Explains the rational approach to reducing drug toxicity and adverse effects, by a survey of modern methods as well as a discussion of future challenges facing the pharmaceuticals industry. Key knowledge for drug development professionals wanting to...Lasīt vairāk
The most comprehensive handbook of modern technology for chemical compound testing covers biological, chemical and physical methods for low- to high-throughput assays. Volume 1 is organized by assay principle, volume 2 by target class....Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
With Kinase inhibitors being widely seen as the long-sought magic bullet to conquer cancer, this fully comprehensive guide to kinase inhibitor drug development covers the entire drug pipeline from target identification to compound development and c...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
A pharmacophore begins with a three-dimensional map of the substituents of a bioactive molecule that contribute to it being bioactive. The three dimensions are then fatten into many by adding the calculated or estimated electronic and geometric prope...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Soon after the first edition was published in 2001, the three authors (affiliated with Pfizer and Astr-Zeneca) began on this second edition to update, fill in gaps, and include new material (especially in the areas of toxicity and high throughput ana...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Contributors identified only by name offer clues to drug designers on designing ligands that will target G protein-coupled receptors, which comprise over 60 of all that receptors, and so should not be all that hard to hit. They emphasize fundamental...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information fo...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Peter Goodford begins by explaining the basic principles of his GRID software for determining energetically favorable binding sites on molecules of known structure, which has been incorporated into many other software packages designed to predict the...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.The first reference devoted to the topic, this up-to-date resource covers all stages of the earl...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Researchers from academia and from pharmaceutical companies present information on how to obtain protein structures suited for rational drug design and how to exploit crystallographic data for the drug discovery process. They examine the crystallogra...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
This clear, coherent and original text is designed to help the reader make informed judgements about appropriate research strategies and the credibility of particular pieces of research. Introductory in pitch and grounded in extensive real-...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms have made quantum chemistry a valuable tool in the search for active substances.Written by a team...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term molecula...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Each of the two volumes focuses on one of the ways that structure the field of bioinformatics. The first, 442 pages, proceeds intrinsically, by the type of problem that is under consideration. The second, 205 pages, proceeds extrinsically, by the app...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
The medical benefits of a drug are not only dependent on its biological effect, but also on its life cycle within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and k...Lasīt vairāk
Šī grāmata vairs netiek publicēta. Jums tiks paziņota lietotas grāmatas cena
Contributors mostly from the Groningen University Institute for Drug Exploration offer a map of the body from the perspective of drug targeting and drug delivery, discuss potential and limitations of targeting strategies in the light of organ-related...Lasīt vairāk
