This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
Chapter
1. Emerging Technologies : Gateway to Understand Molecular
Insight of Diseases, Newer Drugs, Their Design and Targeting.
Chapter
2.
Polypharmacology: New Paradigms in Drug Development.
Chapter
3. Drug
Repurposing in Biomedical Research : Benefits and Challenges.
Chapter
4.
Computational Methods for Drug Repurposing.
Chapter
5. Genomic Approaches
for Drug Repositioning.
Chapter
6. Organ-On-A- Chip: Novel in-Vitro Model
For Drug Discovery.
Chapter
7. Precision Radiomolecular Oncology:
Challenging the Classical Statistical Evidence Based Medicine.
Chapter
8.
Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate
Cancer Treatment.
Chapter
9. Biomarker Based Drug Discovery and Reverse
Translational Approach.
Chapter
10. Nanotechnology in Dentistry.
Chapter
11. Nanoparticles a Potential Breakthrough in Counteracting
Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying
Mechanisms and Antibacterial Properties.
Chapter
12. Emerging Role of
Cannabinoid System Modulators in Treatment of Cancer.
Chapter
13. Nanodrugs
: A Futuristic Approach for Treating Nephrolithiasis.
Chapter
14. Lipo
Dermaceuticals : Technological Transformation.
Chapter
15. The Importance of
Drug Dose Adjustment in Elderly Patients with Special Considerations for
Patients on Diverse Co-Medications and Antidepressants.
Chapter
16. Role of
Microfluidics and Nano Fluidics in Managing CAD.
Chapter
17. Targeted Gene
Delivery Through Magnetofection: The New Face of Medicine.
Chapter
18.
Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital
Precepts, Retrospect and Prospects.
Chapter
19. Nanoemulsions: A Potential
Advanced Nanocarrier Platform for Herbal Drug Delivery.
Chapter
20. Sirna
Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in
Diabetic Neuropathic Pain.
Chapter
21. EGFR Targeted Quinazoline Clubbed
Heterocycles as Anti-Cancer Agents.
Chapter
22. Therapeutic Human Monoclonal
Antibodies.-Chapter
23. Hydroxyapatites and Their Biomedical Applications.-
Chapter
24. Recent Progress in Applications of Magnetic Nanoparticles in
Medicine: A Review.
Chapter
25. Chimeric Antigen Receptor T-Cell Therapy: A
Cutting Edge Therapy for Multiple Myeloma.
Chapter
26.
Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials.-
Chapter
27. Antimicrobial Applications of Engineered Metal-Based
Nanomaterials.
Chapter
28. Strengthening Immunity-Ayurveda & Medicinal
Plants.
Chapter
29. The Pathophysiology of Liver Disorders and
Pharmacotherapy Options with Special Reference to Traditional Herbal
Medicines: A Comprehensive Review.
Chapter
30. Polymeric Vehicles for
Controlled Delivery of Ayurvedic Drugs for Wound Management.
Professor Ranbir Chander Sobti is an Emeritus Professor and Indian National Science Academy (INSA) senior scientist at Punjab University. He is a former Vice-Chancellor of the Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow. He started his career as a cytogeneticist and then moved on to molecular biology, including genomics, to understand the susceptibility and disease process of cancer, COPD, AIDS metabolic syndrome, and kidney diseases. He has also used stem cells and nanoparticles to understand the process of tissue organ development through a designed de-cellularization protocol. He has published more than 300 research articles in the journals of international repute and has also published more than 40 books.
He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy ofAgricultural Sciences, Canadian Academy of Cardiovascular Diseases and few others. He was the General President of the Indian Science Congress for the 102nd session held at the University of Jammu in 2013. Dr. Sobti is the recipient of many prestigious awards like the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration and Sriram Oration Awards and of Life Time Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India.
Dr. Naranjan S. Dhalla is a principal Investigator Experimental Cardiology, Institute of Cardiovascular Sciences Distinguished Professor, Max Rady College of Medicine Professor of Physiology and Pathophysiology, University of Manitoba Senior Fellow, Centre for the Advancement of Medicine Dr. Naranjan S. Dhalla has received more than 170 honours and awards from all over the world. These include the Order of Canada, Order of Manitoba, Order of the Buffalo Hunt from the Province of Manitoba, Fellowship in the Royal Society of Canada, Medal of Honour of the Canadian Medical Association, Research Achievement Award of the Canadian Cardiovascular Society, Chair in Cardiovascular Research and Honorary Professorship at different Universities.
Dr. Dhalla was elected 2nd Greatest Manitoban of All Time and was featured in Greatest Manitobans, a book published by the Winnipeg Free Press. Dr Dhalla has published large number of research papers and book Chapters. He has travelled widely and has addressed various national and international conferences.
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