People have always sought medical care that is tailored to every individual patient. Alongside with the historical development of institutions of care, the vision of personal and 'holistic' care persisted. Patient-centred medicine, interpersonal communication and shared decision making have
become central to medical practice and services.
This evolving vision of 'personalized medicine' is in the forefront of medicine, creating debates among ethicists, philosophers and sociologists of medicine about the nature of disease and the definition of wellness, the impact on the daily life of patients, as well as its implications on low-income
countries. Is increased 'precision' also an improvement on the personal aspects of care or erosion of privacy? Do 'precise' and 'personalized' approach marginalize public health, and can this care be personalized without attention to culture, economy and society?
The book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision/personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science. The contributing scholars come from all over the
world and from different cultural backgrounds providing reflective perspectives of history of ideas, critical theory and technology assessment, together with the actual work done by pioneers in the field. It explores issues such as global justice, gender, public health, pharmaceutical industry,
international law and religion, and explores themes discussed in relation to personalized medicine such as new-born screening and disorders of consciousness.
This book will be of interest to academicians in bioethics, history of medicine, social sciences of medicine as well as general educated readers.
1.
Chapter 1: Precision and Persons in Medicine: An Introduction, Yechiel Michael Barilan and Margherita Brusa
2. The historical background of Personalized Medicine, Diego Gracia Guillen
3,. What 21st Century Medicine Should Be-History, Vision, Implementation and Opportunities, Leroy Hood, Nathan D. Price, and Simon J. Evans
4. The Problematic Side of Precision Medicine: A Short Voyage through Some Questions, Giovanni Boniolo
5. The precision paradox - How personalized medicine increases uncertainty, Henrik Vogt
6. Genomics and Precision Medicine: Through a Different Prism, Farhat Moazam
7. Personalization, Individuation and the Ethos of Precision Medicine, Yechiel Michael Barilan
8. Personalized Medicine and Genetic Newborn Screening, Margherita Brusa and Donna Dickenson
9. The Revolution of Personalized Medicine is Already Upon Us in Rare Diseases, Christopher P. Austin
10. Personalized Medicine and Disorders of Consciousness: An Alternate Convergence of Knowledge towards a New Clinical Nosology, Joseph J. Fins
11. Gender and Personalized Medicine: Methodological and Ethical Pitfalls, Marianne J. Legato
12. Potential Challenges to Doctor-Patient Trust Posed by Personalized Medicine, Shlomo Cohen
13. When does precision matter? Personalised medicine from the perspective of public health, James Wilson
14. CRISPR - A Challenge for National and International Regulation, Dianne Nicol
15. The Advent of Automated Medicine? The values and meanings of precision, Barbara Prainsack
16. Thoughtful Genomics, Jenny Reardon
17. Islamic Sunni perspectives on the ethics of precision medicine, Mehrunisha Suleman
18. Genetics, genetic profiles and Jewish law, Yehoshua Weisinger and Yechiel Michael Barilan
19. Pharmaceutical Contributions to Personalized Medicine, Roger Perlmutter
Yechiel Michael Barilan was born and educated in Israel. He is an expert in Internal Medicine and js most recently a senior physician in the Covid-19 Dept. and Emergency Dept. Tel Aviv Medical Centre. He is a full professor in the Tel Aviv University School of Medicine, specializing in ethics and social history of medicine. He is also a member of national and international ethics committees and is an author of over a hundred peer reviewed academic publications.
Margherita Brusa earned a PhD in bioethics from the University Complutense of Madrid, and a second PhD in paediatric healthcare planning from the University of Padua. She has served in ethics committees in Spain, USA, and Italy, and led the creation of the first ethics committee in the Palestinian Authority. The focus of her research is bioethics and children.
Aaron Ciechanover is an Israeli physician and scientist working currently at the Faculty of Medicine of the Technion-Israel Institute of Technology in Haifa, Israel. He received his MD (1972) from the Hebrew University of Jerusalem and PhD (1982) from the Technion, where along with Professor Avram Hershko and in collaboration with Professor Irwin Rose (Philadelphia, USA) he discovered the Ubiquitin Proteolytic System, a discovery which awarded them numerous prizes, including the Nobel Prize in Chemistry (2004). He is a member of many learned bodies, including the National Academies of Sciences and Medicine of the USA (Foreign Associate), and the Pontifical Academy of Sciences at the Vatican.
