The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.
Chapter 1_Recent advances in in vitro generation of mature
cardiomyocyte.- Chapter 2_Cardiac Reprogramming with Stem Cells: An Advanced
Therapeutic Strategy in Advanced Heart Failure.- Chapter 3_Administration
routes for advanced therapy medicinal products in patients with
cardiovascular diseases.- Chapter 4_Cardiac Progenitor Cells, their
Derivatives and Therapeutic Applications.- Chapter 5_Regenerative medicine:
therapeutic insights from young cardiac stem cells.- Chapter 6_Rejuvenation
and regenerative potential of heart stem cells.- Chapter 7_Cardiac Stem cells
and utilization of atrial appendage microtissues or micrografts in the
treatment of heart failure.- Chapter 8_Stem cells and regenerative medicine
in valvulopathies.- Chapter 9_Cardiac tissue regeneration based on stem cell
therapy.- Chapter 10_Stem Cell Applications in Cardiac Tissue
Regeneration.- Chapter 11_Epicardial progenitors and stem cells in the
cardiovascular applications.- Chapter 12_Human myoblast genome therapy and
the regenerative heart.- Chapter 13_Exosomes and stem cell therapy.- Chapter
14_Mesenchymal stem cells in the clinical perspective for myocardial
regeneration and repair.- Chapter 15_Towards the Human Induced Pluripotent
Stem Cells (hiPSC)-derived Exosomes as Therapeutic Intervention for
Cardiovascular Diseases.- Chapter 16_Stem cell- derived extracellular
vesicles as next generation tools in regenerative medicine.- Chapter
17_Avant-garde Hydrogels as Stem Cell Niche for Cardiovascular Regenerative
Medicine.- Chapter 18_Stem cell-derived cardiac organoids: past, present and
future.- Chapter 19_Stem cell-based organoid engineering.- Chapter
20_Cardiovascular Stem Cell Applications Animal Models.
Dr. Khawaja Husnain Haider is currently a Professor of Cellular and Molecular Pharmacology (Stem cells and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards of various research journals and an invited reviewer for several respected international journals. His research focuses on using DNA, miRNAs, and stem cells as drugs, a topic that has gained popularity in regenerative medicine. He has published nearly 325 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited seven books covering various facets of stem cells and their applications from drug to drug development.
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