"The first of its kind, this comprehensive book, Corneal Collagen Cross-Linking, brings together cross-linking theory, treatment, outcomes, complications and their management. Corneal Collagen Cross-Linking provides a concise yet comprehensive summary ofthe cross-linking (CXL) process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modifications of the standard protocol for special circumstances. Inside the pages of Corneal Collagen Cross-Linking, Dr. Farhad Hafezi and Dr. J. Bradley Randleman include the latest available information on CXL and additional clinical applications, including CXL for infectious keratitis and corneal edema, CXL combined with other treatments for improved refractive outcomes in patients with keratoconus and ectasia after LASIK, and CXL in the pediatric population. Corneal Collagen Cross-Linking is a perfect resource for a wide range of clinicians and researchers, including general ophthalmologists, refractive surgeons, corneal specialists, pediatric ophthalmologists, and optometrists"--Provided by publisher.
The first of its kind, this comprehensive book, Corneal Collagen Cross-Linking, brings together cross-linking theory, treatment, outcomes, complications and their management.
Corneal Collagen Cross-Linking provides a concise yet comprehensive summary of the cross-linking (CXL) process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modifications of the standard protocol for special circumstances.
Inside the pages of Corneal Collagen Cross-Linking, Dr. Farhad Hafezi and Dr. J. Bradley Randleman include the latest available information on CXL and additional clinical applications, including CXL for infectious keratitis and corneal edema, CXL combined with other treatments for improved refractive outcomes in patients with keratoconus and ectasia after LASIK, and CXL in the pediatric population.
Corneal Collagen Cross-Linking is a perfect resource for a wide range of clinicians and researchers, including general ophthalmologists, refractive surgeons, corneal specialists, pediatric ophthalmologists, and optometrists.
Recenzijas
This book is a tour de force, an extremely valuable resource for anyone interested in and performing cornea cross-linking. It is a must-read for cornea specialists and a one-stop source of everything and anything related to cornea cross-linking. -Charles C Lin, MD, Doodys Book Review Service
Dedication |
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About the Editors |
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About the Associate Editor |
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xii | |
Contributing Authors |
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xiii | |
Foreword |
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xix | |
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Introduction |
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xxi | |
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Section I Basic Principles of Corneal Biomechanics and Corneal Cross-Linking |
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1 | (70) |
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Chapter 1 History of Corneal Cross-Linking |
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3 | (6) |
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Chapter 2 Introduction to Corneal Biomechanics |
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9 | (10) |
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Chapter 3 Fundamental Principles of Corneal Cross-Linking |
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19 | (8) |
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Chapter 4 Riboflavin, Ultraviolet Light, and the Photochemical Reaction |
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27 | (6) |
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Chapter 5 The Role of Oxygen in Corneal Cross-Linking |
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33 | (6) |
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Chapter 6 Cross-Linking Initiated by Other Chromophores and by Multiphoton Excitation |
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39 | (4) |
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Chapter 7 Corneal Cross-Linking Safety Considerations |
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43 | (2) |
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Christina Giannikas Starcic |
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Chapter 8 Molecular Aspects of Corneal Cross-Linking |
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45 | (4) |
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Chapter 9 Evaluation and Diagnosis of Keratoconus and Pellucid Marginal Degeneration |
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49 | (12) |
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Chapter 10 Evaluation and Diagnosis of Postoperative Corneal Ectasia |
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61 | (10) |
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Section II Corneal Cross-Linking for Corneal Ectasias |
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71 | (20) |
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Chapter 11 Corneal Cross-Linking for Progressive Keratoconus |
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73 | (8) |
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Chapter 12 Corneal Cross-Linking for Postoperative Corneal Ectasia |
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81 | (6) |
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Chapter 13 Corneal Cross-Linking for Pellucid Marginal Degeneration |
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87 | (4) |
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Section III Corneal Cross-Linking Protocols and Complication Management |
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91 | (50) |
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Chapter 14 The Standard Protocol and Its Parameters |
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93 | (6) |
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Chapter 15 Corneal Cross-Linking Using Accelerated Protocols |
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99 | (4) |
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Konstantinos I. Tsoulnaras |
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Chapter 16 Epithelium-On Protocols: Conceptual/Basic Science |
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103 | (8) |
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Chapter 17 Transepithelial Corneal Cross-Linking in Progressive Keratoconus |
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111 | (4) |
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Chapter 18 Corneal Cross-Linking With Iontophoresis |
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115 | (6) |
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Chapter 19 Cross-Linking Protocols in Thin Corneas |
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121 | (6) |
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Chapter 20 Pediatric Corneal Cross-Linking |
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127 | (6) |
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Chapter 21 Corneal Cross-Linking Complications and Management |
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133 | (8) |
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Section IV Corneal Cross-Linking Imaging and Diagnostic Evaluations |
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141 | (38) |
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Chapter 22 Measuring the Efficacy of Corneal Cross-Linking Using Advanced Corneal Biomechanical Diagnostic Modalities |
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143 | (8) |
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Chapter 23 Measuring the Efficacy of Cross-Linking: Clinical Metrics |
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151 | (6) |
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Chapter 24 Measuring Corneal Cross-Linking Efficacy: Biomechanical Measurement Approach |
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157 | (6) |
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Chapter 25 Confocal Microscopy in Corneal Cross-Linking |
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163 | (6) |
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Chapter 26 Optical Coherence Tomography Use in Corneal Cross-Linking |
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169 | (4) |
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Chapter 27 Epithelial Remodeling After Corneal Cross-Linking |
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173 | (6) |
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Section V Cross-Linking Plus: Combination Procedures |
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179 | (32) |
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Chapter 28 Corneal Cross-Linking in Combination With Transepithelial Phototherapeutic Keratectomy: Cretan Protocol |
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181 | (4) |
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Chapter 29 Corneal Cross-Linking in Combination With Surface Ablation: Athens Protocol |
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185 | (6) |
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Anastasios John Kanellopoulos |
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Chapter 30 Corneal Cross-Linking in Combination With Intracorneal Ring Segment |
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191 | (6) |
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Chapter 31 Corneal Cross-Linking in Combination With Phakic Intraocular Lenses |
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197 | (6) |
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Chapter 32 Corneal Cross-Linking: Combined Treatment Options |
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203 | (4) |
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Chapter 33 Corneal Cross-Linking as a Primary Refractive Procedure |
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207 | (4) |
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Section VI Cross-Linking for Infectious Keratitis: PACK-CXL |
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211 | (12) |
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213 | (6) |
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Chapter 35 PACK-CXL for Viral Keratitis and Acanthamoeba Keratitis |
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219 | (4) |
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Section VII Other Uses for Cross-Linking |
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223 | (10) |
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Chapter 36 Corneal Cross-Linking for Corneal Stromal Edema |
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225 | (4) |
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Chapter 37 Sclera Cross-Linking |
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229 | (4) |
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Section VIII Current Controversies and Perspectives |
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233 | (30) |
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Chapter 38 Epithelium-On Treatments In Favor |
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235 | (8) |
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238 | (5) |
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Chapter 39 Corneal Cross-Linking Can Impact Limbal Stem Cells In Favor |
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243 | (6) |
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246 | (3) |
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Chapter 40 Performing Corneal Cross-Linking After Definitive Signs of Ectasia Progression Are Detected |
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249 | (4) |
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Rosane de Oliveira Correa |
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Rozalia Litewski Beildeck |
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Chapter 41 Prophylactic Cross-Linking Combined With LASIK In Favor |
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253 | (4) |
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Anastasios John Kanellopoulos |
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255 | (2) |
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Chapter 42 Summary of Commercially Available Corneal Cross-Linking Units |
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257 | (6) |
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Financial Disclosures |
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263 | (4) |
Index |
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Farhad Hafezi, MD, PhD, was born in 1967 and grew up in Fribourg, Switzerland. He studied medicine in Fribourg and Berne.Farhad Hafezi fluently speaks German (mother tongue), English, French, Polish, and Farsi. He is married to Nikki Hafezi and has three daughters, Leilah Alina (2008), Lilian Malaya (2010), and Lola Alexandra (2016). Professor Hafezis clinical focus are the cornea and complication management after complicated refractive laser surgery. Being part of the team around Theo Seiler that translated cross-linking from experimental research into the clinical application, he was instrumental in implementing corneal cross-linking technology in ophthalmology. From 2010 to 2014, Farhad Hafezi was Professor and Chairman of the Department of Ophthalmology of the Geneva University Hospitals, Geneva, Switzerland. Currently, Dr. Hafezi holds the following positions: Professor at the Faculty of Medicine, University of Geneva, Switzerland; Clinical Professor of Ophthalmology, Department of Ophthalmology USC Los Angeles, USA; Medical Director, The ELZA Institute, Zürich, Switzerland; Research Group Leader, Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zürich, Switzerland; and Visiting Professor, Faculty of Medicine, University of Wenzhou, China. As of March 2017, Professor Hafezi has published more than 160 scientific articles, his scientific work has been cited more than 5700 times, his total impact factor is 510, and his h-index is 39. He is an Associate Editor for the Journal of Refractive Surgery and is on the Editorial Boards of TVST, the International Journal of Keratoconus and Ectatic Corneal Disease, Eye and Vision and the Iranian Journal of Ophthalmology. Professor Hafezi is also a member of the Advisory Board of Global ONE, the educational network of the American Academy of Ophthalmology (AAO). Professor Hafezi has received 22 national and international awards and distinctions, both for his scientific work and for the development of new technologies (innovation awards). Awards include, among others, the ARVO Foundation/Carl Camras Translational Research Award (USA) 2014, as well as the highest distinctions in ophthalmology from Switzerland and Belgium. In 2014, Professor Hafezi was voted by peers onto the PowerList, a list of the 100 most influential international personalities in ophthalmology. In April 2016, he was again voted onto the PowerList. For more information, please visit: https://en.wikipedia.org/wiki/Farhad_Hafezi or http://www.elza-institute.com
J. Bradley Randleman, MD, is Professor of Ophthalmology at the Keck School of Medicine of USC and Director of the Cornea & Refractive Surgery Service at the USC Roski Eye Institute in Los Angeles, California. A widely respected cornea specialist, his areas of expertise include: corneal and intraocular refractive surgical procedures including LASIK and premium laser-assisted cataract and IOL surgery, complicated cataract surgery, and the management of corneal ectatic disorders. His primary research focuses on identification and management of corneal ectatic diseases including keratoconus and postoperative ectasia after LASIK, and the avoidance, diagnosis, and management of refractive surgical complications. Dr. Randleman received his BA degree from Columbia College at Columbia University in New York City, his M.D. degree from Texas Tech University School of Medicine in Lubbock, Texas, where he was elected to the Alpha Omega Alpha medical honor society in his junior year, followed by his Ophthalmology residency at Emory University in Atlanta, Georgia. Dr. Randleman joined the Emory faculty and served as Assistant Residency Director for two years while also completing a fellowship in Cornea/External Disease, and Refractive Surgery at Emory University. He served as Director of the Emory Corneal Fellowship program until taking over as Director of the Cornea Service. Dr. Randleman has been awarded the Claus Dohlman Fellow Award, the inaugural Binkhorst Young Ophthalmologist Award from the American Society of Cataract and Refractive Surgery, the Kritzinger Memorial Award, the Inaugural ISRS Recognition Award, the Secretariat Award, Achievement Award, and Senior Achievement Award from the American Academy of Ophthalmology. Dr. Randleman has served as Editor-in-Chief for the Journal of Refractive Surgery since 2011. He has authored more than 120 peer-reviewed publications in leading ophthalmology journals in addition to 30 book chapters on refractive surgery evaluation, corneal cross-linking, and management of complications with IOLs, and has authored two additional textbooks, Refractive Surgery: An Interactive Case-Based Approach (2014), and Intraocular Lens Surgery: Selection, Complications, and Complex Cases.