Bioreactor Design Concepts for Viral Vaccine Production covers a range of interdisciplinary chapters from the engineering perspective of bioreactor design to the biotechnological perspectives of vector design for vaccine development. The book covers bioreactor concepts such as static systems, single-use systems, stirred tanks, perfusion, wave and packed-beds. It reviews options for efficient and economical production of human vaccines and discusses basic factors relevant for viral antigen production in mammalian cells, avian cells, and insect cells. This book will be a great resource for those interested in implemented novel bioreactor design or experimental schemes towards intensified or/and enhanced vaccine production.
1. Introduction: Understanding of Bioreactor
2. Stoichiometry for Biochemical Process
3. Biochemical aspects of bioreactor operation
4. Scale-Up of Cell-Culture Bioreactors
5. Application of modeling in bioreactor design and analysis
6. Vaccine and Vaccine types
7. Development a new vaccine at lab scale
8. Animal cell cultivation in bioreactor
9. Characterization of cultured animal cells
10. Bioreactor design for vaccine production
11. Advance development in membranes for virus producing bioreactors
12. Downstream Processing for vaccines
13. Vaccine against RNA viruses
14. Vaccine against DNA viruses
15. Development of a bioprocess for rotavirus vaccine
16. Single-use fixed bed bioreactor for scalable virus production
17. Production of rabies vaccine in the large-scale bioreactor
18. Bioreactor for hepatitis C virus vaccine
19. Bioreactor for Vero cell for the production of viral vector and vaccines.
20. Titration and dose calculation of the vaccine stock
21. Bioreactor process development for DNA vaccine production
Surajbhan Sevda is currently an Assistant Professor at the Department of Biotechnology, National Institute of Technology, Warangal, India. Prior to this, he was a technical officer (research scientist) at IIT Guwahati, India. He completed his Doctoral Degree in 2013 from Indian Institute of Technology, New Delhi, India. He was a visiting scientist at University of Calgary, Canada in 2018. His research experience lies in the bioreactor design, modelling of microbial growth, biofuels, and bioenergy, life cycle analysis (LCA), metal recovery, biosensor development, green chemistry, microbial electrosynthesis, enzyme and antibiotic production.
Dr. Sachin Kumar is currently working as Associate Professor at the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, India. He obtained his Ph.D. in molecular virology from University of Maryland in 2010. His research area is viral Immunology, in broad sense, is the study of viral infections in context of immune responses to such infections which can cause deleterious effect on the functions of the cells. Viruses are highly adaptable and have developed ways to avoid detection by specific immune cells. Immune response to a virus follows a cascade of steps and different routes: via specific targeting cytotoxic immune cells, or chemicals such as interferon, or via antibody binding and subsequent complement system activation. Our current understanding of host immune responses to viruses has progressed in recent years, and 'Viral Immunology' as an area has established itself as a sub-discipline of 'Immunology' tackling the immunological context in viral infections.
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