Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.
- Summarizes contemporary data in the workup and treatment of patients with metastatic colorectal cancer
- Discusses novel patient-centric personalized approaches surrounding the management of such cancer types
- Presents evidenced-based recommendations for precision care among patients with metastatic colorectal cancer
1. Epidemiology and Risk Factors for Metastatic Colorectal Disease
2. Molecular Pathogenesis, Tumor Microenvironment and Future Therapeutic
Targets: Colorectal Liver Metastasis 3. Pre-operative Imaging, Response
Evaluation, and Surgical Planning CT, PET, Radiomics, FLR Measurement
4. Use of Molecular Markers and Other Personalized factors in Treatment
Decisions (KRAS, sidedness etc.) 5. Role of Neoadjuvant Therapy in Treatment
of Patients with Colorectal Liver Metastasis 6. Management of the Disappeared
Colorectal Liver Metastasis 7. Approach to Small Liver Remnant Strategies
to Increase Resectability 8. Two-Stage versus ALPPS for Large Intrahepatic
Burden of Colorectal Liver Metastasis 9. Synchronous Colorectal Liver
Metastasis Simultaneous vs. Staged Approach 10. Minimally Invasive
Approaches to Metastatic Colorectal Cancer 11. Hepatic Resection of
Colorectal Liver Metastasis in the Presence of Extrahepatic Disease
12. Locoregional Approaches to Colorectal Liver Metastasis Ablation
13. Locoregional Approaches to Colorectal Liver Metastasis - Intra-arterial
14. Locoregional Approaches to Colorectal Liver Metastasis - Radiation
Options 15. Adjuvant Therapy following Resection of Colorectal Liver
Metastasis 16. Long-term Prognosis and Surveillance of Patients with Resected
Colorectal Liver Metastasis17. Management of Secondary Recurrence of
Intra-hepatic Colorectal Liver Metastasis following Initial Hepatic Resection
18. Immunotherapy and Targeted Therapies for Colorectal Liver Metastasis
19. Colorectal Liver Metastasis: Survivorship
Aslam Ejaz MD, MPH is a surgical oncologist who specializes in the treatment of pancreatic cancer, liver cancer, bile duct cancer and other gastrointestinal cancers. In addition to his clinical work, he is dedicated to teaching the future generation of surgeons and other cancer care providers as an assistant professor in the Division of Surgical Oncology at The Ohio State University. As a member of the Translational Therapeutics Program at the OSUCCC James, one of his research interests is in the development of clinical trials to help patients receive new therapies that may not be available at other treatment centers. He is also interested in researching how patients do after surgery as well as addressing variations in perioperative surgical care and quality improvement. Dr. Ejazs research is dedicated to improving cancer care, and he has published over 100 peer-reviewed papers in high-impact cancer and surgical journals. Dr. Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, FACS, FSSO is the Chair of Surgery at The Ohio State University Wexner Medical Center where he holds The Urban Meyer III and Shelley Meyer Chair for Cancer Research. His research focuses on determinations of factors associated with prognosis and staging of gastrointestinal cancers with a particular focus on cholangiocarcinoma. He also studies patient/physician communication and patient engagement, as well as patient perception of cancer-care goals and the impact of social determinants of health. Dr. Pawlik is an active participant in multiple national and international surgical societies and has delivered talks on cholangiocarcinoma around the world.
