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Clinical Immunology 2nd Revised edition [Mīkstie vāki]

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Edited by (CSci FIBMS, Laboratory Manager, Department of Infection and Immunity, Imperial College Healthcare NHS Trust), Edited by (Department of Immunology, Barts and the London NHS Trust), Edited by (Department of Immunology, Barts and the London NHS Trust)
  • Formāts: Paperback / softback, 360 pages, height x width x depth: 246x196x15 mm, weight: 786 g, 85 line illustrations and 60 halftones
  • Sērija : Fundamentals of Biomedical Science
  • Izdošanas datums: 10-Mar-2016
  • Izdevniecība: Oxford University Press
  • ISBN-10: 0199657653
  • ISBN-13: 9780199657650
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  • Cena: 71,61 €
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Clinical Immunology 2nd Revised editionPalielināt
  • Formāts: Paperback / softback, 360 pages, height x width x depth: 246x196x15 mm, weight: 786 g, 85 line illustrations and 60 halftones
  • Sērija : Fundamentals of Biomedical Science
  • Izdošanas datums: 10-Mar-2016
  • Izdevniecība: Oxford University Press
  • ISBN-10: 0199657653
  • ISBN-13: 9780199657650
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780199657650.html
Keywords:
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible.

The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis.
Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science.

Clinical Immunology gives the new biomedical scientist an insight into the function of the immune system, the front line of defence against pathological disease, and the diagnostic techniques used to identify associated malfunctions and disorders. By examining the key immunological principles and scientific basis of laboratory techniques with a focus on the biomedical scientist's role in the diagnostic laboratory, the reader is provided with everything needed to prepare for a specialist qualification in immunology. Current tests, the rationale behind their use, the technologies employed, and the quality measures applied are illustrated by specific case studies showing how the clinician interprets the results to help the patient.

Online Resource Centre
The Online Resource Centre to accompany Clinical Immunology features:

For registered adopters of the book:
- Figures from the book, available to download

For students:
- Answers to self-check and end of chapter questions
- Video podcasts including interviews with practicing biomedical scientists and 'in the lab' footage showing biomedical science in practice

Recenzijas

Review from previous edition The main strength is the description of the methods used in a laboratory setting. This is a unique feature and makes it stand out from other textbooks in the area. * Dr Fiona L. Henriquez, University of the West of Scotland * Using case studies really helps to integrate knowledge in an applied context. Students not only get to understand what is happening, but they begin to see why this is important, how this can affect the patient, and what it could mean to them in the diagnostic laboratory. * Glenn Hussey, Keele University * This excellent book would be particularly useful for undergraduates aiming to enter a career in biomedical science, and also a worthwhile read for trainee and practising biomedical scientists. * Immunology News *

1 Introduction to the Clinical Immunology laboratory
1(5)
Angela Hall
Chris Baldwin
Introduction
1(1)
1.1 Immunology
2(1)
1.2 Immunology in biomedical science
3(3)
Chapter summary
5(1)
Discussion questions
5(1)
2 Immunoglobulins
6(37)
Lynn Follows
Phillip A Whitfield
Introduction
6(1)
2.1 Immunoglobulins
6(6)
2.2 The monoclonal gammopathies
12(2)
2.3 Quantification of immunoglobulins
14(19)
2.4 Cerebrospinal fluid and isoelectric focusing
33(4)
2.5 Cryoglobulins
37(6)
Chapter summary
40(1)
Further reading
41(1)
Discussion questions
42(1)
3 Allergy
43(32)
Kirsty Swallow
Introduction
43(1)
3.1 Allergy terminology
43(1)
3.2 Allergens
44(1)
3.3 Allergy mechanisms
45(1)
3.4 Clinical features of allergic diseases
46(3)
3.5 Clinical diagnosis
49(4)
3.6 Allergen-specific IgE tests
53(1)
3.7 Allergen standardization
54(1)
3.8 Cross-reactivity
55(2)
3.9 Component resolved diagnostics
57(2)
3.10 Microarray-based allergy testing
59(2)
3.11 Total IgE measurements
61(1)
3.12 Quality assurance of laboratory allergy tests
62(1)
3.13 Flow cytometric basophil activation test
63(5)
3.14 Measurement of mediators released during allergic reactions
68(3)
3.15 IgG antibodies in hypersensitivity
71(4)
Chapter summary
73(1)
Further reading
73(1)
Discussion questions
74(1)
4 Complement
75(24)
Mo Moody
Tariq El-Shanawany
Paul Williams
B Paul Morgan
Stephen Jolles
Introduction
75(1)
4.1 Actions of complement
76(3)
4.2 Regulation of complement
79(1)
4.3 Complement deficiencies
80(4)
4.4 Measurement of complement activity
84(7)
4.5 C1 inhibitor deficiency
91(4)
4.6 Auto-antibodies against complement components and complexes
95(1)
4.7 Complement allotyping
96(1)
4.8 Molecular testing for complement deficiencies
96(3)
Chapter summary
97(1)
Further reading
97(1)
Discussion questions
98(1)
5 Autoimmune rheumatological disease
99(21)
Chris Scott
Introduction
99(1)
5.1 Systemic lupus erythematosus (SLE)
100(2)
5.2 Rheumatoid arthritis (RA)
102(3)
5.3 Scleroderma
105(2)
5.4 Sjogren's syndrome
107(1)
5.5 Polymyositis and dermatomyositis
107(1)
5.6 Antiphospholipid syndrome (APS)
107(2)
5.7 Overlapping connective tissue diseases
109(1)
5.8 Auto-antibodies
110(10)
Chapter summary
118(1)
Further reading
118(1)
Discussion questions
119(1)
6 Autoimmune kidney disease
120(19)
Angela Hall
Introduction
120(1)
6.1 Vasculitis and classification
121(2)
6.2 Microscopic polyangiitis (MPA)
123(1)
6.3 Granulomatosis with polyangiitis (Wegener's) (GPA)
124(1)
6.4 Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA)
124(1)
6.5 Anti-GBM disease (Goodpasture's syndrome)
125(1)
6.6 Membranous nephropathy (MN)
125(1)
6.7 Pathogenesis of renal related auto-antibodies
126(1)
6.8 Treatment and prognosis of autoimmune renal disease
127(1)
6.9 Auto-antibodies in autoimmune kidney diseases
128(11)
Chapter summary
137(1)
Further reading
138(1)
Discussion questions
138(1)
7 Organ-specific autoimmunity
139(31)
Robert J Lock
Introduction
139(2)
7.1 Autoimmune thyroid disease
141(7)
7.2 Coeliac disease
148(8)
7.3 Pernicious anaemia
156(3)
7.4 Autoimmune endocrinopathies
159(11)
Chapter summary
168(1)
Further reading
168(1)
Discussion questions
169(1)
8 Autoimmune skin disease
170(18)
Robert J Lock
Sarah Johnston
Philip Bright
Introduction
170(1)
8.1 Skin structure
171(1)
8.2 Pemphigoid diseases
172(5)
8.3 Pemphigus diseases
177(6)
8.4 Other autoimmune blistering skin disorders
183(5)
Chapter summary
186(1)
Acknowledgements
187(1)
Further reading
187(1)
Discussion questions
187(1)
9 Autoimmune liver diseases
188(22)
Edward Davies
Introduction
188(1)
9.1 Autoimmune hepatitis (AIH)
189(8)
9.2 Autoimmune sclerosing cholangitis (ASC)
197(2)
9.3 Primary biliary cirrhosis (PBC)
199(5)
9.4 Overlap syndromes
204(2)
9.5 Technical notes
206(4)
Chapter summary
208(1)
Further reading
209(1)
Discussion questions
209(1)
10 Neuroimmunology
210(42)
Abid R Karim
S Jacob
Introduction
210(3)
10.1 Terminology
213(1)
10.2 Epidemiology
213(1)
10.3 Clinical features of paraneoplastic syndromes
214(7)
10.4 Malignancies commonly associated with PNS
221(1)
10.5 Paraneoplastic neurological antibodies (PNA)
221(5)
10.6 Well-characterized paraneoplastic antibodies
226(8)
10.7 Partially characterized paraneoplastic antibodies
234(4)
10.8 Pathogenic antibodies with or without cancer
238(7)
10.9 Miscellaneous antibodies
245(7)
Chapter summary
250(1)
Further reading
250(1)
Discussion questions
251(1)
11 Flow cytometry and primary immunodeficiency
252(30)
Dawn Barge
Introduction
252(1)
11.1 Lymphocyte subsets
253(5)
11.2 T cells
258(6)
11.3 B cells
264(2)
11.4 Natural killer (NK) cells
266(1)
11.5 Additional antibodies
267(3)
11.6 Inducible antigens
270(3)
11.7 Intracellular staining
273(1)
11.8 Functional assays
273(2)
11.9 Neutrophil defects
275(7)
Chapter summary
280(1)
Further reading
281(1)
Discussion questions
281(1)
12 Human immunodeficiency virus (HIV)
282(17)
Alison Cox
Introduction
282(1)
12.1 The human immunodeficiency virus
283(1)
12.2 The life cycle of HIV
283(2)
12.3 Transmission of HIV
285(1)
12.4 Effects of HIV on the immune system
285(1)
12.5 Clinical features of HIV infection
286(1)
12.6 Progression to AIDS
287(1)
12.7 Laboratory diagnosis of HIV infection
288(4)
12.8 Treatment regimens for HIV-1 infections
292(3)
12.9 Prevention of HIV transmission and infection
295(4)
Chapter summary
298(1)
Discussion questions
298(1)
13 Histocompatibility and immunogenetics
299(22)
David Wilson
Vaughan Carter
Introduction
299(1)
13.1 The major histocompatibility complex (MHC)
300(1)
13.2 HLA system
301(2)
13.3 HLA typing
303(2)
13.4 HLA antibody testing
305(1)
13.5 Solid organ transplantation
306(7)
13.6 Post-transplant monitoring
313(1)
13.7 Haematopoietic progenitor cell transplantation
314(1)
13.8 HLA and disease
314(7)
Chapter summary
318(1)
Acknowledgements
319(1)
Discussion questions
319(2)
References 321(6)
Glossary 327(4)
Abbreviations 331(2)
Hints and tips for discussion questions 333(6)
Index 339