Carcinogen-Driven Mouse Models of Oncogenesis, Volume 163 contains a series of protocols written by world-leading experts in the field. Each manuscript provides a detailed methodological description to drive carcinogen-mediated oncogenesis in mice. Chapters in this new release include Chemical carcinogenesis in mice as a model of human cancer: Pros and cons, MPA/DMBA-driven mammary carcinomas, Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis in mice, Urethane-induced lung carcinogenesis, Methylcholanthrene-induced fibrosarcomas, BBN-driven bladder carcinomas, Oral squamous cell carcinomas driven by 4NQO, Analyzing skin tumor development in mice by the DMBA/TPA model, and much more.
Other sections cover DSS/AOM-driven colorectal carcinomas, Diethylnitrosamine-induced liver tumorigenesis in mice, Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice, Lung carcinomas induced by NNK and LPS, Pristane-induced mammary carcinomas, The 4-NQO mouse model: an update on a well-established in vivo model of oral carcinogenesis, and more.
- Provides protocols provided by renowned experts in the field
- Presents detailed descriptions of protocols, hence allowing appropriate reproduction of the models
- Includes author notes for each protocol, covering useful tips and troubleshooting
1. Preface - Chemical carcinogenesis in mice as a model of human cancer:
Pros and cons
Lorenzo Galluzzi
2. MPA/DMBA-driven mammary carcinomas
Aitziber Buqué Martinez
3. Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis in mice
Isabelle Plante
4. Urethane-induced lung carcinogenesis
Silvano Sozzani
5. Methylcholanthrene-induced fibrosarcomas
Awen Gallimore
6. BBN-driven bladder carcinomas
Janos Terzic
7. Oral squamous cell carcinomas driven by 4NQO
Nancy J. Philp
8. Analysing skin tumor development in mice by the DMBA/TPA model
Cord Brakebusch
9. DSS/AOM-driven colorectal carcinomas
David C. Montrose
10. Diethylnitrosamine-induced liver tumorigenesis in mice
Peter Hasselblatt
11. Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung
carcinogenesis in mice
Alison K. Bauer
12. Lung carcinomas induced by NNK and LPS
Peter Di
13. Pristane-induced mammary carcinomas
Bae Hoon Lee
14. The 4-NQO mouse model: an update on a well-established in vivo model of
oral carcinogenesis
Pierre Saintigny
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome La Sapienza. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Aitziber Buqué (born 1980) is currently Post-Doctoral Fellow in the laboratory of Dr. Lorenzo Galluzzi with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA). Prior to joining the Galluzzi lab (2018), Aitziber Buqué was a Post-Doctoral Fellow in the Research Team Apoptosis, Cancer and Immunity at the Cordeliers Research Center (Paris, France; 2014-2018), under the direction of Dr. Guido Kroemer, after receiving her PhD from the University of the Basque Country (Leioa, Spain; 2013). Aitziber Buqué is interested in the molecular, cellular and immunological mechanisms whereby breast cancer evades immunosurveillance and resists to immunotherapy, and she is the author of more than 30 scientific articles in international peer-reviewed journals.
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