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E-grāmata: Cutaneous Lymphoid Proliferations: A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin

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(Harvard Medical School, Boston, MA, USA), (University of Oklahoma and Regional Medical Laboratory, Tulsa, OK, USA), (Department of Pathology, Cornell University, New York, NY, USA)
  • Formāts: PDF+DRM
  • Izdošanas datums: 07-Dec-2015
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781118776520
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Cutaneous Lymphoid Proliferations: A Comprehensive Textbook of Lymphocytic Infiltrates of the SkinPalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 07-Dec-2015
  • Izdevniecība: Wiley-Blackwell
  • Valoda: eng
  • ISBN-13: 9781118776520
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A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease.

  • Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin
  • Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing   the immunohistochemica nd molecular aspects of lymphoid neoplasia. 
  • Each chapter contains an extensive array of  ‘clinical vignettes’ clearly showing the application of principles and treatment techniques discussed in the chapter
  • Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the  interplay between the immune system in  the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail.
  • Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition
Acknowledgments viii
1 Introduction to the Classification of Lymphoma 1(13)
Kiel Lukes-Collins
Working Formulation classifications
1(1)
WHO, REAL, EORTC, the Combined WHO/EORTC classifications
2(5)
Summary
7(1)
References
8(1)
Appendix: Definitions of key terms and techniques
9(5)
2 The Therapy of Cutaneous T Cell Lymphoma 14(9)
Benjamin H. Kaffenberger
Mark A. Bechtel
Pierluigi Porcu
Introduction
14(1)
Diagnostic work-up and staging procedures
14(1)
CTCL therapies
15(1)
Goals of therapy in advanced-stage CTCL
16(1)
Extracorporeal photopheresis (ECP)
17(1)
Interferon
17(1)
Retinoids
17(1)
Immunotoxins
18(1)
Monoclonal antibodies
18(1)
Histone deacetylase inhibitors (HDACi)
19(1)
Antibody drug conjugates (ADC)
19(1)
Cytotoxic chemotherapy
19(1)
Investigational therapies
20(1)
TLR agonists and cytokines
20(1)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
20(1)
References
21(2)
3 Molecular Analysis in Cutaneous Lymphoid Proliferation 23(14)
Shabnam Momtahen
Cynthia Magro
Carl Morrison
Introduction
23(1)
Immunoglobulin and T cell receptor structure
23(1)
PCR design for determination of clonality
24(1)
Detection of PCR products for clonality
24(1)
Evaluation of results
25(1)
The value and utility of molecular diagnostics in primary cutaneous lymphomas
26(1)
Limitations of clonality assessment by PCR
27(2)
Case vignettes
29(7)
References
36(1)
4 Benign Lymphocytic Infiltrates 37(22)
Introduction
37(1)
Spongiotic and eczematous dermatitis
37(3)
Other spongiotic/eczematous tissue reactions
40(1)
Other causes of subacute eczematous dermatitis
40(2)
Interface dermatitis: cell-poor vacuolar interface dermatitis
42(4)
Interface dermatitis: lichenoid pattern
46(5)
Diffuse and nodular lymphocytic dermal infiltrates without atypia
51(2)
Diffuse and nodular lymphocytic infiltrates associated with autoimmune disease
53(4)
References
57(2)
5 Reactive Lymphomatoid Tissue Reactions Mimicking Cutaneous T and B Cell Lymphoma 59(30)
Lymphomatoid drug eruptions
59(2)
Molecular profile of lymphomatoid drug eruptions
61(1)
Pathogenetic basis of lymphomatoid drug reactions
62(1)
Reactive lymphomatoid lesions encountered in lesions of collagen vascular disease
63(4)
Angiomatous Variants of Pseudolymphoma
67(2)
Case vignettes
69(17)
References
86(3)
6 Precursor Lesions of Cutaneous T Cell Lymphoma 89(45)
Cutaneous T cell lymphoid dyscrasia
89(1)
Large plaque parapsoriasis
90(1)
Hypopigmented interface T cell dyscrasia: a unique indolent T cell dyscrasia
91(1)
Pigmented purpuric dermatosis (PPD)
92(2)
Pityriasis lichenoides
94(2)
Idiopathic erythroderma (pre-Sezary)
96(1)
Syringolymphoid hyperplasia with alopecia
96(1)
Folliculotropic T cell lymphocytosis/pilotropic T cell dyscrasia
97(1)
Idiopathic follicular mucinosis/alopecia mucinosa
98(1)
Keratoderma-like T cell dyscrasia
99(1)
Atypical lymphocytic lobular panniculitis
100(2)
Case vignettes
102(30)
References
132(2)
7 Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin 134(35)
Marginal zone lymphoma
134(6)
Blastic marginal zone lymphoma
140(1)
Epidermotropic marginal zone lymphoma
140(1)
Castleman disease
141(1)
Primary cutaneous plasmacytoma
142(3)
Case vignettes
145(21)
References
166(3)
8 Primary Cutaneous Follicle Center Cell Lymphoma 169(18)
Clinical features
169(1)
Pathology
169(2)
Phenotypic profile
171(1)
Molecular studies
172(1)
Pathogenesis
172(1)
Cytogenetics
172(2)
Case vignettes
174(11)
Additional molecular and cytogenetic study
185(1)
References
186(1)
9 Primary Cutaneous Diffuse Large B-Cell Lymphoma Including the Leg Type and Precursor B Cell Lymphoblastic Lymphoma 187(31)
Primary cutaneous diffuse large B cell lymphoma
187(10)
Systemic diffuse large B cell lymphomas with a propensity to involve the skin
197(3)
Case vignettes
200(10)
Additional light microscopic, phenotypic, molecular, cytogenetic studies
210(5)
References
215(3)
10 Intravascular Lymphoma 218(7)
Clinical features
218(1)
Light microscopic findings
219(1)
Phenotypic profile
219(1)
Molecular and cytogenetic studies
219(1)
Pathogenesis
219(1)
Differential diagnosis
219(1)
Intravascular anaplastic large cell lymphoma
219(1)
Benign intravascular proliferations of histiocytes and reactive T cells
220(1)
Case vignettes
221(3)
References
224(1)
11 Cutaneous Mantle Cell Lymphoma 225(11)
Clinical features
225(1)
Light microscopic findings
225(1)
Phenotypic profile
226(1)
Molecular studies
227(1)
Cytogenetic profile
227(1)
Pathogenesis
227(2)
Case vignettes
229(4)
Additional molecular and cytogenetic studies
233(1)
References
234(2)
12 Mycosis Fungoides and Sezary Syndrome 236(38)
Definition
236(1)
Mycosis fungoides
236(7)
Sezary syndrome and erythrodermic mycosis fungoides
243(8)
Large cell transformation of mycosis fungoides
251(3)
Extracutaneous involvement in mycosis fungoides
254(5)
Case vignettes
259(12)
References
271(3)
13 CD3O-Positive Lymphoproliferative Disorders Including Lymphomatoid Papulosis, Borderline CD3O-Positive Lymphoproliferative Disease, Anaplastic Large Cell Lymphoma, T-Cell-Rich CD3O-Positive Large B Cell Lymphoma 274(38)
Introduction
274(1)
Lymphomatoid papulosis
274(4)
CD8+ lymphomatoid papulosis, including the type D variant
278(1)
Type E lymphomatoid papulosis (Case vignette 15)
278(1)
Borderline CD30-positive lymphoproliferative disorders (type C LYP) (Case vignette 9)
279(1)
Lymphomatoid papulosis with a rearrangement of chromosome 6p25.3
279(1)
Cutaneous anaplastic large cell lymphoma
280(2)
Small cell ALCL
282(1)
Additional unusual histologic variants of anaplastic large cell lymphoma
282(1)
Breast-implant-associated anaplastic large cell lymphoma
282(1)
Intravascular anaplastic large cell lymphoma
282(1)
Sarcomatoid anaplastic large cell lymphoma (Case vignette 14)
283(2)
CD30-positive large B cell lymphoma
285(1)
Case vignettes
286(23)
References
309(3)
14 CD4+ Peripheral T Cell Lymphoma, Not Otherwise Specified, Including Primary Cutaneous Cd4+ Small/ Medium-Sized Pleomorphic T Cell Lymphoma 312(22)
Introduction
312(1)
Primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma
312(1)
CD30-negative large cell T cell lymphoma
313(1)
Cutaneous follicular helper T cell lymphoma
314(1)
Overview of overall prognosis of primary cutaneous peripheral T cell lymphoma, unspecified
315(4)
Evolution of the nomenclature of primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma
319(1)
Case vignettes
320(13)
References
333(1)
15 Subcutaneous Panniculitis-Like T Cell Lymphoma 334(17)
Clinical features
334(2)
Morphology
336(1)
Phenotype
337(1)
Molecular studies
337(1)
Differential diagnosis
337(3)
Case vignettes
340(9)
References
349(2)
16 CD8 T Cell Lymphoproliferative Disease of the Skin 351(26)
Overview
351(1)
Introduction
351(1)
Classification of primary CD8+ cutaneous T cell lymphomas
352(1)
Histomorphology of primary cutaneous CD8+ T cell lymphoma: primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma, CD8+ variants of peripheral T cell lymphoma, NOS, including primary cutaneous CD8+ granulomatous T cell lymphoma
353(1)
CD8 variant of lymphomatoid papulosis and other related CD30-positive T cell lymphoproliferative disorders of CD8 subtype
354(1)
Light microscopic findings
354(1)
Indolent CD8 positive lymphoid proliferation of the face and other body sites including acral surfaces
355(1)
CD8 prolymphocytic leukemia
355(1)
CD8 pseudolymphoma related to underlying HIV disease
356(1)
Drug-associated CD8+ pseudolymphoma
356(1)
Actinic reticuloid as a unique form of CD8+ pseudolymphoma
356(1)
Case vignettes
357(18)
References
375(2)
17 Nasal and Related Extranodal Natural Killer Cell/T Cell Lymphomas and Blastic Plasmacytoid Dendritic Cell Neoplasm 377(27)
Introduction
377(1)
Biology of NK and NK-like T cells
377(2)
NK/T-cell lymphoma
379(1)
Nasal NK/T cell lymphoma
379(1)
Nasal type NK/T cell lymphoma
380(1)
Aggressive NK cell lymphoma
380(2)
Role of Epstein-Barr virus in the evolution of NK/T cell lymphomas
382(1)
Blastic plasmacytoid dendritic cell neoplasm
382(1)
CD56-positive γ δ lymphoma involving the subcutaneous fat
383(1)
Chronic granular lymphocytosis/large granular cell leukemia
384(1)
Natural killer-like CD4+ T cell lymphoma
384(1)
EBV-associated NK/T cell lymphomas of the elderly
385(1)
Hydroa vaccineforme (HV)-like lymphoma
385(1)
Cutaneous intravascular NK T cell lymphoma
386(1)
Case vignettes
387(14)
References
401(3)
18 Primary Cutaneous γ δ T Cell Lymphoma 404(11)
Introduction
404(5)
Case vignettes
409(2)
Additional supplemental figures
411(3)
References
414(1)
19 Epstein-Barr Virus-Associated Lymphoproliferative Disease 415(20)
Introduction
415(1)
Hydroa vacciniforme-like EBV-associated T cell lymphoproliferative disease/mosquito bite hypersensitivity
416(4)
EBV+ cutaneous B cell lymphoproliferative disorder of the elderly
420(1)
EBV-associated mucocutaneous ulcer
421(1)
EBV + T cell lymphoproliferative disease of the elderly
421(1)
General principles regarding EBV-associated lymphomagenesis
421(1)
Pathogenetic link between EBV-associated B cell lymphoma and iatrogenic immune dysregulation related to either methotrexate or cyclosporine
421(2)
Case vignettes
423(9)
References
432(3)
20 Hodgkin Lymphoma of the Skin 435(14)
Clinical features
435(1)
Subtypes of Hodgkin lymphoma
436(11)
References
447(2)
21 Chronic Lymphocytic Leukemia of B Cell and T Cell Prolymphocytic Leukemia 449(24)
B cell chronic lymphocytic leukemia
449(3)
T cell prolymphocytic leukemia
452(3)
Case vignettes
455(16)
References
471(2)
22 Adult T Cell Leukemia/Lymphoma 473(13)
Clinical features
473(1)
Pathology
474(1)
Phenotypic studies
475(1)
Pathogenesis
475(1)
Infective dermatitis of childhood
476(1)
Case vignettes
477(7)
References
484(2)
23 Angioimmunoblastic Lymphadenopathy/Angioimmunoblastic T Cell Lymphoma 486(13)
Clinical features
486(1)
Light microscopic findings
487(1)
Phenotypic studies
488(1)
Molecular studies
488(1)
Pathogenesis
489(2)
Case vignettes
491(6)
References
497(2)
24 Lymphomatoid Granulomatosis 499(8)
Introduction
499(1)
Clinical features
499(1)
Histopathology
500(1)
Histogenesis
501(1)
Clonality studies
501(1)
Differential diagnosis
501(1)
Treatment
502(1)
Case vignette
503(3)
References
506(1)
25 Cutaneous Infiltrates of Myeloid Derivation 507(34)
Introduction
507(1)
Leukemia cutis
507(2)
Clonal histiocytopathy syndromes
509(5)
Histiocytopathy of factor XIIIA perivascular dermal dendritic cell origin
514(3)
Case vignettes
517(20)
References
537(4)
Index 541
Cynthia M. Magro MD Professor of Pathology and Laboratory Medicine Department of Pathology, Cornell University Weill Cornell Medicine New York, NY, USA

A. Neil Crowson MD Clinical Professor of Dermatology, Pathology, and Surgery Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory President of Pathology Laboratory Associates Tulsa, OK, USA

Martin C. Mihm MD Clinical Professor of Pathology and Dermatology, Harvard Medical School Director of Melanoma Program, Dermatology, Brigham and Womens Hospital Co-Director of Melanoma Program, Dana-Farber and Brigham and Womens Cancer Center Director, Mihm Cutaneous Pathology Consultative Service Brigham and Womens Hospital Boston, MA, USA
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