This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of total Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. Each chapter contains a brief introduction to the topic, clinical utility of the analyte(s), and useful notes to help laboratorians easily reproduce the protocols discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and thorough, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, is a great resource for laboratorians who are already using mass spectrometry or thinking of introducing this technology to their laboratories.
Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic
Drug Monitoring and Toxicology.- Quantitation of Flecainide, Mexiletine,
Propafenone, and Amiodarone in Serum or Plasma Using Liquid
Chromatography-Tandem Mass Spectrometry (LC-MS/MS).- Quantitation of the Oral
Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Plasma
Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry
(UPLC-MS/MS).- Simultaneous Quantitation of Lamotrigine, Levetiracetam,
10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS
.- Quantification of the Triazole Antifungal Compounds Voriconazole and
Posaconazole in Human Serum or Plasma Using Liquid Chromatography
Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).- Quantitation of
Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma
Using Liquid Chromatography-Tandem Mass Spectrometry
(LC-MS/MS).- Quantitation of Total Buprenorphine and Norbuprenorphine in
Meconium by LC-MS/MS.- Quantitation of Buprenorphine, Norbuprenorphine,
Buprenorphine Glucuronide, Norbuprenorphine Glucuronide, and Naloxone in
Urine by LC-MS/MS.- A Simple Liquid Chromatography Tandem Mass Spectrometry
Method for Quantification of Plasma Busulfan.- High-Throughput Quantitation
of Busulfan in Plasma Using Ultra-Fast Solid Phase Extraction Tandem Mass
Spectrometry (SPE-MS/MS).- Quantification of
11-Carboxy-Delta-9-Tetrahydrocannbinol (THC-COOH) in Meconium Using Gas
Chromatography Mass Spectrometry (GC/MS).- Quantitation of Carisoprodol and
Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass
Spectrometry (LC-MS/MS).- Cetirizine Quantification by High Performance
Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS).- Quantification of
Docetaxel in Serum UsingTurbulent Flow Liquid Chromatography Electrospray
Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS).- Comprehensive Urine Drug
Screen by Gas-Chromatography Mass Spectrometry (GC/MS).- Broad Spectrum Drug
Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion
Trap Mass Spectrometry.- High Resolution Mass Spectrometry for Untargeted
Drug Screening.- Quantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine
Using Liquid Chromatography-Tandem Mass
Spectrometry(LC-MS/MS).- Quantification of Hydroxychloroquine in Blood Using
Turbulent Flow Liquid Chromatography-Tandem mass Soectrometry
(TFLC-MS/MS).- Quantification of Iohexol in Serum by High Performance Liquid
Chromatography Tandem Mass Spectrometry (LC-MS/MS).- Quantitation of
Teriflunomide in Human Serum/Plasma Across a 40,000-Fold Concentration Range
by LC/MS/MS.- Determination of Menthol in Plasma and Urine by Gas
Chromatography-Mass Spectrometry (GC/MS).- Development of an Assay for
Methotrexate and its Metabolites 7-Hydroxy Methotrexate and DAMPA in Serum by
LC-MS/MS.- Quantitative, Multidrug Pain Medication Testing by Liquid
Chromatography Tandem Mass Spectrometry (LC-MSMS).- Quantification of Free
Phenytoin by Liquid Chromatography Tandem Mass Spectrometry
(LC/MS/MS).- Detection of Stimulants and Narcotics by Liquid Chromatography
Tandem Mass Spectrometry and Gas Chromatography Mass Spectrometry for Sports
Doping Control.- Quantification of Tricyclic Antidepressants in Serum Using
Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
