Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set follows the longstanding tradition started with the first edition in 1997 and represents an essential one-stop reference for researchers in toxicology. The focus of the work is on understanding mechanisms by which chemicals effect biological systems and induce adverse health effects. Edited by a world-class editorial board, with 400 outstanding in-depth contributions from renowned experts, this fourth edition spans across fifteen volumes and nearly 9,000 pages. The work is organized to cover all the major organ systems as well as general principles of toxicology, cellular and molecular aspects, biotransformation of chemicals, testing and evaluation of toxicity. Comprehensive Toxicology, Fourth Edition edition has been completely revised and updated to reflect the latest research advances. Around 30 new chapters have been added to cover new approaches in testing strategies, novel in vitro models such as organ on a chip, microphysiological system to name a few; computational approaches, new approaches to risk and safety assessment, harmonization, artificial intelligence and the microbiome amongst others. Comprehensive Toxicology, Fourth Edition is the most extensive and authoritative resource in this area which will continue to support not only researchers, but also faculty and students in Toxicology as well as professionals across the medical, veterinary, food, environmental, chemical and pharmaceutical industries and international regulatory agencies.
Comprehensive Toxicology will comprise of around 400 chapters, organized across the 14 sections listed below:
1. General Principles
2. Hepatic Toxicology
3. Reproductive and Endocrine Toxicology
4. Developmental Toxicology
5. Nervous System and Behavioral Toxicology
6. Carcinogenesis
7. Cellular and Molecular Toxicology
8. Toxicology Testing and Evaluation
9. Biotransformation
10. Immune System Toxicology
11. Hematopoietic Systems Toxicology
12. Cardiovascular Toxicology
13. Gastrointestinal and Renal Toxicology
14. Respiratory Toxicology
Charlene A. McQueen is a Professor in the Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona. Until January 2017, she was a Senior Scientist at the National Health Effects Research Laboratory of the USEPA. She served as the Director of the Integrated Systems Toxicology Division (2011-2016). Prior to that, she held positions at the Harrison School of Pharmacy, Auburn University (2007-2011) and the Department of Pharmacology and Toxicology at the University of Arizona (1990-2007). Dr McQueen received a M.S. in Pharmacology from New York University and Ph.D. in Human Genetics from the University of Michigan. Her work is in the areas of pharmacogenomics, toxicogenomics and chemical carcinogenesis. She has a particular interest in the genetic basis for response to xenobiotics. Her work with the arylamine N-acetyltransferase polymorphism has demonstrated that this genetic variation can affect drug efficacy as well as toxicity of aromatic amines and hydrazines. She was the Editor-in-Chief of the second edition of Comprehensive Toxicology and is continuing in that position for the third edition to be published in 2017. Dr McQueen is an American Association for the Advancement of Science (AAAS) Fellow and a Fellow in the Academy of Toxicological Sciences (ATS). Dr McQueen received the Society of Toxicology (SOT) Public Communications Award, the SOT AstraZeneca Traveling Lectureship Award and has served on numerous SOT committees. Dr McQueen was on the Environmental Health Sciences Committee of the National Institute of Environmental Health Sciences, the Board of Scientific Councilors of the National Toxicology Program and the National Institutes of Health Cancer Etiology Study Section. She is a member of the Editorial Board of the Reference Modules in Biomedical Sciences (Elsevier). Dr McQueen is a member of the Health and Environmental Sciences Institute (HESI) Board of Trustees, serving as the Board Secretary (2012-2017) and is currently Vice-president elect (2017-2018). Her current research interests include the discovery and development of Adverse Outcome Pathways (AOPs) for fatty liver disease and carcinogenesis as well as the role of the microbiome in xenobiotic biotransformation.
