Contributors |
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xi | |
Preface |
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xxi | |
How to use this Book |
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xxiii | |
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Part I Materials Science and Engineering |
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Section 1.1 Overview of Biomaterials |
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1.1.1 Introduction to Biomaterials Science: An Evolving, Multidisciplinary Endeavor |
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3 | (18) |
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Shelly E. Sakiyama-Elbert |
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1.1.2 A History of Biomaterials |
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21 | (14) |
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Section 1.2 Properties of Biomaterials |
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1.2.1 Introduction: Properties of Materials---the Palette of the Biomaterials Engineer |
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35 | (2) |
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1.2.2 The Nature of Matter and Materials |
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37 | (4) |
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1.2.3 Bulk Properties of Materials |
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41 | (12) |
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1.2.4 Surface Properties and Surface Characterization of Biomaterials |
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53 | (24) |
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1.2.5 Role of Water in Biomaterials |
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77 | (6) |
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Section 1.3 Classes of Materials Used in Medicine |
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1.3.1 The Materials Side of the Biomaterials Relationship |
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83 | (2) |
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1.3.2 Polymers: Basic Principles |
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85 | (18) |
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103 | (6) |
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109 | (16) |
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1.3.2C Fluorinated Biomaterials |
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125 | (14) |
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1.3.2D The Organic Matrix of Restorative Composites and Adhesives |
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139 | (14) |
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153 | (14) |
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1.3.2F Degradable and Resorbable Polymers |
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167 | (24) |
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1.3.2G Applications of "Smart Polymers" as Biomaterials |
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191 | (14) |
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1.3.3 Metals: Basic Principles |
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205 | (24) |
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1.3.3A Titanium Alloys, Including Nitinol |
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229 | (20) |
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249 | (8) |
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257 | (14) |
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1.3.3D Biodegradable Metals |
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271 | (18) |
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1.3.4 Ceramics, Glasses, and Glass-Ceramics: Basic Principles |
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289 | (18) |
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1.3.4A Natural and Synthetic Hydroxyapatites |
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307 | (12) |
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1.3.4B Structural Ceramic Oxides |
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319 | (8) |
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1.3.5 Carbon Biomaterials |
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327 | (34) |
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361 | (16) |
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377 | (24) |
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1.3.6B Use of Extracellular Matrix Proteins and Natural Materials in Bioengineering |
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401 | (14) |
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415 | (16) |
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431 | (22) |
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453 | (32) |
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Section 1.4 Materials Processing |
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1.4.1 Introduction to Materials Processing for Biomaterials |
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485 | (2) |
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Shelly E. Sakiyama-Elbert |
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1.4.2 Physicochemical Surface Modification of Materials Used in Medicine |
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487 | (20) |
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1.4.3A Nonfouling Surfaces |
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507 | (8) |
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1.4.3B Nonthrombogenic Treatments and Strategies |
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515 | (24) |
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1.4.4 Surface-Immobilized Biomolecules |
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539 | (14) |
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553 | (22) |
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1.4.6 Medical Fibers and Biotextiles |
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575 | (26) |
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1.4.7 Textured and Porous Biomaterials |
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601 | (22) |
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1.4.8 Biomedical Applications of Additive Manufacturing |
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623 | (20) |
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Elizabeth Cosgriff-Hernandez |
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Part II Biology and Medicine |
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Section 2.1 Some Background Concepts |
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2.1.1 Introduction to Biology and Medicine--- Key Concepts in the Use of Biomaterials in Surgery and Medical Devices |
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643 | (2) |
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2.1.2 Adsorbed Proteins on Biomaterials |
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645 | (16) |
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2.1.3 Cells and Surfaces in Vitro |
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661 | (22) |
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2.1.4 Functional Tissue Architecture, Homeostasis, and Responses to Injury |
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683 | (18) |
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2.1.5 The Extracellular Matrix and Cell-Biomaterial Interactions |
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701 | (16) |
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2.1.6 Effects of Mechanical Forces on Cells and Tissues |
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717 | (18) |
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Section 2.2 Host Reaction to Biomaterials and Their Evaluation |
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2.2.1 Introduction to Biological Responses to Materials |
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735 | (2) |
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Shelly E. Sakiyama-Elbert |
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2.2.2 Inflammation, Wound Healing, the Foreign-Body Response, and Alternative Tissue Responses |
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737 | (10) |
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2.2.3 Innate and Adaptive Immunity: The Immune Response to Foreign Materials |
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747 | (30) |
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Benjamin George Keselowsky |
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2.2.4 The Complement System |
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777 | (14) |
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2.2.5 Systemic and Immune Toxicity of Implanted Materials |
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791 | (10) |
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2.2.6 Blood Coagulation and Blood-Material Interactions |
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801 | (12) |
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2.2.7 Tumorigenesis and Biomaterials |
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813 | (10) |
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2.2.8 Biofilms, Biomaterials, and Device-Related Infections |
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823 | (18) |
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Section 2.3 Characterization of Biomaterials |
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2.3.1 How Well Will It Work? Introduction to Testing Biomaterials |
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841 | (2) |
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2.3.2 The Concept and Assessment of Biocompatibility |
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843 | (8) |
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2.3.3 In Vitro Assessment of Cell and Tissue Compatibility |
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851 | (18) |
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2.3.4 In Vivo Assessment of Tissue Compatibility |
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869 | (10) |
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2.3.5 Evaluation of Blood-Materials Interactions |
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879 | (20) |
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2.3.6 Animal Surgery and Care of Animals |
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899 | (18) |
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Section 2.4 Degradation of Materials in the Biological Environment |
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2.4.1 Introduction: The Body Fights Back-Degradation of Materials in the Biological Environment |
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917 | (2) |
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2.4.2 Chemical and Biochemical Degradation of Polymers Intended to Be Biostable |
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919 | (22) |
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2.4.3 Metallic Degradation and the Biological Environment |
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941 | (14) |
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2.4.4 Degradative Effects of the Biological Environment on Ceramic Biomaterials |
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955 | (18) |
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2.4.5 Pathological Calcification of Biomaterials |
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973 | (22) |
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Section 2.5 Applications of Biomaterials |
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2.5.1 Introduction to Applications of Biomaterials |
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995 | (4) |
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2.5.2A Cardiovascular Medical Devices: Heart Valves, Pacemakers and Defibrillators, Mechanical Circulatory Support, and Other Intracardiac Devices |
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999 | (34) |
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2.5.2B Cardiovascular Medical Devices: Stents, Grafts, Stent-Grafts and Other Endovascular Devices |
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1033 | (18) |
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2.5.3 Extracorporeal Artificial Organs and Therapeutic Devices |
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1051 | (28) |
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Alastair Campbell Ritchie |
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2.5.4 Orthopedic Applications |
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1079 | (40) |
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2.5.5 Dental Applications |
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1119 | (16) |
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2.5.6 Ophthalmologic Applications: Introduction |
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1135 | (18) |
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2.5.7 Bioelectronic Neural Implants |
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1153 | (16) |
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2.5.8 Burn Dressings and Skin Substitutes |
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1169 | (12) |
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2.5.9 Description and Definition of Adhesives, and Related Terminology |
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1181 | (18) |
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2.5.10 Biomaterials for Immunoengineering |
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1199 | (18) |
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2.5.11 Biomaterials-Based Model Systems to Study Tumor-Microenvironment Interactions |
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1217 | (20) |
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2.5.12 Drug Delivery Systems |
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1237 | (30) |
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2.5.13 Responsive Polymers in the Fabrication of Enzyme-Based Biosensors |
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1267 | (20) |
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Section 2.6 Applications of Biomaterials in Functional Tissue Engineering |
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2.6.1 Rebuilding Humans Using Biology and Biomaterials |
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1287 | (2) |
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Shelly E. Sakiyama-Elbert |
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2.6.2 Overview of Tissue Engineering Concepts and Applications |
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1289 | (28) |
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2.6.3 Tissue Engineering Scaffolds |
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1317 | (18) |
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2.6.4 Micromechanical Design Criteria for Tissue-Engineering Biomaterials |
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1335 | (16) |
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2.6.5 Tendon Tissue-Engineering Scaffolds |
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1351 | (22) |
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2.6.6 Bone Tissue Engineering |
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1373 | (16) |
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2.6.7 Biomaterials for Cardiovascular Tissue Engineering |
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1389 | (10) |
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2.6.8 Soft Tissue Engineering |
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1399 | (18) |
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Part III The Medical Product Life Cycle |
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3.1.1 Introduction: Biomaterials in Medical Devices |
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1417 | (4) |
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3.1.2 Total Product Lifecycle for Biomaterial-Based Medical Devices |
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1421 | (4) |
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3.1.3 Safety and Risk Considerations in Medical Device Development |
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1425 | (6) |
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3.1.4 Sterilization and Disinfection of Biomaterials for Medical Devices |
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1431 | (16) |
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3.1.5 Verification and Validation: From Bench to Human Studies |
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1447 | (10) |
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3.1.6 Commercial Considerations in Medical Device Development |
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1457 | (6) |
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3.1.7 Regulatory Constraints for Medical Products Using Biomaterials |
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1463 | (12) |
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3.1.8 Role of Standards for Testing and Performance Requirements of Biomaterials |
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1475 | (10) |
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3.1.9 Medical Device Failure---Implant Retrieval, Evaluation, and Failure Analysis |
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1485 | (12) |
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3.1.10 Legal Concepts for Biomaterials Engineers |
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1497 | (12) |
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3.1.11 Moral and Ethical Issues in the Development of Biomaterials and Medical Products |
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1509 | (10) |
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Appendix A Properties of Biological Fluids |
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1519 | (6) |
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Appendix B Properties of Soft Materials |
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1525 | (6) |
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Appendix C Chemical Composition of Metals and Ceramics Used for Implants |
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1531 | (2) |
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Appendix D The Biomaterials Literature |
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1533 | (4) |
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Appendix E Assessment of Cell and Matrix Components in Tissues, [ Online only] |
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Index |
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1537 | |