This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful
Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who arealready utilizing mass spectrometry or considering bringing this technology to their labs.
Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic
Drug Monitoring and Toxicology.- Quantitative LC-MS/MS Analysis of
Amphetamines and Cocaine in Human Urine.- Quantification of Gabapentin,
Lacosamide, Perampanel, Pregabalin, Rufinamide, and Vigabatrin in Serum Using
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).- Turbulent Flow
Liquid Chromatography-Tandem Mass Spectrometry Methods for Antiepileptic Drug
Quantitation in Serum.- Quantitative LC-MS/MS Method for the Simultaneous
Measurement of Six Antiepileptics and Pentobarbital in Human Serum.- Triazole
Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid
Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole,
Voriconazole, Itraconazole, and Hydroxyitraconazole.- Liquid
Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of
Plasma Atovaquone Concentrations in Pediatric Patients.- Analysis of
Barbiturates in Urine by LC-MS/MS.- High Throughput Quantitative LC-MS/MS
Analysis of Barbiturates in Human Urine.- High Throughput Quantitative
LC-MS/MS Analysis of Benzodiazepines in Human Urine.- Quantitation of
Bupropion in Urine by Liquid Chromatography-Tandem Mass Spectrometry.-
Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their
Glucuronide Metabolites in Human Urine.- Liquid Chromatography-Tandem Mass
Spectrometry Method for the Quantification of Plasma Busulfan.- Determination
of Busulfan and Melphalan in Plasma by Turbulent Flow Chromatography-Tandem
Mass Spectrometry.- Serum and Urine Quantification of Delta-8 and Delta-9
Tetrahydrocannabinol Carboxylic Acid Using Gas Chromatography-Mass
Spectrometry.- 11-Nor-9-Carboxy-8-Tetrahydrocannabinol, 7-Carboxy
Cannabidiol, and 11-Nor-9-Carboxy-9-Tetrahydrocannabinol in Urine by
LC-MS/MS.- Quantification of Clofarabine and Fludarabine in Plasma by High
Performance Liquid Chromatography-Tandem Mass Spectrometry.- Untargeted
High-Resolution Mass Spectrometry for Detection of Natural Products and
Confiscated Powders and Pills.- Drug Screening of 49 Compounds by Liquid
Chromatography-Tandem Mass Spectrometry in Saliva.- High Throughput
Comprehensive Quantitative LC-MS/MS Analysis of a Common Drugs and
Metabolites (62 Compounds) in Human Urine.- Detection of 41 Drugs and
Metabolites in Urine with Internal Hydrolysis Control by Liquid
Chromatography-Tandem Mass Spectrometry.- Comprehensive Urine Drug Screen by
Gas Chromatography-Mass Spectrometry (GC-MS).- Comprehensive Urine Drug
Screen by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry.-
A Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of
Ethyl Glucuronide and Ethyl Sulfate in Urine.- Quantification of Fentanyl and
Norfentanyl in Whole Blood Using Liquid Chromatography-Tandem Mass
Spectrometry.- Quantitative Assay of Fentanyl and Analogues Using LC-MS/MS.-
Analysis of Hypoglycemic Drugs by Liquid Chromatography-Tandem Mass
Spectrometry.- Multiplex Immunosuppressant (ISD) Method for the Measurement
of Cyclosporine A, Tacrolimus, Sirolimus/Rapamycin, and Everolimus in Whole
Blood Using MassTrakTM Kit.- Assessment of Iohexol Serum Clearance by
LC-MS/MS with Isotopically Labeled Internal Standard.- Quantification of
Mycophenolic Acid in Plasma by High Performance Liquid Chromatography-Tandem
Mass Spectrometry (LC-MS/MS).- Quantitation of Urine Nicotine, Cotinine, and
3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).-
Quantification of Olanzapine by Liquid Chromatography-Tandem Mass
Spectrometry (LC-MS/MS).- Quantitative Opiate, Opioid, and Benzodiazepine
Testing by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).-
Quantitative LC-MS/MS Analysis of Opiates and Opioids in Human Urine.-
Quantification of Oxcarbazepine Using Liquid Chromatography-Tandem Mass
Spectrometry (LC-MS/MS).- Liquid Chromatography-Tandem Mass Spectrometry for
Quantitation of Serum Pentobarbital.- Quantification of Phencyclidine (PCP)
in Urine, Serum, or Plasma by Gas Chromatography-Mass Spectrometry (GC-MS).-
Simultaneous Determination of Prednisone and Prednisolone in Serum by
Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry.- Measurement
of ThioTEPA and Its Metabolite TEPA in Plasma and Cerebrospinal Fluid by
Turbulent Flow Chromatography-Tandem Mass Spectrometry.- A Direct Dilute and
Shoot HPLC-MS/MS Method for Tetrahydrocannabinol (THC) Metabolites.-
Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid
Chromatography-Tandem Mass Spectrometry (LC-MS/MS).- Determination of
Treosulfan and Fludarabine in Plasma by Turbulent Flow Liquid
Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS).- Determination of
Thiopurine S-Methyltransferase (TPMT) Activity in Human Erythrocytes by
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
