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E-grāmata: Clinical Trials in Ovarian Cancer

  • Formāts: PDF+DRM
  • Izdošanas datums: 16-Jan-2017
  • Izdevniecība: Rutgers University Press
  • Valoda: eng
  • ISBN-13: 9780813586496
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Clinical Trials in Ovarian CancerPalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 16-Jan-2017
  • Izdevniecība: Rutgers University Press
  • Valoda: eng
  • ISBN-13: 9780813586496
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The first book to collect and synthesize cutting-edge research findings on the treatment of gynecological malignancies into one easy-to-use reference, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions.


When a patient is diagnosed with a gynecological malignancy, she and her doctors must make urgent, high-risk decisions about her course of treatment. In selecting an appropriate plan of care, physicians must weigh the patient’s individual needs, the tumor’s specific characteristics, and the treatment’s potential side effects. Because there is no one-size-fits-all treatment solution, a plethora of clinical trials have been performed on ovarian cancer patients, but clinicians may struggle to keep up with this ever-growing body of research.   
 
Collecting and synthesizing research findings from a wide array of medical journal articles and book chapters, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions. She provides a clear overview of established treatments, as well as still-controversial experimental approaches. 
 
The first book to organize this cutting-edge research into an easy-to-use reference, Clinical Trials in Ovarian Cancer should help medical personnel at all levels provide their patients with the highest standard of care. 
 
List of Tables
ix
Preface and Acknowledgments xi
1 Early Stage Epithelial Ovarian Cancer
1(45)
GOG 7601 (Young, NEJM 1990)
1(4)
GOG 7602 (Young, NEJM 1990)
5(4)
GICOG Trials (Bolis, Ann Oncol 1995)
9(6)
GOG 95 (Young, JCO 2003)
15(4)
ICON1/ACTION Combined Analysis (Trimbos, JNCI 2003)
19(5)
ACTION (Trimbos, JNCI 2003; Trimbos, JNCI 2010)
24(8)
ICON1 (Colombo, JNCI 2003)
32(5)
GOG 157 (Bell, Gynecol Oncol 2006)
37(6)
GOG 157 Exploratory Analysis (Chan, Gynecol Oncol 2010)
43(3)
2 Advanced Stage Epithelial Ovarian Cancer: Adjuvant Chemotherapy
46(116)
GOG 47 (Omura, Cancer 1986)
46(4)
GOG 52 (Omura, JCO 1989)
50(3)
GOG 97 (McGuire, JCO 1995)
53(4)
GOG 111 (McGuire, NEJM 1996)
57(5)
GOG 104 (Alberts, NEJM 1996)
62(4)
ICON2 (Lancet 1998)
66(4)
GOG 132 (Muggia, JCO 2000)
70(5)
Danish Netherlands Trial (Neijt, JCO 2000)
75(5)
OV-10 (Piccart, JNCI 2000)
80(6)
GOG 114 (Markman, JCO 2001)
86(4)
ICON3 (Lancet 2002)
90(5)
GOG 158 (Ozols, JCO 2003)
95(5)
AGO/OVAR-3 (du Bois, JNCI 2003)
100(5)
SCOTROC---Scottish Randomised Trial in Ovarian Cancer (Vasey, JNCI 2004)
105(4)
GOG 172 (Armstrong, NEJM 2006)
109(5)
GOG 182/ICON5 (Bookman, JCO 2009)
114(5)
JGOG 3016 (Katsumata, Lancet 2009; Katsumata, Lancet Oncol 2013)
119(7)
MITO-2 (Pignata, Oncology 2009; Pignata, JCO 2011)
126(6)
AGO-OVAR9 (du Bois, JCO 2010)
132(5)
OV16 (Hoskins, JNCI 2010)
137(8)
ICON7 (Perren, NEJM 2011; Oza, Lancet Oncol 2015)
145(6)
GOG 218 (Burger, NEJM 2011)
151(6)
MITO-7 (Pignata, Lancel Oncol 2014)
157(5)
3 Advanced Stage Epithelial Ovarian Cancer: Timing of Surgery and Interval Cytoreduction
162(24)
EORTC-GCG 55865 (van der Burg, NEJM 1995)
162(6)
GOG 152 (Rose, NEJM 2004)
168(6)
EORTC 55971 (Vergote, NEJM 2010)
174(4)
CHORUS (Kehoe, Lancet 2015)
178(8)
4 Epithelial Ovarian Cancer: Maintenance Therapy
186(14)
GOG 178/SWOG 9701 (Markman, JCO 2003)
186(7)
GOG 175 (Mannel, Gynecol Oncol 2011)
193(7)
5 Recurrent Epithelial Ovarian Cancer
200(63)
Topotecan Versus Paclitaxel (ten Bokkel, JCO 1997)
200(7)
Doxil Study 30-49 (Gordon, JCO 2001; Gordon, Gyn Onc 2004)
207(10)
ICON4/AGO-OVAR 2.2 (Parmar, Lancet 2003)
217(5)
AGO-OVAR, NCIC CTG, EORTC GCG Trial (Pfisterer, JCO 2006)
222(6)
Gemcitabine Versus PLD (Mutch, JCO 2007)
228(7)
OVA-301 (Monk, JCO 2010)
235(7)
CALYPSO (Pujade-Lauraine, JCO 2010)
242(7)
OCEANS (Aghajanian, JCO 2012)
249(7)
AURELIA (Pujade-Lauraine, JCO 2014)
256(7)
Abbreviations 263(4)
References 267(28)
Index 295
CHRISTINE S. WALSH is an associate professor and attending physician at Cedars-Sinai hospital in Los Angeles, California. She is also associate professor at the Geffen School of Medicine at UCLA. She serves as director for the gynecologic oncology fellowship program. 
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