This monograph brings together the proceedings of a workshop held in Geneva, Switzerland in March 2000 under the joint sponsorship of the University of Sheffield and F Hoffmann La Roche Ltd. Chapters by leading scientists present the latest research on biochemical markers of bone remodelling as well as their clinical applications in the management of osteoporosis. The text focuses on four major areas of interest: 1) potential candidates for markers of bone remodelling, 2) sources of biological bone marker variability, 3) use of biochemical markers in monitoring treatment of osteoporosis, and 4) use of biochemical markers in the prediction of bone loss and fractures. The book also includes transcripts of the lively panel discussions from the Geneva workshop.
1. Introduction
2. Potential Candidates for Bone Turnover Markers: N-Telopeptide Cross Links of Type I Collagen
3. C-Telopeptides
4. Pyridinium Crosslinks as Bone Resorption Markers
5. Bone Specific Alkaline Phosphatase
6. Osteocalcin
7. The N- and C-Terminal Propeptides of Human Procollagen Type I (PINP and PICP) Bone Sialoprotein
8. Biochemical Markers of Bone Turnover:
9. Age, Gender, and Race as Sources of Biological Variability
10. Circadian Rhythm Studies of Serum Bone Resorption Markers: Implications for Optimal Sample Timing and Clinical Utility
11. Sources of Biological Bone Marker Variability
12. The Effects of Fracture or Disease on Biochemical Markers of Bone Remodelling
13. Variation in Biochemical Markers of Bone Turnover: Sources, Quantification, Minimisation
14. The Use of Biochemical Markers of Bone Turnover for Monitoring Treatment of Osteoporosis
15. The Use of Biochemical Markers of Bone Turnover to Monitor Response to Therapy: Statistics and Logic
16. Prediction of Response in Bone Mass by Biochemical Markers of Bone Turnover During Anti-Resorptive Therapy for Prevention of Osteoporosis
17. Biochemical Markers of Bone Turnover as Predictors of Bone Loss and Response to Therapy
18. Assessment of Fracture Risk
19. Markers of Bone Turnover, Endogenous Hormones, Rate of Bone Loss and Fracture Risk in the OFELY Study
20. Prediction of Hip Fractures with Markers of Bone Turnover in the EPIDOS Study
21. Which Fractures are Associated with High Bone Resorption in Elderly Women: The Rotterdam Study
22. The Study of Osteoporotic Fractures
23. The Association Between Bone Turnover and Fracture Risk: The Sheffield Osteoporosis Study
24. Panel Discussions
Matthias Baumann, Richard Eastell; Nicholas Hoyle; Lothar Wieczorek
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