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E-grāmata: Biology of Senescence: A Translational Approach

  • Formāts: PDF+DRM
  • Sērija : Practical Issues in Geriatrics
  • Izdošanas datums: 06-Jun-2019
  • Izdevniecība: Springer Nature Switzerland AG
  • Valoda: eng
  • ISBN-13: 9783030151119
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Biology of Senescence: A Translational ApproachPalielināt
  • Formāts: PDF+DRM
  • Sērija : Practical Issues in Geriatrics
  • Izdošanas datums: 06-Jun-2019
  • Izdevniecība: Springer Nature Switzerland AG
  • Valoda: eng
  • ISBN-13: 9783030151119
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This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for treating it.





Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related chronic non-transmissible diseases), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to treat or prevent the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria.





Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.
1 Introduction
1(8)
References
6(3)
2 The Emerging Medical Landscape
9(16)
2.1 The Overwhelming Human Responsibility
9(2)
2.2 The Two Recent Epidemiological Transitions
11(5)
2.2.1 Throughout the World
12(4)
2.3 The Emergencies
16(5)
2.3.1 The Two Out-Of-Control Risks: Nuclear Power and Poverty
16(1)
2.3.2 Age, the First of the Emerging Risks
17(1)
2.3.3 Incidence of Non-Transmissible Chronic Diseases
18(2)
2.3.4 Other Age-Linked Diseases
20(1)
References
21(4)
3 The Origins of Ageing
25(12)
3.1 Genome Instability
27(1)
3.2 Genetics and Heredity
28(2)
3.3 Telomeres and Telomerase
30(1)
3.4 Proteostasis
31(2)
3.5 Epigenetics
33(1)
3.6 Microbiota
34(1)
References
35(2)
4 The Senescent Cell, SC
37(10)
4.1 The Overview
37(4)
4.2 Consequences of Stem/Precursor Cell Proliferation Arrest
41(2)
4.3 The SC Secretome
43(1)
4.4 Fibrosis
44(1)
References
45(2)
5 The Nonfatal Clinical Manifestations of Ageing
47(12)
5.1 Hair, Skin, Adipose Tissue
47(2)
5.2 Bones, Muscles, and Joints
49(1)
5.3 General Conditions, Frailty Syndrome, Fluid Balance, Immune System
50(2)
5.4 Biological Rhythms
52(3)
5.5 The Senses and Sensitivity
55(1)
References
56(3)
6 Age-Linked Non-Transmissible Diseases
59(24)
6.1 Cancers
60(2)
6.2 Neurodegenerative Diseases
62(4)
6.3 Type 2 Diabetes and Metabolic Syndrome
66(1)
6.4 Lungs, Kidneys and Liver Diseases
67(2)
6.5 The Senescent CV System
69(8)
6.5.1 The Senescent Myocardium
69(4)
6.5.2 The Senescent Vascular System
73(1)
6.5.3 Consequences of Change in Characteristic Arterial Impedance
74(1)
6.5.4 The Clinical Manifestations of Atherosclerosis
75(1)
6.5.5 Heart Failure in Senescence
76(1)
6.5.6 Atrial Fibrillation
76(1)
References
77(6)
7 How to Treat or Prevent, or Slow Down, Cellular Ageing and Senescence?
83(6)
7.1 The Various Attempts at Reprogramming
83(2)
7.2 Calorie Restriction
85(1)
7.3 Physical Exercise
86(1)
References
87(2)
8 Senescence: A Darwinian Evolutionary Perspective
89(6)
8.1 Genetic Versus Environmental Factors in Senescence
90(1)
8.2 Senescence and Inflammation
91(2)
References
93(2)
9 Conclusions
95(4)
9.1 The Accession of Gerontechnologies
95(1)
9.2 The Adaptive Capacities
96(1)
9.3 The Gerontological Aspects of the Making of Ignorance
96(1)
References
97(2)
10 Summary
99(2)
Annex A Senescence in Plants and Bacteria 101(2)
Annex B Theories of Ageing 103(2)
Annex C Telomeres and Telomerase 105(2)
Annex D MicroRNAs, miRs 107(2)
Annex E Circadian Rhythms, a Fundamental Basis of Life 109(6)
Annex F The Diabetic Heart 115(2)
Glossary 117(2)
References 119
Bernard Swynghedauw is a former Research Director of the French National Institute of Health and Medical Research (INSERM), Paris, France. In 1974 he became a laboratory director at INSERM and, from 1992 to 1999, served as director of the special course for postgraduate cardiologists and pneumonologists Biologie et Physiologie de la Circulation et de la Respiration. He currently teaches a course on Cardiovascular Geriatrics at Bicźtre Hospital in Paris. He has won a number of prestigious awards (CEDUS in 1996; Peter Debye in 1994, University of Maastricht, NL; Drieux-Cholet in 1996, Académie de Médecine Paris), and is a corresponding member of the French Académie de Médecine, of the Academia Europeae, former member of the Executive Committee of the European Society of Cardiology (ESC), and Past-President of the Federation of European Physiological Societies (FEPS). He has authored several books and numerous articles in prominent international journals.
Biežāk uzdotie jautājumi par e-grāmatām Biežāk uzdotie jautājumi par e-grāmatām
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