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E-grāmata: Biomaterials and Medical Device - Associated Infections

Edited by (Senior Lecturer, Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK), Edited by (Senior Lecturer, Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK)
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Biomaterials and Medical Device - Associated InfectionsPalielināt
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Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection.
  • Provides analysis of biofilms and their relevance to implant associated infections.
  • Assesses technologies for controlling biofilms.
  • Considers advantages and disadvantages of in vivo infection studies.

Papildus informācija

A review of the infections related to biomaterials and medical devices, along with the methods and materials used to prevent these infections.
List of contributors
ix
Woodhead Publishing Series in Biomaterials xi
Part One Introduction to biomaterials and medical device-related infections
1(100)
1 Introduction to biomaterials and medical device-associated infections
3(16)
I. R. Cooper
1.1 History of biomaterials
3(2)
1.2 Overview of current medical devices and applications
5(2)
1.3 Overview of problems associated with medical devices
7(6)
1.4 Introduction to the structure of this book
13(6)
References
14(5)
2 Biofilms and implant-associated infections
19(28)
G. Laverty
S. P. Gorman
B. F. Gilmore
2.1 Introduction
19(1)
2.2 Microbial profile of implant-associated infections
19(4)
2.3 Relevance of biofilms in implant-associated infections
23(1)
2.4 Structure and composition of biofilms
24(2)
2.5 Pathogenesis of biofilm infection
26(10)
2.6 Future trends
36(1)
2.7 Further information and advice
36(11)
References
37(10)
3 In vivo infection studies
47(24)
Y. Achermann
P. Kerns
M. E. Shirtliff
3.1 Introduction
47(1)
3.2 Legitimacy of animal studies
48(1)
3.3 Choosing the right animal model to study device-associated infections
49(11)
3.4 Pros and cons of in vivo infection studies
60(2)
3.5 Correlation of outcome between animal and clinical studies
62(1)
3.6 Conclusion and future trends
63(1)
3.7 Sources of further information and advice
63(8)
Acknowledgments
64(1)
References
64(7)
4 Diagnosis of biofilm-associated infections in medical devices
71(12)
S. Bose
A. K. Ghosh
4.1 Introduction
71(1)
4.2 Importance of detection of biofilm
72(1)
4.3 Sites of biofilm formation
73(1)
4.4 Collection of samples for biofilm detection
73(1)
4.5 Examples of methods for the detection of biofilms associated with infections
74(4)
4.6 Future trends
78(1)
4.7 Conclusion
79(4)
Acknowledgement
79(1)
References
79(4)
5 Diagnosis and treatment of implant-associated infections
83(18)
M. Al-Mayahi
P. Vaudaux
L. Deabate
A. Lomessy
D. Suva
I. Uckay
5.1 Introduction
83(1)
5.2 Risk factors and prevention
84(3)
5.3 Diagnosis
87(1)
5.4 Treatment
88(8)
5.5 Future trends
96(5)
References
96(5)
Part Two Technologies and materials for controlling biofilms
101(154)
6 Surface modification of biomaterials for biofilm control
103(30)
O. Bazaka
K. Bazaka
6.1 Introduction
103(1)
6.2 Principles of bacterial cell--biomaterial surface interactions
103(2)
6.3 Substrate specific biological response
105(1)
6.4 Looking at nature for inspiration
106(1)
6.5 Modifications to prevent initial stages of bacterial adhesion
107(2)
6.6 Methods to prevent irreversible attachment of microorganisms
109(1)
6.7 Mitigation of biofilm formation by attached organisms
110(13)
6.8 Future trends
123(10)
References
124(9)
7 Surface nanoengineering for combating biomaterials infections
133(30)
K. G. Neoh
R. Wang
E. T. Kang
7.1 Introduction
133(1)
7.2 Modification of surface nano topography to inhibit bacterial adhesion
134(2)
7.3 Surface functionalization with eluting antibacterial agent
136(4)
7.4 Surface functionalization with anti-adhesive polymers
140(6)
7.5 Immobilization of bactericidal moieties on surfaces
146(6)
7.6 Conclusion and future trends
152(1)
7.7 Sources of further information and advice
153(10)
References
153(10)
8 Bioactive biomaterials for controlling biofilms
163(22)
B. F. Gilmore
L. Carson
8.1 Introduction
163(2)
8.2 Definition of medical device
165(1)
8.3 Biomaterials
165(2)
8.4 Biomaterial applications in medical devices
167(4)
8.5 Post-implantation device-associated infections
171(2)
8.6 Development of conventional antimicrobial biomaterials
173(7)
8.7 Conclusion
180(5)
References
180(5)
9 Antibiotics and cements for the prevention of biofilm-associated infections
185(14)
G. Massazza
A. Bistolfi
E. Verne
M. Miola
L. Ravera
F. Rosso
9.1 Introduction
185(1)
9.2 Biomaterials, infections and orthopedics
185(1)
9.3 History of antibiotic-loaded bone cement (ALBC)
186(1)
9.4 Indication of ALBC
186(1)
9.5 Method of mixing the ALBC
187(1)
9.6 The choice of antibiotic, its dosage and associations of different drugs
188(3)
9.7 The antibiotic release
191(1)
9.8 Mechanical properties of ALBC
192(1)
9.9 Toxicity
193(1)
9.10 Conclusion
193(6)
References
194(5)
10 Antibacterial composite restorative materials for dental applications
199(24)
I. M. Mehdawi
A. Young
10.1 Introduction
199(1)
10.2 Current direct aesthetic restorative materials
200(1)
10.3 Antibacterial properties of aesthetic restorative materials
201(5)
10.4 Re-mineralizing dental composites
206(2)
10.5 Antibacterial, re-mineralizing and proteinases inhibiting materials
208(5)
10.6 Conclusion and future trends
213(10)
References
213(10)
11 Infection resistant biomaterials
223(32)
Y. Delaviz
J. P. Santerre
D. G. Cvitkovitch
11.1 Introduction
223(1)
11.2 History
224(1)
11.3 Drug-releasing antimicrobial systems
225(6)
11.4 Antimicrobial cationic systems
231(3)
11.5 Antifouling surfaces
234(4)
11.6 Naturally occurring antifouling surfaces
238(2)
11.7 Silver ions and silver-containing surfaces
240(2)
11.8 Conclusion
242(13)
References
242(12)
Appendix: abbreviations
254(1)
Index 255
Dr Barnes is a Senior Lecturer at the University of Brighton
Biežāk uzdotie jautājumi par e-grāmatām Biežāk uzdotie jautājumi par e-grāmatām
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