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xi | |
| About the editors |
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xiii | |
| Preface |
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xv | |
| Acknowledgments |
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xvii | |
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1 Cardiovascular pathology: guide to practice and training |
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1 | (26) |
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2 | (1) |
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2 | (8) |
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Genetics and molecular biology |
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10 | (1) |
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11 | (1) |
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11 | (4) |
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Heart transplant pathology |
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15 | (1) |
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Cardiovascular clinical diagnostic and imaging studies |
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16 | (1) |
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Training in cardiovascular pathology |
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17 | (1) |
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Cardiovascular pathologist roles as diagnostician, teacher, consultant, and care team member |
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18 | (1) |
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19 | (1) |
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19 | (8) |
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2 Anatomic considerations and examination of cardiovascular specimens (excluding devices) |
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27 | (58) |
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Gross examination of the heart |
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28 | (17) |
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Examination of surgical cardiovascular specimens |
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45 | (4) |
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Microscopic examination of the blood vessels and heart |
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49 | (29) |
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78 | (1) |
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79 | (1) |
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79 | (6) |
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3 Age-related cardiovascular changes and diseases |
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85 | (38) |
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86 | (1) |
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Nonspecific cardiovascular changes of aging |
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86 | (8) |
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Changes in the conduction system |
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94 | (1) |
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95 | (3) |
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98 | (12) |
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Genetic and molecular aspects of cardiovascular aging |
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110 | (3) |
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113 | (1) |
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114 | (9) |
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4 Fundamental principles in cardiovascular genetics |
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123 | (26) |
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123 | (1) |
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123 | (1) |
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124 | (3) |
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Modern molecular diagnostics |
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127 | (14) |
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Identifying the genetic basis of cardiovascular disease |
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141 | (2) |
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Molecular diagnostics in cardiovascular pathology practice |
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143 | (4) |
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147 | (1) |
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147 | (2) |
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5 Pathophysiology of heart failure and an overview of therapies |
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149 | (74) |
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Overview of heart failure |
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150 | (1) |
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Clinical presentation and diagnostic criteria |
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151 | (2) |
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Pathophysiology of heart failure |
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153 | (6) |
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Neurohormonal alterations in heart failure |
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159 | (12) |
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171 | (3) |
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Molecular responses and adaptation of cardiac cells |
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174 | (3) |
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Metabolic remodeling in heart failure |
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177 | (9) |
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Short- to intermediate-term circulatory support devices |
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186 | (18) |
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204 | (1) |
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204 | (1) |
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205 | (18) |
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6 Congenital heart disease: pathology, natural history, and interventions |
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223 | (42) |
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223 | (1) |
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224 | (1) |
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224 | (1) |
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224 | (2) |
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226 | (3) |
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Embryology of the cardiovascular system |
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229 | (6) |
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Clinical features and consequences |
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235 | (1) |
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Specific forms of congenital heart disease |
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235 | (19) |
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Surgical and nonsurgical interventions |
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254 | (2) |
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Congenital heart disease in the adult |
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256 | (3) |
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Natural history without and with interventions |
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259 | (1) |
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260 | (1) |
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260 | (5) |
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7 Vascular Pathobiology: Atherosclerosis and Large Vessel Disease |
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265 | (42) |
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Introduction to atherosclerosis |
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265 | (1) |
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Epidemiology and risk factors |
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266 | (2) |
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Gross and microscopic morphology of the fibroinflammatory lipid plaque |
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268 | (3) |
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Steps in atherosclerotic plaque formation and complications |
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271 | (5) |
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Cellular function and pathways in atherogenesis |
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276 | (17) |
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Nonatherosclerotic diseases of the aorta |
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293 | (5) |
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298 | (1) |
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298 | (9) |
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8 Diseases of small and medium-sized blood vessels |
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307 | (46) |
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307 | (1) |
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Vascular activation and common vascular pathologic changes |
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307 | (1) |
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Congenital vascular diseases |
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308 | (1) |
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Genetic vascular disorders |
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309 | (4) |
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Endocrine/metabolic vascular disorders |
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313 | (2) |
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315 | (9) |
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324 | (3) |
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327 | (1) |
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327 | (2) |
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329 | (2) |
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Vascular deposition disorders |
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331 | (3) |
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Intimal proliferative diseases |
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334 | (2) |
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336 | (2) |
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338 | (3) |
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341 | (3) |
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344 | (1) |
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344 | (9) |
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9 Aneurysms of the aorta: ascending, thoracic, and abdominal and their management |
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353 | (54) |
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Maria E. Romero Andjagdish Butany |
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353 | (1) |
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Normal anatomy and histology of the aorta |
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354 | (1) |
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Aging changes of the aorta |
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355 | (1) |
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Thoracic aortic aneurysms |
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355 | (5) |
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Etiology and pathologic findings |
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360 | (19) |
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Clinical presentation and natural history |
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379 | (1) |
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Abdominal aortic aneurysm |
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379 | (5) |
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384 | (7) |
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391 | (6) |
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397 | (1) |
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397 | (10) |
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10 Myocardial ischemia and its complications |
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407 | (40) |
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407 | (1) |
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Universal definition of myocardial infarction |
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408 | (1) |
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409 | (1) |
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410 | (1) |
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Biochemical changes with ischemia and biochemical markers |
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411 | (1) |
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Ultrastructural evolution of acute ischemic injury |
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412 | (1) |
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Cellular and subcellular mechanisms of myocardial injury |
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413 | (2) |
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Microscopic evolution of acute ischemic injury |
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415 | (4) |
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Morphology of coronary arteries and plaques |
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419 | (1) |
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Tako--Tsubo cardiomyopathy |
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420 | (1) |
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Gross evolution of acute ischemic injury |
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421 | (1) |
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Patterns of myocardial infarction |
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422 | (1) |
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Phenomena associated with ischemic injury |
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423 | (3) |
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Reperfusion of ischemic myocardium |
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426 | (1) |
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Complications of myocardial infarction |
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427 | (5) |
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Recognition and quantification of acute ischemic injury |
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432 | (2) |
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Pathology of interventions |
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434 | (1) |
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Pathophysiological and pharmacological interventions |
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435 | (1) |
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Genetics and molecular biology of ischemic heart disease |
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436 | (1) |
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Genetics of coronary artery disease |
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436 | (1) |
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Molecular biology of coronary artery disease |
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437 | (1) |
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Cell-based therapies for ischemic heart disease |
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438 | (1) |
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439 | (1) |
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439 | (8) |
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11 Pathology of sudden death, cardiac arrhythmias, and conduction system |
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447 | (88) |
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447 | (46) |
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Cardiac conduction system |
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493 | (18) |
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511 | (6) |
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Appendix guidelines for postmortem study of sudden death |
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517 | (5) |
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522 | (1) |
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522 | (1) |
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522 | (13) |
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535 | (18) |
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535 | (1) |
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536 | (1) |
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537 | (4) |
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541 | (1) |
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Coronary arteries and ischemia |
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542 | (1) |
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542 | (1) |
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Specific drug considerations |
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543 | (5) |
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548 | (1) |
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Myocardial toxins as a cause of death |
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548 | (1) |
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Genetics and molecular biology |
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549 | (1) |
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549 | (1) |
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550 | (3) |
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553 | (24) |
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553 | (1) |
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Definition of myocarditis |
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554 | (1) |
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555 | (2) |
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Histopathologic patterns of myocarditis |
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557 | (5) |
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Etiologies of myocarditis |
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562 | (8) |
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570 | (1) |
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Molecular and genetic technologies and considerations in myocarditis |
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570 | (1) |
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571 | (1) |
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571 | (6) |
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577 | (56) |
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Definition and classification of cardiomyopathies |
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578 | (1) |
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579 | (9) |
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Hypertrophic cardiomyopathy |
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588 | (16) |
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Arrhythmogenic cardiomyopathy |
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604 | (9) |
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Restrictive cardiomyopathy |
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613 | (9) |
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622 | (3) |
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Genetics and molecular biology |
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625 | (1) |
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626 | (1) |
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627 | (6) |
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15 The pericardium and its diseases |
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633 | (30) |
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633 | (1) |
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634 | (8) |
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642 | (1) |
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643 | (14) |
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657 | (1) |
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657 | (1) |
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658 | (5) |
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16 Valvular heart disease |
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663 | (44) |
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663 | (1) |
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664 | (2) |
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666 | (1) |
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666 | (9) |
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675 | (11) |
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Nonrheumatic mitral stenosis |
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686 | (4) |
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Rheumatic mitral regurgitation |
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690 | (1) |
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Other causes of mitral regurgitation |
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691 | (3) |
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Tricuspid valvular dysfunction |
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694 | (2) |
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Pulmonary valvular dysfunction |
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696 | (1) |
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697 | (8) |
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705 | (1) |
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705 | (2) |
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17 Cardiac valve replacement and related interventions |
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707 | (54) |
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708 | (11) |
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Valve-related complications: clinical importance, morphology, secondary effects, and pathogenesis |
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719 | (13) |
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Other tissue valve substitutes |
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732 | (4) |
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Transcatheter valve implantation |
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736 | (5) |
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Valve repair and valve sparing procedures |
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741 | (3) |
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New developments and future considerations |
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744 | (2) |
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Pathologic considerations in analysis of heart valve substitutes |
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746 | (5) |
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751 | (1) |
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Appendix. Some Heart valve prostheses approved by the FDA |
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751 | (1) |
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752 | (1) |
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753 | (8) |
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18 The pathology of cardiovascular interventions and devices for coronary artery disease, vascular disease, heart failure, and arrhythmias |
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761 | (38) |
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762 | (1) |
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Endovascular therapies and myocardial revascularization |
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762 | (14) |
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Aortic and peripheral vascular replacement and reconstruction |
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776 | (8) |
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Cardiac assist and replacement |
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784 | (3) |
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787 | (6) |
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793 | (1) |
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793 | (6) |
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19 Tumors of the cardiovascular system: heart and blood vessels |
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799 | (46) |
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Incidence and classification |
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799 | (3) |
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802 | (1) |
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Reactive cardiac masses and pseudotumors |
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802 | (4) |
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806 | (2) |
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Hamartomas and benign neoplasms |
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808 | (1) |
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Hamartomas of the cardiac muscle |
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808 | (3) |
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811 | (1) |
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Benign tumors of the myofibroblastic tissue |
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812 | (1) |
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Miscellaneous benign fibrous tumors |
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813 | (1) |
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814 | (6) |
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820 | (9) |
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Primary neoplasms and genetics |
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829 | (1) |
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830 | (2) |
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Sarcomas of the great vessels |
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832 | (5) |
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837 | (1) |
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837 | (8) |
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20 Pathology of cardiac transplantation |
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845 | (44) |
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General clinicopathologic considerations |
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845 | (2) |
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Pathology of the explanted recipient heart |
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847 | (2) |
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Pathology of the donor heart |
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849 | (1) |
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Pathology of the allograft |
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850 | (17) |
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Posttransplant lymphoproliferative disorders |
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867 | (6) |
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Causes of death in heart transplant recipients |
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873 | (1) |
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Heart transplantation in combination with other organs |
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873 | (1) |
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Pathological review of an endomyocardial biopsy |
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874 | (4) |
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Approach to the examination of a failed allograft |
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878 | (1) |
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Noninvasive molecular testing for cardiac allograft rejection |
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879 | (1) |
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879 | (1) |
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880 | (1) |
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880 | (9) |
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21 Basic pathobiology of cell-based therapies and cardiac regenerative medicine |
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889 | (22) |
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890 | (1) |
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The rise (and fall) of the myocardial regeneration hypothesis |
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890 | (1) |
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Classic descriptions of growth, hypertrophy and failure of the heart |
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891 | (5) |
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Contemporary overview of cardiomyocytes biology |
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896 | (1) |
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Contemporary perspectives on myocardial pathobiology |
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897 | (1) |
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Experimental studies of stem cell therapy |
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898 | (4) |
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Clinical studies and trials of stem cell therapy |
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902 | (1) |
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Challenges to the rationale for cardiac stem cell therapy |
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903 | (1) |
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Regulatory considerations |
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903 | (1) |
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Alternatives to exogenous stem cell therapy |
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904 | (1) |
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904 | (1) |
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905 | (1) |
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906 | (5) |
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22 Forensic aspects of cardiovascular pathology |
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911 | (30) |
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Investigative information |
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911 | (1) |
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912 | (2) |
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Cardiovascular pathology consultation |
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914 | (1) |
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Injuries of the heart and major vessels |
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914 | (4) |
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Primary diseases of the heart |
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918 | (3) |
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Infectious and inflammatory conditions affecting the heart |
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921 | (2) |
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Diseases of the cardiac valves |
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923 | (1) |
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Anomalies and diseases of the aorta and coronary arteries |
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924 | (5) |
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Systemic diseases affecting the heart and major vessels |
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929 | (3) |
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932 | (4) |
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Sudden death following surgical and medical procedures |
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936 | (1) |
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Organ and tissue procurement |
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936 | (1) |
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937 | (1) |
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|
937 | (4) |
| Index |
|
941 | |
