty Ltd v FC of T
Point v FC of T
Poole v FC of T; Dight v FC of T
Powell v Evreniades
Pratt Holdings Pty Ltd v FC of T
Prince v FC of T
Pritchard (Inspector of Taxes) v Arundale
Provan v HCL Real Estate ltd
Punjab Co-Operative Bank Ltd, Amritsar v Income Tax Commissioner, Lahore
Purcell; DFC of T v
Q 862(5)
Qantas Airways Ltd; FC of T v (employee car parking)
Qantas Airways Ltd; FC of T v (GST on refunds)
Quarries Ltd v FC of T
Queensland Meat Export Co Ltd v DFC of T
R 867(71)
RAC Insurance Pty Ltd v FC of T
RACV Insurance Pty Ltd v FC of T
RCI Pty Ltd v FC of T
Radilo Enterprises Pty Ltd; FC of T v
Radnor Pty Ltd; FC of T v
Raftland Pty Ltd as Trustee of The Raftland Trust v FC of T
Ramsay; IRC v
Raymor Contractors Pty Ltd v FC of T
Raymor (NSW) Pty Ltd; FC of T v
Reckitt & Colman Pty Ltd v FC of T
Reliance Carpet Co Pty Ltd; FC of T v
Resch v FC of T
Reseck v FC of T
Reynolds v Commissioner of State Taxation (WA)
Rhodesia Metals Ltd (In Liq) v Taxes Commissioner
Rhodesia Railways Ltd v Collector of Income Tax, Bechuanaland Protectorate
Richard Walter Pty Ltd; DFC of T v
Richardson v FC of T
Riches v Westminster Bank Ltd
Risby Forest Industries Pty Ltd v FC of T
Riverside Road Lodge Pty Ltd (IN LIQ; FC of T v
Roads and Traffic Authority of NSW v FC of T
Robert v Collier's Bulk Liquid Transport Pty Ltd
Robert Coldstream Partnership v FC of T
Roberts, FC of T v; FC of T v Smith
Roberts, MI; FC of T v
Rolls-Royce Ltd v Jeffrey (Inspector of Taxes)
Ronpibon Tin NL v FC of T; Tongkah Compound NL v FC of T
Rose v FC of T
Rotherwood Pty Ltd v FC of T
Rowe; FC of T v
Roy Morgan Research Pty Ltd v FC of T
Royal Automobile Club of Victoria v FC of T
Ruhamah Property Co Ltd v FC of T
Ryan; FC of T v
S 938(155)
S Hoffnung & Company Ltd; FC of T v
SP Investments Pty Ltd (as Trustee of The Lm Brennan Trust) v FC of T; Perron Investments Pty Ltd v FC of T
Sacca v Adam
Saga Holidays Limited v FC of T
St George Bank Ltd v FC of T
St Hubert's Island Pty Ltd; FC of T v
St Marys Rugby League Club Ltd v FC of T
Sara Lee Household & Body Care (Aust) Pty Ltd; FC of T v
Saunig; DFC of T v
Scott v C of T (NSW)
Scott v FC of T
Scottish Australian Mining Company Ltd v FC of T
Scottish & Newcastle Breweries Ltd; Inland Revenue Commissioners v
Scully; FC of T v
Selleck v FC of T
Seymour v REED
Shaw v Director of Housing (No 2)
Sheehan; DFC of T v
Sheil v FC of T
Shepherd v FC of T
Sherritt Gordon Mines Limited; FC of T v
Shields v FC of T
Single v FC of T
Skase v FC of T
Slater Holdings Ltd (No 2); FC of T v
Slaven; FC of T v
Slutzkin v FC of T
Smith; FC of T v
Smith v FC of T (disability insurance)
Smith v FC of T (study payments)
Sneddon v FC of T
Snowden & Willson Pty Ltd; FC of T v
Softwood Pulp and Paper Ltd v FC of T
Somers Bay Investment Pty Ltd v FC of T
Soong v DFC of T
South Australia v The Commonwealth
State of South Australia (The) v The Commonwealth of Australia
South Australian Battery Makers Pty Ltd; FC of T v
South Steyne Hotel Pty Ltd v FC of T
Southern v Borax Consolidated Limited
Southern Farmers Group Ltd v DFC of T
Spedley Securities Ltd; FC of T v
Spotless Services Ltd; FC of T v
Spriggs v FC of T; Riddell v FC of T
Squatting Investment Company Limited; FC of T v
Stanton v FC of T
Stapleton v FC of T
Star City Pty Limited; FC of T v
State Bank of New South Wales; DFC of T v
State Chamber of Commerce and Industry v Commonwealth of Australia
State of Queensland v Commonwealth of Australia
Statham v FC of T
Steele v DFC of T
Steinberg, M v FC of T; Trustee of Judith Steinberg No 2 Trust v FC of T; MD Steinberg v FC of T
Stephenson (Inspector of Taxes) v Barclay's Bank Trust Co Ltd
Stergis v FC of T
Sterling Guardian Pty Ltd v FC of T
Stokes; FC of T v
Stone; FC of T v
Studdert; FC of T v
Studebaker Corporation of Australasia Ltd (as agent for the Studebaker Corporation of America) v C of T (NSW)
Sun Newspapers Ltd v FC of T
Sunchen Pty Ltd v FC of T
Sunraysia Broadcasters Pty Ltd v FC of T
Suttons Motors (Chullora) Wholesale Pty Ltd; FC of T v
Swinford v FC of T
Sydney Refractive Surgery Centre Pty Ltd; FC of T v
Sydney Water Board Employees' Credit Union Ltd v FC of T
Szajntop v FC of T
T 1093(47)
TNT Skypak International (Aust) Pty Ltd v FC of T
Taplin v Pickford
Task Technology Pty Ltd v FC of T
Taylor v FC of T r
Temelli v FC of T
Tennant v Smith (Surveyor of Taxes)
Terranora Lakes Country Club Ltd v FC of T
Terrule Pty Ltd v DFC of T; Manners v DFC of T
Thiel v FC of T
Thomas v FC of T
Thorpe Nominees Pty Ltd v FC of T
Tikva Investments Pty Ltd v FC of T
Tinkler v FC of T
Tooheys Ltd v C of T (NSW); Sydney Ferries Ltd v C of T (NSW)
Total Holdings (Australia) Pty Ltd; FC of T v
Totledge Pty Ltd; FC of T v
Toyama Pty Ltd v Landmark Building Developments Pty Ltd
Trail Bros Steel & Plastics Pty Ltd; FC of T v
Trautwein v FC of T
Travelex Ltd v FC of T
Travelodge Papua New Guinea Ltd v Chief Collector of Taxes
Trent Investments Pty Ltd v FC of T
Truesdale v FC of T
Tuite v Exelby
Tupicoff v FC of T
U 1140(14)
Unilever Australia Securities Ltd; FC of T v
Union Fidelity Trustee Co of Australia Ltd v FC of T
Unit Construction Co Ltd v Bullock (Inspector of Taxes)
United Aircraft Corporation; FC of T v
Unit Trend Services Pty Ltd; FC of T v
Ure v FC of T
Uther; FC of T v
V 1154(22)
Vabu Pty Ltd v FC of T
Vallambrosa Rubber Co Ltd v Farmer (Surveyor of Taxes)
Van Den Berghs Ltd v Clark (Inspector of Taxes)
Vegners v FC of T
Vestey v Inland Revenue Commissioners
Victorian Women Lawyers' Association Inc v FC of T
Vidler v FC of T
Vincent v FC of T
Virgin Blue Airlines Pty Ltd v FC of T
Visy Industries USA Pty Ltd; FC of T v
Vogt; FC of T v
W 1176(76)
W Angliss & Co Pty Ltd; FC of T v
W Nevill & Co Ltd v FC of T
W Thomas & Co Pty Ltd v FC of T
WD & HO Wills (Australia) Pty Ltd v FC of T
WE Fuller Pty Ltd; FC of T v
WP Keighery Pty Ltd v FC of T
WR Carpenter Holdings Pty Ltd v FC of T; WR Carpenter Australia Pty Ltd v FC of T
WR Moran Pty Ltd v DFC of T (NSW)
Wade; FC of T v
Walker; FC of T v
Walker v FC of T
Walsh Bay Developments Pty Ltd v FC of T
Walstern Pty Ltd v FC of T
Wangaratta Woollen Mills Ltd v FC of T
Ward; Commissioner of Inland Revenue (New Zealand) v
Warner Music Australia Pty Ltd v FC of T
Wattie; Commr of IR v
Wells; FC of T v
Western Suburbs Cinemas Ltd; FC of T v
Westfield Ltd v FC of T
Westley Nominees Pty Ltd v Coles Supermarkets Australia Pty Ltd
Westminster (Duke of); Inland Revenue Commissioners v
Westpac Banking Corporation v FC of T
Westraders Pty Ltd; FC of T v
Wharf Properties Ltd v Commr of Inland Revenue (Hong Kong)
Whitaker v FC of T
Whitfords Beach Pty Ltd; FC of T v
Whiting; FC of T v
Wiener; FC of T v
Wilkinson; FC of T v
Williams; FC of T v
Woite; FC of T v
Woolcombers (WA) Pty Ltd; FC of T v
Word Investments Limited; FC of T v
World Book (Australia) Pty Ltd v FC of T
X 1252(2)
XCO Pty Ltd v FC of T
Y 1254(3)
Yeung v FC of T
Z 1257(7)
Zarzycki; DFC of T v
Zeta Force Pty Ltd v FC of T
Zim Properties Ltd v Procter (Inspector of Taxes)
Zobory v FC of T
Case Table 1264(20)
Index 1284
James Morris - Professor of Biology at Brandeis University. He teaches a wide variety of courses for majors and non-majors, including introductory biology, evolution, genetics and genomics, epigenetics, comparative vertebrate anatomy, and a first-year seminar on Darwins On the Origin of Species. He is the recipient of numerous teaching awards from Brandeis and Harvard. His research focuses on the rapidly growing field of epigenetics, making use of the fruit fly Drosophila melanogaster as a model organism. Daniel Hartl - Higgins Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University and Professor of Immunology and Infectious Diseases at the Harvard Chan School of Public Health. He has taught highly popular courses in genetics and evolution at both the introductory and advanced levels. His lab studies molecular evolutionary genetics and population genetics and genomics. Dr. Hartl is the recipient of the Samuel Weiner Outstanding Scholar Award as well as the Gold Medal of the Stazione Zoologica Anton Dohrn, Naples. Andrew Knoll - Fisher Professor of Natural History in the Department of Organismic and Evolutionary Biology at Harvard University. He is also Professor of Earth and Planetary Sciences. Dr. Knoll teaches introductory courses in both departments. His research focuses on the early evolution of life, Precambrian environmental history, and the interconnections between the two. He has also worked extensively on the early evolution of animals, mass extinction, and plant evolution. Robert Lue - Professor of Molecular and Cellular Biology at Harvard University and the Richard L. Menschel Faculty Director of the Derek Bok Center for Teaching and Learning. Dr. Lue has a longstanding commitment to interdisciplinary teaching and research, and chaired the faculty committee that developed the first integratedscience foundation in the country to serve science majors as well as pre-medical students. Melissa Michael - Director for Core Curriculum and Assistant Director for Undergraduate Instruction for the School of Molecular and Cellular Biology at the University of Illinois at Urbana-Champaign. A cell biologist, she primarily focuses on the continuing development of the Schools undergraduate curricula.

Andrew Berry - Lecturer in the Department of Organismic and Evolutionary Biology and an undergraduate advisor in the Life Sciences at Harvard University. With research interests in evolutionary biology and history of science, he teaches courses that either focus on one of the areas or combine the two.

Andrew Biewener - Charles P. Lyman Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University and Director of the Concord Field Station. He teaches both introductory and advanced courses in anatomy, physiology, and biomechanics.

Brian D. Farrell - Director of the David Rockefeller Center for Latin American Studies and Professor of Organismic and Evolutionary Biology and Curator in Entomology at the Museum of Comparative Zoology at Harvard University. He is an authority on coevolution between insects and plants and a specialist on the biology of beetles.

N. Michele Holbrook -