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E-grāmata: Containment in the Pharmaceutical Industry

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Thirteen chapters explore the main elements and applications of containment as it is currently practiced by members of the pharmaceutical industry. The book first presents a brief historical perspective on containment in the industry, a workable definition of the term, and containment's relationship to other industries. Along with definitions, one chapter focuses on recent research of what makes powders dusty in the first place and how that is being defined, quantified, and used in containment design. The contributors also discuss approaches for both new and retrofitted installations, and people protection versus product protection along with source containment's potential role in each. Topics include engineered local exhaust, flexible containment for primary manufacturing/bulk operations, the production line of a dry products secondary manufacturing operation, and containment in the hospital setting. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Delivering an encompassing overview of the factors, varieties, and applications determining product containment, this concise reference provides authoritative information on containment processes. It reviews the historical context, definition, evolution, and application of containment technology, analyzes a variety of containment techniques in new and retrofitted construction, and examines "people protection" vs. "product protection" and the role of source-contamination in each. It also suggests conceptualizing containment options from the inception of a project for economical, at-the-source containment, identifies containment requirements and monitoring methods, as well as the current state of emission controls, and discusses the "dustiness" of powders and how this research is being defined, quantified, and used in containment design.

Containment in the Pharmaceutical Industry provides authoritative, multidisciplinary information on containment processes. It reviews the historical context, definition, evolution, and application of containment technology, analyzes a variety of containment techniques in new and retrofitted construction, and examines "people protection" vs. "product protection" and the role of source-contamination in each. It also suggests conceptualizing containment options from the inception of a project, identifies containment requirements, monitoring methods, and current emission controls, and discusses the "dustiness" of powders and how this research is being used in containment design.
Preface iii Contributors ix Why Contain? Then and Now 1(8) James P. Wood Containment and Good Manufacturing Practices 9(10) Melvin J. Crichton Industrial Hygiene Aspects of Pharmaceutical Manufacturing 19(10) Donna S. Heidel Effect of Individual Particle Characteristics on Airborne Emissions 29(26) Chetan P. Pujara Dane O. Kildsig Particle Monitoring: Old and New 55(32) Brian G. Ward Particle Monitoring: Case Studies 87(28) Brian G. Ward Selecting the Correct Technology 115(14) Hank Rahe Engineered Local Exhaust 129(36) Edwin A. Kleissler Flexible Containment for Primary Manufacturing/Bulk Operations 165(20) Steven M. Lloyd Ronald W. Wizimirski An Array of Containment Designs: Following the Production Line in a Dry Products Secondary Manufacturing Operation 185(26) James P. Wood Containment System Selection 211(12) David Palister An Architectural/Engineering Firms Perspective 223(18) Walter W. Czander Containment in the Hospital Setting 241(6) M. Michele Moore Index 247
JAMES P. WOOD is an Associate Engineering Consultant with the Containment Engineering Technology Group of Eli Lilly and Company, Indianapolis, Indiana. An advisor to many international organizations, Mr. Wood is the author or coauthor of numerous articles, patents, and presentations related to containment issues, and a member of the National Society of Professional Engineers. He received the B.S. degree (1979) from Purdue University, West Lafayette, Indiana.