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Cardiac Regeneration and Repair: Biomaterials and Tissue Engineering [Hardback]

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  • Formāts: Hardback, 486 pages, height x width: 234x156 mm, weight: 890 g, Contains 1 Hardback and 1 Digital (delivered electronically)
  • Sērija : Woodhead Publishing Series in Biomaterials
  • Izdošanas datums: 22-Jan-2014
  • Izdevniecība: Woodhead Publishing Ltd
  • ISBN-10: 0857096591
  • ISBN-13: 9780857096593
Citas grāmatas par šo tēmu:
Cardiac Regeneration and Repair: Biomaterials and Tissue EngineeringPalielināt
  • Formāts: Hardback, 486 pages, height x width: 234x156 mm, weight: 890 g, Contains 1 Hardback and 1 Digital (delivered electronically)
  • Sērija : Woodhead Publishing Series in Biomaterials
  • Izdošanas datums: 22-Jan-2014
  • Izdevniecība: Woodhead Publishing Ltd
  • ISBN-10: 0857096591
  • ISBN-13: 9780857096593
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780857096593.html
Keywords:
This is the first of two volumes on cardiac regeneration and repair (the second is subtitled Biomaterials and tissue engineering). Coverage begins with the pathogenesis of congestive heart failure, followed by chapters on cell therapy--optimal cells, cell delivery routes for cardiac stem cell therapy, regeneration of the ischemic heart, the feasibility of allogeneic stem cells for heart regeneration, and bone marrow cells and their role in cardiac repair after myocardial infarction, among other topics. Subsequent coverage focuses on stem cells, and on gene therapy. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)

Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure.

Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes ofCardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.

  • Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels.
  • Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineering
  • Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels


Heart disease is the leading cause of death in the UK and the United States. For those who survive heart disease, few recover completely. Cell therapies, tissue engineering, and biomaterials technologies have advanced and now offer the potential to reverse the damage caused by heart disease. Chapters in Volume 2 of this important set look at biomaterials and tissue engineering strategies for regeneration and repair. The concluding section reviews vascular modeling and regeneration.

Papildus informācija

A cutting-edge look at the promise of biomaterials and tissue engineering in combating heart disease and damage
Contributor contact details xi
Woodhead Publishing Series in Biomaterials xv
Foreword xix
Introduction xxi
Part I Biomaterials for cardiac regeneration and repair
1(124)
1 Nanotechnology and nanomaterials for cardiac repair
3(14)
M. Xing
1.1 Introduction
3(1)
1.2 Electrospinning nanofibrous scaffolds
4(3)
1.3 Conductive nanomaterial for myocardial infarction (MI)
7(2)
1.4 Nanomedicine
9(4)
1.5 Future trends
13(1)
1.6 References
13(4)
2 Hydrogels for cardiac repair
17(32)
J. J. Wang
K. L. Christman
2.1 Introduction
17(1)
2.2 Hydrogels
18(2)
2.3 Injectable hydrogels alone for cardiac repair
20(11)
2.4 Hydrogels as a platform for co-delivery
31(7)
2.5 Delivery strategies of hydrogels
38(2)
2.6 Future trends
40(1)
2.7 Sources of further information and advice
41(1)
2.8 References
41(8)
3 Injectable biomaterials for cardiac regeneration and repair
49(33)
L. Reis
L. L. Y. Chiu
N. Feric
L. Fu
M. Radisic
3.1 Introduction
49(2)
3.2 Design criteria for biomaterials in cardiac tissue engineering
51(2)
3.3 Injectable biomaterials
53(4)
3.4 Bioactive molecules used in cardiac tissue engineering
57(3)
3.5 Hydrogels to promote endogenous cardiac regeneration and repair
60(5)
3.6 Hydrogels for the delivery of cells for cardiac regeneration
65(3)
3.7 Hydrogels for the artificial maintenance of ventricle geometry and repair
68(4)
3.8 Future trends
72(1)
3.9 References
73(9)
4 Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration
82(28)
B. McNeill
R. Tiwari-Pandey
M. Ruel
E. J. Suuronen
4.1 Introduction
82(1)
4.2 Endothelial progenitor cells (EPCs)
83(4)
4.3 Enhancing EPC therapy
87(7)
4.4 Future trends
94(1)
4.5 Conclusion
95(1)
4.6 References
95(15)
5 Endothelial progenitor cell (EPC)-seeded intravascular stents
110(15)
C. Zhu
5.1 Intravascular stents
110(3)
5.2 Endothelial progenitor cells (EPCs)
113(3)
5.3 EPC-seeded intravascular stents
116(3)
5.4 Conclusion
119(1)
5.5 Sources of further information and advice
119(2)
5.6 References
121(4)
Part II Tissue engineering for cardiac regeneration and repair
125(188)
6 Biomaterials and cells for cardiac tissue engineering
127(53)
T. D. Vu
T. Kofidis
6.1 Introduction
127(1)
6.2 Cardiac structure
128(3)
6.3 Cardiac remodeling in myocardial infarction (MI)
131(2)
6.4 Cells for cardiac tissue engineering
133(4)
6.5 Materials for cardiac tissue engineering
137(7)
6.6 Creation of heart tissue using cell and biomaterials: an in vitro approach
144(14)
6.7 Creation of heart tissue using cell and biomaterials: an in vivo approach of injectable matrices
158(3)
6.8 Vascularization in myocardial tissue engineering
161(2)
6.9 Ventricular aneurysm repair using cells and biomaterials
163(1)
6.10 Clinical applications
163(1)
6.11 Conclusion and future trends
164(1)
6.12 References
165(15)
7 Decellularized biological scaffolds for cardiac repair and regeneration
180(21)
D. M. Faulk
S. A. Johnson
S. F. Badylak
7.1 Introduction
180(1)
7.2 Methods of bioscaffold preparation
181(4)
7.3 Cardiac repair with non-cardiac bioscaffolds
185(4)
7.4 Tissue specificity of extracellular matrix bioscaffolds
189(2)
7.5 Current methods for decellularizing cardiac tissue
191(2)
7.6 Whole organ engineering
193(3)
7.7 References
196(5)
8 Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix
201(24)
D. O. Freytes
A. Godier-Furnemont
Y. Duan
J. D. O'Neill
G. Vunjak-Novakovic
8.1 Heart failure and cardiac tissue engineering
201(2)
8.2 Extracellular matrix (ECM) as a biomaterial
203(5)
8.3 Cardiac ECM as a scaffold for cardiac tissue engineering
208(4)
8.4 Hybrid scaffolds for cell delivery into the heart
212(2)
8.5 Native heart ECM hydrogels for cardiac differentiation
214(2)
8.6 Current limitations and future trends
216(1)
8.7 Acknowledgements
217(1)
8.8 References
217(8)
9 Cell sheet engineering for cardiac repair and regeneration
225(23)
Y. Haraguchi
T. Shimizu
K. Matsuura
D. Chang
M. Yamato
T. Okano
9.1 Introduction
225(2)
9.2 Skeletal myoblasts
227(3)
9.3 Cardiac progenitor cells and cardiac stem cell sheets
230(1)
9.4 Other tissue stem/progenitor cells and cell sheets
231(2)
9.5 Pulsatile cardiac cell sheet and transplantation into animal models
233(1)
9.6 Cardiac differentiation from human embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs)
234(1)
9.7 Engineered cardiac tissue using ESC/iPSC-derived cardiomyocytes
235(3)
9.8 Future trends
238(1)
9.9 Conclusion
239(1)
9.10 Acknowledgements
239(1)
9.11 References
239(9)
10 Maturation of functional cardiac tissue patches
248(35)
G. C. Engelmayr Jr.
D. Zhang
N. Bursac
10.1 Introduction
248(1)
10.2 Native cardiac development
249(2)
10.3 Engineering and functional maturation of biomimetic cardiac tissues
251(9)
10.4 Promoting the maturation of cardiac tissue patches
260(1)
10.5 MicroRNAs
261(1)
10.6 Pluripotent stem cells and their associated molecular effectors
262(4)
10.7 Mechanical forces and stiffness in cardiac tissue engineering
266(2)
10.8 Conclusions and future trends
268(4)
10.9 Acknowledgements
272(1)
10.10 References
272(11)
11 Vascularizing engineered tissues for in vivo and in vitro applications
283(16)
S. C. George
11.1 Introduction
283(1)
11.2 Strategies to vascularize engineered tissues
284(4)
11.3 In vitro applications
288(2)
11.4 In vivo applications
290(1)
11.5 Major barriers and future trends
291(1)
11.6 Conclusion
292(1)
11.7 References
293(6)
12 Clinical considerations for cardiac tissue engineering
299(14)
W.-H. Zimmermann
12.1 Introduction
299(2)
12.2 Heart muscle engineering concepts and applications
301(1)
12.3 Cell types for clinical translation
302(2)
12.4 Extracellular matrix from within or outside
304(1)
12.5 In vivo studies in large animal models
305(1)
12.6 Clinical translation
306(1)
12.7 Future trends
307(1)
12.8 Sources of further information and advice
308(1)
12.9 Acknowledgements
308(1)
12.10 References
309(4)
Part III Vascular remodelling for regeneration and repair
313(140)
13 Aortic extra cellular matrix (ECM) remodeling
315(35)
J. B. Wheeler
J. A. Jones
J. S. Ikonomidis
13.1 Introduction
315(1)
13.2 The aorta
316(4)
13.3 Pathophysiological changes in thoracic aortic aneurysm (TAA) development
320(5)
13.4 Extracellular matrix (ECM) remodeling
325(2)
13.5 Protease activity
327(4)
13.6 Regulation of protease activity
331(3)
13.7 Challenges and pitfalls of clinical therapy
334(5)
13.8 Conclusion
339(1)
13.9 References
339(11)
14 Cell-biomaterial interactions for blood vessel formation
350(39)
S. Kusuma
L. E. Dickinson
S. Gerecht
14.1 Introduction
350(1)
14.2 Blood vessel architecture
351(4)
14.3 Matrices to investigate vasculogenesis mechanisms
355(4)
14.4 Matrices to direct in vitro prevascularization
359(5)
14.5 Scaffolds to induce and study angiogenesis
364(5)
14.6 Manipulating materials to guide vascular assembly and formation
369(8)
14.7 Future trends
377(1)
14.8 Conclusion
377(1)
14.9 Sources of further information and advice
377(1)
14.10 References
378(11)
15 Stem cells in tissue-engineered blood vessels for cardiac repair
389(21)
H. Kurobe
M. W. Maxfield
Y. Naito
C. Breuer
T. Shinoka
15.1 Introduction
389(1)
15.2 Development of biodegradable tissue-engineered vascular grafts (TEVGs)
390(6)
15.3 Techniques for in vivo experiments and evaluation
396(5)
15.4 Clinical application of TEVGs
401(3)
15.5 Future trends
404(1)
15.6 Sources of further information and advice
405(1)
15.7 References
405(5)
16 Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESA™)
410(43)
C. Mount
N. Dusserrre
T. McAllister
N. L'Heureux
16.1 Introduction
410(1)
16.2 Clinical setting
411(4)
16.3 Current options and the need for alternative conduits
415(5)
16.4 Evolution of cardiovascular tissue engineering
420(7)
16.5 Tissue engineering by self-assembly (TESA™): a scaffold-free technology
427(2)
16.6 Clinical results with TESA™ technology
429(5)
16.7 Future trends
434(4)
16.8 References
438(15)
Index 453
Ren-Ke Li, University of Toronto, Canada. Richard D. Weisel, University of Toronto, Canada.