The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.
PrefacePart I. The Biology of Cancer Stem CellsChapter 1Cancer Stem Cells: A Quick Walk through the ConceptsKatayoon Pakravan, Mohammad Amin Mahjoub, Sadegh BabashahChapter 2Cellular Plasticity, Cancer Stem Cells and MetastasisPaola Ferrari, Andrea Nicolini Chapter 3Cytokine Networks and Cancer Stem CellsClifford Liongue, Alister C Ward, Wei Duan, Sarah ShigdarChapter 4Implications of CXCR4/CXCL12 Interaction for Cancer Stem Cell Maintenance and Cancer ProgressionClaudia Peitzsch, Monica Cojoc, Ina Kurth, Anna DubrovskaChapter 5Non-coding RNAs in Cancer and Cancer Stem CellsRyou-u Takahashi, Hiroaki Miyazaki, Takahiro OchiyaChapter 6Self-renewal Pathways in Mammary Stem Cells and CarcinogenesisLu Deng, Jiahui Xu, Dong Wang, Suling Liu Part II. Cancer Stem Cells in Human MalignanciesChapter 7Breast Cancer Stem CellsGiorgia G. Silveira, Joao Paulo Oliveira-Costa, Alfredo Ribeiro-SilvaChapter 8Lung Cancer Stem CellsGavitt A. Woodard
, David M. JablonsChapter 9Colorectal Cancer Stem CellsPratima Nangia-Makker, Yingjie Yu, Lulu Farhana, Kulsoom Ahmed, Adhip P.N. MajumdarChapter 10Pancreatic Cancer Stem CellsDeepak Ray, Reyhaneh Khoshchehreh, Alexandra Aicher, Christopher Heeschen Chapter 11Glioblastoma Cancer Stem CellsLuca Persano, Alessandro Della Puppa, Elena Porcł, Francesca Maule, Giampietro ViolaChapter 12Head and Neck Cancer Stem CellsChiara Bianchini, Andrea Ciorba Chapter 13Leukemic and Lymphoid Stem CellsMichael W. Becker, Kristen M. O"DwyerChapter 14Leukemic Stem Cells in Acute Lymphoblastic LeukemiaUgo TestaPart III. Novel Approaches for Targeting Cancer Stem Cells Chapter 15Targeting Key Stemness-Related Pathways in Human CancersKyrsta M Coyle, Margaret L Thomas, Mohammad Sultan, Paola MarcatoChapter 16Targeting Cancer Stem Cells and the Tumor MicroenvironmentAlice Turdo, Matilde Todaro, Giorgio Stassi Chapter 17Cancer Stem Cells and Chemoresist
ance: Strategies to Overcome Therapeutic ResistanceMargaret L Thomas, Krysta M Coyle, Mohammad Sultan, Paola MarcatoChapter 18Cancer Stem Cells and Tumor RadioresistanceAadel A Chaudhuri, Michael S Binkley, Maximilian DiehnChapter 19Therapeutic Implications of Cancer Stem Cell : Challenges and Opportunities in Translational StudiesChunguang Yang, Kunlin Jin, Yue Zhang, Hong Sun, William C Cho Index
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