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E-grāmata: Current Developments in Biotechnology and Bioengineering: Production, Isolation and Purification of Industrial Products

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Edited by (Research Group Leader, Department of Bioprocess Engineering and Biotechnol), Edited by (Motilal Nehru National Institute of Tech., Trivandrum, India), Edited by (Executive Director, Centre for Energy and Environmental Sustainability-India, Lucknow, India)
  • Formāts: EPUB+DRM
  • Izdošanas datums: 17-Sep-2016
  • Izdevniecība: Elsevier Science Ltd
  • Valoda: eng
  • ISBN-13: 9780444636737
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Current Developments in Biotechnology and Bioengineering: Production, Isolation and Purification of Industrial ProductsPalielināt
  • Formāts: EPUB+DRM
  • Izdošanas datums: 17-Sep-2016
  • Izdevniecība: Elsevier Science Ltd
  • Valoda: eng
  • ISBN-13: 9780444636737
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The past decade has witnessed unprecedented growth and development in biotechnology and bioengineering, positioning bio-economy as a major indicator of advancement. Providing extensive coverage of new developments, state-of-the-art technologies and potential future trends, Current Developments in Biotechnology and Bioengineering is a package of nine books that compile the latest ideas from across the entire arena of biotechnology and bioengineering.

This volume, Production, Isolation and Purification of Industrial Products, focuses on industrial biotechnology and bioengineering for the production of industrial products such as enzymes, organic acids, biopolymers and biosurfactants, and the processes for isolating and purifying them from a production medium. During the last few years, the tools of molecular biology, genetic and metabolic engineering have rendered tremendous improvements in the production of industrial products by fermentation. Structured by industrial product classifications, this book provides an overview of the current practise, status and future potential for the production of these agents, as well as reviewing the industrial scenario relating to their production.

  • Provides information on industrial bioprocesses for the production of microbial products by fermentation
  • Includes separation and purification processes of fermentation products
  • Includes economic and feasibility assessments of the various processes and their scaling up
  • Links biotechnology and bioengineering for industrial process development

Papildus informācija

Single compendium detailing information on recent developments in industrial bioprocesses for the production of highly significant microbial products
List of Contributors
xxi
About the Editors xxvii
Preface xxxi
Part 1 Industrial and Therapeutic Enzymes
1(540)
1 α-Amylases
3(22)
R. Sindhu
P. Binod
A. Pandey
1.1 Introduction
3(2)
1.2 Sources of α-Amylase
5(1)
1.3 Production of α-Amylase
6(5)
1.4 Assay of α-Amylases
11(1)
1.5 α-Amylase Inhibitors
11(1)
1.6 Strain Improvement
11(4)
1.7 Purification and Characterization of α-Amylases
15(2)
1.8 Applications of α-Amylase
17(2)
1.9 Conclusion and Perspectives
19(6)
References
19(6)
2 Amylolytic Enzymes: Glucoamylases
25(22)
S. Negi
K. Vibha
2.1 Introduction
25(1)
2.2 Sources of Glucoamylase
26(2)
2.3 Glucoamylase Production
28(3)
2.4 Purification and Characterization
31(5)
2.5 Enzyme Assay
36(1)
2.6 Strain Improvement
37(1)
2.7 Commercially Available Glucoamylases
38(2)
2.8 Conclusion and Perspective
40(7)
References
41(6)
3 Pectinolytic Enzymes
47(26)
Hector A. Ruiz
Rosa M. Rodriguez-Jasso
Ayerim Hernandez-Almanza
Juan C. Contreras-Esquivel
Cristobal N. Aguilar
3.1 Introduction
47(1)
3.2 Pectic Substances
48(1)
3.3 Pectinase Classification
48(1)
3.4 Pectinase Assays
49(2)
3.5 Pectinase Production Processes
51(7)
3.6 Downstream and Purification Methods
58(3)
3.7 Technoeconomic Analysis of Pectinase Production
61(2)
3.8 Conclusions and Perspectives
63(10)
References
64(9)
4 Cellulases
73(30)
Reeta R. Singhania
M. Adsul
A. Pandey
A.K. Patel
4.1 Introduction
73(1)
4.2 Sources
74(2)
4.3 The Cellulase System
76(3)
4.4 Regulation of Cellulase Expression
79(1)
4.5 Research on Bioprocesses for Improved Cellulase Production
80(5)
4.6 Strain Improvement
85(4)
4.7 Cellulase Global Market
89(2)
4.8 Protocol for Assay of Filter Paper Activity
91(2)
4.9 Challenges for Enzymatic Biomass Conversion
93(1)
4.10 Future Perspectives
94(2)
4.11 Conclusion
96(7)
References
97(6)
5 Industrial Enzymes:β-Glucosidases
103(24)
Reeta R. Singhania
A.K. Patel
R. Saini
A. Pandey
5.1 Introduction
103(1)
5.2 Classification of β-Glucosidases
104(1)
5.3 Mechanism of Action
105(2)
5.4 Sources of β-Glucosidases
107(1)
5.5 Production of β-Glucosidases
107(4)
5.6 Assay of β-Glucosidases
111(1)
5.7 Strain Improvement
112(4)
5.8 Applications of β-Glucosidases
116(3)
5.9 Conclusions and Perspectives
119(8)
References
120(7)
6 Industrial Enzymes: Xylanases
127(22)
L. Thomas
A. Joseph
Reeta R. Singhania
A.K. Patel
A. Pandey
6.1 Introduction
127(1)
6.2 Sources of Xylanases
128(1)
6.3 Production of Xylanases
129(3)
6.4 Purification and Characterization of Xylanases
132(2)
6.5 Xylanase Assays
134(5)
6.6 Strain Improvement
139(1)
6.7 Conclusions and Perspectives
140(9)
References
141(8)
7 Proteolytic Enzymes
149(26)
A. Dhillon
K. Sharma
V. Rajulapati
A. Goyal
7.1 Introduction
149(1)
7.2 Sources of Proteolytic Enzymes
150(2)
7.3 Production of Proteolytic Enzymes
152(3)
7.4 Industrial Production Scenario
155(1)
7.5 Purification and Characterization of Proteolytic Enzymes
156(2)
7.6 Assay of Proteolytic Enzymes
158(1)
7.7 Properties of Proteolytic Enzymes
159(1)
7.8 Strain Improvement
160(4)
7.9 Conclusions and Perspectives
164(11)
References
165(10)
8 Lipolytic Enzymes
175(24)
R. Gaur
R. Hemamalini
S.K. Khare
8.1 Introduction
175(2)
8.2 Microbial Sources of Enzymes
177(2)
8.3 Production of Enzyme
179(4)
8.4 Purification and Characterization of Lipases
183(5)
8.5 Studies on Pseudomonas aeruginosa Lipase Genes
188(1)
8.6 Assay of Enzyme Lipolytic Activity
189(1)
8.7 Conclusions and Perspectives
190(9)
References
190(9)
9 Laccases
199(18)
L.R.C. Guimaraes
A.L. Woiciechowski
S.G. Karp
J.D. Coral
A. Zandona Filho
C.R. Soccol
9.1 Introduction
199(1)
9.2 Possible Substrates for Laccases
199(4)
9.3 Laccase Action Mechanism
203(2)
9.4 The Ideal Physicochemical Conditions for Laccases
205(1)
9.5 Sources of Laccases
206(1)
9.6 Laccase Applications
207(3)
9.7 Future Trends in Uses and Applications
210(1)
9.8 Conclusions and Perspectives
211(6)
References
211(6)
10 Peroxidases
217(16)
J.D.C. Medina
A.L. Woiciechowski
L.R.C. Guimaraes
S.G. Karp
C.R. Soccol
10.1 Introduction
217(1)
10.2 Lignin Structure
218(1)
10.3 Peroxidases
219(1)
10.4 Lignin Peroxidase
220(1)
10.5 Sources of Peroxidases
221(3)
10.6 Enzymes as Biocatalysts
224(1)
10.7 Peroxidase Applications
225(3)
10.8 Trends and Future of Peroxidases
228(1)
10.9 Conclusions and Perspectives
228(5)
References
229(4)
11 Therapeutic Enzymes: L-Glutaminase
233(16)
N. Vijayan
T.S. Swapna
M. Haridas
A. Sabu
11.1 Introduction
233(1)
11.2 Isozymes of Glutaminase
233(1)
11.3 Glutaminase as a Therapeutic Agent
234(1)
11.4 Glutaminase in the Food Industry
234(1)
11.5 Sources of L-Glutaminases
235(2)
11.6 Production of L-Glutaminase
237(4)
11.7 Enzyme Characteristics
241(2)
11.8 Glutaminase Assay
243(1)
11.9 Strain Improvement
243(1)
11.10 Conclusion and Perspectives
244(5)
References
244(5)
12 Therapeutic Enzymes: L-Asparaginases
249(18)
J. Vidya
S. Sajitha
M. V. Ushasree
P. Binod
A. Pandey
12.1 Introduction
249(1)
12.2 Sources of Asparaginases
250(1)
12.3 Production of L-Asparaginase
251(3)
12.4 Purification and Characterization of L-Asparaginases
254(1)
12.5 Assays for L-Asparaginase
255(1)
12.6 Strain Improvement
256(3)
12.7 Commercially Available L-Asparaginases
259(1)
12.8 Carriers of Asparaginase for Better Delivery Methods
259(1)
12.9 Conclusions and Future Perspectives
260(7)
References
260(7)
13 Industrial and Therapeutic Enzymes: Penicillin Acylase
267(42)
A. Illanes
P. Valencia
13.1 Introduction: Industrial Applications of Penicillin Acylase
267(4)
13.2 Sources of Penicillin Acylase
271(3)
13.3 Improvement of Penicillin Acylase-Producing Strains
274(3)
13.4 Improvement of Penicillin Acylase Catalysts for Industrial Use
277(1)
13.5 Production of Penicillin Acylase
278(2)
13.6 Purification of Penicillin Acylase
280(6)
13.7 Characterization of Penicillin Acylase
286(2)
13.8 Assays for Penicillin Acylase Activity
288(3)
13.9 Conclusions and Perspectives
291(18)
References
291(16)
Other Enzymes
307(2)
14 Other Enzymes: Phytases
309(26)
M. V. Ushasree
J. Vidya
A. Pandey
14.1 Introduction
309(1)
14.2 Phytase Sources
310(4)
14.3 Phytase Market and Production
314(4)
14.4 Purification and Characterization
318(2)
14.5 Phytase Assay
320(1)
14.6 Strain Improvement
321(2)
14.7 Summary and Conclusions
323(12)
References
324(11)
15 Chitinases
335(34)
N. Karthik
P. Binod
A. Pandey
15.1 Introduction
335(2)
15.2 Sources of Chitinases
337(2)
15.3 Production of Microbial Chitinases
339(6)
15.4 Assay of Chitinases
345(3)
15.5 Strain Improvement
348(2)
15.6 Purification and Characterization of Chitinases
350(5)
15.7 Biocontrol Properties of Chitinases
355(2)
15.8 Conclusions and Perspectives
357(12)
Acknowledgments
358(1)
References
358(11)
16 α-Galactosidases
369(26)
G.S. Anisha
16.1 Introduction
369(1)
16.2 Substrates for α-Galactosidases
370(3)
16.3 Sources of α-Galactosidases
373(1)
16.4 Production of α-Galactosidases
374(2)
16.5 Industrial Production Scenario
376(2)
16.6 Purification and Characterization of α-Galactosidases
378(8)
16.7 Strain Improvement
386(1)
16.8 Conclusion and Perspectives
387(8)
References
387(8)
17 β-Galactosidases
395(28)
G.S. Anisha
17.1 Introduction
395(1)
17.2 Assay of β-Galactosidase Activity
396(1)
17.3 Sources of β-Galactosidase
396(2)
17.4 Production of β-Galactosidase
398(3)
17.5 Extraction of β-Galactosidase
401(1)
17.6 Purification and Characterization
402(5)
17.7 Strain Improvement
407(5)
17.8 Industrial Scenario
412(2)
17.9 Conclusion and Perspectives
414(9)
References
415(8)
18 Inulinases
423(24)
R.S. Singh
R.P. Singh
18.1 Introduction
423(1)
18.2 Inulinase Production
424(5)
18.3 Purification and Characterization of Inulinases
429(4)
18.4 Inulinase Assay
433(1)
18.5 Strain Improvement
433(1)
18.6 Applications of Inulinases
434(2)
18.7 Conclusions and Perspectives
436(11)
References
437(10)
19 Keratinases
447(24)
D. Kothari
A. Rani
A. Goyal
19.1 Introduction
447(1)
19.2 Sources
448(2)
19.3 Production of Keratinase
450(2)
19.4 Industrial Production Scenario
452(1)
19.5 Purification of Keratinase
453(2)
19.6 Biochemical Characterization of Keratinases
455(2)
19.7 Assays of Keratinase
457(1)
19.8 Strain Improvement Techniques
458(3)
19.9 Conclusions and Perspectives
461(10)
References
461(10)
20 Tannases
471(20)
M.L. Chavez Gonzalez
J. Buenrostro-Figueroa
L. V. Rodriguez Duran
P.A. Zarate
R. Rodriguez
Rosa M. Rodriguez-Jasso
Hector A. Ruiz
Cristobal N. Aguilar
20.1 Introduction
471(1)
20.2 Chemical Structure of Tannins
472(1)
20.3 Methods for Tannases Assay
473(1)
20.4 Production of Tannases
474(6)
20.5 Downstream Processing
480(3)
20.6 Scientific and Technological Perspectives
483(1)
20.7 Conclusions
483(8)
References
483(8)
21 Microbial Aminopeptidases
491(18)
A. Nandan
K.M. Nampoothiri
21.1 Introduction
491(1)
21.2 Classification and Nomenclature of Aminopeptidases
492(1)
21.3 Catalytic Mechanism of Aminopeptidases
493(2)
21.4 Localization of Aminopeptidase
495(1)
21.5 Physiological Role of Bacterial Aminopeptidases
496(2)
21.6 Fermentative Production of Aminopeptidases
498(1)
21.7 Commercial Aminopeptidases
499(1)
21.8 Industrial Applications of Aminopeptidases
500(2)
21.9 Conclusions and Perspectives
502(7)
References
503(6)
22 Nattokinases
509(18)
M.G.B. Pagnoncelli
M.J. Fernandes
C. Rodrigues
C.R. Soccol
22.1 Introduction
509(2)
22.2 Fibrinolytic Enzymes
511(2)
22.3 Nattokinase Production
513(4)
22.4 In Vitro and In Vivo Tests
517(2)
22.5 Purification and Characterization
519(1)
22.6 Enzyme Assay
520(1)
22.7 Conclusion and Perspectives
521(6)
References
522(5)
23 Polysaccharide Lyases
527(14)
S. Chakraborty
A. Rani
A. Dhillon
A. Goyal
23.1 Introduction
527(1)
23.2 Sources of Polysaccharide Lyase
528(2)
23.3 Production of Polysaccharide Lyases
530(1)
23.4 Enzyme Assay
530(1)
23.5 Industrial Scenario
531(1)
23.6 Purification and Characterization
531(1)
23.7 Biochemical Characterization of Polysaccharide Lyase
532(1)
23.8 Strain Improvement
533(2)
23.9 Conclusion and Perspectives
535(6)
References
536(5)
Part 2 Organic Acids
541(90)
24 Production and Application of Lactic Acid
543(14)
C. Rodrigues
L.P.S. Vandenberghe
A.L. Woiciechowski
J. de Oliveira
L.A.J. Letti
C.R. Soccol
24.1 Introduction
543(1)
24.2 Production of Lactic Acid
544(3)
24.3 Metabolic Pathways of Lactic Acid Synthesis
547(3)
24.4 Recovery Processes
550(1)
24.5 Demand and Products
551(1)
24.6 Conclusions and Future Perspectives
552(5)
References
553(4)
25 Production and Application of Citric Acid
557(20)
L.P.S. Vandenberghe
C. Rodrigues
J.C. de Carvalho
A.B.P. Medeiros
C.R. Soccol
25.1 Introduction
557(1)
25.2 Production
558(4)
25.3 Metabolic Pathways
562(2)
25.4 Factors Affecting Citric Acid Production
564(4)
25.5 Citric Acid Recovery Processes
568(2)
25.6 Demand and Products
570(1)
25.7 Conclusions and Perspectives
571(6)
References
573(4)
26 Gluconic Add
577(24)
S. Ramachandran
S. Nair
C. Larroche
A. Pandey
26.1 Introduction
577(1)
26.2 History
578(1)
26.3 Properties
579(2)
26.4 Applications
581(1)
26.5 Sources of Gluconic Acid
582(1)
26.6 Glucose Oxidase
582(5)
26.7 Production of Gluconic Acid
587(7)
26.8 Downstream Processing
594(7)
References
595(6)
27 Production and Applications of Succinic Acid
601(30)
R.K. Saxena
S. Saran
J. Isar
R. Kaushik
27.1 Introduction
601(2)
27.2 Market and Companies Involved in Succinic Acid Production
603(2)
27.3 Microorganisms Involved in the Production of Succinic Acid
605(2)
27.4 Synthesis and Enzyme Regulation of Succinic Acid
607(3)
27.5 Estimation of Enzymes Involved in Succinic Acid Production
610(2)
27.6 Enzymatic Regulation of Succinic Acid Production
612(1)
27.7 Production and Regulation of Succinic Acid
613(3)
27.8 Recovery Systems for Succinic Acid
616(5)
27.9 Applications and Uses of Succinic Acid
621(1)
27.10 Conclusions and Perspectives
622(9)
Acknowledgment
624(1)
References
624(7)
Part 3 Biopolymers and Other Products
631(150)
28 Production and Application of Polylactides
633(22)
J. de Oliveira
L.P.S. Vandenberghe
S.F. Zawadzki
C. Rodrigues
J.C. de Carvalho
C.R. Soccol
28.1 Introduction
633(1)
28.2 Properties of Polylactide
634(1)
28.3 Synthesis of Polylactide
635(7)
28.4 Applications of Polylactide
642(4)
28.5 Polylactide Global Market
646(1)
28.6 Conclusion and Perspectives
646(9)
References
647(8)
29 Production of Polyhydroxyalkanoates
655(38)
D. Tan
J. Yin
G.-Q. Chen
29.1 Introduction to Polyhydroxyalkanoates
655(6)
29.2 Applications of Polyhydroxyalkanoates
661(3)
29.3 Laboratory Production of Polyhydroxyalkanoates
664(11)
29.4 Industrial Production of Polyhydroxyalkanoates
675(5)
29.5 Open and Continuous Production of Polyhydroxyalkanoates by Halophilic Microorganisms
680(2)
29.6 Extraction and Purification of Polyhydroxyalkanoates
682(1)
29.7 Conclusions
683(10)
References
684(9)
30 Production and Application of Poly-γ-glutamic Acid
693(26)
Q. Wang
X. Wei
S. Chen
30.1 Introduction
693(1)
30.2 Poly-γ-glutamic Acid Biosynthesis by Microorganisms
693(5)
30.3 Fermentative Production of Poly-γ-glutamic Acid
698(5)
30.4 Purification and Characterization of Poly-γ-glutamic Acid
703(3)
30.5 Applications of Poly-γ-glutamic Acid
706(5)
30.6 Conclusions and Perspectives
711(8)
References
712(7)
31 Production and Applications of 1,3-Propanediol
719(20)
N. Vivek
A. Pandey
P. Binod
31.1 Introduction
719(1)
31.2 Properties of 1,3-Propanediol
720(1)
31.3 Substrates and Cosubstrates for 1,3-Propanediol Production
720(1)
31.4 Chemical Synthesis of 1,3-Propanediol
720(1)
31.5 Biological Production of 1,3-Propanediol
721(10)
31.6 Downstream Process
731(1)
31.7 Problems in Biotransformation
732(1)
31.8 Applications of 1,3-Propandiol
733(1)
31.9 Conclusions and Perspectives
733(6)
Acknowledgments
734(1)
References
734(5)
32 Biodegradation of Biopolymers
739(18)
N.R. Nair
V.C. Sekhar
K.M. Nampoothiri
A. Pandey
32.1 Introduction
739(1)
32.2 Types of Biopolymers
740(1)
32.3 Mechanisms Involved and Factors Affecting Biodegradability
741(1)
32.4 Biodiversity of Biopolymer-Degrading Microorganisms
742(1)
32.5 Biodegradation of Bio-Based Plastics
742(1)
32.6 Starch-Based Polymers
743(2)
32.7 Cellulose-Based Polymers
745(1)
32.8 Aliphatic Polyesters of Microbial Origin
745(2)
32.9 Polymers From Bio-Derived Monomers: Polylactic Acid
747(1)
32.10 Polymers From Petrochemical Products
748(3)
32.11 Conclusion and Future Perspectives
751(6)
References
751(6)
33 Production of Fungal Spores for Biological Control
757(24)
F. Miranda-Hernandez
A. Angel-Cuapio
O. Loera-Corral
33.1 Introduction
757(1)
33.2 Insect Pests and Their Effects on Agricultural Production
757(1)
33.3 Chemical Pesticides
758(1)
33.4 Current Alternatives for Pest Control
758(1)
33.5 Biological Control: Concept and Agents
759(1)
33.6 Entomopathogenic Fungi
760(4)
33.7 Substrates Used to Produce Entomopathogenic Fungi
764(3)
33.8 Production Types
767(3)
33.9 Quality Evaluation
770(3)
33.10 Unsolved Problems and Perspectives
773(8)
References
773(8)
Part 4 Products Isolation and Purification
781(42)
34 Approaches for the Isolation and Purification of Fermentation Products
783(24)
J.C. de Carvalho
A.B.P. Medeiros
L.P.S. Vandenberghe
A.I. Magalhaes
C.R. Soccol
34.1 Introduction
783(3)
34.2 From Molecule Properties to Process Selection
786(1)
34.3 Separation Principles
786(2)
34.4 Process Development for Bioseparations
788(1)
34.5 Typical Separation Steps for Selected Classes of Biomolecules
789(1)
34.6 Alternative Separations
789(2)
34.7 Sizing Guide for Operations
791(9)
34.8 Niche Operations and Single-Use Systems
800(2)
34.9 Selected Guidelines for Process Development
802(1)
34.10 Conclusions and Perspectives
803(4)
References
804(3)
35 Cell Disruption and Isolation of Intracellular Products
807(16)
J.C. de Carvalho
A.B.P. Medeiros
L.A.J. Letti
P.C.S. Kirnev
C.R. Soccol
35.1 Introduction
807(1)
35.2 Cell Disruption Methods
808(9)
35.3 Choosing Cell-Disruption Equipment
817(1)
35.4 Selected Microorganisms and Disruption Conditions
817(2)
35.5 Product Isolation Rationale
819(1)
35.6 Conclusions and Future Perspectives
820(3)
Acknowledgments
820(1)
References
820(3)
Index 823
Prof. Ashok Pandey is currently Executive Director, Centre for Energy and Environmental Sustainability-India, Lucknow. His major research and technological development interests are industrial and environmental biotechnology and energy biosciences, focusing on biomass to biofuels and chemicals, waste to wealth and energy, etc.

Dr Sangeeta Negi is Assistant Professor in the Department of Biotechnology at the Motilal Nehru National Institute of Technology, India. She has a first class Masters degree in Biochemistry and a PhD in Biotechnology from the Indian Institute of Technology, Kharagpur. She has also worked as an academic guest at the Biological Engineering Department; Polytech Clermont-Ferrand; Universite Baise Pascal, France; and at the Bioenergy and Energy Planning Research Group (BPE); Swiss Federal Institute of Technology, Lausanne (EPFL) Switzerland. Dr Negis current research interests are in the area of biofuels, industrial enzymes, and bioremediation. She is an editorial board member of the Journal of Waste Conversion, Bioproducts and Biotechnology, and Journal of Environmental Science and Sustainability. She has been awarded as "Outstanding reviewer" by Elsevier and has won the Young Scientist Award by DST at the National Seminar on Biological and Alternative Energies Present and Future organized by Andhra University, Visakhapatnam in 2009. She has also won Best Poster Award at the International Congress on Bioprocesses in Food Industries (ICBF 2008) at Hyderabad. Dr Negi has contributed to nearly 50 publications, including review articles, original papers, and conference communications. Professor Carlos Ricardo Soccol is the research group leader of DEBB (Department of Bioprocess Engineering and Biotechnology) at the Federal University of Paranį, Brazil, with twenty years of experience in biotechnological research and development of bioprocesses with industrial application. He is graduated in Chemical Engineering (UFPR, 1979), Master in Food Technology (UFPR, 1986) and Ph.D. in Genie Enzymatique, Microbiologie et Bioconversion (Université de Technologie de Compičgne,- France, 1992). Postdoctor at Institut ORSTOM/IRD (Montpellier, 1994 and 1997) and at the Université de Provence et de la Méditerranée (Marseille, 2000). He is HDR Professor at Ecole d'Ingénieurs Supériure of Luminy, Marseille-France. He has experience in the areas of Science and Food Technology, with emphasis on Agro-industrial and Agroalimentary Biotechnology, acting in the following areas: bioprocess engineering and solid state fermentation, submerged fermentation, bioseparations, industrial bioprocesses, enzyme technology, tissue culture, bio-industrial projects and bioproduction. He is currently Coordinator of Master BIODEV-UNESCO, Associate Editor of five international journals and Editor in Chief of Brazilian Archives of Biology and Technology Journal. Professor Soccol received several national and international awards which include Science & Technology award of the Govt. of Paranį (1996), Scopus/Elsevier award (2009), Dr. Honoris Causa, University Blaise Pascal-France (2010), Outstanding Scientist 5th International Conference on Industrial Bioprocesses, Taipei, Taiwan (2012), Elected Titular Member of the Brazilian Academy of Sciences (2014). He is a technical and scientific consultant of several companies, agencies and scientific journals in Brazil and abroad. He has supervised and formed 96 Master Science students, 48 PhD students and 14 Post-Doctorate Students. He has 995 publications/communications which include 17 books, 107 book chapters, 270 original research papers, 557 research communications in international and national conferences and has registered 44 patents. His research articles until the moment were cited (Scopus DataBase) 5600 Times with Index h=36.
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