The noninvasive cytogenetic method of cancer diagnosis, according to the authors (whose credentials are not given), employs "mathematical/statistical techniques of pattern recognition and state of the art results in oncomorphology and cytometry to identify malignancy-associated DNA changes in patient's buccal epithelium, which occur in the presence of breast cancer and cancer of the thyroid gland." After reviewing the problem associated with conventional methods of noninvasive diagnosis for early diagnosis, they turn to problems associated with cytogenetic diagnosis of malignant neoplasms, particularly the malignancy-associated DNA changes that occur in the nuclei of cells of buccal epithelium, and present the materials and methodology of cytogenetic diagnosis. They then introduce the mathematical and statistical basis for the algorithm used in their methodology. Finally, they present results justifying the validity of the method and provide quantitative estimates of malignancy-associated DNA changes for fibroadenomatosis and breast cancer, adenocarcinoma of the thyroid gland, nodular goiter, and autoimmune thyroiditis. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)
