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E-grāmata: Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

  • Formāts: PDF+DRM
  • Sērija : SpringerBriefs in Materials
  • Izdošanas datums: 16-Oct-2014
  • Izdevniecība: Springer International Publishing AG
  • Valoda: eng
  • ISBN-13: 9783319097558
  • Formāts - PDF+DRM
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  • Formāts: PDF+DRM
  • Sērija : SpringerBriefs in Materials
  • Izdošanas datums: 16-Oct-2014
  • Izdevniecība: Springer International Publishing AG
  • Valoda: eng
  • ISBN-13: 9783319097558

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This book addresses important biomaterials which are commonly used to fabricate scaffolds and it describes two major protocols employed in scaffold fabrication. Tissue engineering or regenerative medicine aims at restoring ex-novo tissues and organs whose functionality has been compromised as a consequence of diseases or traumatic events. The innovative concept underlying tissue engineering is the use of autologous cells, obtained from a biopsy of the patient. Cells are seeded on a porous scaffold which has the role of supporting and guiding cells towards the development of tissue-like structures as well as providing a platform for the delivery under controlled condition of growth factor release, etc. The successful manufacture of scaffolds for tissue engineering applications is crucial. In this book, these biomaterials are discussed. The book also covers illustrated examples, structure and properties of scaffolds, cellular interactions and drug delivery.

Scaffolding Biomaterials.- Scaffold Fabrication Protocols.- Fabrication of Polymer and Composite Scaffolds using Electrospinning Techniques.- Fabrication of Polymer and Composite scaffolds using Thermally Induced Phase Separation Technique.
1 Scaffolding Biomaterials
1(12)
1.1 Introduction
1(1)
1.2 Biomaterials
2(11)
1.2.1 Biopolymers
2(1)
1.2.2 Bioceramics
2(2)
1.2.3 Polycaprolactone (PCL)
4(1)
1.2.4 Poly(ortho esters) and Poly(anhydrides)
5(1)
1.2.5 Poly(glycolic acid), Poly(lactic acid) and Their Copolymers
5(1)
1.2.6 Chitosan
6(1)
1.2.7 Gelatin
6(1)
1.2.8 Biodegradable Metals
7(1)
1.2.9 Biodegradable Polymer Blends
8(1)
1.2.10 Composites
8(1)
References
9(4)
2 Scaffold Fabrication Protocols
13(12)
2.1 Techniques of Producing Scaffolds
13(4)
2.1.1 Electrospinning
14(1)
2.1.2 Solvent Casting and Particulate Leaching
14(1)
2.1.3 Polymer Phase Separation
14(1)
2.1.4 Rapid Prototyping
15(1)
2.1.5 Melt Molding
15(1)
2.1.6 Gas Foaming
16(1)
2.2 Electrospinning Protocol
17(3)
2.2.1 Electrospinning Process and Principle
18(1)
2.2.2 Nozzle Configuration
19(1)
2.2.3 Solution Versus Melt Electrospinning
20(1)
2.3 Parameters in Electrospinning
20(3)
2.3.1 Processing Parameters
21(1)
2.3.2 Solution Parameters
22(1)
2.4 In Vitro Degradation of Scaffolds
23(2)
References
23(2)
3 Fabrication of Polymer and Composite Scaffolds Using Electrospinning Techniques
25(20)
3.1 Fabrication of Poly(Caprolactone) Nano-fibrous Scaffolds Using Electrospinning Technique
25(9)
3.1.1 Conclusions
33(1)
3.2 Fabrication of Electrospun Hydroxyapatite/Polycaprolactone Scaffolds
34(11)
3.2.1 Conclusions
40(1)
References
41(4)
4 Fabrication and Characterization of Polymer and Composite Scaffolds Using Freeze-Drying Technique
45(16)
4.1 Hydroxyapatite/Chitosan Scaffolds Using Freeze-Drying Technique
45(10)
4.2 HA/PCL Composite Scaffolds Using Freeze-Drying Technique
55(3)
4.3 Conclusions
58(3)
References
59(2)
Summary 61