Cellular Bioenergetics: Role of Coupled Creatine Kinases Softcover reprint of the original 1st ed. 1994 [Mīkstie vāki]

Preface.- I Muscle Energy Metabolism.- 1a. Introduction: history of
the problem.- 1b. A brief summary of the history of the detection of creatine
kinase isoenzymes.-
2. Metabolic regulation of in vivo myocardial contractile
function: multiparameter analysis.-
3. Compartmentation of ATP synthesis and
utilization in smooth muscle: roles of aerobic glycolysis and creatine
kinase.-
4. Creatine metabolism and the consequences of creatine depletion in
muscle.- II Substrate and Creatine Kinase Isoenzyme Compartmentation.-
1.
The importance of the outer mitochondrial compartment in regulation of energy
metabolism.-
2. The influence of the cytosoliconcotic pressure on the
permeability of the mitochondrial outer membrane for ADP: implications for
the kinetic properties of mitochondrial creatine kinase and for ADP
channelling into the intermembrane space.-
3. Influence of mitochondrial
creatine kinase on the mitochondrial/extramitochondrial distribution of high
energy phosphates in muscle tissue: evidence for a leak in the creatine
shuttle.-
4. The structure of mitochondrial creatine kinase and its membrane
binding properties.-
5. Myofibrillar creatine kinase and cardiac
contraction.-
6. Interaction of creatine kinase and adenylate systems in
muscle cells.- III Creatine Kinases and Metabolic Integration.-
1.
Metabolic compartmentation and substrate channelling in muscle cells. Role of
coupled creatine kinases in in vivo regulation of cellular respiration a
synthesis.-
2. Creatine kinase in non-muscle tissues and cells.-
3. The
creatine kinase system in smooth muscle.- IV Molecular Biology of Creatine
Kinases.-
1. Expression of the mitochondrial creatine kinase genes.-
2.
Sequence homology and structure predictions of the creatine kinase
isoenzymes.- 3.Approaching the multifaceted nature of energy metabolism:
inactivation of the cytosolic creatine kinases via homologous recombination
in mouse embryonic stem cells.- V Development and Pathological Alterations
of Creatine Kinases.-
1. Compartmentation of creatine kinases during
perinatal development of mammalian heart.-
2. In situ study of myofibrils,
mitochondria and bound creatine kinases in experimental cardiomyopathies.-
3.
Thyroid hormones and the creatine kinase system in cardiac cells.- VI
Metabolic Regulation: Theoretical Basis.-
1. Control theory of metabolic
channelling.-
2. Mathematical modeling of intracellular transport processes
and the creatine kinase systems: a probability approach.