Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression.
- Presents cancer stem characteristics and their signaling pathways
- Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery
- Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers
1. Origin of cancer stem cells (CSCs) and the signalling pathways associated with stem cells and cancer stem cells
2. The importance of niche in therapeutic strategies targeting normal and cancer stem cells
3. Cancer stem cell research: A phosphoproteomic approach
4. Role of Mechanotransduction in stem cells and cancer progression
5. Cancer stem cell signaling in neuroblastoma progression- In touch with reality
6. Role of cancer stem cells in developing chemoresistance of solid tumor
7. The cell surface markers and signaling pathways of cancer stem cells: Target for potent Therapeutics
8. Lung cancer stem cells markers and its potential therapeutic molecular targets
9. Role of cancer stem cells in maintenance of tumor heterogeneity in brain tumors
10. Colorectal cancer stem cells: Overview and potential targeted therapy
11. Pancreatic cancer stem cells and inflammation: Milestones achieved and challenges ahead
12. Epigenetic modification: Key regulator of reprogramming in cancer stem cells
13. Regulation of cancer stemness, cell signaling, reactive oxygen species, and microRNAs in cancer stem cells
14. The stem cell niche: Key role on cell therapy in regenerative medicine
15. Controlled and targeted proliferation of stem cells for therapeutic application
16. MicroRNAs as theranostics: Combating breast cancer stem cells
17. Chemical approaches to stem cell and signaling pathways for therapeutics
18. Responsive biomimetic nanocarriers and its role in stem cell-based targeting therapeutics
19. Stem cell signalling in nephroblastoma with reference to Wilms tumor
20. Brain cancer stem cells: Overview and potential targeted therapy
21. Pancreatic cancer and stem cell
22. Epigenetic modulation of cancer stem cells in vitro 3D models
23. Epigenetic signalling: Regulation of cancer stem cells in colorectal cancer
24. Cancer stem cells, signalling pathways and chemopreventive effects of phytochemicals in androgen-regulated cancers
25. Biomarkers and signalling pathways of esophageal cancer stem cells: promising targets to limit the metastatic potential and stemness.
26. miRNA signalling networks of therapeutic interest involved in angiogenesis regulation by cancer stem cells
27. An altered metabolic landscape drives quiescence to the reawakening of cancer stem cells.
28. Canonical WNT signaling pathway in cancer stem cells and potential inhibitors of therapeutic importance
29. A mechanistic view of the role of thyroid cancer stem cells in microenvironment
30. Cancer stem cells and maintenance of tumor heterogeneity/microenvironment
31. An overview of the role of proto-oncogenes in tissue-specific stem cells
32. Components of cancer stem cells microenvironment: Influence on the tumorigenic property and stemness in cancer stem cells.
33. An overview of hepatocellular carcinoma stem cells and potential targeted therapies
34. Cancer stems cell-derived exosomes: What is known to date
35. Signaling mechanisms of chemoresistance in breast cancer stem cells for therapeutics
Prof. Surajit Pathak, PhD, is currently working as a professor at Chettinad Academy of Research and Education (CARE), Chennai, India (from 2015 to date). He is currently serving as a principal research scientist (2022 JuneDec 2022) at Linkoping University, Linkoping, Sweden. He received his PhD degree from India in 2007 and completed his postdoctoral training (200715) from the University of Alabama, United States, the University of Padova, Italy, and the University of Linkoping, Sweden. His current research focuses on Biomarker discoveries for early detection of colorectal cancer. He has published more than 100 research articles in peer-reviewed international journals of repute with 2233 citations and 27 H-index. Dr. Pathak has edited Elsevier book Stem Cells and Aging in 2021. He is the member of various professional research bodies of India, including the Indian Association of Cancer Research and the Indian Science Congress. Dr. Antara Banerjee, PhD, is presently working as an associate professor at CARE, Chennai from 2016 to date. After completing her PhD in 2008 from India, Dr. Banerjee pursued her postdoctoral work at the University of Padova, Italy and Linkoping University, Sweden (200915). She has published over 95 peer-reviewed research articles in international and national journals with citation index-1408 and H-index 19. The Banerjees lab at Chettinad Hospital and Research Institute is now focused on understanding the role of mesenchymal stem cells niche in tissue regeneration and exploring signaling pathways in governing stem cell fate. She is the editor of Elsevier book Stem Cells and Aging in 2021. She is the member of various professional research bodies, including the Indian Association of Cancer Research and the Indian Science Congress.
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