This book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena.
The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter.
Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.
ATP and Oxygen: the Energy Economy of the Cell.- Physiological Functions
of Blood.- Hemoglobin: Physiology and Hemoglobinopathy.- The Global Burden of
Anemia.- Blood Component Therapy: the History, Efficacy, and Adverse Effects
in Clinical Practice.- Allogeneic Blood Transfusion: Complications and Side
Effects.- The real-time effects of artificial blood substitutes on
the microcirculation.- Vascular endothelium and nitric oxide.- A Brief
History of Development of Nanobiotechnology-based Blood
Substitutes.- Classification of Blood Substitutes.- Hemoglobin-based Oxygen
Carriers.- Complications of HBOCs including clinical safety issues.- Free
Hemoglobin Toxicity.- Nanotechnology-based oxygen and drug
carriers.- Perfluorocarbon-based Oxygen Carriers.- Platelet
Substitutes.- Plasma Substitutes.- Novel nanobiotherapeutic based blood
substitutes.- Paradigm Shift.- Hemoglobin-Based Blood Substitute.- Hemoglobin
vesicles as artificial red cells.- Low Volume Resuscitation Agents in
Prehospital Medicine.- ErythroMer: Bio-Inspired Artificial Red Blood
Cell.- OxyVita-Erythrocruorin.- HemAssist: History, clinical trials.-
Development of Recombinant Hemoglobin.- Hemolink-PolyHeme.- Safety and
Tolerability Study -in Stable Adult Patients with Sickle Cell disease.-
Oxygent-Sanguinate.- M101, the Hemoglobin from the Sea-Hemopure: clinical
trials and current status.- Perftoran:
History-Oxycyte-Hemoximer.- Transplantation.- Hemorrhagic Shock: HBOCs in
Trauma.- Use of Oxygen.- Regulatory Update.
Henry Liu M.D
Pennsylvania State University College of Medicine
Milton S. Hershey Medical Center
Anesthesiology & Perioperative Medicine
Hershey, Pennsylvania 17033
USA
Dr. Alan David Kaye, MD, PhD, DABA, DABPM, DABIPP, FASA
Vice-Chancellor of Academic Affairs, Chief Academic Officer, and Provost,
Tenured Professor of Anesthesiology and Pharmacology, Toxicology, and Neurosciences,
Pain Fellowship Program Director,
LSU School of Medicine, 1501 Kings Hwy, Shreveport, LA 71103
Jonathan S. Jahr
David Geffen school of Medicine at UCLA
Los Angeles
California
