About the editor |
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xix | |
Preface |
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xxi | |
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1 Blockchain technology and its relevance in healthcare |
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1 | (24) |
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1 | (5) |
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1.1.1 Evolution of blockchain technology |
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2 | (1) |
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1.1.2 Characteristics of blockchain technology |
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3 | (1) |
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1.1.3 Overview of blockchain architecture |
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4 | (1) |
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1.1.4 Merkle tree structure |
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5 | (1) |
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1.2 Basic components of blockchain |
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6 | (2) |
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1.2.1 Cryptographic hash functions |
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6 | (1) |
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1.2.2 Asymmetric-key cryptography |
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6 | (1) |
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7 | (1) |
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7 | (1) |
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7 | (1) |
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8 | (1) |
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8 | (1) |
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1.3.3 Practical byzantine fault tolerance |
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8 | (1) |
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1.3.4 Delegated proof of stake |
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9 | (1) |
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1.3.5 Round robin consensus model |
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9 | (1) |
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1.3.6 Proof of authority (identity) model |
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9 | (1) |
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1.3.7 Proof of elapsed time (PoET) consensus model |
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9 | (1) |
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1.4 Challenges and opportunities of blockchain technology |
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9 | (3) |
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1.4.1 Security and privacy of the data |
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9 | (1) |
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10 | (1) |
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10 | (1) |
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10 | (1) |
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10 | (1) |
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10 | (1) |
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1.4.7 Blockchain vulnerabilities |
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11 | (1) |
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11 | (1) |
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11 | (1) |
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11 | (1) |
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1.4.12 Fighting counterfeit drugs |
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11 | (1) |
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11 | (1) |
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1.4.14 Improving research and development |
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12 | (1) |
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12 | (5) |
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13 | (1) |
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13 | (1) |
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1.5.3 Consortium blockchain |
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14 | (2) |
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1.5.4 Permissioned blockchain |
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16 | (1) |
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1.5.5 Permissionless blockchain |
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17 | (1) |
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1.6 Relevance of blockchain for healthcare |
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17 | (5) |
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1.6.1 Blockchain for medical record management |
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18 | (1) |
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1.6.2 Blockchain for medicinal research |
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19 | (1) |
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1.6.3 Blockchain for insurance claims |
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19 | (2) |
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1.6.4 Blockchain for counterfeit drugs |
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21 | (1) |
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1.6.5 Blockchain to prevent future pandemics |
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22 | (1) |
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1.6.6 Blockchain to save cost |
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22 | (1) |
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22 | (3) |
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22 | (3) |
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2 Privacy issues in blockchain |
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25 | (32) |
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2.1 National and Corporate Support |
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26 | (2) |
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2.2 Asia trade and European trade |
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28 | (1) |
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2.3 Multinational policies vs blockchain |
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29 | (6) |
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2.3.1 Security of blockchain? |
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30 | (1) |
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2.3.2 Shifting security to the end user |
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31 | (1) |
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31 | (3) |
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2.3.4 Key developments of blockchain for voting |
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34 | (1) |
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2.3.5 Improving productivity in agriculture |
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34 | (1) |
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2.3.6 Guarantee straightforwardness, supportability in fishing |
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34 | (1) |
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2.3.7 Cryptocurrency regulations |
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34 | (1) |
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35 | (1) |
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2.4 Blockchain approaches to data privacy in healthcare |
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35 | (8) |
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2.4.1 Blockchain for electronic medical record (EMR) data management |
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37 | (1) |
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2.4.2 Blockchain for personal health record (PHR) data management |
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38 | (1) |
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2.4.3 Blockchain for point-of-care genomics |
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38 | (1) |
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2.4.4 Blockchain for EHR data management |
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39 | (1) |
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2.4.5 Fast health-care interoperability resources |
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40 | (1) |
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2.4.6 Health-care blockchain |
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40 | (1) |
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40 | (1) |
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41 | (1) |
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2.4.9 Network is the concern not a database |
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41 | (1) |
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2.4.10 Clear definition of use cases |
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41 | (1) |
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2.4.11 Throughput and scalability |
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42 | (1) |
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42 | (1) |
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2.4.13 Blockchain privacy poisoning |
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42 | (1) |
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2.4.14 Consent management and the blockchain |
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43 | (1) |
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2.5 Blockchain privacy poisoning in the context of other privacy issues |
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43 | (3) |
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2.5.1 Who should be accountable for blockchain privacy poisoning? |
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44 | (1) |
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2.5.2 Problems of blockchain security/privacy |
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44 | (1) |
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45 | (1) |
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2.6 Blockchain security for health data: promises, risks, and future development: blockchain security issues |
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46 | (6) |
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2.6.1 Challenges and limitations |
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49 | (3) |
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52 | (5) |
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52 | (5) |
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3 Reforming the traditional business network |
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57 | (28) |
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57 | (3) |
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3.2 Applications of blockchain |
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60 | (6) |
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3.2.1 Blockchains in electronic health records (EHR) |
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60 | (3) |
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3.2.2 Blockchains in clinical research |
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63 | (1) |
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3.2.3 Blockchains in medical fraud detection |
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63 | (1) |
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3.2.4 Blockchains in neuroscience |
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64 | (1) |
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3.2.5 Blockchains in pharmaceutical industry and research |
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65 | (1) |
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3.3 Business benefits of blockchain |
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66 | (1) |
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3.4 Reliance on blockchain usage |
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67 | (1) |
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67 | (1) |
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67 | (1) |
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3.4.3 Coordination's activities |
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68 | (1) |
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3.5 Market resistance to blockchain |
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68 | (2) |
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68 | (1) |
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3.5.2 Level support and resistance |
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68 | (1) |
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69 | (1) |
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3.6 Role of blockchain in healthcare |
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70 | (3) |
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71 | (1) |
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3.6.2 Clinical data exchange and interoperability |
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71 | (1) |
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3.6.3 Billing and claims management |
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71 | (1) |
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3.6.4 Cybersecurity and healthcare IoT |
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72 | (1) |
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3.6.5 Population health research and pharma clinical trials |
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72 | (1) |
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3.7 Blockchain in hospital management services |
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73 | (1) |
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3.7.1 Blockchain in healthcare |
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73 | (1) |
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3.7.2 New business opportunities |
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73 | (1) |
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3.7.3 Electronic medical records |
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73 | (1) |
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3.7.4 Guideline compliance |
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74 | (1) |
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3.7.5 Decreased billing and speedy claim settlement |
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74 | (1) |
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3.7.6 Decrease in information risks |
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74 | (1) |
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3.7.7 Coordination of data |
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74 | (1) |
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3.8 Blockchain---the new age business disruptor |
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74 | (7) |
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75 | (1) |
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76 | (1) |
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76 | (1) |
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77 | (1) |
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78 | (1) |
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79 | (1) |
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3.8.7 The Internet of Things (IoT)---connected devices |
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79 | (2) |
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81 | (4) |
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81 | (4) |
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4 A deep dive into Hyperledger |
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85 | (24) |
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Venkatesan Meenakshi Sundaram |
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4.1 Hyperledger Frameworks |
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85 | (10) |
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86 | (1) |
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87 | (2) |
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89 | (1) |
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90 | (1) |
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91 | (1) |
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4.1.6 Hyperledger Sawtooth |
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91 | (2) |
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93 | (2) |
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4.2 Hyperledger Libraries |
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95 | (1) |
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95 | (1) |
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95 | (1) |
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4.2.3 Hyperledger Transact |
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95 | (1) |
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95 | (1) |
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96 | (1) |
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96 | (1) |
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4.3.2 Hyperledger Caliper |
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96 | (1) |
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96 | (1) |
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4.3.4 Hyperledger Explorer |
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97 | (1) |
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4.3.5 Hyperledger Composer |
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97 | (1) |
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4.4 Blockchain in enterprise |
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97 | (4) |
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98 | (3) |
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4.5 Blockchain in e-healthcare |
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101 | (3) |
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4.5.1 Improve medical record access |
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101 | (1) |
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4.5.2 Improve clinical trials |
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102 | (1) |
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4.5.3 Improve drug traceability |
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103 | (1) |
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4.6 An example of healthcare data management using IBM blockchain platform |
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104 | (5) |
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106 | (3) |
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109 | (28) |
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109 | (3) |
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5.1.1 Machine learning life cycle |
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110 | (2) |
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5.1.2 Components in machine learning |
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112 | (1) |
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5.2 Different types of learning |
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112 | (8) |
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5.2.1 Supervised learning |
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112 | (3) |
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5.2.2 Unsupervised learning |
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115 | (2) |
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5.2.3 Reinforcement learning |
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117 | (3) |
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5.3 Types of machine learning algorithms |
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120 | (14) |
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5.3.1 Classification algorithms |
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120 | (2) |
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5.3.2 Regression algorithm |
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122 | (1) |
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5.3.3 Dimensionality reduction algorithm |
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123 | (1) |
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5.3.4 Clustering algorithms |
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124 | (3) |
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5.3.5 Reinforcement algorithm |
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127 | (2) |
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5.3.6 Machine learning in healthcare |
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129 | (2) |
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5.3.7 Advantages and disadvantages of machine learning |
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131 | (2) |
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5.3.8 Limitations of ML in healthcare industry |
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133 | (1) |
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134 | (3) |
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135 | (2) |
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6 Machine learning in blockchain |
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137 | (24) |
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Venkata Raghavendra Naga Pawan |
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138 | (3) |
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6.1.1 What is machine learning? |
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138 | (1) |
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6.1.2 Importance of ML in blockchain |
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139 | (1) |
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6.1.3 Merits and demerits |
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140 | (1) |
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141 | (1) |
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6.2.1 Supervised learning |
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141 | (1) |
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6.2.2 Unsupervised learning |
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141 | (1) |
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6.2.3 Reinforcement learning |
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141 | (1) |
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6.3 Different ML algorithms |
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142 | (5) |
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142 | (1) |
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6.3.2 Logistic regression |
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143 | (2) |
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6.3.3 Decision tree and SVM |
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145 | (1) |
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146 | (1) |
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147 | (1) |
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147 | (1) |
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6.3.7 Gradient boosting algorithms---GBM, XGBoost, LightGBM, CatBoost |
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147 | (1) |
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6.4 Significance of ML in the health-care industry |
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147 | (8) |
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6.4.1 Identifying diseases and diagnosis |
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148 | (1) |
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6.4.2 Drug discovery and manufacturing |
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149 | (1) |
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6.4.3 Medical imaging diagnosis |
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150 | (1) |
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6.4.4 Personalized medicine |
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151 | (1) |
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6.4.5 Machine-learning-based behavioral modification |
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152 | (1) |
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6.4.6 Smart health records |
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152 | (1) |
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6.4.7 Clinical trial and research |
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153 | (1) |
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6.4.8 Crowd-sourced data collection, better radiotherapy and outbreak prediction |
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154 | (1) |
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6.5 Implementation difficulties of using ML in healthcare |
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155 | (2) |
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6.6 Applications and future scope of research |
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157 | (1) |
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158 | (3) |
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158 | (3) |
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7 Framework for approaching blockchain in healthcare using machine learning |
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161 | (24) |
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161 | (1) |
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7.1.1 Introduction to machine learning |
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162 | (1) |
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7.1.2 Introduction to blockchain |
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162 | (1) |
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7.2 The steps in machine learning |
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162 | (2) |
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7.3 Gathering health data |
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164 | (3) |
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7.3.1 Influence of data assemblage in healthcare |
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164 | (2) |
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7.3.2 Recent trends in data collection |
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166 | (1) |
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7.3.3 Healthcare datasets |
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166 | (1) |
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167 | (3) |
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7.4.1 Benefits of data preparation and the cloud |
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167 | (1) |
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7.4.2 Data preparation steps |
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168 | (2) |
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170 | (4) |
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7.5.1 Types of machine learning algorithms |
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170 | (1) |
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7.5.2 Most familiar machine learning algorithms |
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171 | (2) |
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7.5.3 Need for models in healthcare using blockchain |
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173 | (1) |
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174 | (2) |
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7.6.1 The purpose of train/test sets |
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174 | (2) |
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7.6.2 Blockchain for privacy in healthcare |
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176 | (1) |
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7.6.3 Quantum of training data requirements |
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176 | (1) |
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176 | (2) |
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177 | (1) |
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7.7.2 Evaluation metrics and assessment of machine learning algorithms in healthcare |
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177 | (1) |
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178 | (1) |
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178 | (2) |
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7.9.1 Requirement collection |
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178 | (1) |
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179 | (1) |
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7.9.3 Data analysis and massaging |
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179 | (1) |
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7.9.4 Statistics, machine learning |
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179 | (1) |
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7.9.5 Predictive modelling |
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180 | (1) |
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7.9.6 Prediction and monitoring |
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180 | (1) |
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7.10 Benefits of integrating machine learning and blockchain |
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180 | (1) |
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181 | (4) |
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181 | (4) |
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8 Reforming the traditional business network |
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185 | (26) |
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185 | (2) |
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8.2 Artificial intelligence in healthcare |
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187 | (6) |
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8.2.1 Artificial intelligence doctors |
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187 | (1) |
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8.2.2 AI---robot treatment |
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188 | (2) |
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190 | (2) |
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8.2.4 Non-adherence to prescriptions |
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192 | (1) |
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8.3 Blockchain in healthcare |
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193 | (3) |
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8.3.1 Blockchain in healthcare |
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193 | (1) |
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8.3.2 Medical credential tracking |
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194 | (1) |
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195 | (1) |
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196 | (6) |
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8.4.1 Dataset and data files |
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197 | (1) |
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8.4.2 Images and photographs |
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198 | (1) |
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199 | (1) |
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200 | (2) |
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8.5 New medical imaging modalities |
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202 | (4) |
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8.5.1 Multivalued data images |
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202 | (1) |
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8.5.2 Phase contrast magnetic resonance angiography (MRA) |
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203 | (1) |
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8.5.3 Diffusion tensor MRI |
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203 | (1) |
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8.5.4 Federated tensor factorization |
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204 | (2) |
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8.6 Medical appliance of norms |
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206 | (5) |
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8.6.1 Significance of medical devices |
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206 | (1) |
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8.6.2 Medical device safety |
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207 | (1) |
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8.6.3 Global Harmonization Task Force |
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207 | (1) |
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8.6.4 Classification of medical devices |
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208 | (1) |
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209 | (2) |
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211 | (20) |
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211 | (2) |
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213 | (4) |
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9.2.1 Descriptive analytics |
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214 | (1) |
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9.2.2 Predictive analytics |
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215 | (1) |
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9.2.3 Perspective analysis |
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215 | (2) |
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9.3 Emerging technologies in healthcare analytics |
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217 | (5) |
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9.3.1 Big data technology in healthcare analytics |
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218 | (1) |
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9.3.2 Internet of Things in healthcare analytics |
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219 | (2) |
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9.3.3 Artificial intelligence in healthcare |
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221 | (1) |
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9.3.4 Blockchain in healthcare |
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221 | (1) |
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9.4 History of healthcare analytics |
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222 | (1) |
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9.5 Exploring software for healthcare analytics |
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223 | (3) |
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224 | (1) |
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225 | (1) |
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9.6 Challenges with healthcare analytics |
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226 | (1) |
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9.6.1 High-dimensional data |
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226 | (1) |
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9.6.2 Irregularities in data |
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226 | (1) |
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227 | (1) |
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227 | (4) |
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227 | (4) |
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10 Blockchain for healthcare |
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231 | (36) |
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231 | (2) |
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10.1.1 Bitcoin blockchain |
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232 | (1) |
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232 | (1) |
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232 | (1) |
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233 | (1) |
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10.3 Contracts and healthcare: the arising need of smart contracts |
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234 | (7) |
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234 | (4) |
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10.3.2 Zero-knowledge-proofs and smart contracts |
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238 | (1) |
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10.3.3 Ricardian contracts for healthcare |
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239 | (1) |
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10.3.4 Hybrid smart--Ricardian contracts |
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240 | (1) |
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10.4 Applications of blockchain |
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241 | (1) |
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241 | (2) |
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10.5.1 Structured data sets |
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242 | (1) |
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10.5.2 Non-structured data sets |
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242 | (1) |
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10.6 Popular resources for gathering healthcare data |
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243 | (1) |
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10.7 Need of healthcare data |
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243 | (1) |
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10.8 Services offered by the blockchain in healthcare |
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244 | (2) |
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10.8.1 Data sharing and privacy issues |
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244 | (1) |
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10.8.2 Longitudinal patient records and health data accuracy |
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245 | (1) |
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10.8.3 Drug track ability |
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245 | (1) |
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10.8.4 Fake medical credentials |
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245 | (1) |
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245 | (1) |
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10.8.6 Supply chain management |
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246 | (1) |
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10.8.7 Interoperability of data among medical institutes |
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246 | (1) |
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10.9 Medicines and supply chain tracking enabled by blockchain |
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246 | (1) |
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10.10 Data security concerns in EMR and healthcare domain |
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247 | (1) |
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10.11 Choices of blockchain platforms for healthcare |
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248 | (6) |
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249 | (1) |
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250 | (1) |
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250 | (1) |
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250 | (1) |
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251 | (1) |
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252 | (1) |
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252 | (1) |
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253 | (1) |
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10.11.9 Quorum blockchain platform |
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253 | (1) |
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10.11.10 EOS blockchain platform |
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253 | (1) |
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10.11.11 Internet-of-Things application (IOTA) blockchain platform |
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254 | (1) |
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10.12 Major healthcare blockchain use cases under development |
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254 | (2) |
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10.13 Storage challenges and need for inter planetary file system (IPFS) enabled blockchain for healthcare |
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256 | (1) |
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256 | (1) |
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10.15 Why do we need IPFS? |
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257 | (1) |
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10.16 Blockchain and IPFS |
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257 | (1) |
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10.17 Challenges and roadblocks to the realisation of blockchain-enabled healthcare |
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258 | (3) |
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261 | (6) |
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261 | (6) |
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11 Improved interop blockchain applications for e-healthcare systems |
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267 | (28) |
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Jesu Rethnam Rethna Virgil Jeny |
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268 | (2) |
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11.1.1 How blockchain is used in healthcare? |
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269 | (1) |
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11.1.2 Challenges in interoperability between various sections of healthcare system |
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269 | (1) |
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270 | (5) |
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11.2.1 Electronic health records |
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270 | (1) |
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271 | (1) |
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11.2.3 Blockchain in future healthcare |
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271 | (1) |
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11.2.4 Blockchain and cryptocurrencies |
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271 | (4) |
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275 | (15) |
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11.3.2 Smart-contract system design |
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275 | (2) |
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11.3.3 Smart contract implementation |
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277 | (4) |
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11.3.4 Drug traceability using blockchain |
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281 | (6) |
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11.3.5 Clinical trials using blockchain |
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287 | (3) |
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11.4 Conclusion and future scope |
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290 | (5) |
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291 | (4) |
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12 Blockchain: lifeline care for breast cancer patients in developing countries |
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295 | (24) |
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296 | (1) |
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297 | (3) |
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297 | (1) |
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12.2.2 Kind of blockchains |
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298 | (1) |
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12.2.3 Agreement instruments |
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298 | (1) |
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299 | (1) |
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12.2.5 The capability of blockchain in the human services space |
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299 | (1) |
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12.3 Healthcare data management |
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300 | (8) |
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12.3.1 Blockchain-based smart contracts for healthcare |
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301 | (2) |
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12.3.2 The process for issuing and filling of medical prescriptions |
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303 | (1) |
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12.3.3 Sharing laboratory test/results data |
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303 | (2) |
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12.3.4 Enabling effective communication between patients and service providers |
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305 | (1) |
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12.3.5 Smart-contracts-based clinical trials |
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306 | (2) |
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12.4 Healthcare data management |
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308 | (2) |
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12.4.1 Medication revelation and pharmaceutical research |
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308 | (1) |
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12.4.2 Flexibly chain and counterfeit medications discovery |
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309 | (1) |
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12.5 Challenges and future scope |
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310 | (3) |
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12.5.1 Interoperability and integration with the legacy systems |
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310 | (1) |
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12.5.2 Selection and motivating forces for support |
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311 | (1) |
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12.5.3 Uncertain expense of activity |
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311 | (1) |
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312 | (1) |
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312 | (1) |
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312 | (1) |
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313 | (6) |
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314 | (5) |
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13 Machine learning for health care |
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319 | (24) |
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B.K.S.P. Kumar Raju Alluri |
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13.1 Machine learning pipelining |
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319 | (1) |
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13.2 Applications of ML in health care |
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320 | (1) |
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13.3 Common machine learning approaches in machine learning |
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321 | (2) |
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13.3.1 Artificial neural networks |
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321 | (1) |
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13.3.2 Tree-like reasoning |
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321 | (1) |
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13.3.3 Other common ML algorithms |
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322 | (1) |
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13.4 Application of machine learning in health care |
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323 | (8) |
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13.4.1 COVID-19---interpretation, detection and drug discovery using machine learning |
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323 | (8) |
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13.5 Breaking the blackbox of neural networks through explainable AI |
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331 | (6) |
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337 | (6) |
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338 | (5) |
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14 Machine learning in healthcare diagnosis |
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343 | (24) |
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Sugumaran Muthukumarasamy |
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344 | (1) |
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14.1.1 State of art of diagnosing system using machine learning |
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344 | (1) |
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14.2 Heart diseases diagnosing system using machine learning |
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345 | (8) |
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14.2.1 Various methods for diagnosis of heart disease using ML |
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349 | (4) |
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14.3 Breast cancer diagnosing system using machine learning |
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353 | (3) |
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14.3.1 k-NN method for breast cancer prediction |
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355 | (1) |
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14.4 Neurological diseases diagnosing system using machine learning |
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356 | (6) |
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14.4.1 Detecting the neurodegenerative diseases and the traumatic brain related injuries using D-CNN |
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357 | (3) |
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14.4.2 Diagnosis using 3D-CNN |
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360 | (1) |
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14.4.3 Training of 3D sparse autoencoder and 3D-CNN |
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361 | (1) |
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14.5 Challenges and future direction of medical diagnosing system |
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362 | (1) |
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362 | (5) |
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363 | (4) |
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15 Python for healthcare analytics made simple |
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367 | (26) |
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368 | (2) |
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368 | (1) |
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15.1.2 Importance of data quality in healthcare |
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368 | (1) |
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15.1.3 Elements of data quality |
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369 | (1) |
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15.1.4 Ensuring data and information quality |
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369 | (1) |
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370 | (8) |
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15.2.1 Implementing NER with NLTK |
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371 | (4) |
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15.2.2 Implementing Named Entity Recognition using SpaCy |
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375 | (3) |
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15.3 Data visualization and tools |
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378 | (4) |
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15.4 Advanced visualization methods |
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382 | (4) |
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386 | (2) |
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15.5.1 Descriptive analytics |
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386 | (1) |
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15.5.2 Diagnostic analytics |
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386 | (1) |
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15.5.3 Predictive analytics |
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386 | (1) |
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15.5.4 Prescriptive analytics |
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387 | (1) |
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15.6 Healthcare and technology: open issues |
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388 | (2) |
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389 | (1) |
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15.6.2 Data interoperability |
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389 | (1) |
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389 | (1) |
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15.6.4 Application of big data in biomedical research |
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389 | (1) |
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390 | (3) |
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390 | (3) |
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16 Identification and classification of hepatitis C virus: an advance machine-learning-based approach |
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393 | (24) |
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394 | (2) |
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396 | (2) |
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16.2.1 Artificial neural network |
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396 | (1) |
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397 | (1) |
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397 | (1) |
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16.2.4 Support vector machine |
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397 | (1) |
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16.3 Proposed methodology |
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398 | (3) |
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16.3.1 Bagging classifier |
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398 | (3) |
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401 | (5) |
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16.4.1 Data preprocessing |
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401 | (1) |
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16.4.2 Dataset description |
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402 | (1) |
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16.4.3 Attribute information |
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403 | (1) |
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16.4.4 Evaluation metrics |
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404 | (2) |
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16.4.5 Environmental setup |
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406 | (1) |
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406 | (6) |
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412 | (5) |
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412 | (5) |
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17 Data visualization using machine learning for efficient tracking of pandemic -- COVID-19 |
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417 | (26) |
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417 | (1) |
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418 | (3) |
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17.2.1 Importance of data preprocessing |
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419 | (1) |
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17.2.2 Data preprocessing consist of following steps |
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419 | (2) |
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17.3 Exploratory data analysis |
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421 | (1) |
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17.3.1 Univariate analysis |
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421 | (1) |
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17.3.2 Bivariate analysis |
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422 | (1) |
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17.4 Data visualization techniques |
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422 | (3) |
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423 | (1) |
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423 | (2) |
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425 | (1) |
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426 | (1) |
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426 | (1) |
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426 | (1) |
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426 | (1) |
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17.8 Importance of data visualization in healthcare |
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427 | (1) |
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17.8.1 Uses of data visualization |
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428 | (1) |
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17.9 COVID-19 gripping the world |
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428 | (4) |
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17.10 COVID-19 India situation |
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432 | (6) |
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17.11 Issue and challenges |
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438 | (1) |
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439 | (4) |
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439 | (4) |
Index |
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443 | |