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1 | (39) |
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1.1 What and how the brain computes: introduction |
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1 | (2) |
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1.2 What and how the brain computes: plan of the book |
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3 | (2) |
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5 | (1) |
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6 | (2) |
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1.5 Synaptic modification |
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8 | (2) |
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1.6 Long-term potentiation and long-term depression |
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10 | (4) |
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1.7 Information encoding by neurons, and distributed representations |
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14 | (4) |
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16 | (1) |
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1.7.2 Advantages of different types of coding |
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16 | (2) |
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1.8 Neuronal network approaches versus connectionism |
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18 | (1) |
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1.9 Introduction to three neuronal network architectures |
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18 | (3) |
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1.10 Systems-level analysis of brain function |
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21 | (2) |
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23 | (3) |
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1.12 The fine structure of the cerebral neocortex |
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26 | (14) |
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1.12.1 The fine structure and connectivity of the neocortex |
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27 | (1) |
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1.12.2 Excitatory cells and connections |
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27 | (2) |
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1.12.3 Inhibitory cells and connections |
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29 | (3) |
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1.12.4 Quantitative aspects of cortical architecture |
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32 | (2) |
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1.12.5 Functional pathways through the cortical layers |
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34 | (4) |
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1.12.6 The scale of lateral excitatory and inhibitory effects, and modules |
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38 | (2) |
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2 The ventral visual system |
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40 | (136) |
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2.1 Introduction and overview |
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40 | (7) |
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40 | (1) |
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2.1.2 Overview of what is computed in the ventral visual system |
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40 | (3) |
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2.1.3 Overview of how computations are performed in the ventral visual system |
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43 | (2) |
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2.1.4 What is computed in the ventral visual system is unimodal, and is related to other `what' systems after the inferior temporal visual cortex |
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45 | (2) |
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2.2 What: V1 -- primary visual cortex |
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47 | (1) |
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2.3 What: V2 and V4 -- intermediate processing areas in the ventral visual system |
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48 | (1) |
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2.4 What: Invariant representations of faces and objects in the inferior temporal visual cortex |
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49 | (22) |
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2.4.1 Reward value is not represented in the ventral visual system |
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49 | (1) |
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2.4.2 Translation invariant representations |
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50 | (1) |
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2.4.3 Reduced translation invariance in natural scenes |
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50 | (3) |
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2.4.4 Size and spatial frequency invariance |
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53 | (1) |
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2.4.5 Combinations of features in the correct spatial configuration |
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54 | (1) |
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2.4.6 A view-invariant representation |
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54 | (4) |
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2.4.7 Learning in the inferior temporal cortex |
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58 | (2) |
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2.4.8 A sparse distributed representation is what is computed in the ventral visual system |
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60 | (6) |
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2.4.9 Face expression, gesture, and view |
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66 | (1) |
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2.4.10 Specialized regions in the temporal cortical visual areas |
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66 | (5) |
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2.5 How the computations are performed: approaches to invariant object recognition |
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71 | (11) |
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72 | (1) |
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2.5.2 Structural descriptions and syntactic pattern recognition |
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73 | (2) |
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2.5.3 Template matching and the alignment approach |
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75 | (1) |
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2.5.4 Invertible networks that can reconstruct their inputs |
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76 | (1) |
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76 | (1) |
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2.5.6 Feature hierarchies |
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77 | (5) |
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2.6 Hypotheses about how the computations are performed in a feature hierarchy approach |
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82 | (4) |
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2.7 VisNet: a model of how the computations are performed in the ventral visual system |
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86 | (75) |
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2.7.1 The architecture of VisNet |
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87 | (9) |
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2.7.2 Initial experiments with VisNet |
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96 | (6) |
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2.7.3 The optimal parameters for the temporal trace used in the learning rule |
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102 | (2) |
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2.7.4 Different forms of the trace learning rule, and error correction |
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104 | (8) |
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2.7.5 The issue of feature binding, and a solution |
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112 | (13) |
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2.7.6 Operation in a cluttered environment |
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125 | (7) |
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2.7.7 Learning 3D transforms |
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132 | (5) |
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2.7.8 Capacity of the architecture, and an attractor implementation |
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137 | (3) |
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2.7.9 Vision in natural scenes -- effects of background versus attention |
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140 | (8) |
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2.7.10 The representation of multiple objects in a scene |
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148 | (2) |
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2.7.11 Learning invariant representations using spatial continuity |
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150 | (1) |
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2.7.12 Lighting invariance |
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151 | (2) |
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2.7.13 Deformation-invariant object recognition |
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153 | (1) |
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2.7.14 Learning invariant representations of scenes and places |
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154 | (2) |
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2.7.15 Finding and recognising objects in natural scenes |
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156 | (3) |
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2.7.16 Non-accidental properties, and transform invariant object recognition |
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159 | (2) |
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2.8 Further approaches to invariant object recognition |
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161 | (6) |
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2.8.1 Other types of slow learning |
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161 | (1) |
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161 | (5) |
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2.8.3 Hierarchical convolutional deep neural networks |
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166 | (1) |
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167 | (1) |
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2.9 Visuo-spatial scratchpad memory, and change blindness |
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167 | (2) |
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2.10 Processes involved in object identification |
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169 | (1) |
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2.11 Top-down attentional modulation is implemented by biased competition |
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170 | (3) |
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2.12 Highlights on how the computations are performed in the ventral visual system |
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173 | (3) |
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3 The dorsal visual system |
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176 | (16) |
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3.1 Introduction, and overview of the dorsal cortical visual stream |
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176 | (1) |
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3.2 Global motion in the dorsal visual system |
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177 | (2) |
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3.3 Invariant object-based motion in the dorsal visual system |
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179 | (2) |
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3.4 What is computed in the dorsal visual system: visual coordinate transforms |
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181 | (4) |
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3.4.1 The transform from retinal to head-based coordinates |
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182 | (1) |
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3.4.2 The transform from head-based to allocentric bearing coordinates |
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183 | (1) |
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3.4.3 A transform from allocentric bearing coordinates to allocentric spatial view coordinates |
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184 | (1) |
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3.5 How visual coordinate transforms are computed in the dorsal visual system |
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185 | (7) |
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185 | (1) |
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3.5.2 Mechanisms of gain modulation using a trace learning rule |
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186 | (1) |
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3.5.3 Gain modulation by eye position to produce a head-centered representation in Layer 1 of VisNetCT |
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187 | (1) |
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3.5.4 Gain modulation by head direction to produce an allocentric bearing to a landmark in Layer 2 of VisNetCT |
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188 | (1) |
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3.5.5 Gain modulation by place to produce an allocentric spatial view representation in Layer 3 of VisNetCT |
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189 | (1) |
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3.5.6 The utility of the coordinate transforms in the dorsal visual system |
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190 | (2) |
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4 The taste and flavour system |
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192 | (25) |
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4.1 Introduction and overview |
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192 | (2) |
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192 | (1) |
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4.1.2 Overview of what is computed in the taste and flavour system |
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192 | (2) |
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4.1.3 Overview of how computations are performed in the taste and flavour system |
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194 | (1) |
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4.2 Taste and related pathways: what is computed |
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194 | (18) |
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4.2.1 Hierarchically organised anatomical pathways |
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194 | (3) |
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4.2.2 Taste neuronal tuning become more selective through the taste hierarchy |
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197 | (1) |
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4.2.3 The primary, insular, taste cortex represents what taste is present and its intensity |
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198 | (1) |
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4.2.4 The secondary, orbitofrontal, taste cortex, and its representation of the reward value and pleasantness of taste |
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199 | (2) |
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4.2.5 Sensory-specific satiety is computed in the orbitofrontal cortex |
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201 | (3) |
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4.2.6 Oral texture is represented in the primary and secondary taste cortex: viscosity and fat texture |
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204 | (3) |
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4.2.7 Vision and olfaction converge using associative learning with taste to represent flavour in the secondary but not primary taste cortex |
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207 | (1) |
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4.2.8 Top-down attention and cognition can modulate taste and flavour representations in the taste cortical areas |
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208 | (2) |
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4.2.9 The tertiary taste cortex in the anterior cingulate cortex provides the rewards for action-reward learning |
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210 | (2) |
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4.3 Taste and related pathways: how the computations are performed |
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212 | (5) |
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4.3.1 Increased selectivity of taste and flavor neurons through the hierarchy by competitive learning and convergence |
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212 | (1) |
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4.3.2 Pattern association learning of associations of visual and olfactory stimuli with taste |
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212 | (1) |
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4.3.3 Rule-based reversal of visual to taste associations in the orbitofrontal cortex |
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212 | (1) |
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4.3.4 Sensory-specific satiety is implemented by adaptation of synapses onto orbitofrontal cortex neurons |
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212 | (1) |
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4.3.5 Top-down cognitive and attentional modulation is implemented by biased activation |
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213 | (4) |
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217 | (15) |
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217 | (2) |
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5.1.1 Overview of what is computed in the olfactory system |
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217 | (1) |
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5.1.2 Overview of how the computations are performed in the olfactory system |
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218 | (1) |
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5.2 What is computed in the olfactory system |
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219 | (7) |
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5.2.1 1000 gene-encoded olfactory receptor types, and 1000 corresponding glomerulus types in the olfactory bulb |
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219 | (2) |
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5.2.2 The primary olfactory, pyriform, cortex: olfactory feature combinations are what is represented |
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221 | (1) |
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5.2.3 Orbitofrontal cortex: olfactory neuronal response selectivity |
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221 | (1) |
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5.2.4 Orbitofrontal cortex: olfactory to taste convergence |
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222 | (1) |
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5.2.5 Orbitofrontal cortex: olfactory to taste association learning and reversal |
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223 | (2) |
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5.2.6 Orbitofrontal cortex: olfactory reward value is represented |
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225 | (1) |
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5.3 How computations are performed in the olfactory system |
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226 | (6) |
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5.3.1 Olfactory receptors, and the olfactory bulb |
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226 | (1) |
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5.3.2 Olfactory (pyriform) cortex |
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227 | (4) |
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5.3.3 Orbitofrontal cortex |
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231 | (1) |
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6 The somatosensory system |
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232 | (12) |
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6.1 What is computed in the somatosensory system |
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232 | (10) |
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6.1.1 The receptors and periphery |
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232 | (1) |
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6.1.2 The anterior somatosensory cortex, areas 1, 2, 3a, and 3b, in the anterior parietal cortex |
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232 | (1) |
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6.1.3 The ventral somatosensory stream: areas S2 and PV, in the lateral parietal cortex |
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233 | (1) |
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6.1.4 The dorsal somatosensory stream to area 5 and then 7b, in the posterior parietal cortex |
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234 | (2) |
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6.1.5 Somatosensory representations in the insula |
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236 | (1) |
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6.1.6 Somatosensory and temperature inputs to the orbitofrontal cortex, affective value, pleasant touch, and pain |
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236 | (4) |
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6.1.7 Decision-making in the somatosensory system |
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240 | (2) |
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6.2 How computations are performed in the somatosensory system |
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242 | (2) |
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6.2.1 Hierarchical computation in the somatosensory system |
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242 | (1) |
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6.2.2 Computations for pleasant touch and pain |
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243 | (1) |
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6.2.3 The mechanisms for somatosensory decision-making |
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243 | (1) |
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244 | (9) |
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7.1 Introduction, and overview of computations in the auditory system |
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244 | (1) |
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7.2 Auditory Localization |
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245 | (3) |
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7.3 Ventral and dorsal cortical auditory pathways |
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248 | (1) |
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7.4 The ventral cortical auditory stream |
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249 | (2) |
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7.5 The dorsal cortical auditory stream |
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251 | (1) |
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7.6 How the computations are performed in the auditory system |
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251 | (2) |
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253 | (7) |
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8.1 Introduction and overview |
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253 | (1) |
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8.2 Middle temporal gyrus and face expression and gesture |
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253 | (2) |
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8.3 Semantic representations in the temporal lobe neocortex |
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255 | (4) |
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255 | (1) |
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256 | (1) |
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8.3.3 Functional neuroimaging |
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256 | (1) |
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257 | (2) |
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8.4 The mechanisms for semantic learning in the human anterior temporal lobe |
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259 | (1) |
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9 The hippocampus, memory, and spatial function |
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260 | (103) |
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9.1 Introduction and overview |
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260 | (3) |
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9.1.1 Overview of what is computed by the hippocampal system |
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260 | (2) |
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9.1.2 Overview of how the computations are performed by the hippocampal system |
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262 | (1) |
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9.2 What is computed in the hippocampus |
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263 | (30) |
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9.2.1 Systems-level anatomy |
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263 | (2) |
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9.2.2 Evidence from the effects of damage to the hippocampus |
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265 | (2) |
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9.2.3 Episodic memories need to be recalled from the hippocampus, and can be used to help build neocortical semantic memories |
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267 | (3) |
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9.2.4 Systems-level neurophysiology of the primate hippocampus |
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270 | (15) |
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9.2.5 Head direction cells in the presubiculum |
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285 | (1) |
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9.2.6 Perirhinal cortex, recognition memory, and long-term familiarity memory |
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286 | (7) |
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9.3 How computations are performed in the hippocampal system |
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293 | (51) |
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9.3.1 Historical development of the theory of the hippocampus |
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293 | (3) |
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9.3.2 Hippocampal circuitry |
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296 | (1) |
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9.3.3 Medial entorhinal cortex, spatial processing streams, and grid cells |
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297 | (4) |
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9.3.4 Lateral entorhinal cortex, object processing streams, and the generation of time cells in the hippocampus |
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301 | (6) |
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9.3.5 CA3 as an autoassociation memory |
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307 | (18) |
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9.3.6 Dentate granule cells |
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325 | (3) |
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328 | (5) |
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9.3.8 Backprojections to the neocortex, memory recall, and consolidation |
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333 | (3) |
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9.3.9 Backprojections to the neocortex -- quantitative aspects |
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336 | (3) |
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9.3.10 Simulations of hippocampal operation |
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339 | (2) |
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9.3.11 The learning of spatial view and place cell representations |
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341 | (1) |
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9.3.12 Linking the inferior temporal visual cortex to spatial view and place cells |
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342 | (2) |
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9.3.13 A scientific theory of the art of memory: scientia artis memoriae |
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344 | (1) |
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9.4 Tests of the theory of hippocampal cortex operation |
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344 | (14) |
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9.4.1 Dentate gyrus (DG) subregion of the hippocampus |
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345 | (3) |
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9.4.2 CA3 subregion of the hippocampus |
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348 | (7) |
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9.4.3 CA1 subregion of the hippocampus |
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355 | (3) |
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9.5 Comparison with other theories of hippocampal function |
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358 | (5) |
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10 The parietal cortex, spatial functions, and navigation |
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363 | (16) |
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10.1 Introduction and overview |
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363 | (2) |
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363 | (1) |
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10.1.2 Overview of what is computed in the parietal cortex |
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363 | (1) |
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10.1.3 Overview of how the computations are performed in the parietal cortex |
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364 | (1) |
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10.2 Precuneus and medial area 7 |
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365 | (1) |
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10.3 Navigation: What computations are performed in the parietal and related cortex |
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366 | (1) |
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10.4 How navigation is performed |
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367 | (12) |
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10.4.1 Navigation using a hippocampal allocentric Euclidean cognitive map |
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367 | (1) |
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10.4.2 Navigation using an entorhinal cortex goal vector system |
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367 | (1) |
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10.4.3 Transforms between allocentric and egocentric representations |
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368 | (3) |
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10.4.4 Navigational computations using neuron types found in primates |
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371 | (8) |
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11 The orbitofrontal cortex, amygdala, reward value, and emotion |
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379 | (68) |
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11.1 Introduction and overview |
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379 | (4) |
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379 | (1) |
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11.1.2 Overview of what is computed in the orbitofrontal cortex |
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379 | (2) |
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11.1.3 Overview of how the computations are performed by the orbitofrontal cortex |
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381 | (2) |
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11.2 The topology and connections of the orbitofrontal cortex |
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383 | (4) |
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11.2.1 Inputs to the orbitofrontal cortex |
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383 | (3) |
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11.2.2 Outputs of the orbitofrontal cortex |
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386 | (1) |
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11.3 What is computed in the orbitofrontal cortex |
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387 | (41) |
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11.3.1 The orbitofrontal cortex represents reward value |
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387 | (5) |
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11.3.2 Neuroeconomic value is represented in the orbitofrontal cortex |
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392 | (4) |
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11.3.3 A representation of face and voice expression and other socially relevant stimuli in the orbitofrontal cortex |
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396 | (3) |
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11.3.4 Negative reward prediction error neurons in the orbitofrontal cortex |
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399 | (4) |
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11.3.5 The human medial orbitofrontal cortex represents rewards, and the lateral orbitofrontal cortex non-reward and punishers |
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403 | (3) |
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11.3.6 Decision-making in the orbitofrontal / ventromedial prefrontal cortex |
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406 | (2) |
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11.3.7 The ventromedial prefrontal cortex and memory |
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408 | (1) |
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11.3.8 The orbitofrontal cortex and emotion |
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409 | (2) |
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11.3.9 Emotional orbitofrontal vs rational routes to action |
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411 | (8) |
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11.3.10 Comparison between the functions of the orbitofrontal cortex and amygdala in emotion |
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419 | (9) |
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11.4 How the computations are performed in the orbitofrontal cortex |
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428 | (16) |
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11.4.1 Decision-making in attractor networks in the brain |
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429 | (4) |
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11.4.2 Analyses of reward-related decision-making mechanisms in the orbitofrontal cortex |
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433 | (5) |
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11.4.3 A model for reversal learning in the orbitofrontal cortex |
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438 | (5) |
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11.4.4 A theory and model of non-reward neural mechanisms in the orbitofrontal cortex |
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443 | (1) |
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11.5 Highlights: the special computational roles of the orbitofrontal cortex |
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444 | (3) |
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447 | (17) |
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12.1 Introduction to and overview of the cingulate cortex |
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447 | (3) |
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447 | (1) |
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12.1.2 Overview of what is computed in the cingulate cortex |
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447 | (2) |
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12.1.3 Overview of how the computations are performed by the cingulate cortex |
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449 | (1) |
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12.2 Anterior Cingulate Cortex |
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450 | (7) |
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12.2.1 Anterior cingulate cortex anatomy and connections |
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450 | (1) |
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12.2.2 Anterior cingulate cortex: A framework |
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451 | (2) |
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12.2.3 Pregenual anterior cingulate representations of reward value, and supracallosal anterior cingulate representations of punishers and non-reward |
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453 | (2) |
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12.2.4 Anterior cingulate cortex and action-outcome representations |
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455 | (1) |
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12.2.5 Anterior cingulate cortex lesion effects |
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455 | (1) |
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12.2.6 Subgenual cingulate cortex |
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456 | (1) |
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12.3 Mid-cingulate cortex, the cingulate motor area, and action-outcome learning |
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457 | (1) |
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12.4 The posterior cingulate cortex |
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458 | (1) |
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12.5 How the computations are performed by the cingulate cortex |
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459 | (2) |
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12.5.1 The anterior cingulate cortex and emotion |
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459 | (1) |
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12.5.2 Action-outcome learning |
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459 | (1) |
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12.5.3 Connectivity of the posterior cingulate cortex with the hippocampal memory system |
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460 | (1) |
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12.6 Synthesis and conclusions |
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461 | (3) |
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13 The motor cortical areas |
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464 | (4) |
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13.1 Introduction and overview |
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464 | (1) |
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13.2 What is computed in different cortical motor-related areas |
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464 | (2) |
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13.2.1 Ventral parietal and ventral premotor cortex F4 |
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464 | (2) |
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13.2.2 Superior parietal areas with activity related to reaching |
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466 | (1) |
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13.2.3 Inferior parietal areas with activity related to grasping, and ventral premotor cortex F5 |
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466 | (1) |
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13.3 The mirror neuron system |
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466 | (1) |
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13.4 How the computations are performed in motor cortical and related areas |
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467 | (1) |
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468 | (29) |
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14.1 Introduction and overview |
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468 | (1) |
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14.2 Systems-level architecture of the basal ganglia |
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469 | (2) |
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14.3 What computations are performed by the basal ganglia? |
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471 | (14) |
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14.3.1 Effects of striatal lesions |
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471 | (2) |
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14.3.2 Neuronal activity in different parts of the striatum |
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473 | (12) |
|
14.4 How do the basal ganglia perform their computations? |
|
|
485 | (9) |
|
14.4.1 Interaction between neurons and selection of output |
|
|
485 | (4) |
|
14.4.2 Convergence within the basal ganglia, useful for stimulus-response habit learning |
|
|
489 | (2) |
|
14.4.3 Dopamine as a reward prediction error signal for reinforcement learning in the striatum |
|
|
491 | (3) |
|
14.5 Comparison of computations for selection in the basal ganglia and cerebral cortex |
|
|
494 | (3) |
|
|
497 | (8) |
|
|
497 | (1) |
|
15.2 Architecture of the cerebellum |
|
|
498 | (4) |
|
15.2.1 The connections of the parallel fibres onto the Purkinje cells |
|
|
498 | (1) |
|
15.2.2 The climbing fibre input to the Purkinje cell |
|
|
499 | (1) |
|
15.2.3 The mossy fibre to granule cell connectivity |
|
|
500 | (2) |
|
15.3 Modifiable synapses of parallel fibres onto Purkinje cell dendrites |
|
|
502 | (1) |
|
15.4 The cerebellar cortex as a perceptron |
|
|
502 | (1) |
|
15.5 Highlights: differences between cerebral and cerebellar cortex microcircuitry |
|
|
503 | (2) |
|
|
505 | (22) |
|
16.1 Introduction and overview |
|
|
505 | (3) |
|
16.2 Divisions of the lateral prefrontal cortex |
|
|
508 | (4) |
|
16.2.1 The dorsolateral prefrontal cortex |
|
|
509 | (1) |
|
16.2.2 The caudal prefrontal cortex |
|
|
510 | (2) |
|
16.2.3 The ventrolateral prefrontal cortex |
|
|
512 | (1) |
|
16.3 The lateral prefrontal cortex and top-down attention |
|
|
512 | (3) |
|
16.4 How the computations are performed in the prefrontal cortex |
|
|
515 | (12) |
|
16.4.1 Cortical short-term memory systems and attractor networks |
|
|
515 | (2) |
|
16.4.2 Prefrontal cortex short-term memory networks, and their relation to perceptual networks |
|
|
517 | (5) |
|
16.4.3 Mapping from one representation to another in short-term memory |
|
|
522 | (2) |
|
16.4.4 The mechanisms of top-down attention |
|
|
524 | (1) |
|
16.4.5 Computational necessity for a separate, prefrontal cortex, short-term memory system |
|
|
525 | (1) |
|
16.4.6 Synaptic modification is needed to set up but not to reuse short-term memory systems |
|
|
525 | (1) |
|
|
525 | (1) |
|
16.4.8 Working memory, and planning |
|
|
526 | (1) |
|
17 Language and syntax in the brain |
|
|
527 | (27) |
|
17.1 Introduction and overview |
|
|
527 | (2) |
|
|
527 | (1) |
|
|
527 | (2) |
|
17.2 What is computed in different brain systems to implement language |
|
|
529 | (5) |
|
17.2.1 The Wernicke-Lichtheim-Geschwind hypothesis |
|
|
529 | (1) |
|
17.2.2 The dual-stream hypothesis of speech comprehension |
|
|
529 | (1) |
|
17.2.3 Reading requires different brain systems to hearing speech |
|
|
530 | (1) |
|
17.2.4 Semantic representations |
|
|
531 | (2) |
|
17.2.5 Syntactic processing |
|
|
533 | (1) |
|
17.2.6 The parietal cortex: supramarginal and angular gyri |
|
|
533 | (1) |
|
17.3 Hypotheses about how semantic representations are computed |
|
|
534 | (1) |
|
17.4 A neurodynamical hypothesis about how syntax is computed |
|
|
535 | (19) |
|
17.4.1 Binding by synchrony? |
|
|
535 | (1) |
|
17.4.2 Syntax using a place code |
|
|
536 | (1) |
|
17.4.3 Temporal trajectories through a state space of attractors |
|
|
536 | (1) |
|
17.4.4 Hypotheses about the implementation of language in the cerebral cortex |
|
|
537 | (3) |
|
17.4.5 Tests of the hypotheses -- a model |
|
|
540 | (5) |
|
17.4.6 Tests of the hypotheses -- findings with the model |
|
|
545 | (3) |
|
17.4.7 Evaluation of the hypotheses |
|
|
548 | (4) |
|
17.4.8 Further approaches |
|
|
552 | (2) |
|
18 Cortical attractor dynamics and connectivity, stochasticity, psychiatric disorders, and aging |
|
|
554 | (55) |
|
18.1 Introduction and overview |
|
|
554 | (1) |
|
|
554 | (1) |
|
|
554 | (1) |
|
|
555 | (18) |
|
18.2.1 Reasons why the brain is inherently noisy and stochastic |
|
|
556 | (3) |
|
18.2.2 Attractor networks, energy landscapes, and stochastic neurodynamics |
|
|
559 | (5) |
|
18.2.3 A multistage system with noise |
|
|
564 | (2) |
|
18.2.4 Stochastic dynamics and the stability of short-term memory |
|
|
566 | (4) |
|
18.2.5 Stochastic dynamics in decision-making, and the evolutionary utility of probabilistic choice |
|
|
570 | (1) |
|
18.2.6 Selection between conscious vs unconscious decision-making, and free will |
|
|
571 | (1) |
|
18.2.7 Stochastic dynamics and creative thought |
|
|
572 | (1) |
|
18.2.8 Stochastic dynamics and unpredictable behaviour |
|
|
573 | (1) |
|
18.3 Attractor dynamics and schizophrenia |
|
|
573 | (9) |
|
|
573 | (1) |
|
18.3.2 A dynamical systems hypothesis of the symptoms of schizophrenia |
|
|
574 | (3) |
|
18.3.3 Reduced functional connectivity of some brain regions in schizophrenia |
|
|
577 | (1) |
|
18.3.4 Beyond the disconnectivity hypothesis of schizophrenia: reduced forward but not backward connectivity |
|
|
578 | (4) |
|
18.4 Attractor dynamics and obsessive-compulsive disorder |
|
|
582 | (4) |
|
|
582 | (1) |
|
18.4.2 A hypothesis about obsessive-compulsive disorder |
|
|
582 | (3) |
|
18.4.3 Glutamate and increased depth of the basins of attraction |
|
|
585 | (1) |
|
18.5 Depression and attractor dynamics |
|
|
586 | (14) |
|
|
586 | (1) |
|
18.5.2 A non-reward attractor theory of depression |
|
|
587 | (1) |
|
18.5.3 The orbitofrontal cortex, and the theory of depression |
|
|
588 | (2) |
|
18.5.4 Altered connectivity of the orbitofrontal cortex in depression |
|
|
590 | (5) |
|
18.5.5 Activations of the orbitofrontal cortex related to depression |
|
|
595 | (1) |
|
18.5.6 Implications, and possible treatments, and subtypes of depression |
|
|
595 | (3) |
|
18.5.7 Mania and bipolar disorder |
|
|
598 | (2) |
|
18.6 Attractor stochastic dynamics, aging, and memory |
|
|
600 | (7) |
|
18.6.1 NMDA receptor hypofunction |
|
|
600 | (2) |
|
18.6.2 Dopamine and norepinephrine |
|
|
602 | (1) |
|
18.6.3 Impaired synaptic modification |
|
|
602 | (1) |
|
18.6.4 Cholinergic function and memory |
|
|
603 | (4) |
|
18.7 High blood pressure, reduced hippocampal functional connectivity, and impaired memory |
|
|
607 | (1) |
|
18.8 Brain development, and structural differences in the brain |
|
|
608 | (1) |
|
19 Computations by different types of brain, and by artificial neural systems |
|
|
609 | (25) |
|
19.1 Introduction and overview |
|
|
609 | (1) |
|
19.2 Computations that combine different computational systems in the brain to produce behaviour |
|
|
610 | (1) |
|
19.3 Brain computation compared to computation on a digital computer |
|
|
610 | (6) |
|
19.4 Brain computation compared with artificial deep learning networks |
|
|
616 | (2) |
|
19.5 Reinforcement Learning |
|
|
618 | (2) |
|
19.6 Levels of explanation, and the mind-brain problem |
|
|
620 | (2) |
|
19.7 Levels of explanation, and levels of investigation |
|
|
622 | (1) |
|
19.8 Brain-Inspired Intelligence |
|
|
623 | (1) |
|
19.9 Brain-Inspired Medicine |
|
|
624 | (4) |
|
19.9.1 Computational psychiatry and neurology |
|
|
624 | (1) |
|
19.9.2 Reward systems in the brain, and their application to understanding food intake control and obesity |
|
|
625 | (3) |
|
19.9.3 Multiple Routes to Action |
|
|
628 | (1) |
|
19.10 Primates including humans have different brain organisation than rodents |
|
|
628 | (6) |
|
19.10.1 The visual system |
|
|
628 | (1) |
|
|
629 | (1) |
|
19.10.3 The olfactory system |
|
|
629 | (1) |
|
19.10.4 The somatosensory system |
|
|
630 | (1) |
|
19.10.5 The auditory system |
|
|
630 | (1) |
|
19.10.6 The hippocampal system and memory |
|
|
630 | (1) |
|
19.10.7 The orbitofrontal cortex and amygdala |
|
|
631 | (1) |
|
19.10.8 The cingulate cortex |
|
|
632 | (1) |
|
|
632 | (1) |
|
|
633 | (1) |
|
A Introduction to linear algebra for neural networks |
|
|
634 | (12) |
|
|
634 | (6) |
|
A.1.1 The inner or dot product of two vectors |
|
|
634 | (2) |
|
A.1.2 The length of a vector |
|
|
636 | (1) |
|
A.1.3 Normalizing the length of a vector |
|
|
636 | (1) |
|
A.1.4 The angle between two vectors: the normalized dot product |
|
|
636 | (1) |
|
A.1.5 The outer product of two vectors |
|
|
637 | (1) |
|
A.1.6 Linear and non-linear systems |
|
|
638 | (1) |
|
A.1.7 Linear combinations, linear independence, and linear separability |
|
|
639 | (1) |
|
A.2 Application to understanding simple neural networks |
|
|
640 | (6) |
|
A.2.1 Capability and limitations of single-layer networks |
|
|
641 | (2) |
|
A.2.2 Non-linear networks: neurons with non-linear activation functions |
|
|
643 | (1) |
|
A.2.3 Non-linear networks: neurons with non-linear activations |
|
|
644 | (2) |
|
B Neuronal network models |
|
|
646 | (128) |
|
|
646 | (1) |
|
B.2 Pattern association memory |
|
|
646 | (17) |
|
B.2.1 Architecture and operation |
|
|
647 | (2) |
|
|
649 | (3) |
|
B.2.3 The vector interpretation |
|
|
652 | (1) |
|
|
653 | (3) |
|
B.2.5 Prototype extraction, extraction of central tendency, and noise reduction |
|
|
656 | (1) |
|
|
656 | (1) |
|
B.2.7 Local learning rule |
|
|
657 | (5) |
|
B.2.8 Implications of different types of coding for storage in pattern associators |
|
|
662 | (1) |
|
B.3 Autoassociation or attractor memory |
|
|
663 | (23) |
|
B.3.1 Architecture and operation |
|
|
663 | (2) |
|
B.3.2 Introduction to the analysis of the operation of autoassociation networks |
|
|
665 | (2) |
|
|
667 | (7) |
|
B.3.4 Diluted connectivity and the storage capacity of attractor networks |
|
|
674 | (11) |
|
B.3.5 Use of autoassociation networks in the brain |
|
|
685 | (1) |
|
B.4 Competitive networks, including self-organizing maps |
|
|
686 | (21) |
|
|
686 | (1) |
|
B.4.2 Architecture and algorithm |
|
|
687 | (1) |
|
|
688 | (5) |
|
B.4.4 Utility of competitive networks in information processing by the brain |
|
|
693 | (1) |
|
B.4.5 Guidance of competitive learning |
|
|
694 | (2) |
|
B.4.6 Topographic map formation |
|
|
696 | (4) |
|
B.4.7 Invariance learning by competitive networks |
|
|
700 | (2) |
|
B.4.8 Radial Basis Function networks |
|
|
702 | (1) |
|
B.4.9 Further details of the algorithms used in competitive networks |
|
|
703 | (4) |
|
B.5 Continuous attractor networks |
|
|
707 | (11) |
|
|
707 | (2) |
|
B.5.2 The generic model of a continuous attractor network |
|
|
709 | (1) |
|
B.5.3 Learning the synaptic strengths in a continuous attractor network |
|
|
709 | (2) |
|
B.5.4 The capacity of a continuous attractor network: multiple charts |
|
|
711 | (1) |
|
B.5.5 Continuous attractor models: path integration |
|
|
712 | (3) |
|
B.5.6 Stabilization of the activity packet within a continuous attractor network |
|
|
715 | (2) |
|
B.5.7 Continuous attractor networks in two or more dimensions |
|
|
717 | (1) |
|
B.5.8 Mixed continuous and discrete attractor networks |
|
|
717 | (1) |
|
B.6 Network dynamics: the integrate-and-fire approach |
|
|
718 | (14) |
|
B.6.1 From discrete to continuous time |
|
|
718 | (2) |
|
B.6.2 Continuous dynamics with discontinuities |
|
|
720 | (3) |
|
B.6.3 An integrate-and-fire implementation |
|
|
723 | (2) |
|
B.6.4 The speed of processing of attractor networks |
|
|
725 | (2) |
|
B.6.5 The speed of processing of a four-layer hierarchical network |
|
|
727 | (4) |
|
B.6.6 Spike response model |
|
|
731 | (1) |
|
B.7 Network dynamics: introduction to the mean-field approach |
|
|
732 | (1) |
|
B.8 Mean-field based neurodynamics |
|
|
733 | (9) |
|
B.8.1 Population activity |
|
|
733 | (2) |
|
B.8.2 The mean-field approach used in a model of decision-making |
|
|
735 | (2) |
|
B.8.3 The model parameters used in the mean-field analyses of decision-making |
|
|
737 | (1) |
|
B.8.4 A basic computational module based on biased competition |
|
|
737 | (2) |
|
B.8.5 Multimodular neurodynamical architectures |
|
|
739 | (3) |
|
B.9 Interacting attractor networks |
|
|
742 | (3) |
|
B.10 Sequence memory implemented by adaptation in an attractor network |
|
|
745 | (1) |
|
B.11 Error correction networks |
|
|
745 | (8) |
|
B.11.1 Architecture and general description |
|
|
746 | (1) |
|
B.11.2 Generic algorithm for a one-layer error correction network |
|
|
746 | (1) |
|
B.11.3 Capability and limitations of single-layer error-correcting networks |
|
|
747 | (4) |
|
|
751 | (2) |
|
B.12 Error backpropagation multilayer networks |
|
|
753 | (4) |
|
|
753 | (1) |
|
B.12.2 Architecture and algorithm |
|
|
753 | (3) |
|
B.12.3 Properties of multilayer networks trained by error backpropagation |
|
|
756 | (1) |
|
B.13 Convolution networks |
|
|
757 | (1) |
|
B.14 Contrastive Hebbian learning: the Boltzmann machine |
|
|
758 | (2) |
|
B.15 Deep Belief Networks |
|
|
760 | (1) |
|
B.16 Reinforcement learning |
|
|
760 | (7) |
|
B.16.1 Associative reward-penalty algorithm of Barto and Sutton |
|
|
761 | (2) |
|
B.16.2 Reward prediction error or delta rule learning, and classical conditioning |
|
|
763 | (1) |
|
B.16.3 Temporal Difference (TD) learning |
|
|
764 | (3) |
|
B.17 Learning in the neocortex |
|
|
767 | (2) |
|
B.18 Forgetting in cortical associative neural networks, and memory reconsolidation |
|
|
769 | (4) |
|
|
773 | (1) |
|
C Information theory, and neuronal encoding |
|
|
774 | (66) |
|
|
775 | (8) |
|
C.1.1 The information conveyed by definite statements |
|
|
775 | (1) |
|
C.1.2 Information conveyed by probabilistic statements |
|
|
776 | (1) |
|
C.1.3 Information sources, information channels, and information measures |
|
|
777 | (1) |
|
C.1.4 The information carried by a neuronal response and its averages |
|
|
778 | (3) |
|
C.1.5 The information conveyed by continuous variables |
|
|
781 | (2) |
|
C.2 The information carried by neuronal responses |
|
|
783 | (14) |
|
C.2.1 The limited sampling problem |
|
|
783 | (1) |
|
C.2.2 Correction procedures for limited sampling |
|
|
784 | (1) |
|
C.2.3 The information from multiple cells: decoding procedures |
|
|
785 | (4) |
|
C.2.4 Information in the correlations between cells: a decoding approach |
|
|
789 | (5) |
|
C.2.5 Information in the correlations between cells: second derivative approach |
|
|
794 | (3) |
|
C.3 Information theory results |
|
|
797 | (41) |
|
C.3.1 The sparseness of the distributed encoding used by the brain |
|
|
798 | (11) |
|
C.3.2 The information from single neurons |
|
|
809 | (3) |
|
C.3.3 The information from single neurons: temporal codes versus rate codes |
|
|
812 | (2) |
|
C.3.4 The information from single neurons: the speed of information transfer |
|
|
814 | (11) |
|
C.3.5 The information from multiple cells: independence versus redundancy |
|
|
825 | (4) |
|
C.3.6 Should one neuron be as discriminative as the whole organism? |
|
|
829 | (1) |
|
C.3.7 The information from multiple cells: the effects of cross-correlations |
|
|
830 | (4) |
|
C.3.8 Conclusions on cortical neuronal encoding |
|
|
834 | (4) |
|
C.4 Information theory terms - a short glossary |
|
|
838 | (1) |
|
|
839 | (1) |
|
D Simulation software for neuronal networks, and information analysis of neuronal encoding |
|
|
840 | (10) |
|
|
840 | (1) |
|
D.2 Autoassociation or attractor networks |
|
|
841 | (2) |
|
D.2.1 Running the simulation |
|
|
841 | (2) |
|
|
843 | (1) |
|
D.3 Pattern association networks |
|
|
843 | (3) |
|
D.3.1 Running the simulation |
|
|
843 | (2) |
|
|
845 | (1) |
|
D.4 Competitive networks and Self-Organizing Maps |
|
|
846 | (2) |
|
D.4.1 Running the simulation |
|
|
846 | (1) |
|
|
847 | (1) |
|
|
848 | (1) |
|
D.6 Matlab code for a tutorial version of VisNet |
|
|
848 | (1) |
|
D.7 Matlab code for information analysis of neuronal encoding |
|
|
849 | (1) |
|
D.8 Matlab code to illustrate the use of spatial view cells in navigation |
|
|
849 | (1) |
|
|
849 | (1) |
References |
|
850 | (74) |
Index |
|
924 | |