Atjaunināt sīkdatņu piekrišanu

E-grāmata: Cell Culture Bioprocess Engineering, Second Edition

4.00/5 (4 ratings by Goodreads)
(University of Minnesota, Minneapolis, USA)
  • Formāts: 466 pages
  • Izdošanas datums: 06-Mar-2020
  • Izdevniecība: CRC Press Inc
  • Valoda: eng
  • ISBN-13: 9780429531897
Citas grāmatas par šo tēmu:
  • Formāts - EPUB+DRM
  • Cena: 144,01 €*
  • * ši ir gala cena, t.i., netiek piemērotas nekādas papildus atlaides
  • Ielikt grozā
  • Pievienot vēlmju sarakstam
  • Šī e-grāmata paredzēta tikai personīgai lietošanai. E-grāmatas nav iespējams atgriezt un nauda par iegādātajām e-grāmatām netiek atmaksāta.
  • Bibliotēkām
Cell Culture Bioprocess Engineering, Second EditionPalielināt
  • Formāts: 466 pages
  • Izdošanas datums: 06-Mar-2020
  • Izdevniecība: CRC Press Inc
  • Valoda: eng
  • ISBN-13: 9780429531897
Citas grāmatas par šo tēmu:

DRM restrictions

  • Kopēšana (kopēt/ievietot):

    nav atļauts

  • Drukāšana:

    nav atļauts

  • Lietošana:

    Digitālo tiesību pārvaldība (Digital Rights Management (DRM))
    Izdevējs ir piegādājis šo grāmatu šifrētā veidā, kas nozīmē, ka jums ir jāinstalē bezmaksas programmatūra, lai to atbloķētu un lasītu. Lai lasītu šo e-grāmatu, jums ir jāizveido Adobe ID. Vairāk informācijas šeit. E-grāmatu var lasīt un lejupielādēt līdz 6 ierīcēm (vienam lietotājam ar vienu un to pašu Adobe ID).

    Nepieciešamā programmatūra
    Lai lasītu šo e-grāmatu mobilajā ierīcē (tālrunī vai planšetdatorā), jums būs jāinstalē šī bezmaksas lietotne: PocketBook Reader (iOS / Android)

    Lai lejupielādētu un lasītu šo e-grāmatu datorā vai Mac datorā, jums ir nepieciešamid Adobe Digital Editions (šī ir bezmaksas lietotne, kas īpaši izstrādāta e-grāmatām. Tā nav tas pats, kas Adobe Reader, kas, iespējams, jau ir jūsu datorā.)

    Jūs nevarat lasīt šo e-grāmatu, izmantojot Amazon Kindle.

This book is the culmination of three decades of accumulated experience in teaching biotechnology professionals. It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized.

This second edition consists of major updates to all relevant topics contained within this work. The previous edition has been successfully used in training courses on cell culture bioprocessing over the past seven years. The format of the book is well-suited to fast-paced learning, such as is found in the intensive short course, since the key take-home messages are prominently highlighted in panels. The book is also well-suited to act as a reference guide for experienced industrial practitioners of mammalian cell cultivation for the production of biologics.
Preface ix
1 Overview of Cell Culture Processes
An Introduction to Cell Culture: A Historical Perspective
2(4)
Cell Culture as Process Technology
6(10)
Industrial Cell Lines
16(3)
Other Production Systems
19(2)
Manufacturing
21(1)
Upstream Process
21(4)
Product Quality in Cell Culture Processing
25(1)
Quality of the Product
25(5)
From Discovery to Clinical Products
30(8)
2 Cell Biology for Bioprocessing
Introduction
38(1)
Tissue Cells and Their Isolation
39(6)
Cell Membrane
45(5)
Cytoplasm and Organelles
50(7)
Protein Secretion through the ER and Golgi Apparatus
57(5)
Transport across Cellular Membranes
62(6)
Cell Shape, Mechanics, and Movement
68(7)
Growth Control
75(8)
Concluding Remarks
83(3)
3 Cell Physiology
Introduction
86(1)
Glucose and Energy Metabolism
87(14)
Regulation of Glucose Metabolism
101(7)
Transport and Transporters
108(4)
Metabolic Homeostasis and Lactate Consumption
112(7)
Amino Acid Metabolism
119(3)
Lipid Metabolism
122(4)
Glycan Biosynthesis and Protein Glycosylation
126(12)
Concluding Remarks
138(4)
4 Product Quality and Process
Introduction
142(3)
Quality of Protein Product
145(5)
Structural Homogeneity of the Product
150(8)
Biological Activities
158(2)
Quality by Design (QbD) of Cell Culture Products
160(2)
QTPP and CQAs
162(6)
Quality Risk Management
168(4)
Design Space and Control Strategy
172(5)
QbD in Different Stages of the Product's Life Cycle
177(3)
Concluding Remarks
180(4)
5 Stoichiometry and the Kinetics of Cell Cultivation
Introduction
184(1)
Material Conversion in Cell Culture
185(5)
Material Balance on Cell Growth
190(3)
Kinetic Description of Cell Growth & Product Formation
193(5)
Kinetic Model of Cell Growth
198(2)
Modeling Productivity
200(1)
Modeling a Cell Culture System
201(3)
Concluding Remarks
204(4)
6 Cell Line Development
Introduction
208(1)
Transient Production vs. Stable Expression Cell Line
209(1)
Host Cells
210(3)
Generating a Recombinant Protein High-Producing Cell Line
213(22)
Concluding Remarks: Genomic Technology & Cell Line Development
235(5)
7 Medium Design for Cell Culture Processing
Introduction
240(3)
Types of Media and Classes of Medium Components
243(5)
Process Medium Design: Kinetics, Stoichiometry, Omics & Optimization
248(6)
Components of Basal Medium
254(18)
High Molecular Weight and Complex Supplements
272(4)
Concluding Remarks
276(4)
8 Cell Culture Bioreactors
Introduction
280(1)
Basic Types of Bioreactors
281(5)
Tissue Culture and Disposable Cell Culture Systems
286(4)
Adherent Cell Support Systems
290(5)
Bioreactors Developed for Cell Culture
295(7)
Concluding Remarks
302(4)
9 Fed-Batch Culture Processes
Introduction
306(3)
Batch Cultures
309(1)
Fed-Batch Cultures
310(5)
Stoichiometric Feeding
315(3)
Delivery of Feed Medium
318(2)
Product Quality in Fed-Batch Culture
320(3)
Concluding Remarks
323(5)
10 Continuous Cell Culture Processes
Introduction
328(2)
Analysis of Continuous Culture and Steady State
330(10)
Methods of Cell Retention
340(6)
Continuous Culture & Continuous Process
346(2)
Concluding Remarks
348(4)
11 Oxygen Transfer in Cell Culture Bioreactors
Introduction
352(1)
Oxygen Concentration across the Gas-Liquid Interface
353(3)
Oxygen Transfer at the Gas-Liquid Interface
356(9)
Damage to Cells by Gas Sparging
365(3)
Oxygen Transfer in Aggregates and Membrane Bioreactors
368(3)
Concluding Remarks
371(5)
12 Scaling Up and Scaling Down for Cell Culture Bioreactors
Introduction
376(2)
Mechanical Agitation
378(2)
Power Consumption for Mixing Tanks
380(8)
Mixing Time
388(4)
Scaling Up and Mechanical Forces on Cells
392(2)
Oxygen and Carbon Dioxide Transfer
394(9)
Process Scale-Up and Scale-Down Models
403(2)
Concluding Remarks
405(5)
Appendix A: Cell Culture Process Data Analysis
Overview of Process Data
410(3)
Data Processing Pipeline
413(5)
Metabolic Flux Analysis
418(6)
Time Series Data Analysis
424(3)
Aggregation and Analysis of Process Data
427(3)
Concluding Remarks 430(7)
Index 437
Wei-Shou Hu is a Distinguished McKnight University Professor in the Department of Chemical Engineering and Materials Science at the University of Minnesota. His education and research efforts focus on bioprocess engineering and systems biotechnology. He is the author of Engineering Principles in Biotechnology and co-author of the textbook Bioseparations. For over three decades, he has been an active member in the cell culture bioprocess community. He is the founder of both a popular training course in cell culture bioprocess technology and an important cell technology conference that served as an important forum for cell technology advancement.
Biežāk uzdotie jautājumi par e-grāmatām Biežāk uzdotie jautājumi par e-grāmatām
Permanent link: https://www.kriso.lv/db/97804295318976e.html
Keywords: