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E-grāmata: Comparative Pharmacokinetics: Principles, Techniques and Applications

Edited by (North Carolina State University, North Carolina, USA)
  • Formāts: EPUB+DRM
  • Izdošanas datums: 14-Jan-2011
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9780470959886
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  • Formāts: EPUB+DRM
  • Izdošanas datums: 14-Jan-2011
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9780470959886
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"Now in a newly revised edition, Comparative Pharmacokinetics presents the principles and techniques of pharmacokinetics in a detailed, yet practical and easily understandable manner. Coverage includes an overview of the basic physiologic processes of drug absorption and disposition and detailed explanation of pharmacokinetic means of measuring and predicting these processes by way of mechanistic and empirical models, as well as extensive coverage of dosage regimens and adjustments, interspecies extrapolation, experimental design, data collection and analysis, and residues and withdrawal times"--Provided by publisher.

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine. New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Recenzijas

"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation." (Doody's, 21 October 2011)  

Coauthors vii
Preface ix
1 Introduction
3(10)
2 Principles of Drug Movement in the Body
13(14)
3 Quantitative Structure-Permeability Relationships
27(12)
Xin-Rui Xia
4 Absorption
39(34)
5 Distribution
73(18)
Jennifer Buur
6 Renal Elimination
91(22)
7 Hepatic Biotransformation and Biliary Excretion
113(30)
Ronald Baynes
8 Compartmental Models
143(44)
9 Noncompartmental Models
187(20)
10 Nonlinear Models
207(18)
11 Physiological Models
225(16)
Teresa Leavens
12 Dosage Regimens
241(14)
13 Simultaneous Pharmacokinetic-Pharmacodynamic Modeling
255(40)
Pierre-Louis Toutain
14 Study Design and Data Analysis
295(20)
Jason Chittenden
15 Bioequivalence Studies
315(32)
Marilyn Martinez
16 Population Pharmacokinetic Models
347(32)
Jason Chittenden
17 Dosage Adjustments in Disease States
379(20)
Jennifer Davis
18 Interspecies Extrapolations
399(14)
19 Tissue Residues and Withdrawal Times
413(12)
Shawn Mason
Index 425
Jim Riviere, DVM, PhD, DSc (hon), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics.