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E-grāmata: Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research

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Challenges and Opportunities of Next-Generation Sequencing for Biomedical ResearchPalielināt
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research.

Covers reviews of methodology and research in all aspects of protein chemistry.
Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

Recenzijas

"The authority, originality, and editing of the reviews are first class." --Nature

Papildus informācija

Covers reviews of methodology and research in all aspects of protein chemistry. Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.
Preface vii
1 Next Generation Sequencing Methodologies - An Overview
1(26)
William O. Pickrell
Mark I. Rees
Seo-Kyung Chung
1 Introduction/NGS
2(1)
2 Sample Submission Strategies
3(3)
3 Phenotyping Challenges and Strategies
6(3)
4 Development of NGS Technologies
9(7)
5 Application of NGS
16(1)
6 Bioinformatics
16(11)
References
21(6)
2 Next Generation Sequencing in the Clinical Domain: Clinical Advantages, Practical, and Ethical Challenges
27(38)
Rose Thompson
Cheney J. G. Drew
Rhys H. Thomas
1 Introduction
28(1)
2 What is NGS?
28(2)
3 Explosion of Exome Sequencing Papers
30(1)
4 The Successes of Exome Sequencing
31(18)
5 The Successes of Genome Sequencing
49(1)
6 Ethics of WES
49(7)
7 NGS in Routine Clinical Practice?
56(9)
References
58(7)
3 Opportunities and Challenges for Genome Sequencing in the Clinic
65(20)
Gianpiero L. Cavalleri
Norman Delanty
1 Introduction
65(1)
2 Milestones in the Development of Genetic Mapping
66(4)
3 Strategies for the Application of Next-Generation Sequencing in Genetic Mapping
70(2)
4 Consequence of GENE DISCOVERY in Research Programs
72(5)
5 Challenges Around Incorporating Sequencing to the Clinic
77(8)
References
79(6)
4 Polymorphisms in Neuropsychiatric and Neuroinflammatory Disorders and the Role of Next Generation Sequencing in Early Diagnosis and Treatment
85(32)
Rossen M. Donev
Owain W. Howell
1 Polymorphisms in Major Depressive Disorders
86(4)
2 Polymorphisms in ADHD
90(3)
3 Polymorphisms in Neuroinflammatory Diseases
93(1)
4 Multiple Sclerosis
93(5)
5 Alzheimer's Disease
98(4)
6 Parkinson's Disease
102(4)
7 Role of the NGS in Early Diagnostic and Treatment
106(2)
8 Conclusions
108(9)
References
108(9)
5 Structural Modelling Pipelines in Next Generation Sequencing Projects
117(52)
Jonathan G. L. Mullins
1 Introduction
118(1)
2 Protein Structure and Function
118(2)
3 Structural Modeling Methods
120(15)
4 Assessing Functional Impact of nsSNPs
135(20)
5 Protein-Protein Interaction Networks
155(14)
References
160(9)
Author Index 169(22)
Subject Index 191
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