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Blood Science: Principles and Pathology 2nd edition [Mīkstie vāki]

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(Manchester Metropolitan University, UK), (Institute of Biomedical Science, æLondon, UK)
  • Formāts: Paperback / softback, 640 pages, height x width x depth: 254x178x36 mm, weight: 1383 g
  • Izdošanas datums: 24-Nov-2022
  • Izdevniecība: John Wiley & Sons Inc
  • ISBN-10: 1119864119
  • ISBN-13: 9781119864110
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Blood Science: Principles and Pathology 2nd editionPalielināt
  • Formāts: Paperback / softback, 640 pages, height x width x depth: 254x178x36 mm, weight: 1383 g
  • Izdošanas datums: 24-Nov-2022
  • Izdevniecība: John Wiley & Sons Inc
  • ISBN-10: 1119864119
  • ISBN-13: 9781119864110
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9781119864110.html
Keywords:
Blood Science The second edition of the leading introduction to blood science, with updated new illustrations and case studies

Blood Science: Principles and Pathology integrates hematology and blood transfusion, ­clinical biochemistry, and immunology to provide a thorough introduction to this rapidly expanding discipline. Reflecting recent changes in education and training for healthcare scientists, this comprehensive textbook covers the analytical techniques used in blood ­science, the diagnosis and management of various blood disorders, and more.

Fully revised, the second edition presents new case studies and high-quality images ­throughout, illustrating the practical skills and knowledge required by todays under­graduate students and practitioners. Detailed yet accessible chapters contain learning objectives and summaries, links to further readings and resources, and real-world case studies with easy-to-follow interpretations. Throughout the text, the authors highlight how laboratory data and clinical details are used to investigate patients with actual or suspected diseases in real-world scenarios:





Multi-disciplinary view merging biochemical, hematological, immunological, and genetical knowledge into a single discipline: Blood science Discusses advances in molecular genetics identifying mutations resulting in the occurrence of certain pathological conditions such as leukaemia Presents an expanded concluding chapter with detailed case reports that integrate biochemistry, immunology, and haematology, which all contribute to the investigation of respective conditions Explains the potentials for developing tests such as non-coding RNAs Offers further reading suggestions to dive even deeper into discussed subjects and concepts

Designed to meet the needs of undergraduate students taking blood science modules in biomedical, biological, and healthcare science programs, Blood Science: Principles and Pathology, Second Edition is also an invaluable guide for new graduates entering the field, as well as those training for professional qualifications or working with blood samples in laboratory-based environments.
Preface To The Second Edition xiii
Acknowledgements xiv
About The Companion Website xv
1 Introduction to Blood Science
1(26)
1.1 What is Blood Science?
1(6)
1.2 Clinical Biochemistry
7(2)
1.3 Blood Transfusion
9(2)
1.4 Genetics
11(6)
1.5 Haematology
17(4)
1.6 Immunology
21(2)
1.7 The Role of Blood Science in Modern Healthcare
23(2)
1.8 What this Book will Achieve
25(2)
Summary
26(1)
Further Reading
26(1)
Websites
26(1)
2 Analytical Techniques in Blood Science
27(30)
2.1 Venepuncture
28(1)
2.2 Anticoagulants
28(1)
2.3 Sample Identification and Tracking
29(1)
2.4 Technical and Analytical Confidence
30(6)
2.5 Major Techniques
36(11)
2.6 Molecular Genetics
47(4)
2.7 Point of Care Testing
51(2)
2.8 Health and Safety in the Laboratory
53(2)
2.9 Case Studies
55(2)
Summary
55(1)
Further Reading
55(1)
Websites
56(1)
3 The Physiology of the Red Blood Cell
57(28)
3.1 Introduction
57(2)
3.2 The Development of Blood Cells
59(4)
3.3 Erythropoiesis
63(2)
3.4 The Red Cell Membrane
65(2)
3.5 The Cytoplasm of the Red Cell
67(8)
3.6 Oxygen Transport
75(2)
3.7 Recycling the Red Cell
77(2)
3.8 Red Cell Indices in the Full Blood Count
79(2)
3.9 Morphology of the Red Cell
81(4)
Summary
84(1)
Further Reading
84(1)
Website
84(1)
4 The Pathology of the Red Blood Cell
85(40)
4.1 Introduction: Diseases of Red Cells
86(3)
4.2 Anaemia Resulting from Attack on, or Stress to, the Bone Marrow
89(2)
4.3 Anaemia Due to Micronutrient Deficiency
91(6)
4.4 Intrinsic Defects in the Red Cell
97(16)
4.5 External Factors Acting on Healthy Cells
113(4)
4.6 Erythrocytosis and Polycythaemia
117(3)
4.7 Inclusion Bodies
120(1)
4.8 Molecular Genetics and Red Cell Disease
120(2)
4.9 Case Studies
122(3)
Summary
124(1)
Further Reading
124(1)
Websites
124(1)
5 White Blood Cells in Health and Disease
125(32)
5.1 Introduction
125(3)
5.2 Leukopoiesis
128(4)
5.3 Neutrophils
132(2)
5.4 Lymphocytes
134(1)
5.5 Monocytes
135(1)
5.6 Eosinophils
136(1)
5.7 Basophils
137(1)
5.8 Leukocytes in Action
138(10)
5.9 White Cells in Clinical Medicine
148(6)
5.10 Case Studies
154(3)
Summary
156(1)
Further Reading
156(1)
6 White Blood Cell Malignancy
157(34)
6.1 The Genetic Basis of Leukocyte Malignancy
158(4)
6.2 Tissue Techniques in Haemato-oncology
162(2)
6.3 Leukaemia
164(10)
6.4 Lymphoma
174(5)
6.5 Myeloma and Related Conditions
179(6)
6.6 Myelofibrosis and Myelodysplasia
185(1)
6.7 Non-coding RNAs
186(1)
6.8 Case Studies
187(4)
Summary
189(1)
Further Reading
189(2)
7 The Physiology and Pathology of Haemostasis
191(23)
Virchow's Triad
192(1)
7.1 The Blood Vessel Wall
192(2)
7.2 Platelets
194(2)
7.3 The Coagulation Pathway
196(5)
7.4 Haemostasis as the Balance Between Thrombus Formation and Removal
201(3)
7.5 The Haemostasis Laboratory
204(3)
7.6 The Pathology of Thrombosis
207(4)
7.7 Case Study
211(3)
Summary
212(1)
Further Reading
212(2)
8 The Diagnosis and Management of Disorders of Haemostasis
214(40)
8.1 Thrombosis 1: Overactive Platelets and Thrombocytosis
215(4)
8.2 Thrombosis 2: Overactive Coagulation
219(16)
8.3 Haemorrhage 1: Platelet Underactivity and Thrombocytopenia
235(5)
8.4 Haemorrhage 2: Coagulation Underactivity
240(6)
8.5 Disseminated Intravascular Coagulation (DIC)
246(1)
8.6 Molecular Genetics in Haemostasis
247(2)
8.7 Case Studies
249(5)
Summary
252(1)
Further Reading
253(1)
Websites
253(1)
9 Immunopathology
254(37)
9.1 Introduction
255(1)
9.2 Immunopathology 1: Immunodeficiency
256(6)
9.3 Immunopathology 2: Hypersensitivity
262(6)
9.4 Immunopathology 3: Autoimmune Disease
268(9)
9.5 Immunotherapy
277(5)
9.6 The Immunology Laboratory
282(5)
9.7 Case Studies
287(4)
Summary
289(1)
Further Reading
290(1)
Websites
290(1)
10 Immunogenetics and Histocompatibility
291(24)
10.1 The Genetics of Antigen Recognition
292(4)
10.2 Human Leucocyte Antigens (HLA)
296(2)
10.3 Mechanisms of Lymphocyte Activation
298(5)
10.4 Transplantation
303(8)
10.5 Autoimmunity and HLA
311(4)
Summary
314(1)
Further Reading
314(1)
Websites
314(1)
11 Blood Transfusion
315(31)
What Can Be Transfused?
315(1)
The Basis of Transfusion Science
316(1)
11.1 Blood Collection and Processing
317(3)
11.2 Blood Groups
320(10)
11.3 Laboratory Practice of Blood Transfusion
330(8)
11.4 Clinical Practice of Blood Transfusion
338(3)
11.5 Hazards of Blood Transfusion
341(5)
Summary
344(1)
Further Reading
344(1)
Websites
345(1)
12 Waste Products, Electrolytes, and Renal Disease
346(23)
12.1 Renal Anatomy and Physiology
347(2)
12.2 Homeostasis
349(7)
12.3 Excretion
356(2)
12.4 Renal Endocrinology
358(2)
12.5 Renal Disease
360(6)
12.6 Case Studies
366(3)
Summary
367(1)
Further Reading
368(1)
Websites
368(1)
13 Hydrogen Ions, pH, and Acid-Base Disorders
369(16)
13.1 Ions and Molecules
370(3)
13.2 Blood Gases
373(4)
13.3 Acidosis (pH> 7.3)
377(2)
13.4 Alkalosis (pH<7.5)
379(1)
13.5 Mixed Acid-Base Conditions
379(1)
13.6 Clinical Interpretation
380(1)
13.7 Genetics of Acid/Alkali Homeostasis
381(1)
13.8 Case Studies
381(4)
Summary
383(1)
Further Reading
384(1)
Website
384(1)
14 Glucose, Lipids, and Atherosclerosis
385(43)
14.1 Glucose
386(18)
14.2 Dyslipidaemia
404(13)
14.3 Atherosclerosis
417(7)
14.4 Case Studies
424(4)
Summary
426(1)
Further Reading
426(1)
Websites
427(1)
15 Calcium, Phosphate, Magnesium, and Bone Disease
428(24)
15.1 Calcium
429(3)
15.2 Phosphates
432(1)
15.3 Magnesium
433(1)
15.4 The Laboratory
433(2)
15.5 Disordersof Calcium Homeostasis
435(4)
15.6 Disorders of Phosphate Homeostasis
439(2)
15.7 Disordersof Magnesium Homeostasis
441(1)
15.8 Bone Physiology
442(2)
15.9 Bone Disease
444(4)
15.10 Case Studies
448(4)
Summary
450(1)
Further Reading
450(1)
Websites
451(1)
16 Nutrients and Gastrointestinal Disorders
452(17)
16.1 Nutrients
452(6)
16.2 Intestinal Tract Physiology
458(2)
16.3 Intestinal Tract Pathology
460(6)
16.4 Case Studies
466(3)
Summary
467(1)
Further Reading
468(1)
17 Liver Function Tests and Plasma Proteins
469(29)
17.1 Anatomy and Physiology of the Liver
470(5)
17.2 Liver Function Tests
475(2)
17.3 Diseases of the Liver
477(5)
17.4 LFTs in Liver Disease
482(2)
17.5 Plasma Proteins
484(9)
17.6 Molecular Genetics in Liver Disease
493(2)
17.7 Case Studies
495(3)
Summary
497(1)
Further Reading
497(1)
Websites
497(1)
18 Endocrinology
498(38)
18.1 Endocrine Physiology
499(13)
18.2 The Pathology of the Endocrine System
512(20)
18.3 Case Studies
532(4)
Summary
534(1)
Further Reading
535(1)
Websites
535(1)
19 Cancer and Tumour Markers
536(15)
19.1 General Concepts in Cancer Biology
536(4)
19.2 Blood Science and Cancer
540(6)
19.3 Molecular Genetics
546(1)
19.4 Case Studies
547(4)
Summary
549(1)
Further Reading
549(1)
Websites
550(1)
20 Inherited Metabolic Disorders
551(12)
20.1 The Genetics of Inheritance
552(1)
20.2 Molecular Inherited Metabolic Disorders
553(5)
20.3 Organelle-Inherited Metabolic Disorders
558(1)
20.4 Ante-natal Diagnosis and Neonatal Screening
559(1)
20.5 Case Studies
560(3)
Summary
561(1)
Further Reading
562(1)
21 Drugs and Poisons
563(14)
21.1 Toxicology
563(2)
21.2 Toxicology of Specific Compounds
565(5)
21.3 Therapeutic Drug Monitoring
570(4)
21.4 Case Studies
574(3)
Summary
576(1)
Further Reading
576(1)
22 Case Reports in Blood Science
577(28)
Abbreviations
577(1)
Case Report 1
578(1)
Additional Analyses
579(1)
Case Report 2
579(2)
Case Report 3
581(1)
Case Report 4
582(3)
Case Report 5
585(2)
Case Report 6
587(2)
Case Report 7
589(2)
Case Report 8
591(1)
Case Report 9
592(3)
Case Report 10
595(3)
Case Report 11
598(1)
Case Report 12
598(3)
Case Report 13
601(1)
Case Report 14
602(1)
Case Report 15
602(2)
Acknowledgements
604(1)
Further Reading 605(1)
Appendix: Reference Ranges 606(5)
Index 611
Dr Andrew Blann, Consultant Clinical Scientist, The Institute of Biomedical Science, ­London, UK.

Dr Nessar Ahmed, Reader in Clinical Biochemistry, Department of Life Sciences, ­Manchester Metropolitan University, UK.