Comprises nine articles that were assembled in response to expanded understanding of the role of clusterin (apol) in research on neural systems. Some topics discussed include: regulation of clusterin expression in neural systems during normal and pathological conditions; the regulation of clusterin by steroid hormones and cytokines; the roles of clusterin in cholesterol transport and as a molecular chaperone; and the neuroprotective and neurodegenerative activities of clusterin. Annotation c. by Book News, Inc., Portland, Or.
Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury 1(17) Guang Zhu Arthur Barrie III Catherine Ebert Mark E. Rosenberg David P. Witte Judith A.K. Harmony Bruce J. Aronow Introduction 1(1) Clusterin Expression 2(3) Gene Structure and Regulation 5(6) Summary 11(6) Clusterin and Apolipoprotein E Gene Expression in the Adult Brain 17(18) Marc Danik Jean-Guy Chabot Denis Michel Remi Quirion Introduction 17(1) Clusterin Expression in the Adult Brain of Mammals 18(7) Apolipoprotein E Expression in the Adult Brain of Mammals 25(2) Concluding Remarks 27(8) Regulation of apoJ and apoE by Ovarian Steroids in the Brain 35(14) David J. Stone Irina Rozovsky Introduction 35(1) Estrogen and Apolipoproteins E and J in the Periphery 35(1) Steroids and Lipoproteins in the CNS 36(4) Estrogen, AD, and Possible Mechanisms of Estrogen-Induced Neuroprotection 40(1) Estrogen and Synaptic Sprouting: The Role of Apolopoprotein E 41(3) Possible Compensatory Role of Apolopoprotein J 44(1) Summary 44(5) Lipoprotein Receptors in Brain 49(12) G. William Rebeck Bradley T. Hyman Lipoproteins in the CNS--Source and Structure 49(1) Lipoprotein Receptors in the CNS 49(4) Functions of Lipoproteins and Their Receptors in the CNS 53(1) Relationship to Alzheimers Disease 54(7) Clusterin-apoE Lipoprotein Particles 61(10) David M. Holtzman Mary Jo LaDu Anne M. Fagan Clusterin/apoJ: An Apolipoprotein in Plasma and CSF 61(1) apoE and apoJ: Presence and Potential Roles in CNS 62(3) Potential Roles for apoE and apoJ in CNS Disease 65(1) Summary 66(5) Neurovascular Interactions of Alzheimers Amyloid β Peptide with Apolipoproteins J and E 71(18) Berislav V. Zlokovic Blas Frangione Jorge Ghiso Amyloid β 71(3) Apolipoprotein J 74(1) Apolipoprotein E 75(4) Conclusions 79(10) Apolipoprotein E and Apolipoprotein J (Clusterin) in the Brain in Alzheimers disease 89(10) Edith G. McGeer Claudia Schwab Patrick L. McGeer Introduction 89(1) Association with Lesions in Alzheimer Brains 89(4) Specificity to Alzheimers Disease 93(1) Possible Mechanisms for Changes in Clusterin and Apolipoprotein E in AD 94(5) Clusterin in Models of Central and Peripheral Injury and for Ischemia and Trauma 99(10) Hakan Aldskogius Li Liu Mikael Svensson Introduction 99(1) Peripheral Nerve Injury Produces an Increased Expression of Clusterin in CNS Neuronal Perikarya 100(1) Peripheral Nerve Injury Produces an Increased Expression of Clusterin in Perineuronal Astrocytes 100(2) Injury of Central Neural Pathways Also Produces an Increased Expression of Clusterin in Axotomized Neuronal Perikarya and Perineuronal Astrocytes 102(1) Wallerian Degeneration of Nerve Fibers in the CNS Is Accompanied by Increased Expression of Clusterin in Astrocytes and Oligodendrocytes 102(1) Neuronal and Glial Cell Structures at a Lesion Site in the CNS Express High Levels of Clusterin 103(3) Clusterin Expression Following CNS Ischaemia Appears to Be Primarily Astrocyte-Associated 106(1) Possible Functional Implications of Clusterin Expression Following Acute Insults of the Nervous System 106(3) Clusterin as a Neuroprotectant 109(12) Todd Morgan Patrick May Introduction 109(1) Clusterin Expression and Localization in the Brain 109(1) Elucidation of Clusterins Role in the Brain 110(5) Concluding Remarks 115(6) Index 121
